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아동의 스트레스 대처방식과 안녕감 간의 관계에서 강인성의 매개효과
최원아(Won-Ah Choi),김진영(Jin-Young Kim) 한국심리치료학회 2020 한국심리치료학회지 Vol.12 No.1
본 연구는 스트레스 대처방식과 강인성, 안녕감의 관계를 살펴보고 스트레스 대처방식과 안녕감의 관계에서 강인 성의 매개효과를 확인하였다. 이를 위해 초등학생 5~6학년 467명을 대상으로 스트레스 대처방식 척도, 강인성 척 도, 안녕감 척도를 실시하고 분석하였다. 본 연구의 결과는 다음과 같다. 첫째, 적극적 대처방식과 사회지지 추구 적 대처방식은 몰입, 통제, 도전, 통합적 안녕감과 정적 상관관계를 나타냈으며, 소극·회피적 대처방식과 공격적 대처방식은 몰입, 통제, 통합적 안녕감과 부적 상관관계를 나타냈다. 둘째, 스트레스 대처방식이 안녕감에 미치는 영향에서 강인성의 매개효과가 있음을 확인하였다. 적극적 대처방식, 사회지지 추구적 대처방식이 안녕감에 미치 는 영향에서 몰입, 통제, 도전이 부분매개효과를 갖는 것으로 나타났다. 몰입은 소극·회피적 대처방식과 안녕감의 관계에서 완전매개효과를 갖는 것으로 나타났으며, 통제는 소극·회피적 대처방식과 안녕감의 관계에서 부분매개 효과를 갖는 것으로 나타났다. 공격적 대처방식이 안녕감에 미치는 영향에서 몰입과 통제가 완전매개효과를 갖는 것으로 나타났다. 도전은 소극·회피적 대처방식, 공격적 대처방식과 안녕감의 관계에서 매개효과를 갖지 않는 것 으로 나타났다. 끝으로 연구의 의의와 제한점을 논의하고 추후 연구에 대한 제언을 하였다. This study aims to investigate hardiness as a mediator in the relationship between children’s stress coping and well-being. Participants consisted of 467 5th and 6th grade students of elementary school. They are asked to answer the three questionnaires: The Stress Coping Scale, the Hardiness Scale and Korean Well-Being Scale of Adolescent (K-WBSA). The results are summarized as follows: First, the active coping and social support seeking coping were positively correlated with commitment, control, challenge, and overall well-being. Passive/avoidant coping and aggressive coping were negatively correlated with commitment, control, and overall well-being. Second, the effects of hardiness as a mediator of the relationship between stress coping and well-being were significant. Lastly, implications of the present study and suggestions for future research were discussed.
소아 천식 환자의 혈청 총 IgE에서 IL-13 (+2044G/A)과 FCER1B (E237G)의 유전자 상호작용
최원아 ( Won Ah Choi ),송영화 ( Young Hwa Song ),김병주 ( Byoung Ju Kim ),유진호 ( Jin Ho Yu ),김효빈 ( Hyo Bin Kim ),이소연 ( So Yeon Lee ),김자형 ( Ja Hyung Kim ),김봉성 ( Bong Seong Kim ),강미진 ( Mi Jin Kang ),장성옥 ( Seong O 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.4
Background: Interleukin-13 (IL-13) is essential for the synthesis of Immunoglobulin E (IgE) which is a critical risk factor for the development of asthma. The high-affinity IgE receptor β (FCER1B), which is expressed on mast cells and basophils, plays an important role in the IgE-mediated allergic response. Objective: To analyze the association between IL-13 (+2044G/A) and FCER1B (E237G) polymorphisms, and IgE production in asthmatic children. Method: Seven hundred sixty asthmatic children and 235 healthy controls were enrolled, and the levels of serum total IgE and blood eosinophil counts were evaluated. Pulmonary function test and methacholine challenge test were also performed. The genotypes of IL-13 (+2044G/A) and FCER1B (E237G) polymorphisms were analyzed by using the restriction fragment length polymorphism method. Result: IL-13 (+2044G/A) and FCER1B (E237G) polymorphisms were not associated with the development and phenotypes of asthma. However, in homozygote of variant genotypes, gene-gene interaction of IL-13 (+2044G/A) and FCER1B (E237G) polymorphisms was associated with an increase of serum total IgE, whereas in homozygote of wild genotypes, this interaction was not associated with an increase of serum total IgE (P=0.030). Conclusion: Gene-gene interaction between IL-13 (+2044G/A) and FCER1B (E237G) polymorphisms may be associated with increased levels of serum total IgE in children with asthma. (Korean J Asthma Allergy Clin Immunol 2008;28:284-291)
고지방 식이로 유도된 비만쥐에서 식이 베타글루칸이 체지방 형성 및 혈청 지질에 미치는 영향
강순아(Soon Ah Kang),장기효(Ki-Hyo Jang),홍경희(Kyunghee Hong),최원아(Won-A Choi),정경희(Kyung-Hee Jung),이인영(In-Young Lee) 한국식품영양과학회 2002 한국식품영양과학회지 Vol.31 No.6
본 연구는 글루코즈 중합체인 β-glucan의 에너지 대사 조절에 미치는 영향과 항 비만 효과를 살펴보기 위하여 수행하였다. 6주간 고지방 섭취로 유도된 비만 쥐에게 β-glucan을 식이의 1%, 5%로 6주간 공급하였고, 체지방 형성 및 분포와 지방세포 크기를 측정하였고 혈중 지질함량을 분석하였다. 연구 결과를 종합해 보면 다음과 같다. 1) 체중 증가량과 식이효율은 고지방 식이군에서 높았으며 β-glucan 군에서는 고지방 식이군과 비교시 감소하는 경향을 보였다. 2) 고지방식이군에서 단위체중당 체지방이 많았으며, β-glucan 식이군에서 내장 지방무게와 복막 지방 무게가 감소하여 β-glucan 섭취에 의해 체지방 축적이 억제됨을 보여주었다. 3) β-glucan 식이군에서 지방 세포 크기가 감소하여 β-glucan 섭취가 지방 세포의 지방축적을 억제함으로써 체지방 형성을 감소시킴을 나타내었다. 4) β-glucan 식이군에서 HDL 콜레스테롤 수준은 증가하여 β-glucan 섭취가 지질 대사를 개선시킬 수 있음을 보여주었다. 결론적으로, β-glucan은 지질 대사 개선을 유도하여 체지방형성과 축적을 억제함으로써 항 비만 효과를 나타내는 것으로 보인다. This study was aimed to investigate the effect of dietary β-glucan obtained from bacterial fermentation on the adiposity and serum lipids level in dietary high fat induced obese rats. Experimentally, four weeks old male Sprague Dawley rats fed high fat diet for 6 weeks to induce obesity, and subsequently fed one of three diets for further 6 weeks: 1) high fat control diet (0% β-glucan) 2) 1% β-glucan diet 3) 5% β-glucan diet. For comparison, normal control group fed AIN-76A diet. Food efficiency ratio of rats were tended to be decreased with β-glucan diet, but was not significantly affected. Visceral and peritoneal fat masses were lower in β-glucan groups compared to high fat control group and the effect of β-glucan was dose-dependent. Intake of β-glucan increased HDL cholesterol level and significantly reduced adipocyte size, and free fatty acid, when compared to those of high fat control group. These results suggest that anti-obesity effect of β-glucan may attributed to anti-lipogenesis.
