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A Simulation Study of Urban Public Transport Transfer Station Based on Anylogic
( Weiwei Liu ),( Fu Wang ),( Chennan Zhang ),( Jingyu Zhang ),( Lei Wang ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.4
With the increase in the population of our cities and the rapid increase in the number of private cars, urban traffic has become more and more congested. At this stage, urban public transportation has become one of the main ways to improve urban traffic congestion. Aiming at the problem of how to improve the basic capacity of buses in multi-line transfer stations, this paper conducts simulation research based on anylogic software. Through micro-simulation analysis of vehicles entering, stopping, and exiting the station, combined with the delay model theory, the vehicle is given Stop organization optimization and station layout improvement methods, so that vehicles can run in the station more stably, smoothly and safely. Case analysis shows that applying this method to the roadside parking problem, the main and auxiliary bus stations have a significant improvement in operating capacity compared with the conventional tandem double bus stations, and the service level of the main and auxiliary bus stations has been significantly improved.
Coexistence of OSCR-Based IR-UWB System with IEEE 802.11a WLAN
Weiwei Wu,Han Huang,Huarin Yin,Weidong Wang,Dongjin Wang 한국전자통신연구원 2006 ETRI Journal Vol.28 No.1
Impulse radio (IR) is a competitive candidate for ultra-wideband (UWB) systems. In this letter, we evaluated the coexistence of an IR-UWB system based on an orthogonal sinusoidal correlation receiver (OSCR) with an IEEE 802.11a WLAN through a detailed simulation. The coexistence performance of the two systems is characterized in terms of the receiver’s bit-error rates. Then, some approaches to interference mitigation are discussed.
Numerical analysis of wind field induced by moving train on HSR bridge subjected to crosswind
Wang, Yujing,Xia, He,Guo, Weiwei,Zhang, Nan,Wang, Shaoqin Techno-Press 2018 Wind and Structures, An International Journal (WAS Vol.27 No.1
To investigate the characteristics of the combined wind field produced by the natural wind field and the train-induced wind field on the bridge, the aerodynamic models of train and bridge are established and the overset mesh technology is applied to simulate the movement of high-speed train. Based on ten study cases with various crosswind velocities of 0~20 m/s and train speeds of 200~350 km/h, the distributions of combined wind velocities at monitoring points around the train and the pressure on the car-body surface are analyzed. Meanwhile, the difference between the train-induced wind fields calculated by static train model and moving train model is compared. The results show that under non-crosswind condition, the train-induced wind velocity increases with the train speed while decreases with the distance to the train. Under the crosswind, the combined wind velocity is mainly controlled by the crosswind, and slightly increases with the train speed. In the combined wind field, the peak pressure zone on the headstock surface moves from the nose area to the windward side with the increase of wind velocity. The moving train model ismore applicable in analyzing the train induced wind field.
( Weiwei Wang ),( Wentao Xing ),( Sichen Wei ),( Qiaoying Gao ),( Xinliang Wei ),( Liang Shi ),( Yu Kong ),( Zhenhua Su ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.9
Ulcerative colitis (UC), a chronic inflammatory bowel disease, substantially impacts patients’ health-related quality of life. In this study, an effective strategy for discovering high-efficiency probiotics has been developed. First, in order to survive in the conditions of the stomach and intestine, high bile salt-resistant and strong acid-resistant strains were screened out from the fecal flora of healthy adults. Next, the probiotic candidates were rescreened by examining the induction ability of IL-10 (anti-inflammatory factor) production in dextran sodium sulfate (DSS)-induced colitis mice, and Lactobacillus sakei 07 (L07) was identified and selected as probiotic P. In the end, fourteen bifidobacterium strains isolated from stools of healthy males were examined for their antimicrobial activity. Bifidobacterium bifidum B10 (73.75% inhibition rate) was selected as probiotic B. Moreover, the colonic IL-6 and TNF-α expression of the DSS-induced colitis mice treated with L. sakei 07 (L07) - B. bifidum B10 combination (PB) significantly decreased and the IL-10 expression was up-regulated by PB compared to the DSS group. Furthermore, Bacteroidetes and Actinobacteria decreased and Firmicutes increased in the DSS group mice, significantly. More interestingly, the intestinal flora biodiversity of DSS colitis mice was increased by PB. Of those, the level of B. bifidum increased significantly. The Bacteriodetes/Firmicutes (B/F) ratio increased, and the concentration of homocysteine and LPS in plasma was down-regulated by PB in the DSS-induced colitis mice. Upon administration of PB, the intestinal permeability of the the DSS-induced colitis mice was decreased by approximately 2.01-fold. This method is expected to be used in high-throughput screening of the probiotics against colitis. In addition, the L. sakei 07 - B. bifidum B10 combination holds potential in UC remission by immunomodulatory and gut microbiota modulation.
