SSiCP : a new SVM based Recursive Feature Elimination Algorithm for Multiclass Cancer Classification

Xiaobo Li,Xue Gong,Xiaoning Peng,Sihua Peng 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.6

Security Model for Sensitive Information Systems and Its Applications in Sensor Networks

Tianbo Lu,Xiaobo Guo,Lingling Zhao,Yang Li,Peng Lin,Binxing Fang 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.5

The study of security models for sensitive information systems has been taken on for years, but still lag far away behind the progress of information security practice. During this century, the thought of seeking the system security to the source of system development lifecycle received huge improvement in the system and software assurance domain. This paper firstly expounds the understanding of information security by illustrating information security study development progress since pre-computer age and presents a description of cyberspace and cyberization security by summarizing the status quo of cyberization. Then a security model called PDRL, which includes six core security attributes of sensitive information systems, is proposed to protect the security of sensitive information systems in the whole system life-cycle. At last, this paper probes into further discussion about controllability attribute and proposes a controllability model in sensitive sensor networks, followed by a probability computing formula and the example for computing the controllability of sensitive sensor networks. By dividing each single element of sensitive information and each element-related operation into a corresponding classification, this paper makes a reasonable description of the quantitative description about controllability.

3.2-kW 9.7-GHz Polarization-maintaining Narrow-linewidth All-fiber Amplifier

Hang Liu,Yujun Feng,Xiaobo Yang,Yao Wang,Hongming Yu,Jue Wang,Wanjing Peng,Yanshan Wang,Yinhong Sun,Yi Ma,Qingsong Gao,Chun Tang 한국광학회 2024 Current Optics and Photonics Vol.8 No.1

We present a Yb-doped narrow-linewidth polarization-maintaining (PM) all-fiber amplifier that achieves a high mode-instability (MI) threshold, high output power, and 9.7-GHz spectral linewidth. Six wavelength-multiplexed laser diodes are used to pump this amplifier. First, we construct a high-power fiber amplifier based on a master oscillator-power amplifier (MOPA) configuration for experiments. Subsequently, we examine the MI threshold by individually pumping the amplifier with wavelengths of 976, 974, 981, 974, and 981 nm respectively. The experimental results demonstrate that the amplifier exhibits a high MI threshold (>3.5 kW) when pumped with a combination of wavelengths at 974 and 981 nm. Afterward, we inject an optimized phase-modulated seed with a nearly flat-top spectrum into this amplifier. Ultimately, laser output of 3.2 kW and 9.7 GHz are obtained.

Identification of Medium-Length Antineurofilament Autoantibodies in Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Shisi Wang,Cancan Xu,Xiaobo Sun,Yifan Zhou,Yaqing Shu,Shangzhou Xia,Zhengqi Lu,Wei Qiu,Xiaofen Zhong,Lisheng Peng 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.3

Background and Purpose Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe central nervous system disorder mediated by NMDAR antibodies that damages neurons. We investigated the correlation between cytoskeletal autoantibodies and the clinical severity in patients with anti-NMDAR encephalitis. Methods Non-NMDAR autoantibodies were identified by screening matched cerebrospinal fluid (CSF) and the serum samples of 45 consecutive patients with anti-NMDAR encephalitis and 60 healthy individuals against N-methyl-D-aspartate receptor 1-transfected and nontransfected human embryonic kidney 293T cells. Immunocytochemistry was performed to assess antibody binding in rat brain sections and primary cortical neurons. Cell-based assays and Western blotting were applied to identify autoantibodies targeting medium neurofilaments (NFMs). We compared clinical characteristics between patients with NMDAR encephalitis who were positive and negative for anti-NFM-autoantibodies. Results Anti-NFM autoantibodies were detected in both the serum and CSF in one patient (2%) and in the serum only in six patients (13%). No antibodies were detected in the serum of healthy controls (7/45 vs. 0/60, p=0.0016). Four of the seven patients with anti-NFM autoantibodies in serum were children (57%), and three (43%) had abnormalities in brain magnetic resonance imaging. These patients responded well to immunotherapy, and either no significant or only mild disability was observed at the last follow-up. Anti-NMDAR encephalitis did not differ with the presence of anti-NFM autoantibodies. Conclusions Anti-NFM autoantibodies may be present in patients with anti-NMDAR encephalitis, indicating underlying neuronal damage. A large cohort study is warranted to investigate the clinical differences between patients with NMDAR encephalitis according to their anti- NFM antibody status.

Comparative Study of Bioactive Constituents in Crude and Processed Glycyrrhizae radix and Their Respective Metabolic Profiles in Gastrointestinal Tract In Vitro by HPLC-DAD and HPLC-ESI/MS Analyses

Wen-wu Huang,Xiaobo Li,Meng Yue Wang,Hai-ming Shi,Ying Peng,Chong-sheng Peng,Min Zhang,Yue Li,Jing Lu 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.11

Two HPLC methods with diode array detection (HPLC-DAD) and electrospray ionization-mass spectrometry (HPLC-ESI/MS), respectively, were developed to investigate the differences of chemical constituents and their metabolism in gastrointestinal tract in vitro between two decoctions of crude and processed Glycyrrhizae radix. Total of eleven constituents (liquiritin apioside, liquiritin, licuraside, isoliquiritin, ononin, glycyrrhizin, liquiritigenin-7,4'-diglucoside, licorice saponin A3, 22β-acetoxylglycyrrhizic acid, licorice saponin G2, and yunganoside E2) were identified in the two decoctions, whereas lower contents of these constituents were usually found in the decoction of processed G. radix. Furthermore, these constituents were metabolized into their respective aglycons in human intestinal bacteria juice, and the metabolism ratios were all higher in processed G. radix decoction. No change was found in artificial gastric or intestinal juice. This study revealed that the processing can alter the contents of main constituents in crude G. radix and their metabolism in gastrointestinal tract, in which intestinal bacteria play an important role in the metabolism of licorice constituents.

