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오늘 본 자료
Hoa Thi Tran,Giang Thu Nguyen,Hong Ha Thi Nguyen,Huyen Thi Tran,Quang Hong Tran,Quang Ho Tran,Ngoc Thi Ninh,Phat Tien Do,Ha Hoang Chu,Ngoc Bich Pham 한국균학회 2022 Mycobiology Vol.50 No.5
Endophytic fungi are promising sources for the production of podophyllotoxin-an important anticancer compound, replacing depleted medical plants. In this study, the endophytes asso- ciated with Dysosma difformis-an ethnomedicinal plant species were isolated to explore novel sources of podophyllotoxin. Fifty-three endophytic fungi were isolated and identified by morphological observation and ITS-based rDNA sequencing, assigning them to 27 genera in 3 divisions. Fusarium was found the most prevalent genus with a colonization frequency of 11.11%, followed by Trametes (9.26%) and Penicillium (7.41%). Phylogenetic trees were constructed for the endophytic fungi community in two collection sites, Ha Giang and Lai Chau, revealing the adaptation of the species to the specific tissues and habitats. Cytotoxic activity of endophytic fungal extracts was investigated on cancer cell lines such as SK-LU-1, HL-60, and HepG2, demonstrating strong anti-cancer activity of six isolates belonging to Penicillium, Trametes, Purpureocillium, Aspergillus, and Ganoderma with IC50 value of lower than 10 mg/mL. The presence of podophyllotoxin was indicated in Penicillium, Trametes, Aspergillus and for the first time in Purpureocillium and Ganoderma via high-performance liquid chromatography, which implied them as a potential source of this anti- cancer compound.
An overview bioactive compounds on the skin of frogs (Anura)
Tran Thi Huyen,Phan Thi Hoang Anh,Nguyen Thi Anh Hong,Nguyen Ngoc Duyen,Le Pham Tan Quoc,Tran Dinh Thang 한국수산과학회 2023 Fisheries and Aquatic Sciences Vol.26 No.4
The robust development of frog farming offered high economic benefits but created a large waste residue of frog bones and skin that received little attention. Over the years, inedible by-products have often been processed into biomolecules of potential value and environmental benefits, such as collagen, gelatin, and bioactive peptides. An overview of bioactive compounds on frog skins from various countries indicated that brevinin was the most abundant biological peptide found in frog skin. Other remaining compounds also possessed their highlighted activities, including antibacterial, stimulating insulin release and gastric hormone release, anti-cancer, and neuroregulatory. Notably, various components have been analyzed in the structure and sequence to give meaningful insight into clustering components related to their biological activity. This review may create a source of raw materials for the developmental research of by-products from frog skin and concomitantly reduce environmental pollution.
The Impact of Foreign Ownership and Management on Firm Performance in Vietnam
NGUYEN, Thi Xuan Hong,PHAM, Thu Huyen,DAO, Thi Nhung,NGUYEN, Thi Nga,TRAN, Thi Kim Ngoc Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9
The human and capital resources from foreign investors are important sources of finance for developing countries. Foreign ownership can help the firm to raise funds for operations and the foreign management can help the firm expand the market and improve management. However, does this really happen to Vietnamese firm? To find the answer to that question, this paper examines the impact of foreign ownership and management on the financial performance of listed firms on Vietnam's stock market. The data collected include 427 listed firms in all fields over five years, from 2014 to 2018. The financial performance is measured by Tobin's Q, ROA and ROE. The study carried out testing of each model by the least squares method of Pool OLS, assessing random effects (REM) and evaluating fixed effects (FEM). The most effective model is the FEM model. The results show that the foreign ownership ratio and the size of the firm have a positive impact on the financial performance. The foreign management, the age of the firms, the liquidity and financial leverage have a negative impact on the financial performance. Based on the research results, the study proposes some recommendations to improve the financial performance of listed firms in Vietnam.