Wang Weiwei,Ling Xiaofei,Bashir Nawaz Haider,Lu Qin,Zhang Jinwen,Li Tichu,Chen Hang 한국곤충학회 2022 Entomological Research Vol.52 No.2
The screening and identification of suitable reference genes are key steps in experiments involving the quantitative real-time polymerase chain reaction. However, the reference genes of Kerria lacca, a lac insect with considerable economic significance, have not been investigated. In this study, we used five statistical algorithms (ΔCt, geNorm, NormFinder, BestKeeper, and RefFinder) to evaluate the stability of eight candidate reference genes (18S rRNA, 28S rRNA, β-ACT, EF1-α, RPL10, RPL13, RPS11,andRPS15) in different developmental stages and tissues of K. lacca and under dsRNA treatment. Our results showed that the most stable reference genes were 28S rRNA and RPS11 for the developmental stages, RPL13 and RPS11 for different tissues, and β-ACT and EF1-α for dsRNA treatments. Although the target genes FA S and 17β-HSD showed consistent expression profiles (alone or in combination) when normalized to the expression levels of the stable genes, those changed when the least stable reference gene (18S rRNA) was used. These results highlight that suitable reference genes should be chosen according to the specific experimental conditions used. The reliability and stability of different reference genes can provide a firm foundation for gene expression analysis in lac insects.
Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage
Wang Guangyu,Wang Yongsi,Jiang Shaofeng,Fan Wentao,Mo Chune,Gong Weiwei,Chen Hui,He Dan,Huang Jinqing,Ou Minglin,Hou Xianliang 한국유전학회 2022 Genes & Genomics Vol.44 No.7
Background: The current pandemic of coronavirus disease 2019 (COVID-19), transmitted person-to-person by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2), poses a threat to global public health. Objective: In this study, we performed the comprehensive analysis of the T cell receptor (TCR) repertoire may contribute to a more in-depth understanding of the pathogenesis of COVID-19. Methods: A comprehensive immunological analysis was performed to explore the features of the TCR repertoire and identified TCR sequences correlated with SARS-CoV-2 viral antigens. Results: we analyzed the COVID-19 patients' TCR repertoires in peripheral blood mononuclear cells (PBMC) which obtained before (baseline), during (acute), and after rehabilitation (convalescent) by ImmunoSEQ-technology, and found that repertoire features of TCRβ-chain (TCRβ) complementary-determining region 3 (CDR3) in COVID-19 patients were remarkable difference, including decreased TCR diversity, abnormal CDR3 length, difference of TRBV/J gene usage and higher TCR sequence overlap. Besides, we identified some COVID-19 disease-associated TCRβ clones, and the abundance of them changed with the progression of the disease. Importantly, these disease-associated TCRβ clones could be used to distinguish COVID-19 patients from healthy controls with high accuracy. Conclusions: We provide a clear understanding of the TCR repertoire of COVID-19 patients, which lays the foundation for better diagnosis and treatment of COVID-19 patients.
An X-ray Image Panorama System Using Robust Feature Matching and Per ception-Based Image Enhancement
Wang, Weiwei,Gwun, Oubong Korea Multimedia Society 2012 멀티미디어학회논문지 Vol.15 No.5
This paper presents an x-ray medical image panorama system which can overcome the smallness of the images that exist on a source computer during remote medical processing. In the system, after the standard medical image format DICOM is converted to the PC standard image format, a MSR algorithm is used to enhance X-ray images of low quality. Then SURF and Multi-band blending are applied to generate a panoramic image. Also, this paper evaluates the proposed SURF based system through the average gray value error and image quality criterion with X-ray image data by comparing with a SIFT based system. The results show that the proposed system is superior to SIFT based system in image quality.