SSiCP : a new SVM based Recursive Feature Elimination Algorithm for Multiclass Cancer Classification

Xiaobo Li,Xue Gong,Xiaoning Peng,Sihua Peng 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.6

Caenorhabditis elegans as a useful model to assess the effect of spermiogenesis induced by three teratogens

Yunhui Li,Minhui Zhang,Xiaobo Li,Juan Zhang,Ran Liu,Geyu Liang,Yuepu Pu,Lihong Yin 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.2

Caenorhabditis elegans (C. elegans), with homologous genes and conservative spermiogenesis in mammals, has a series of advantages to illuminate and study many biological processes including reproductive toxicity. So it is a very useful model to assess environmental and ecological toxicity. Here we introduce C. elegans as an animal model and three known mammalian sperm teratogens methyl methanesulfonate, mitomycin C and cyclophosphamide as experimental materials to elucidate the efficient and reliability for the assessment of chemicals altering spermiogenesis. The results showed that, with the aid of the brood size, spermatids activation, trans-activation, sperm competition as the endpoints, the adverse effects of three teratogens on C. elegans were detected. Thus, while the data of chemicals induced spermiogenesis abnormality is incomplete, we speculated that C. elegans could be a useful animal model to explore the effects on spermiogenesis of chemicals. And we propose an increased application of C. elegans that complements other model system in the reproductive toxicity.

Global Finite-time Stabilization for a Class of High-order Nonlinear Systems with Multiple Unknown Control Directions

Jing Li,Jian Wu,Xiguo Yuan,Xiaobo Li,Liefu Ai 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.1

This paper considers the problem of the global finite-time stabilization for the high-order nonlinear systemswith unknown control directions. Due to the uncertainty of control directions, the paper analyzes all possibleconditions of the directions. The Lyapunov-based logic switching rule ensures that we can find the correct controldirections. The adaptive switching controller with a switching parameter which is to be tuned online guarantees thatthe derivative of Lyapunov function is less than a negative definite function and the closed-loop system is globallyfinite-time stable. The effectiveness of the proposed method is illustrated by an example.

Towards an Innovation-driven Nation

Xiaobo Wu,Jing Li 과학기술정책연구원 2015 STI Policy Review Vol.6 No.1

The rise of latecomer countries across the world directs academic attention to their catching-up and innovation processof seizing technological opportunities and combining internal and external knowledge. Different from the developed economies as well as the newly industrialized economies, China presents a special innovation environment, wherein its technology regime, market opportunities, and institutions are complex and the globalization trend affects competition in a broader way. In thiscontext, we clarify and extend the framework of “secondary innovation”. This framework describes the dynamics of those with relatively poor resources and capabilities in their efforts to capture the values of mature/emerging technology or business models by acquiringthem from across borders and then adapting to catching-up contexts. Such processes, differentiated from original innovation that involves the whole process from R&D to commercialization, has become a prevailing regime during paradigm shifts. In particular, unlike the traditional catch-up literature that focuses more on technology, the secondary innovation framework inclusively contains both technology and business model innovation, and puts forward the co-evolution between the two elements, which is more applicable to China’s context. In accordance, we also provide implications towards fulfilling the goal of building an innovation-driven nation.

Melting Cell Based Compensated Design Method for Improving Dimensional Accuracy of Additively Manufactured Thin Channels

Li Sun,Xiaobo Ren,Jianying He,Zhiliang Zhang 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.2

Powder-bed fusion additive manufacturing technology makes it possible to produce parts with complicated geometry and high accuracy. However, dimensional deviation caused by powder overmelting and dross formation is still a challenge for manufacturing thin channels. In this study, the origins of the overmelting of printed thin channels were analyzed and a concept called “melting cell” is proposed to describe and quantify the geometric error. Based on the geometrical relationship between the melting cell and target channel, a method for predicting and optimizing the final geometry of thin channels is outlined. In order to verify the method, geometries of thin horizontal circular channels in various sizes are studied as examples. The predicted results by the proposed method show a remarkable agreement with available experimental results. Moreover, a new egg-shaped compensated design, which is able to improve the dimensional accuracy of thin horizontal circular channels, is presented. The proposed method is simple yet very effective. It can be easily extended to the manufacturing of thin channels with various shapes, materials, and different powder bed fusion processes.

Nonlinear Wave and Currents Loads Analysis of Offshore Wind Turbines

Xiaobo Chen,Jing Li,Jianyun Chen 대한토목학회 2014 KSCE JOURNAL OF CIVIL ENGINEERING Vol.18 No.6

In recent years, the offshore wind energy has increased in popularity due to the demand for renewable energy. Being built in a verydynamic environment, the nonlinear wave and current loads on offshore wind turbines are required to be investigated for design. Thewave and current kinematics were calculated by the model that the wave propagates on a linear shear current which was developedby Dalrymple based on the stream function wave theory. The wave and current loads were calculated based on the Morison equation. For the engineering application purpose, some problems such that the wave and current kinematics models, the wave and currentcombination schemes in statistics, and the free surface’s influences on wave and current loads were discussed. At the end, thenonlinear results were compared with linear results to verify the calculation correctness.

