http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mechanical response of rockfills in a simulated true triaxial test: A combined FDEM study
Ma, Gang,Chang, Xiao-Lin,Zhou, Wei,Ng, Tang-Tat Techno-Press 2014 Geomechanics & engineering Vol.7 No.3
The study of the mechanical behavior of rockfill materials under three-dimensional loading conditions is a current research focus area. This paper presents a microscale numerical study of rockfill deformation and strength characteristics using the Combined Finite-Discrete Element Method (FDEM). Two features unique to this study are the consideration of irregular particle shapes and particle crushability. A polydisperse assembly of irregular polyhedra was prepared to reproduce the mechanical behavior of rockfill materials subjected to axial compression at a constant mean stress for a range of intermediate principal stress ratios in the interval [0, 1]. The simulation results, including the stress-strain characteristics, relationship between principal strains, and principal deviator strains are discussed. The stress-dilatancy behavior is described using a linear dilatancy equation with its material constants varying with the intermediate principal stress ratio. The failure surface in the principal stress space and its traces in the deviatoric and meridian plane are also presented. The modified Lade-Duncan criterion most closely describes the stress points at failure.
Expression and Clinical Significance of miRNA-34a in Colorectal Cancer
Ma, Zhi-Bin,Kong, Xiao-Lin,Cui, Gang,Ren, Cui-Cui,Zhang, Ying-Jie,Fan, Sheng-Jin,Li, Ying-Hua Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Background: The aim of this study was to investigate differences of miRNA-34a expression in benign and malignant colorectal lesions. Materials and Methods: Samples of cancer, paraneoplastic tissues and polyps were selected and total RNA was extracted by conventional methods for real-time PCR to detect the miRNA-34a expression. In addition, the LOVO colorectal cancer cell line was cultured, treated with the demethylating agent 5-azacytidine and screened for differentially expressed miRNA-34a. Results: After the drug treatment, the miRNA-34a expression of colorectal cancer cell line LOVO was increased and real-time PCR showed that levels of expression in both cell line and colorectal cancer tissues were low, as compared to paraneoplastic tissue (p<0.05). Polyps tissues had significantly higher expression than paraneoplastic and colorectal cancer samples (p<0.05). Conclusions: miRNA-34a-5p may play a role as a tumor suppressor gene in colorectal cancer, with involvement of DNA methylation.
Gang Wang,Peng-yu Duan,Yuan Ma,Xi-na Li,Feng-zhi Qu,Liang Ji,Xiao-yu Guo,Wang-jun Zhang,Fan Xiao,Le Li,Ji-sheng Hu,Bei Sun 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Currently, preliminary results have confirmed the existence of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL)-dependent necroptosis of pancreatic acinar cells during early acute pancreatitis (AP), which might be a potential target for the effective regulation of necroinflammatory injury. However, the exact effect of receptor-interacting protein kinase 1 (RIPK1)-dependent regulated acinar cell necrosis on AP is still uncertain. In our study, we first explored the changes in the degree of local and systemic inflammation in AP rats when the activation of acinar cell RIPK1 was inhibited. The RIPK1 inhibitor Nec-1 was used to treat rats, and the levels of related inflammatory markers, necrosis indicators and apoptotic indicators were measured. Changes in pancreatic nuclear factor κB (NF-κB) and aquaporin 8 (AQP8) expression were noted. Next, the expression of AQP8 in AR42J cells was inhibited, and the degree of cell necrosis and inflammatory damage was found to be significantly reduced. Most importantly, we demonstrated that the RIPK1/NF-ĸB/AQP8 axis might be a potential regulatory pathway mediating RIPK1-dependent regulated acinar cell necrosis in early AP. Finally, we used the NF-κB inhibitor PDTC and Nec-1 to treat rats in different groups and measured the degree of pathological pancreatic injury, the activation of RIPK1, and the expression of NF-κB and AQP8. In summary, we hypothesized that there might be a RIPK1/NF-ĸB/AQP8 pathway controlling RIPK1-dependent regulated necrosis of acinar cells in AP, which might be a promising therapeutic target against AP-related injury.
Compound Heterozygous Mutations in the DUOX2/DUOXA2 Genes Cause Congenital Hypothyroidism
Xiao Zheng,Shao-Gang Ma,Man-Li Guo,Ya-Li Qiu,Liu-Xue Yang 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.4
The mutations in the dual oxidase 2 (DUOX2) and dual oxidase maturation factor 2 (DUOXA2) genes can cause congenital hypothyroidism(CH). This study reports the pedigree with goitrous congenital hypothyroidism (GCH) due to the coexistence of heterozygousmutations in the DUOX2 and DUOXA2 genes. The two sisters with GCH were diagnosed with CH at neonatal screeningand were enrolled in this study. The DUOX2, DUOXA2, and thyroid peroxidase (TPO) genes were considered for genetic defects screening. Family members of the patients and normal controls were also enrolled and evaluated. The two girls harbored compound heterozygous mutations, including a new mutation of c.2654G>T (p.R885L) in the maternal DUOX2 allele and c.738C>G (p.Y246X) in the paternal DUOXA2 allele, that has been previously reported. The germline mutations from the families were consistent with an autosomal recessive inheritance pattern. No mutations in the TPO gene and the controls were observed.
