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Park, Subin,Lee, Yeeun,Jun, Jin Yong Elsevier/North Holland Biomedical Press 2017 Psychiatry research Vol.257 No.-
<P><B>Abstract</B></P> <P>North Korean adolescent defectors experience adaptation difficulties along with a wide range of psychosocial problems, but no study has yet examined their Internet addiction symptoms. We compared early traumatic experiences, self-esteem, negative cognition, and Internet addiction symptoms, as well as the relationships between these variables, between North Korean adolescent defectors and South Korean adolescents. Fifty-six North Korean adolescent defectors and 112 age- and sex- matched South Korean adolescents participated. The analyses examined the relationship between traumatic experiences and Internet addiction symptoms, with negative automatic thoughts or low self-esteem as mediators of these relations. North Korean adolescent defectors tended to have higher levels of negative automatic thoughts and more severe Internet addiction symptoms, as well as better self-esteem, than did South Korean adolescents. Furthermore, only among North Korean adolescent defectors, traumatic experiences were positively associated with Internet addition symptoms via increasing negative automatic thoughts. North Korean adolescent defectors are more susceptible to Internet addiction, negative cognitions, and early traumatic experiences compared to South Korean adolescents. However, the cross-sectional design of this study precludes consideration of the causality of these relationships. Interventions aiming to correct negative cognitions and increase self-esteem may be helpful for North Korean adolescent defectors with problematic Internet use.</P> <P><B>Highlights</B></P> <P> <UL> <LI> North Korean adolescent defectors had higher trauma and Internet addiction (IA). </LI> <LI> North Korean defectors also had greater self-esteem and negative automatic thoughts. </LI> <LI> Self-esteem and negative thoughts were mediators in the relation of trauma and IA. </LI> <LI> Country of origin (North vs. South Korea) moderated the mediating effects. </LI> </UL> </P>
Clinical outcomes of low-dose aspirin administration in patients with variant angina pectoris
Kim, M.C.,Ahn, Y.,Park, K.H.,Sim, D.S.,Yoon, N.S.,Yoon, H.J.,Kim, K.H.,Hong, Y.J.,Park, H.W.,Kim, J.H.,Jeong, M.H.,Cho, J.G.,Park, J.C.,Kang, J.C. Elsevier/North-Holland Biomedical Press 2013 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.167 No.5
Choi, S.H.,Jung, S.Y.,Yoo, S.M.,Asahara, T.,Suh, W.,Kwon, S.M.,Baek, S.H. Elsevier/North-Holland Biomedical Press 2013 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.168 No.1
Background: Stem cells have a low expansion rate and are difficult to maintain in vitro. To overcome the problems of cardiovascular regeneration, we developed a novel method of stem cell cultivation in culture vessels with amine and carboxyl coatings. Methods and results: We isolated cardiac stem/progenitor cells from infant-derived heart tissue by using c-kit antibody (human cardiac-derived c-kit positive progenitor cells; hCPC<SUP>c-kit+</SUP>); the cells differentiated into endothelial cells, smooth muscle cells, and cardiomyocytes. To characterize the effect of surface modification on hCPC<SUP>c-kit+</SUP> expansion, cellular attachment, c-kit expression maintenance, and cardiomyocyte differentiation, we tested hCPC<SUP>c-kit+</SUP> cultured on non-coated (control), amine-coated (amine), and carboxyl-coated (carboxyl) vessels. Ex vivo proliferation, c-kit maintenance, and cellular attachment were significantly enhanced in the amine group. The amine coating also increased procollagen type I (pro-COL1) expression and increased phosphorylation signals, such as focal adhesion kinase (FAK) and cytosolic Src, as well as enhanced ERK/CDK2 signaling. In addition, there was significant downregulation of the stress signal transducer, JNK, in the amine group. However, cardiomyogenesis remained unchanged in the control, amine, and carboxyl groups. Conclusions: Although surface modifications had no effect on early induction cardiomyogenesis, amine-enriched surface modification may increase hCPC<SUP>c-kit+</SUP> expansion. The amine-enriched surface improved cellular proliferation and attachment during ex vivo hCPC<SUP>c-kit+</SUP> expansion, possibly by modulating intracellular signal transducers.
