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Dong-Hui Zhou,Hong-Hui Shi,Hui-Xia Jia 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.1
The multiphase flow field with supercavitation induced by successively fired underwater projectiles is very complicated. It involves the interaction of two or more supercavitating flow fields, which is very different from the supercavitating flow of single underwater projectile. In the paper, the multiphase flow field with supercavitation induced by two successively fired projectiles underwater and cross-media (water-entry and water-exit) was simulated. The interaction effect between supercavities induced by two projectiles was particularly analyzed. The influence mechanism of the supercavity evolution on the motion of two projectiles was also analyzed. The results indicate that, the supercavitating flow fields of two successively fired underwater projectiles interact on each other. The coalescence, separation and collapse of cavities occur during the interaction stage of the supercavitating flow fields, which causes that the second-fired projectile enters the supercavity of the first one. The second-fired projectile can catch up with the first one and then a rear-end collision happens. The collision causes disturbances on the supercavity contour. The impact load of the secondfired projectile during the water-entry period is smaller than that of the first one. The cavities induced by the first- and second-fired projectiles coalesce each other into a cavity, and the second-fired projectile is finally completely wrapped by a supercavity. During the water-entry process, a rear-end collision also happens. In the process of water-exit, the supercavity induced by the first-fired projectile is blocked under the free surface, and then the first-fired projectile flies into the air after throwing off the water layer. Under the influence of the supercavity separated by the first-fired projectile, the second-fired projectile can escape from its own supercavity, and then enter the supercavity of the first-fired projectile. With the supercavity collapse of the first-fired projectile, a new partial cavity generates around the second-fired projectile.
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Dong Hui,Zhu Kai-hui,Zhao Qian,Bai Xue-ping,Zhou Jin-cheng,Zhang Li-sheng 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.3
The fall armyworm, Spodoptera frugiperda, is a dangerous pest of cereals originating from the tropical and sub tropical parts of the Americas. It has invaded over a hundred countries and is spreading rapidly throughout East Asia. Biological control programs are a “model strategy” for the control of invasive pests. Egg parasitoids Tele nomus remus and Trichogramma pretiosum are viewed as candidates for the control of S. frugiperda. The aim of this study was to evaluate the behavioral patterns and parasitism efficacy of Te. remus, Tr. pretiosum, and Tricho gramma dendrolimi on S. frugiperda egg masses with and without scales. The proportion of parasitism by Te. remus was significantly higher than that by Tr. dendrolimi and Tr. pretiosum. The proportion of parasitism by Tr. pre tiosum and Tr. dendrolimi on egg masses with scales was significantly lower than that on egg masses without scales. However, Te. remus had a similar proportion of parasitism on egg masses with and without scales. Residence time, oviposition time, oviposition frequency, risk of host being found, and risk of parasitism by Te. remus were significantly higher than the corresponding parameters of Tr. pretiosum and Tr. dendrolimi. Tr. pre tiosum females exhibited a higher residence time, oviposition time, oviposition frequency, risk of host being found, and risk of parasitism than those of Tr. dendrolimi females. In addition, Te. remus females often crept into the scale layer covering the egg masses, whereas Tr. dendrolimi and Tr. pretiosum females did not; they could only parasitize the eggs located on the periphery of the egg mass. Both Te. remus and Tr. pretiosum females had similar proportions of superparasitism, which were significantly higher than that of Tr. dendrolimi. Therefore, Te. remus is the dominant egg parasitoid of S. frugiperda and this has important implications for developing augmentative biological control strategies for S. frugiperda.
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Hui-wen Xiao,Yuan Li,Dan Luo,Jia-li Dong,Li-xin Zhou,Shu-yi Zhao,Qi-sheng Zheng,Hai-chao Wang,Ming Cui,Sai-jun Fan 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Although radiation therapy is a cornerstone of modern management of malignancies, various side effects are inevitably linked to abdominal and pelvic cancer after radiotherapy. Radiation-mediated gastrointestinal (GI) toxicity impairs the life quality of cancer survivors and even shortens their lifespan. Hydrogen has been shown to protect against tissue injuries caused by oxidative stress and excessive inflammation, but its effect on radiation-induced intestinal injury was previously unknown. In the present study, we found that oral gavage with hydrogen-water increased the survival rate and body weight of mice exposed to total abdominal irradiation (TAI); oral gavage with hydrogen-water was also associated with an improvement in GI tract function and the epithelial integrity of the small intestine. Mechanistically, microarray analysis revealed that hydrogen-water administration upregulated miR-1968-5p levels, thus resulting in parallel downregulation of MyD88 expression in the small intestine after TAI exposure. Additionally, high-throughput sequencing showed that hydrogen-water oral gavage resulted in retention of the TAI-shifted intestinal bacterial composition in mice. Collectively, our findings suggested that hydrogen-water might be used as a potential therapeutic to alleviate intestinal injury induced by radiotherapy for abdominal and pelvic cancer in preclinical settings.
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Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.