Lipoxygenase Inhibitory Constituents from Rhubarb
Tran Minh Ngoc,Pham Thi Hong Minh,Tran Manh Hung,IkSoo Lee,민병선,Phuong Thien Thuong,배기환 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
Phytochemical study on the ethanol extract of rhubarb led to the isolation of fifteen compounds, including five anthraquinones: chrysophanol (1), physcion (2), emodin (7), chrysophanol- 8-O-β-D-glucopyranoside (9) and emodin-8-O-β-D-glucopyranoside (15), and ten stilbenes: desoxyrhaponticin (3), rhaponticin (4), resveratrol (5), desoxyrhapotigenin (6), rhapontigenin (8), piceatannol-3'-O-β-D-glucopyranoside (10), piceid (11), ε -viniferin (12), ampelopsin B (13) and isorhaponticin (14). Their structures were identified by comparing the physicochemical data with those of published papers. Among the isolated compounds, stilbene derivatives (3-6, 8 and 10-14) showed remarkable inhibitory effect on lipoxygenase with IC50 values ranging from 6.7 to 74.1 μM. The inhibition kinetics analyzed by Lineweaver-Burk plots found that they were competitive inhibitors with the linoleic acid at the active site of lipoxygenase. In addition, stilbenes exhibited significantly free radical scavenging activity against ABTS•+ with trolox equivalent activity capacity (TEAC) values ranging from 1.16 to 4.64. Whereas, anthraquinone derivatives (1-2, 7, 9 and 15) neither inhibited lipoxygenase nor scavenged free radical ABTS•+. These results indicated that stilbene derivatives were considerate to be mainly lipoxygenase inhibitor and free radical scavenger constituents of rhubarb.
Lipoxygenase Inhibitory Constituents from Rhubarb
Ngoc, Tran Minh,Minh, Pham Thi Hong,Hung, Tran Manh,Thuong, Phuong Thien,Lee, Ik-Soo,Min, Byung-Sun,Bae, Ki-Hwan 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
Phytochemical study on the ethanol extract of rhubarb led to the isolation of fifteen compounds, including five anthraquinones: chrysophanol (1), physcion (2), emodin (7), chrysophanol-8-O-$\beta$-D-glucopyranoside (9) and emodin-8-O-$\beta$-D-glucopyranoside (15), and ten stilbenes: desoxyrhaponticin (3), rhaponticin (4), resveratrol (5), desoxyrhapotigenin (6), rhapontigenin (8), piceatannol-3'-O-$\beta$-D-glucopyranoside (10), piceid (11), $\varepsilon$-viniferin (12), ampelopsin B (13) and isorhaponticin (14). Their structures were identified by comparing the physicochemical data with those of published papers. Among the isolated compounds, stilbene derivatives (3-6, 8 and 10-14) showed remarkable inhibitory effect on lipoxygenase with $IC_{50}$ values ranging from 6.7 to $74.1\;{\mu}M$. The inhibition kinetics analyzed by Lineweaver-Burk plots found that they were competitive inhibitors with the linoleic acid at the active site of lipoxygenase. In addition, stilbenes exhibited significantly free radical scavenging activity against $ABTS^{\bullet+}$ with trolox equivalent activity capacity (TEAC) values ranging from 1.16 to 4.64. Whereas, anthraquinone derivatives (1-2, 7, 9 and 15) neither inhibited lipoxygenase nor scavenged free radical $ABTS^{\bullet+}$. These results indicated that stilbene derivatives were considerate to be mainly lipoxygenase inhibitor and free radical scavenger constituents of rhubarb.
Improvement of Tomato Seedling Quality under Low Temperature by Application of Silicate Fertilizer
Ngoc-Thang Vu(넉탕부),Anh-Tuan Tran(안추안트란),Thi-Tuyet-Cham Le(띠투엣참리),Jong-Kuk Na(라종국),Si-Hong Kim(김시홍),Jong-Man Park(박종만),Dong-Cheol Jang(장동철),Il-Seop Kim(김일섭) (사)한국생물환경조절학회 2017 시설원예‧식물공장 Vol.26 No.3