Correlation between red blood cell distribution width/platelet count and prognosis of newly diagnosed diffuse large B-cell lymphoma

Xiaobo Liu,Yanliang Bai,Ying Liu,Weiya Li,Yabin Cui,Jinhui Xu,Xingjun Xiao,Xiaona Niu,Kai Sun 대한혈액학회 2023 Blood Research Vol.58 No.4

Background Red blood cell distribution width/platelet count ratio (RPR) is a reliable prognostic assessment indicator for numerous diseases. However, no studies to date have examined the relationship between RPR and the prognosis of diffuse large B-cell lymphoma (DLBCL). Therefore, this study aimed to investigate the correlation between RPR and the clinical characteristics and prognosis of patients with diffuse large B-cell lymphoma. Methods We retrospectively studied 143 patients with newly diagnosed DLBCL and used the median value as the RPR threshold. We also investigated the correlation of pretreatment RPR level with clinical characteristics and its impact on DLBCL prognosis. Results Using the median value as the cut-off, patients with DLBCL were divided into a low RPR group (<0.0549) and a high RPR group (≥0.0549). Patients in the high RPR group were older, had a later Ann Arbor stage, were prone to bone marrow invasion, and had a higher National Comprehensive Cancer Network International Prognostic Index score (P < 0.05). A survival analysis showed that progression-free survival (PFS) (P =0.003) and overall survival (OS) (P <0.0001) were significantly shorter in the high versus low RPR group. A multifactorial Cox analysis showed that bone marrow invasion and elevated lactate dehydrogenase (LDH) were separate risk factors for PFS (P <0.05), while an RPR ≥0.0549 and elevated LDH were separate risk factors for OS (P <0.05). Conclusion A high RPR (≥0.0549) in patients with newly diagnosed DLBCL is an independent risk factor for a poor prognosis.

Modeling and analysis of a rotational piezoelectric energy harvester with limiters

Xiaobo Rui,Zhoumo Zeng,Yibo Li,Yu Zhang,Zi Yang,Xinjing Huang,Zhou Sha 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.11

A rotational piezoelectric energy harvester has the ability to convert rotation mechanical energy into electric power. The piezoelectric harvester with cantilever based on gravity excitation has received great attention. Given that gravity excitation is greater than conventional vibration excitation, and large mass are often used in low-frequency applications, large amplitudes pose a significant threat to the life of a harvester. In this study, a rotational energy harvester with limiters is investigated to promote practical development. This study establishes a theoretical model verified by experiments. Results show that stiffness has little influence on the limiting effect. In the experimental conditions, the output after 2000 N/m is basically the same. The peak value of the output voltage is linearly proportional to the space. Given that an impact excitation is generated in the collision, the limiter widens the frequency band of the output in the upsweep.

Transcriptome comparison between newly emerged and sexually matured bees of Apis mellifera

Xiaobo Wu,ZilongWang,Hai-Yan Gan,Shu-Yun Li,Zhi Jiang Zeng 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.3

In order to understand the transcriptome characteristics of queens and drones of honeybee Apis mellifera, the transcriptome differences between newly emerged stage and sexually matured stage of queens and drones of A. mellifera L. were compared using high-throughput RNA-Seq. In drones, a total of 1618 DEGs were detected between the two stages. Out of these, 782 geneswere up-regulated and 836 geneswere down-regulated in sexually matured drones compared to newly emerged drones. In queens, the DEGs between the two stages were 1340, with 667 up-regulated and 673 down-regulated genes in matured queens compared to newly emerged queens. 411 genes showed the same expression trend in drones and queens during sexual maturing, with 233 (56.69%) up-regulated genes and 178 (43.31%) down-regulated at newly emerged stage. We found that genes encoding cuticular proteins (CP), cytochrome P450 (CYP), odorant binding proteins (OBP) and odorant receptor (OR), which are related to developments of bones, reproductive system and olfaction system, were differentially expressed between the sexually matured bees and the newly emerged bees. The results indicated that the expression levels of a large number of genes changed during sexual maturing of A. mellifera L. bees, which give us an insight into the characteristics of the gene expression during sexual maturing of adult queens and drones.

Decreasing Global Greenhouse Effects by Biochar Amendment in a Double Rice Field of South China

Xiaobo Qin,Yue Li,Yunfan Wan 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6