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Load rating of box girder bridges based on rapid testing using moving loads
Dong-Hui Yang,Hong Zhou,Ting-Hua Yi,Hong-Nan Li 국제구조공학회 2023 Smart Structures and Systems, An International Jou Vol.32 No.6
Box girder bridges are now widely used in bridge construction, and it is necessary to perform load rating regularly to evaluate the load capacity of box girder bridges. Load testing is a common measure for load rating. However, the bridge must be loaded by many trucks under different loading conditions, which is time-consuming and laborious. To solve this problem, this paper proposes a load rating method for box girder bridges based on rapid moving loads testing. The method includes three steps. First, the quasi-influence factors of the bridge are obtained by crossing the bridge with rapidly moving loads, and the structural modal parameters are simultaneously obtained from the dynamic data to supplement. Second, an objective function is constructed, consisting of the quasi-influence factors at several measurement points and structural modal parameters. The finite element model for load rating is then updated based on the Rosenbrock method. Third, on this basis, a load rating method is proposed using the updated model. The load rating method proposed in this paper can considerably reduce the time duration of traditional static load testing and effectively utilize the dynamic and static properties of box girder bridges to obtain an accurate finite element model. The load capacity obtained based on the updated model can avoid the inconsistency of the evaluation results for the different structural members using the adjustment factors specified in codes.
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Hui-Dong Qian,Jung Tae Lim,Yang Yang,Jong-Woo Kim,Tian Hong Zhou,Su Yeon Ahn,Hankuk-Jeon,Kyung Mox Cho,Jihoon Park,Chul-Jin Choi 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2
Rare-earth intermetallic compounds of R(Fe,M)12 (R = rare earth elements, M = transition metals) with ThMn12 structure have been known to be promising permanent magnetic materials since the 1980s. Recently, increasing rare earth price has pushed the industry to seek ways to reduce the R-content in the hard magnetic materials. In case, strong magnets with the ThMn12 type of structure received much attention. However, during the several tens of years, the research about ThMn12 magnetic materials was not made a breakthrough. As a turning point of the ThMn12-type Fe-rich compounds research, ThMn12-type Sm(Fe1-xCox)12 compound films with a saturation magnetization of 1.78 T, an anisotropy field of 12 T, and a Curie temperature of 586 °C, all of which are superior to those for Nd₂Fe14B, were successfully produced. However, it still has difficulty in stabilizing the unstable ThMn12 phase in magnetic powders and bulks. In previous research, the ThMn12 structure is also unstable and partial Fe atoms must be substituted with phase stabilizing element(s), such as Ti, V, Cr, Mn, Mo, W, Al, and Si, which results in magnetization reduction. So, decreasing magnetization or coercivity with the non-magnetic elements substitution is a new challenge for the ThMn12-type Sm(Fe1-xCox)12 compound research. Therefore, we have developed a new fabrication method to produce a high-density Sm(Fe0.8Co0.2)11Ti bulk with high purity and magnetic properties and investigated Si substitution or doping effects on this work"s magnetic and physical properties. The purity of the hard magnetic ThMn12 phase in the bulk magnet reached higher than 97 wt.%. The remanent magnetization and maximum energy product of the prepared Sm(Fe0.8Co0.2)11Ti bulk reached high values of 96.0 emu/g and 12.22 MGOe, respectively. The phase transformation behavior from amorphous to ThMn12 phase during heat treatment was systematically investigated by transmission electron microscopy. The magnetic properties and grain sizes of Sm(Fe0.8Co0.2)11Ti bulk magnets with different annealing times were shown in Fig. 1 (a). To investigate the effect of substituted elements in the ThMn12-type Fe-rich compounds and compare with the Ti substitution, Si was selected to dop into the ThMn12-type Fe-rich compounds. Sm(Fe0.8Co0.2)10Si₂ and Sm(Fe0.8Co0.2)11Ti+Six (x = 0, 0.5, and 1) ribbons were produced using a melt spinning method. The magnetic properties of the Sm(Fe0.8Co0.2)10Si₂ ribbons with different melt spinning speeds and the Sm(Fe0.8Co0.2)11Ti+Six ribbons with melt spinning speed of 39 m/s are shown in Fig. 1 (b). The maximum coercivity of the Sm(Fe0.8Co0.2)10Si₂ and Sm(Fe0.8Co0.2)11Ti+Six ribbons reached 1745 and 3140 Oe, respectively. The details of the fabrication procedure, microstructure, and magnetic properties of as mentioned compounds will be discussed. 〈그림 본문참조〉
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Dong-Feng Chen,Xican Li,Zhiwei Xu,Xiaobing Liu,Shao-Hui Du,Hui Li,Jian-Hong Zhou,He-Ping Zeng,Zi-Chun Hua 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.4
Buzhong Yiqi decoction (BYD) is a well-known ancient tonic prescription in traditional Chinese medicine (TCM). The purpose of this study is to identify active components of BYD involved in promoting proliferation of mesenchymal stem cells (MSCs) and to investigate its mechanism. BYD was extracted with petroleum ether, ethanol, and water. Evidence provided by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, bromodeoxyuridine, proliferation cell nuclear antigen immunoreactivity, cell cycle analysis, and gas chromatography-mass spectrometry indicated that hexadecanoic acid (HA) in BYD extracted with petroleum ether is the active compound responsible for increasing proliferation of MSCs. Western blot analysis show that HA significantly increase retinoic acid receptor (RAR) levels of MSCs, but not estrogen receptor, thyroid hormone receptor, vitamin D receptor, glucocorticoid receptor, and peroxisome proliferator-activated receptor. Reverse transcription-polymerase chain reaction revealed that HA significantly increased RAR mRNA levels. Furthermore, the mechanism of HA action depends on RAR pathway and up-regulates expression of mRNA for insulin-like growth factor-I, the target gene of RAR. Our findings have now allowed for a refinement in our understanding of TCM with respect to pharmacological regulation of stem cells and may be useful to stem cell biology and therapy.
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