Park, J.,Shim, J.,Uhm, J.S.,Joung, B.,Lee, M.H.,Pak, H.N. Elsevier/North-Holland Biomedical Press 2013 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.168 No.3
Background: Electro-anatomical remodeling of the atria has been reported to be associated with sinus node dysfunction in patients with atrial fibrillation (AF). We hypothesized that post-shock sinus node recovery time (PS-SNRT: the time from cardioversion to the earliest sinus node activation) is related to the degree of left atrial (LA) remodeling and the clinical outcome of radiofrequency catheter ablation (RFCA) in patients with longstanding persistent AF (L-PeAF). Methods and results: We included 117 patients with L-PeAF (82.0% males, 55.4+/-10.7years old) who underwent RFCA. PS-SNRTs were measured after internal cardioversion (serial shocks 2, 3, 5, 7, 10, and 15J) before RFCA. All patients underwent the same ablation design, and we compared regional LA volume (3D-CT imaging) and LA voltage (NavX). Results: 1. During the 13.5+/-5.8-month follow-up period, it was noted that the patients with recurrent AF 3months after RFCA (n=31) had longer PS-SNRTs (1622.90+/-1196.92ms vs. 1112.53+/-690.68ms, p=0.005) and greater anterior LA volume (p=0.032) than those who remained in sinus rhythm. 2. The patients with PS-SNRT ≥1100ms showed lower AF-free rates (58.3%) compared to those with PS-SNRT <1100ms (89.5%, p<0.001). However, shock energy, number of cardioversion, and LA volume were not different between two groups. 3. Multivariate Cox regression analysis demonstrated PS-SNRT ≥1100ms was a significant predictor of clinical recurrence of AF (HR 5.426, 95% CI 2.099-14.028, p<0.001). Conclusion: In patients with L-PeAF, prolonged PS-SNRT is an independent predictor of clinical recurrence of AF after RFCA, but not closely associated with electro-anatomical remodeling of LA.
Lee, S.H.,Moon, S.J.,Park, M.J.,Kim, E.K.,Moon, Y.M.,Cho, M.L. Elsevier/North-Holland Biomedical Press 2014 IMMUNOLOGY LETTERS Vol.160 No.1
Graft-versus-host disease (GVHD) caused by transplanted donor T cells remains the major obstacle of allogeneic bone marrow transplantation (BMT). Previous reports have suggested that IL-17-producing helper T (Th17) cells mediate the development of acute GVHD (aGVHD). Protein inhibitor of activated STAT3 (PIAS) inhibits the activity of the transcription factor STAT3, which is a pivotal transcription factor for Th17 differentiation. To elucidate whether PIAS3 could inhibit the development of aGVHD, pcDNA-PIAS3 or mock vector was administered in a murine model of aGVHD by intramuscular injection and subsequent electroporation. The results demonstrated that PIAS3 overexpression by pcDNA-vector administration significantly attenuated the clinical severity and histopathological severities of aGHVD involving the skin, liver, intestine, and lung. Additionally, the STAT3 activities in aGVHD target organs were suppressed by PIAS3 overexpression. Furthermore, phosphorylated (p) STAT3 activity in the spleen was profoundly attenuated in PIAS3-overexpressing GVHD mice. Interestingly, flow cytometric analysis demonstrated that the populations of CD21<SUP>high</SUP>CD23<SUP>low</SUP> marginal zone B cells were dramatically expanded in PIAS3-overexpressing mice. PIAS3-induced inhibition of aGVHD was largely related to the downregulation of Th1 and Th17 and the upregulation of Th2 and Treg populations. Both populations of pSTAT3<SUP>Tyr705</SUP>-expressing Th17 cells and B cells were significantly reduced in the spleens of PIAS3-overexpressing mice, whereas pSTAT5 activity was increased. In addition to CD4<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells, the populations of CD8<SUP>+</SUP>CD25<SUP>+</SUP>Foxp3<SUP>+</SUP> Treg cells were also expanded by treatment with PIAS3. These data suggest the therapeutic potential of PIAS3 in the development of aGVHD through reciprocal regulation of Th17/Treg lineages.