Jian Ma,Dingquan Xiao,Bo Wu,Jia-gang Wu,Jian-guo Zhu 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.2
0.95(Na0.96−xKxLi0.04)(Nb0.89Sb0.07Ta0.04)O3-0.05KNbO3 (abbreviated as KxNLNST-KN, x =0.32 − 0.52) lead-free piezoelectric ceramics were prepared by using the conventional solid-statesintering method, and the intentional addition of a pre-calcined KNbO3 powder was used as asintering aid that might inhibit and compensate for the volatilization of alkali metals during thesintering process. The preparation of the ceramics and the effects of K/Na ratio on the structureand the electrical properties of these ceramics were studied in detail. Compared with the relativelyhigher sintering temperature of Li-, Sb-, and Ta-modified KNN ceramics reported in the literature,the dense ceramic samples were obtained at a reduced temperature of 1060 C, and the ceramicswith x = 0.44 possessed optimal properties: d33 = 298 pC/N, kp = 48%, Pr = 21.9 μC/cm2, andEc = 11.5 kV/cm.
Yang, Xiao-Ping,Han, Yue-Dong,Ye, Jian-Jun,Chen, Gang,Luo, Ying,Ma, Hong-Xia,Yu, Xue-Wen,Niu, Juan-Qin,Ren, Fang-Yuan,Guo, You-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Background: As a common and essential contrast medium at present, gadobenate dimeglumine has shown better performance than some other agents when applied to Breast Magnetic Resonance Imaging Screening (Breast MRI Screening). Nevertheless, reports on the diagnostic performance of these two mediums (gadobenate dimeglumine and gadopentetate dimeglumine) are not completely consistent. Objective: To assess the diagnostic value of gadobenate dimeglumine and gadopentetate dimeglumine for Breast MRI Screening in patients suffering from breast cancer and to provide more convinced evidence to guide clinical practice in terms of appropriate contrast agents. Data Sources and Review Methods: Original articles in English and Chinese published before January 2013 were selected from available databases (The Cochrane Library, PUBMED, EMBASE, Chinese Biomedical Literature Database, Chinese Scientific Journals Full-text Database, Chinese Journal Full-text). The criteria for inclusion and exclusion were based on the standard for diagnosis tests. Meta-Disc software (Version 1.4) was used for data analysis. Then, the area under curve (AUC) of SROC and the spearman rank correlation of sensitivity against (1-specificity) were calculated. Results: Total of 17 researches involving 1934 patients were included. The pooled sensitivity of gadobenate dimeglumine and gadopentetate dimeglumine were 0.99 (0.97, 1.00) and 0.93 (0.88, 1.00) respectively. The pooled specificity for these two contrast agents were 0.924 (0.902, 0.943) and 0.838 (0.817, 0.858) respectively, and the AUC of SROC curve were 0.9781 and 0.9215 respectively. Conclusions: Gadobenate dimeglumine can be regarded as a more effective and feasible contrast medium for Breast MRI Screening. At least 5% differences in diagnostic performance are usually considered as clinically relevant.
Ding, Xiao-Yu,Xu, Qiu,Zhu, Xiao-yong,Luo, Lai-Ma,Huang, Jian-Jun,Yu, Bin,Gao, Xiang,Li, Jian-Gang,Wu, Yu-Cheng Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.12
Oxide dispersion-strengthened materials W-1wt%Pr<sub>2</sub>O<sub>3</sub> and W-1wt%La<sub>2</sub>O<sub>3</sub> were synthesized by wet chemical method and spark plasma sintering. The field emission scanning electron microscopy (FE-SEM) analysis, XRD and Vickers microhardness measurements were conducted to characterize the samples. The irradiations were carried out with a 5 keV helium ion beam to fluences up to 5.0 × 10<sup>21</sup> ions/m<sup>2</sup> under 600 ℃ using the low-energy ion irradiation system. Transmission electron microscopy (TEM) study was performed to investigate the microstructural evolution in W-1wt%Pr<sub>2</sub>O<sub>3</sub> and W-1wt%La<sub>2</sub>O<sub>3</sub>. At 1.0 × 10<sup>20</sup> He<sup>+</sup>/m<sup>2</sup>, the average loops size of the W-1wt%Pr<sub>2</sub>O<sub>3</sub> was 4.3 nm, much lower than W-1wt% La<sub>2</sub>O<sub>3</sub> of 8.5 nm. However, helium bubbles were not observed throughout in both doped W materials. The effects of pre-irradiation with 1.0 × 10<sup>21</sup> He<sup>+</sup>/m<sup>2</sup> on trapping of injected deuterium in doped W was studied by thermal desorption spectrometry (TDS) technique using quadrupole mass spectrometer. Compared with the samples without He<sup>+</sup> pre-irradiation, deuterium (D) retention of doped W materials increased after He<sup>+</sup> irradiation, whose retention was unsaturated at the damage level of 1.0 × 10<sup>22</sup>D<sub>2</sub><sup>+</sup>/m<sup>2</sup>. The present results implied that irradiation effect of He<sup>+</sup> ions must be taken into account to evaluate the deuterium retention in fusion material applications.
Jian Xiao,Gang Xu,Lu Wang,Pengyu Li,Wenqin Zhang,Ning Ma,Minli Tao 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.77 No.-
Four categories of sulfonic acid functionalizedfiber catalysts with different surface microenvironmentswere synthesized by covalent grafting using polyacrylonitrilefiber (PANF) as the support. After the effectof acid structure on catalytic activity has been investigated by Friedlander reaction, PANEOSF was chosenfor the synthesis of quinolines and coumarin derivatives with high yields and extensive substrate scope(51 examples) in ethanol or water. The effect of electrostatic microenvironment and solvent has beendiscussed, and a “release-catch-release-catch” catalytic pattern was proposed accordingly. PANEOSF canbe easily recycled for 20 times without any decrease of catalytic activity.