규산 시비가 토마토 플러그 묘소질에 미치는 영향과 묘의 저온저장시 규산의 저온장해 경감효과를 검토하였다. ‘Rapito’품종을 공시하여 30일간 32구 규격의 플러그 트레이에서 육묘한 뒤, 여섯 개의 규산 처리농도구 (8, 16, 32, 64, 128 및 256mM)를 설계하여 20일 동안 주 2회 관주 처리한 뒤, 묘소질을 대조구와 비교하였다. 처리 농도는 16mM과 32mM 처리가 초장, 엽면적, 생체중, T/R율 및 근권부 발육 등 대부분의 생육지표에서 타 처리구에 비해 양호했으며, 특히 16mM의 농도에서 가장 좋은 묘소질을 보였으나, 64mM 이상의 고농도에서는 대조구에 비해 전반적으로 생육이 억제되는 경향을 보였다. 토마토 묘의 생리적 반응에서 엽온에서는 처리구별 차이가 나타나지 않았으나, 증산율은 32mM이상의 농도 처리구에서 기공확산 저항이 증가하면서 증산율이 감소되는 경향을 보였다. 또한, 처리 횟수에 따른 효과를 검토하기 위해 16mM농도의 규산을 20일 동안 6, 10, 20회 관주처리 한 결과, 대부분의 생육지표에서 처리 횟수간에는 큰 차이가 없었으나, 무처리구에 비해 묘소질이 향상되었으며, 특히 뿌리표면적, 근장, root tip수등 근권부의 생육이 현저히 증가하였다. 아울러 규산처리가 저온저장시 토마토 묘의 저온장해를 감소시키는 효과가 있음을 확인하였다. The object of this study was to improve tomato seedling quality in low temperature(below 7, 10℃ during night time or daily mean air temperature was 18℃) by application of silicate fertilizer. Six different silicate fertilizer concentrations (8, 16, 32, 64, 128, and 256mM) or water as the control were applied to tomato seedlings twice a week for 20 days. Positive effects were observed in the growth parameters of the seedlings treated with 16 and 32mM silicate fertilizer; the most effective concentration of silicate at which seedlings showed the best performance was 16mM. However, a high concentration of silicate (256mM) caused negative effects on the growth. The transpiration rate decreased alongside with the increase of silicate concentration up to 32mM, possibly due to the increased stomatal diffusive resistance. Silicate stimulated the growth and development of tomato seedlings, resulting in increased growth parameters and root morphology. However, no significant differences were observed among treatment numbers of soil-drenching wuth the silicate (6, 10, or 20 times with 16mM) for 20 days, suggesting that silicate treatment with 6 times may be sufficient to induce the silicate effects. The application of 16mM of silicate fertilizer reduced relative ion leakage and chilling injury during low temperature storage. In addition, the seedlings treated with silicate fertilizer recovered faster than those without silicate treatment after low temperature storage.
Tran Thi Thu Thuy,Nguyen Manh Cuong,Tran Quoc Toan,Ngo Ngoc Thang,Bui Huu Tai,Nguyen Xuan Nhiem,Hye-Jin Hong,Sohyun Kim,Stephanie Legoupy,고영상,Young Ho Kim 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.7
A series of N-substituted-1,2,3-triazole murrayafolineAderivativeswere successfully synthesized usingclick azide–alkyne Huisgen cycloaddition reaction between1-methoxy-3-methyl-9-(3-azido)-propyl-9H-carbazole andsubstituted alkynes. Their chemical structures were confirmedby 1H, 13C NMR and HR-ESI–MS spectral data. Inaddition, the interested effects on LPS-stimulated productionof pro-inflammatory cytokines in bone marrow-deriveddendritic cells of synthetic murrayafoline A derivatives werealso investigated. Our results indicated that murrayafoline Aderivatives containing 1,2,3-triazole nucleus potentiallypossessed anti-inflammatory action through inhibiting productionof IL-6, IL-12 p40 and TNF-a.
Hai Thi Hong Truong,김수연,Hung Ngoc Tran,Thuy Thi Thu Nguyen,Long Tien Nguyen,Toan Kim Hoang 한국원예학회 2015 Horticulture, Environment, and Biotechnology Vol.56 No.4
We report the development of a codominant sequence characterized amplified region (SCAR) marker linked to resistance to a Korean R. solanacearum isolate in tomato line Hawaii 7996. Bulked segregant analysis was employed for rapid identification of RAPD markers linked to resistance genes. Genomic DNA from six resistant F9 recombinant inbred lines (RILs) and six susceptible F9 RILs, which derived from a cross between S. lycopersicum Hawaii 7996 (resistant parent) and S. pimpinellifolium WVa 700 (susceptible parent) were pooled in to an R-pool and an S-pool, respectively. A total of 800 RAPD primers were screened and only six primers (UBC#176, 205, 287, 317, 350, and 676) showed polymorphism between R- and S- pools. Of these, only two markers UBC#176 and 317 revealed a 100% linkage in the individual plants comprising the contrasting bulks. Of these, the marker UBC#176 was converted into a co-dominant SCAR marker and designated as SCU176-534. The marker SCU176-534 was confirmed by genotyping the individual of the R- and S- pools and gave the same result as UBC#176. When the marker SCU176-534 was further validated for association with resistance and its potential for maker-assisted selection (MAS) in 92 tomato lines and cultivars, the results showed that none of these carries the resistance gene. Thus, SCAR marker SCU176-534 can be used in early selection of resistant lines when Hawaii 7996 is used as a parent in a breeding program.