An Improved Method of Maximum Power Point Tracking Strategy for Wind Power Conversion System

CHEN Ran,CHEN Jie,CHEN Jia-wei,CHEN Zhi-hui,GONG Chun-ying,YAN Yang-guang 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5

The turbine speed loop adjustment is the key link of the designing of the controller for the fixed pitch variable speed wind energy conversion systems (WECS). Because of the strong nonlinear, big inertia and mechanical damping characteristics, it’s difficult to designing the controller of the wind power systems. In this paper, a small signal model is present, and based on the analyzing; a wind turbine speed loop regulator is designed. Then, a method of tracking the peak power conversion system is proposed, which is independent of the turbine parameters and air density. At last, simulation system is built, and the results of the simulation experiments show that, the performance of the controller algorithm meet the requirements of the MPPT without wind measurement.

Korean Learners’ L2 Performance in Syntax-Semantics interface: Chinese Wh-Words as Existential Polarity Words

Chen Hui,유석훈 고려대학교 언어정보연구소 2018 언어정보 Vol.0 No.26

Chen Hui & You, Seok-Hoon. 2018. Korean Learner’s L2 Performance in Syntax-Semantics interface: Chinese Wh-words as Existential Polarity Words. Language Information. Volume 26. 103-128. This study aims to test applicability of the Interface Hypothesis (Sorace & Tsimpli, 2006) in L2 through investigating L2 acquisition of Chinese Wh-Words as Existential Polarity Words (hence force EPWs) by L1 Korean speakers. The present study compares the results of the acceptability judgment test of Chinese EPWs between learner group and native speaker group to investigate 1. Are the interface properties concerning Chinese EPWs and their licensors acquirable by Korea-speaking learners of Chinese? 2. If not, what are the linguistic or non-linguistic effects which cause the interface breakdown? The results show that L2 Chinese learners are unable to establish a complete semantics-syntax relationship with the EPW embedded in the sentence, even at the final state of L2 acquisition. And the results also show that L2 Chinese acquisition is not linear development.

Effectiveness of a Case Management Program for Women with Abnormal Findings from Mammography Screening

Chen-Chen Kuo,Miaofen Yen,Shu-Ping Chu,Hui-Chen Lin 한국간호과학회 2009 한국간호과학회 학술대회 Vol.2009 No.10

Korean Learners’ L2 Performance in Syntax-Semantics interface : Chinese Wh-Words as Existential Polarity Words

Chen Hui,You, Seok-Hoon 고려대학교 언어정보연구소 2018 언어정보 Vol.26 No.-

Chen Hui & You, Seok-Hoon. 2018. Korean Learner’s L2 Performance in Syntax-Semantics interface: Chinese Wh-words as Existential Polarity Words. Language Information. Volume 26. 103-128. This study aims to test applicability of the Interface Hypothesis (Sorace & Tsimpli, 2006) in L2 through investigating L2 acquisition of Chinese Wh-Words as Existential Polarity Words (hence force EPWs) by L1 Korean speakers. The present study compares the results of the acceptability judgment test of Chinese EPWs between learner group and native speaker group to investigate 1. Are the interface properties concerning Chinese EPWs and their licensors acquirable by Korea-speaking learners of Chinese? 2. If not, what are the linguistic or non-linguistic effects which cause the interface breakdown? The results show that L2 Chinese learners are unable to establish a complete semantics-syntax relationship with the EPW embedded in the sentence, even at the final state of L2 acquisition. And the results also show that L2 Chinese acquisition is not linear development.

AHP 기법을 활용한 지역디지털콘텐츠 구성요소 간 상대적 중요도 및 우선순위에 관한 연구 -충남 공주시를 대상으로-

진휘휘(Hui-Hui Chen),김은지(Eun-Ji Kim),박창수(Chang-Soo Park),노희경(Hee-Kyung Noh) 한국콘텐츠학회 2023 한국콘텐츠학회논문지 Vol.23 No.2