NC/Nga 마우스에서 Dermatophagoides farinae의 피부 적용과 기도 유발에 의해 발생한 기도 염증에 대한 CpG Oligodeoxynucleotide의 효과
김영준 ( Young Joon Kim ),장성옥 ( Seong Ok Jang ),최원아 ( Won Ah Choi ),강미진 ( Mi Jin Kang ),정현돈 ( Hyun Don Jung ),김하정 ( Ha Jung Kim ),김형영 ( Hyung Young Kim ),서주희 ( Ju Hee Seo ),유진호 ( Jin Ho Yu ),홍수종 ( Soo Jo 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.2
Background: Atopic dermatitis (AD) is the initial step of allergic march that progresses to airway allergic disease. There has been much interest in the interruption of the allergic march, but the results are not promising. CpG oligodeoxynucleotide (ODN) has been reported to have both preventive and therapeutic effects on the development of asthma in mouse models. Objective: To identify the development of airway inflammation after having atopic dermatitis-like skin lesions induced by topical application of Dermatophagoides farinae (Df), and to evaluate the preventive effect of CpG ODN on the development of airway inflammation. Method: We injected 5 μg of Df intradermally 8 times for 2 weeks into 8-week-old NC/Nga mice and then challenged them with 3 times of Df intranasally. CpG ODN with or without Df was injected subcutaneously before airway challenge. Airway hyperreactivity was determined by the change inenhanced pause (Penh) during methacholine provocation. Lung tissue and bronchoalveolar lavage specimens were evaluated. Result: Topical Df application induced AD-like skin lesion microscopically, but not macroscopically. NC/Nga mice with topical Df application developed more severe airway inflammation upon intranasal Df challenge than those with topical PBS application. However, the mice with CpG ODN injection before airway challenge showed reduced airway inflammation. The levels of Df-specific IgG1 were increased in the mice with both topical Df application and intranasal Df challenge but were decreased in the mice with CpG ODN injection. Conclusion: These results suggest that CpG may inhibit the development of airway inflammation from those with previous AD-like skin lesions induced by Df. (Korean J Asthma Allergy Clin Immunol 2011;31:131-139)
장성옥 ( Seong Ok Jang ),김병주 ( Byoung Ju Kim ),유진호 ( Jin Ho Yu ),송영화 ( Young Hwa Song ),강미진 ( Mi Jin Kang ),최원아 ( Won Ah Choi ),정현돈 ( Hyun Don Jung ),이소연 ( So Yeon Lee ),홍수종 ( Soo Jong Hong ) 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.3
Background: CD4+ T helper cells which differentiate into the Th2 cells are crucial for the initiation and progression of allergic asthma. Human Cytotoxic T Lymphocyte-associated Antigen 4-immunoglobulin (CTLA4-Ig) has been widely used in order to block T-cell costimulation in an array of experimental animal models of T-cell-mediated diseases. Objective: To evaluate whether human CTLA4-Ig fusion protein inhibits airway inflammation in a murine model of OVA-induced asthma. Method: Six-weeks-old BALB/c mice were used and airway inflammation was induced by OVA. Human CTLA4-Ig fusion protein was administered intravenously before and after sensitization with OVA. Airway responsiveness to methacholine was measured after antigen challenge. Total IgE, OVA-specific IgE, IgG1 and IgG2a in serum samples were assessed by ELISA. Bronchoalveolar lavage (BAL) and lung section were also performed. Result: In mice which were treated with the CTLA4-Ig fusion protein before and after sensitization OVA, airway hyperresponsiveness and eosinophil BAL were markedly decreased. In mice which were with human CTLA4-Ig before sensitization with serum total IgE level were more significantly reduced that of positive control mice. Peribronchial inflammatory infiltration was desreased by the treatment of CTLA4-Ig before and after sensitization with OVA. Conclusion: These results suggest that human CTLA4-Ig fusion protein may inhibit eosinophilic airway inflammation and airway hyperresponsivness in OVA-sensitized airway challenged mice. (Korean J Asthma Allergy Immunol 2008;28:205-213)