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천식 환아에서 집먼지진드기 항원을 이용한 면역요법이 혈액내 호산구, 항원-특이 IgE, 피부반응도 및 기도과민성에 미치는 영향
김봉성 ( Bong Seong Kim ),김자형 ( Ja Hyung Kim ),이소연 ( So Yeon Lee ),홍수종 ( Soo Jong Hong ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2003 소아알레르기 및 호흡기학회지 Vol.13 No.1
목적:집먼지진드기 항원에 감작된 천식환아에서 집먼지진드기 항원을 이용한 면역요법은 효과가 있는 것으로 알려져 있으나, 그 기전은 명확히 알려져 있지 않다. 본 연구는 소아 천식 환아에서 면역요법이 말초혈액 호산구수, 항원 특이 IgE, 피부반응도 및 기도과민성에 어떠한 영향을 유도하는지 조사하였다. 방법:D.f 및 D.p를 이용하여 고식적인 방법으로 면역치료를 받은 D.f 및 D.p에 감작된 소아 천식환자 24명과 대조군으로 D.f 및 D.p에 감작된 Purpose: Immunotherapy(IT) with house dust mite may be effective to treat house dust mite allergic disease, but the mechanism and prognostic index of IT are not completely understood. Generally allergen specific-IgE antibody significantly initially increa
분만 방법이 소아 천식의 발생에 영향을 미칠 수 있는가?
김봉성 ( Bong Seong Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.4
Under the hygiene hypothesis, children born by cesarean section (CS) may consequently have an increased risk of asthma and other allergic diseases. CS has been shown to have a delayed and altered development in establishment of gut flora and altered cytokine production. Concerns about the relations between CS and the risk of children`s asthma are rising due to the growing number of CS performed in many countries. However, finding the concrete evidence to correlate CS with higher risk of asthma is still controversial. There were significant covariate imbalance between groups of children born by CS vs. vaginal delivery that include the number of maternal age, gestational age, birth weight, complication during pregnancy, complication during labor, socioeconomic status, a parental history of atopy, and maternal smoking history. And there were considerable heterogeneity in methods and study subjects between the studies of delivery by CS and the offspring`s risk of asthma and other allergic diseases. Therefore, as we proceed into the further study, researchers must refer to the literatures and look for the best way proving their hypothesis that are based on the methodological subject group. Of which should be accordance with the research purposes. Also, researchers have to search for identifying the core biological mechanism in order to know whether there is a causal relationship exists between the CS and asthma. (Pediatr Allergy Respir Dis(Korea) 2011;21:250-260)
한국 3개 지역 고등학생에서 알레르기질환의 유병률에 대한 조사
김봉성 ( Bong Seong Kim ),김효빈 ( Hyo Bin Kim ),이소연 ( So Yeon Lee ),김자형 ( Ja Hyeung Kim ),진현승 ( Hyun Seung Jin ),김병주 ( Byung Ju Kim ),유진호 ( Jin Ho Yu ),유선미 ( Sun Mi Yoo ),홍수종 ( Soo Jong Hong ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.3
Background: Whereas allergic disease has a high morbidity among adolescents, there have been few reports concerning asthma prevalence using objective parameters such as methacholine bronchial provocation tests in this age group. Objective: Thus we investigate the prevalence of asthma and other allergic diseases using questionnaires and measuring bronchial hyperresponsiveness (BHR) in high school students in Korea. Method: A questionnaire survey was conducted among 1499 high school students, from 3 regions in Korea between April and May, 2006. They responded to a modified International Study of Asthma and Allergies in Childhood (ISAAC) written (WQ) and video (AVQ) questionnaires. 709 subjects of them underwent methacholine bronchial challenge test. Result: The WQ showed that the lifetime and 12-month prevalences of wheeze were 16.0% and 8.9%. The lifetime prevalence of asthma diagnosis was 7.0% and 12-month prevalence of asthma treatment was 1.5%. By video questionnaire, the lifetime prevalence and 12-month prevalence of wheeze were 7.9% and 5.5%. The prevalence of current asthma based on the questionnaire and bronchial challenge tests was 3.2%. The prevalence of current asthma and BHR were higher in female than in male subjects. For 12-month prevalence of allergic rhinitis and atopic dermatitis were 37.7% and 11.4%, respectively. Conclusion: The prevalence of current asthma in high school students were 3.2%. Despite the fact that 12-month prevalence of wheeze and lifetime prevalence of asthma diagnosis were 8.9% was 7.0%, only 1.5% of answered subjects received asthma treatment. Its prevalence was still low compared to asthma prevalence. (Korean J Asthma Allergy Clin Immunol 2007;27:168-175)
IL-13 +2044G/A Polymorphism 과 소아천식의 관련성 및 그 기능 연구
김효빈 ( Hyo Bin Kim ),이소연 ( So Yeon Lee ),진현승 ( Hyun Seung Jin ),김자형 ( Ja Hyeong Kim ),김봉성 ( Bong Seong Kim ),강미진 ( Mi Jin Kang ),장성옥 ( Seong Ok Jang ),홍수종 ( Soo Jong Hong ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.4
Background: The IL-13 +2044G/A is known to be associated with increased serum total IgE levels and asthma development. Variant type of IL-13 was significantly more active than wild type in inducing CD23 expression in monocytes. Objective: We investigated the association of asthma susceptibility and asthma-related phenotypes with +2044G/A and the functional difference between wild (+2044G, R110) and variant types (+2044A, Q110). Method: We enrolled 358 atopic asthmatic, 81 non-atopic asthmatic, and 146 control children and evaluated total IgE and bronchial hyperresponsiveness. Genotypes were analyzed by PCR-RFLP method. We applied wild and variant types of IL-13 to B cells and evaluated CD23 expression by flow cytometry. Result: The group with more than one variant alleles of +2044G/A was associated with asthma development, but not with increased total IgE levels than those with wild homozygote in children with asthma. When Q110 was applied to peripheral blood B cells of normal subjects and EBV-transformed B cells from children with atopic asthma, CD23 expressions was higher than those when R110 applied. Conclusion: IL-13 +2044G/A was associated with asthma development in Korean children with asthma, but not with total IgE. In addition, Q110 enhanced CD23 expression on B cells. These findings suggest that IL-13 +2044A (Q110) polymorphism may play a role in asthma development or IgE production. (Korean J Asthma Allergy Clin Immunol 2006;26:271-276)