본 연구는 정보화 사회에서 지역의 디지털존재감을 확보하기 위해 지역의 특성이 반영된 디지털콘텐츠를 개발 및 유통하는데 있어 고려되어야 할 요소가 무엇인지 파악하고자 하였다. 이를 위해 선행연구 고찰을 통해 지역디지털콘텐츠의 개념화를 실시하였으며, 구성요소 도출, 계층화 및 우선순위 도출을 위해 관련 전문가를 대상으로 AHP 분석을 진행하였다. 공주시를 대상으로 분석한 결과 상위계층은 지역정체성, 디지털독창성, 상호작용성 순으로 중요도가 높게 나타났으며, 하위계층은 지역정체성의 문화적요소와 사회적요소, 디지털독창성의 시나리오, 지역정체성의 자연적요소 등의 순으로 중요도가 도출되었다. 결론적으로 지역디지털콘텐츠의 구성요소 및 우선순위 도출은 향후 민간 및 공공분야에서 지역디지털콘텐츠를 기획 · 제작 · 유통 및 확산함에 있어 타지역과 차별성 확보에 실무적 기여를 할 수 있는 것으로 기대되며, 지역디지털콘텐츠에 대한 다학제적 접근과 향후 연구에서의 기준이 될 수 있을 것으로 판단된다. The purpose of the study is to grasp the considered elements when developing and circulating digital content that reflect the characteristics of the region, in order to ensure the regional digital presence in the information society. Therefore, the conceptualization of regional digital content is realized through the investigation of the previous research. The questionnaire survey is conducted by the AHP analysis method with relevant experts as the research object so as to derive its constituent elements, structuralization, and priority order. The results of this study show that the importance of regional integrity, digital originality, and interaction of the upper class is ranked in turn, while the importance of each element of the lower class is ranked in turn according to the cultural and social elements of regional integrity, the script of digital originality and the natural elements of regional integrity, etc. Research results present that the derivation of the elements and priority of regional digital content is expected to make a practical contribution to ensuring the differences with other regions in the planning, production, circulation, and diffusion of regional digital content in the private and public spheres in the future, and can become a multi-disciplinary approach to regional digital content and a standard for future research.

Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury

Yang Hui-Hui,Jiang Hui-Ling,Tao Jia-Hao,Zhang Chen-Yu,Xiong Jian-Bing,Yang Jin-Tong,Liu Yu-Biao,Zhong Wen-Jing,Guan Xin-Xin,Duan Jia-Xi,Zhang Yan-Feng,Liu Shao-Kun,Jiang Jian-Xin,Zhou Yong,Guan Cha-Xi 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We found an accumulation of mitochondrial citrate (citratemt) in lipopolysaccharide (LPS)-treated AECs because of the downregulation of Idh3α and citrate carrier (CIC, also known as Slc25a1). shRNA- or inhibitor–mediated inhibition of Idh3α and Slc25a1 induced citratemt accumulation and necroptosis in vitro. Mice with AEC-specific Idh3α and Slc25a1 deficiency exhibited exacerbated lung injury and AEC necroptosis. Interestingly, the overexpression of Idh3α and Slc25a1 decreased citratemt levels and rescued AECs from necroptosis. Mechanistically, citratemt accumulation induced mitochondrial fission and excessive mitophagy in AECs. Furthermore, citratemt directly interacted with FUN14 domain-containing protein 1 (FUNDC1) and promoted the interaction of FUNDC1 with dynamin-related protein 1 (DRP1), leading to excessive mitophagy-mediated necroptosis and thereby initiating and promoting ALI. Importantly, necroptosis induced by citratemt accumulation was inhibited in FUNDC1-knockout AECs. We show that citratemt accumulation is a novel target for protection against ALI involving necroptosis.

High Alpha-Folate Binding Protein Correlates with Poorer Survival in Serous Ovarian Carcinoma (초)

( I Hui Chen ),( Yu Li Chen ),( Ying Cheng Chiang ),( Ming Cheng Chang ),( Han Wei Lin ),( Chang Yao Hsieh ),( Chi An Chen ),( Wen Fang Cheng ) 대한산부인과학회 2010 서울심포지움 Vol.15 No.-

Telbivudine-Induced Myopathy: Clinical Features, Histopathological Characteristics, and Risk Factors

Min-Yu Lan,Hui-Chen Lin,Tsung-Hui Hu,Shu-Fang Chen,Chien-Hung Chen,Yung-Yee Chang,King-Wah Chiu,Tsu-Kung Lin,Shun-Sheng Chen 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.1