Novel self-expandable, stent-based transcatheter pulmonic valve: A preclinical animal study
Kim, G.B.,Lim, H.G.,Kim, Y.J.,Choi, E.Y.,Kwon, B.S.,Jeong, S. Elsevier/North-Holland Biomedical Press 2014 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.173 No.1
Background: Because transcatheter implantation of pulmonary valve is indicated for limited-size dysfunctional right ventricular outflow tract only as a balloon-expandable stent, we investigated the feasibility of a large-diameter self-expandable valved stent and the durability of the valve after >6months. Methods: We made a nitinol-wire-based, self-expandable valved stent with leaflets made from porcine pericardium. The porcine pericardium was treated with α-galactosidase, glutaraldehyde, and glycine after decellularization. After cutting the inguinal or cervical area, we implanted a valved stent in 12 sheep through the femoral or jugular vein by using an 18-Fr delivery catheter, controlling the catheter handles and hook block under fluoroscopic and echocardiographic guidance. Results: The mean body weight of sheep was 43.9kg. We successfully implanted valved stents (diameter: 24mm in 7 sheep, 26mm in 5 sheep) in good position in 8 sheep, in the main pulmonary artery (PA) in 2 sheep, and in the right ventricular outlet tract (RVOT) in 2 sheep. We sacrificed 8 sheep (6 sheep in good position, 1 sheep in the main PA, and 1 sheep in the RVOT) after >6months. Five of the 6 sheep implanted in good position showed well-preserved valve morphology at the time of sacrifice. Histologic findings after routine sacrifice showed well-maintained collagen wave structure and no visible calcification in all explanted valve leaflets. Conclusions: Transcatheter implantation of a nitinol-wire-based, self-expandable valved stent in the pulmonic valve was feasible, and stents implanted in good position showed well-preserved valve leaflets with functional competence in the mid-term results.
Ha, C.H.,Kim, S.,Chung, J.,An, S.H.,Kwon, K. Elsevier/North-Holland Biomedical Press 2013 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.168 No.4
Background: Extracorporeal shock wave has been used in the noninvasive treatment of various diseases including musculoskeletal disorders. In particular, shock wave with low energy level showed anti-inflammatory effect and increased angiogenesis in ischemic tissues. However, the detailed cellular pathway in endothelial signaling is not fully understood. We investigate the role of shock wave with low energy level in angiogenic gene expression and underlying molecular mechanism by comparing the laminar and oscillatory fluid shear stresses in endothelial cells. Methods and results: We show that shock wave with low energy level (0.012-0.045mJ/mm<SUP>2</SUP>) stimulated phosphorylation of Akt, eNOS and Erk ½ in a time-dependent manner which is similar to the effect of laminar fluid shear stress. The transfection of endothelial cells with siRNA encoding VEGFR2, VE-cadherin and PECAM-1 inhibited shock wave-induced phosphorylation of Akt, eNOS and Erk ½ and angiogenic gene expressions, including Akt, eNOS, KLF2/4, and Nur77. Moreover, mechanical stimulation through extracorporeal shock wave induced endothelial cell migration and tube formation. Conclusions: Our results demonstrate that shock wave-induced Akt/eNOS phosphorylation and angiogenic gene expression were mediated through the mechanosensory complex formation involving VEGFR-2, VE-cadherin and PECAM-1 which was similar to the effect of laminar shear stress.
Predictors of recurrent sudden cardiac death in patients associated with coronary vasospasm
Lee, K.H.,Park, H.W.,Cho, J.G.,Yoon, N.S.,Kim, S.S.,Rhew, S.H.,Jeong, Y.W.,Jang, S.Y.,Cho, J.Y.,Jeong, H.C.,Park, K.H.,Sim, D.S.,Yoon, H.J.,Kim, K.H.,Hong, Y.J.,Kim, J.H.,Ahn, Y.,Jeong, M.H.,Park, J.C Elsevier/North-Holland Biomedical Press 2014 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.172 No.2