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Kim Ye-Seul,Choi Jae-Woong,Song Sang Hoon,Hwang Ho Young,Sohn Suk Ho,Kim Ji Seong,Kang Yoonjin,Gu Ja-Yoon,Kim Kyung-Hwan,Kim Hyun Kyung 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.4
Background: Point-of-care testing (POCT) coagulometers are increasingly used for monitoring warfarin therapy. However, in high international normalized ratio (INR) ranges, significant discrepancy in the INR between POCT and conventional laboratory tests occurs. We compared the INR of POCT (CoaguChek XS Plus; Roche Diagnostics, Mannheim, Germany) with that of a conventional laboratory test (ACL TOP 750; Instrumentation Laboratory SpA, Milan, Italy) and explored possible reasons for discrepancy. Methods: Paired POCT and conventional laboratory test INRs were analyzed in 400 samples from 126 patients undergoing warfarin therapy after cardiac surgery. Coagulation factor and thrombin generation tests were compared using the Mann–Whitney U test. Correlations between coagulation factors and INRs were determined using Pearson correlation coefficients. Results: The mean difference in the INR between the tests increased at high INR ranges. Endogenous thrombin potential levels were decreased at INR <2.0 for CoaguChek XS Plus and 2.0< INR <3.0 for ACL TOP 750 compared with those at INR <2.0 for both tests, indicating a better performance of ACL TOP 750 in assessing thrombin changes. The correlation coefficients of coagulation factors were stronger for ACL TOP 750 INR than for CoaguChek XS Plus INR. Vitamin K-dependent coagulation factors were found to contribute to the INR discrepancy. Conclusions: Decreases in vitamin K-dependent coagulation and anticoagulation factors can explain the significant discrepancy between the two tests in high INR ranges. Since conventional laboratory test INR values are more reliable than POCT INR values, a confirmatory conventional laboratory test is required for high INR ranges.
Persistence of Genetically Modified Potatoes in the Field
Kim, Chang-Gi,Kim, Do-Young,Moon, Ye-Seul,Kim, Hyo-Jeong,Kim, Dae-In,Chun, Young-Jin,Park, Kee-Woong,Jeong, Soon-Chun,Kim, Soo-Young,Kim, Hwan-Mook 한국식물학회 2010 Journal of Plant Biology Vol.53 No.6
Volunteers from genetically modified (GM) potatoes may pose an environmental problemif allowed to grow in the field after the annual crop is harvested. We tested whether they are more likely to produce volunteers than non-GM potatoes. Specifically, we compared the number of volunteers, number of tubers per plant, tuber size, and their vertical distribution in the soil. More volunteer plants came from non-GM potatoes than from GM potatoes, but the number and size of tubers were similar between the two. Vertical distribution of the tubers differed significantly, with most non-GM tubers being found in shallower soil (<2 cm deep). Our results suggest that spontaneous GM volunteers may emerge and produce tubers to a degree similar to that of the non-GM plants. No viable volunteers emerged from GM tubers in the next growing season, probably deterred by winter frost and a period of low soil temperatures (below $-2^{\circ}C$) at our study site. However, in regions with warmer climates, such GM volunteers may survive Winter and produce more plants the following year.
Kim Ye Seul,Yoon Jung Won,Kim Dasol,Choi Seunghak,Kim Hyoung Kyu,Youm Jae Boum,Han Jin,Heo Soon Chul,Hyun Sung-Ae,Seo Jung-Wook,Kim Deok-Ho,Kim Jae Ho 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been reported to exhibit immature embryonic or fetal cardiomyocyte-like phenotypes. To enhance the maturation of hESC-CMs, we identified a natural steroidal alkaloid, tomatidine, as a new substance that stimulates the maturation of hESC-CMs. Treatment of human embryonic stem cells with tomatidine during cardiomyocyte differentiation stimulated the expression of several cardiomyocyte-specific markers and increased the density of T-tubules. Furthermore, tomatidine treatment augmented the number and size of mitochondria and enhanced the formation of mitochondrial lamellar cristae. Tomatidine treatment stimulated mitochondrial functions, including mitochondrial membrane potential, oxidative phosphorylation, and ATP production, in hESC-CMs. Tomatidine-treated hESC-CMs were more sensitive to doxorubicin-induced cardiotoxicity than the control cells. In conclusion, the present study suggests that tomatidine promotes the differentiation of stem cells to adult cardiomyocytes by accelerating mitochondrial biogenesis and maturation and that tomatidine-treated mature hESC-CMs can be used for cardiotoxicity screening and cardiac disease modeling.
Construction of Science Museum Platform for Sharing and Exchange of Insects Exhibit Contents
Ye-Seul Kim,Da-Som Kim,Ju-Hee Lee,Se Ryeong Lee,Bong-Kyu Byun 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04
국내 과학관 수는 지난 10여년 동안 양적으로는 팽창하고 있으나, 대부분이 중소규모의 과학관으로 인력부족 및 과학전시 컨텐츠 부족에 따라 운영에 어려움을 겪고 있다. 이에 따라 과학관이 보유하고 있는 전시 컨텐츠의 DB구축 및 정보 공유를 통해 과학관간 상호 교환 및 교류를 촉진할 수 있는 과학관 전시 플랫폼 구축이 요구되고 있는 실정이다. 국외 선진 과학관의 경우 자연사 컨텐츠의 전산화 및 DB 구축을 통해 대국민 검색서비스를 제공하여 전시품 등을 다양하게 활용하고 있는 추세이다. 따라서 본 연구에서는 과학관에서 활용가능한 자연사 컨텐츠 중, 곤충을 중심으로 이들의 전시 컨텐츠 발굴 및 DB확보 현황과 향후 플랫폼 구축 계획에 대해 소개하고자 한다.
Ustekinumab, an effective therapeutic option for erythrodermic psoriasis
( Ye Seul Kim ),( Ga Hee Jung ),( Je Min An ),( Kyu Uang Whang ),( Jong Suk Lee ),( Young Lip Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Erythrodermic psoriasis is a severe form of psoriasis, presenting as prominent erythema, affecting the whole body. Ustekinumab (Stelara®) is a human monoclonal antibody targeting the p40 subunit shared by interleukin IL-12 and IL-23. Erythrodermic psoriasis has been an exclusion criteria in studies looking at the efficacy of ustekinumab against psoriasis, but recently, a few reports have proven its efficacy on erythrodermic psoriasis. Herein, we report 2 cases of erythrodermic psoriasis that successfully improved with ustekinumab. A 42-year-old man presented with a 7-year history of erythrodermic psoriasis and psoriatic arthritis. The patient was treated with ustekinumab 45 mg subcutaneously at 0, week 4, and every 12 weeks thereafter. At week 28, his Psoriasis Areaand Severity Index (PASI) score decreased from 64.8 to 9.6. The second case is a 26-year-old man suffering from erythrodermic psoriasis for 10 years. Four months after the first administration of ustekinumab, the patient achieved 75% improvement of the PASI score and 90% improvement after 112 weeks. Although further studies are required, it is likely that ustekinumab can be an effective therapeutic option for patients affected by erythrodermic psoriasis.