Identification of Novel Subregions of LOH in Gastric Cancer and Analysis of the HIC1 and TOB1 Tumor Suppressor Genes in These Subregions

Jingcui Yu,Songbin Fu,Peng Liu,Xiaobo Cui,Yu Sui,Guohua Ji,Rongwei Guan,Donglin Sun,Wei Ji,Fangli Liu,An Liu,Yuzhen Zhao,Yang Yu,Yan Jin,Jing Bai,Jingshu Geng,Yingwei Xue,Jiping Qi,Ki-Young Lee 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.1

Previously, we identified 3 overlapping regions showing loss of heterozygosity (LOH, R_1-R_3 from 11 to 30 cM) on chromosome 17 in 45 primary gastric cancers (GCs). The data indicated the presence of tumor suppressor genes (TSGs) on chromosome 17 involved in GC. Among the putative TSGs in these regions, HIC1 (in SR_1) and TOB1 (in SR_3) remain to be examined in GC. By immunohistochemistry (IHC), methylation-specific PCR (MSP) and western blot, we evaluated the expression and regulation status for HIC1 and TOB1 protein in GC. We narrowed down the deletion intervals on chromosome 17 and defined five smaller LOH subregions, SR_1-SR_5 (0.54 to 3.42 cM), in GC. We found that HIC1 had downregulated expression in 86% (91/106) and was methylated in 87% (26/30) of primary GCs. Of the primary GCs showing downregulation of HIC1 protein, 75% (18/24) had methylated HIC1 gene. TOB1 was either absent or expressed at reduced levels in 75% (73/97) of the GC samples. In addition, a general reduction was found in total and the ratio of unphosphorylated to phosphorylated TOB1 protein levels in the differentiated GC cell lines. Further analysis revealed significant simultaneous downregulation of both HIC1 and TOB1 protein in GC tissue microarray samples (67%, 52/78) and in primary GCs (65%, 11/17). These results indicate that silencing of HIC1 and TOB1 expression is a common occurrence in GC and may contribute to the development and progression of the disease.

Synthesis and Characterization of Compound Coupling Agent-Modified Hollow Glass Microspheres/Epoxy Composites

Zhaolin Zhu,Yin Liu,Guiyang Xian,Yan Wang,Chongmei Wu,Xiaobo Peng,Lingbing Kong 한국섬유공학회 2023 Fibers and polymers Vol.24 No.9

In this study, hollow glass microsphere/epoxy composites modified with compound coupling agent of titanate (CS201) and silane (KH540) were prepared and characterized. The addition of the compound coupling agent improves the interfacial bonding between the microbeads and the resin matrix. Scanning electron microscopy results indicated that the compound coupling agent can effectively reduce the number of voids between the microbeads and the resin. FTIR and XPS spectra showed that new chemical bonds were formed between the hollow glass microspheres and resin, which enhanced the interfacial bonding between them. By testing the water absorption and mechanical properties of the composites, it found that the addition of the hybrid coupling agent can reduce the water absorption to a minimum level of 1.184%. Due to the improvement of interfacial compatibility, mechanical properties of the composites were enhanced, (with tensile strength of 43.03 MPa, bending strength of 44.56 MPa, bending modulus of 1407 MPa and compressive strength of 81.55 MPa). When the content of the coupling agent was 5% and the volume ratio of CS201 to KH540 was 1:1, the synergistic enhancement effect was the most significant.

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

He, Meian,Xu, Min,Zhang, Ben,Liang, Jun,Chen, Peng,Lee, Jong-Young,Johnson, Todd A.,Li, Huaixing,Yang, Xiaobo,Dai, Juncheng,Liang, Liming,Gui, Lixuan,Qi, Qibin,Huang, Jinyan,Li, Yanping,Adair, Linda S IRL Press 2015 Human molecular genetics Vol.24 No.6

<P>Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at <I>P</I> < 5 × 10<SUP>−8</SUP>, together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.</P>

Effect of compound coupling agent treatment on mechanical property and water absorption of hollow glass microspheres/epoxy composite

Zhaolin Zhu,Yin Liu,Guiyang Xian,Yan Wang,Chongmei Wu,Xiaobo Peng,Jinxiang Wang,Lingbing Kong 한국고분자학회 2023 Macromolecular Research Vol.31 No.8

Hollow glass microspheres (HGMs), as a reinforcing material to prepare lightweight high-performance composites, have excellent mechanical properties. However, the composites prepared by simply mixing hollow glass microspheres with polymer resin have poor performance. In this study, compound coupling agent-modified HGM/EP composites were prepared by casting process with two silane coupling agents as compound coupling agents. Scanning electron microscopy and infrared (IR) spectroscopy were used to characterize the treated HGM. Meanwhile density, water absorption behavior, and mechanical properties of the modified HGM-filled epoxy composites were examined. It is found that the compound coupling agent could effectively improve the interfacial bonding between HGM and the matrix resin. A new chemical bond was formed between HGM and EP, which was confirmed by IR spectroscopy. Compared with their untreated counterparts, the composites treated with the complex coupling agent exhibited excellent mechanical properties, along with lower density and lower water absorption.