Background and Purpose Oral nucleos(t)ide analogs (NAs) are the mainstay treatment for chronic hepatitis B (CHB). Myotoxicity is an important extrahepatic effect related to NA treatment. Telbivudine is the NA for CHB that is frequently associated with muscle-related side effects. The risk factors for telbivudine-induced myopathy (TIM) are not yet clear. Methods This study characterized the clinical, magnetic resonance images (MRI), and pathological features of 12 TIM cases. A group of telbivudine-tolerant (TT) patients with CHB who received regular telbivudine treatment during the same period without the occurrence of myopathy was collected. Demographic and clinical factors were compared between the patients with TIM and the TT controls. Factors independently associated with TIM were identified using logistic regression analysis. Results The patients with TIM (males/females: 7/5, mean age: 57 years) developed myopathy after using telbivudine for a median period of 19.5 months. Muscle histopathology revealed abnormal proliferation, subsarcolemmal or sarcoplasmic accumulations, and ultrastructural defects of mitochondria. When compared with TT cases, patients with TIM had a lower estimated glomerular filtration rate and were more frequently positive for hepatitis B e antigen (HBeAg). Conclusions Mitochondrial abnormalities are characteristic histopathological features, and impaired renal function and HBeAg positivity are risk factors for TIM. Telbivudine-induced mitochondrial dysfunction and immune activation related to mitochondrial damage and HBeAg serostatus changes may underlie TIM. Constant clinical surveillance of myopathy during telbivudine treatment is needed due to the significant latency of its development. Dose adjustment for impaired renal function does not eliminate the risk of TIM occurrence.

The Ca _V 3.2 T-Type Ca ²⁺ Channel Is Required for Pressure Overload-Induced Cardiac Hypertrophy in Mice

Chiang, Chien-Sung,Huang, Ching-Hui,Chieng, Hockling,Chang, Ya-Ting,Chang, Dory,Chen, Ji-Jr,Chen, Yong-Cyuan,Chen, Yen-Hui,Shin, Hee-Sup,Campbell, Kevin P.,Chen, Chien-Chang Ovid Technologies Wolters Kluwer -American Heart A 2009 Circulation research Vol.104 No.4

<P>Voltage-gated T-type Ca(2+) channels (T-channels) are normally expressed during embryonic development in ventricular myocytes but are undetectable in adult ventricular myocytes. Interestingly, T-channels are reexpressed in hypertrophied or failing hearts. It is unclear whether T-channels play a role in the pathogenesis of cardiomyopathy and what the mechanism might be. Here we show that the alpha(1H) voltage-gated T-type Ca(2+) channel (Ca(v)3.2) is involved in the pathogenesis of cardiac hypertrophy via the activation of calcineurin/nuclear factor of activated T cells (NFAT) pathway. Specifically, pressure overload-induced hypertrophy was severely suppressed in mice deficient for Ca(v)3.2 (Ca(v)3.2(-/-)) but not in mice deficient for Ca(v)3.1 (Ca(v)3.1(-/-)). Angiotensin II-induced cardiac hypertrophy was also suppressed in Ca(v)3.2(-/-) mice. Consistent with these findings, cultured neonatal myocytes isolated from Ca(v)3.2(-/-) mice fail to respond hypertrophic stimulation by treatment with angiotensin II. Together, these results demonstrate the importance of Ca(v)3.2 in the development of cardiac hypertrophy both in vitro and in vivo. To test whether Ca(v)3.2 mediates the hypertrophic response through the calcineurin/NFAT pathway, we generated Ca(v)3.2(-/-), NFAT-luciferase reporter mice and showed that NFAT-luciferase reporter activity failed to increase after pressure overload in the Ca(v)3.2(-/-)/NFAT-Luc mice. Our results provide strong genetic evidence that Ca(v)3.2 indeed plays a pivotal role in the induction of calcineurin/NFAT hypertrophic signaling and is crucial for the activation of pathological cardiac hypertrophy.</P>

Dose-Dependent Associations between Wine Drinking and Breast Cancer Risk - Meta-Analysis Findings

Chen, Jia-Yan,Zhu, Hong-Cheng,Guo, Qing,Shu, Zheng,Bao, Xu-Hui,Sun, Feng,Qin, Qin,Yang, Xi,Zhang, Chi,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3

Purpose: To investigate any potential association between wine and breast cancer risk. Materials and Methods: We quantitatively assessed associations by conducting a meta-analysis based on evidence from observational studies. In May 2014, we performed electronic searches in PubMed, EmBase and the Cochrane Library to identify studies examining the effect of wine drinking on breast cancer incidence. The relative risk (RR) or odds ratio (OR) were used to measure any such association. Results: The analysis was further stratified by confounding factors that could influence the results. A total of twenty-six studies (eight case-control and eighteen cohort studies) involving 21,149 cases were included in our meta-analysis. Our study demonstrated that wine drinking was associated with breast cancer risk. A 36% increase in breast cancer risk was observed across overall studies based on the highest versus lowest model, with a combined RR of 1.0059 (95%CI 0.97-1.05) in dose-response analysis. However, 5 g/d ethanol from wine seemed to have protective value from our non-linear model. Conclusions: Our findings indicate that wine drinking is associated with breast cancer risk in a dose-dependent manner. High consumption of wine contributes to breast cancer risk with protection exerted by low doses. Further investigations are needed for clarification.