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      • KCI등재

        Clavulanic Acid Is a Leading Culprit Beta-Lactam in Immediate Allergic Reactions to Penicillins

        Torres-Rojas Isabel,Pérez-Alzate Diana,Somoza Maria Luisa,Pfeifer Ana Prieto-Moreno,Diaz Elisa Haroun,Jimenez-Rodriguez Teodorikez W,Sánchez Javier Fernández,Ruano Francisco J,Blanca Miguel,Blanca-Lóp 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.2

        Purpose: Clavulanate, a beta-lactam associated with amoxicillin, is frequently prescribed in patients at all ages. Recent data implicate amoxicillin-clavulanate in up to 80% of beta-lactam allergy cases. We assessed clavulanate’s role in inducing allergic reactions to this combination treatment, with a focus on selective immediate reactions. Methods: Adults (≥ 16 years) reporting a history of immediate reactions to amoxicillin-clavulanate were evaluated through a beta-lactam allergological workup, using modified European Academy of Allergy and Clinical Immunology guidelines. Patients first underwent skin testing, and if negative, drug provocation tests. Expected outcomes were: Group A, subjects with immediate reaction to classical penicillin group determinants (penicilloyl polylysine, minor determinants mixture, and/or penicillin G); Group B, subjects with selective immediate reaction to amoxicillin; Group C, subjects with selective immediate reaction to clavulanate and Group D, those immediate reactions with co-sensitization to clavulanate plus penicillin group determinants or amoxicillin. Results: Of 1,170 included patients, 104 had immediate reactions: 36.5% to penicillin group determinants (Group A), 26.9% to amoxicillin (Group B), 32.7% to clavulanate (Group C), and 3.8% to clavulanate plus penicillin determinants or amoxicillin (Group D). Diagnosis was made by skin testing in 79%, 75% and 47% of the patients, respectively, in the first 3 groups (P < 0.001). Drug provocation tests were necessary to establish most other diagnoses. Anaphylaxis predominated over urticaria/angioedema in all groups. Conclusions: Selective immediate reactions to clavulanate accounted for over a third of cases with confirmed reactions after amoxicillin-clavulanate intake, with more than half experiencing anaphylaxis. Within this group, skin test sensitivity was below 50%. People taking amoxicillin-clavulanate may also be co-sensitized to both drugs.

      • KCI등재

        First-principles calculation of volatile organic compound adsorption on carbon nanotubes: Furan as case of study

        Torres Ana M.,Correa J. D. 한국탄소학회 2021 Carbon Letters Vol.31 No.5

        Sensing of volatile organic compounds (VOCs) is a growing research topic because of the concern about their hazard for the environment and health. Furan is a VOC produced during food processing, and it has been classifed as a risk molecule for human health and a possible biomarker of prostate cancer. The use of carbon nanotubes for VOCs sensing systems design could be a good alternative. In this work, a theoretical evaluation of the interactions between furan and zigzag single-wall carbon nanotubes takes into account diferent positions and orientations of the furan molecule, within a density-functional theory frst-principles approach. The van der Waals interactions are considered using diferent exchange-correlation functionals (BH,C09, DRSLL and KBM). The results indicate that vdW-functionals do not signifcantly afect geometry; however, the binding energy and the distance between furan and nanotube are strongly dependent on the selected exchange-correlation functional. On the other hand, the efects of single and double vacancies on carbon nanotube are considered. It was found that the redistribution of charge around the single-vacancy afects the bandgap, magnetic moment, and binding energy of the complex, while furan interaction with a double-vacancy does not considerably change the electronic structure of the system. Our results suggest that to induce changes in the electronic properties of carbon nanotubes by furan, it is necessary to change the nanotube surface, for example, by means of structural defects.

      • KCI등재

        Technology Convergence in Tourism Education: Modelling a Multimedia Technology Inclusive Academic Instruction

        Torres, Arnelyn Manaluz 차세대컨버전스정보서비스학회 2022 디지털예술공학멀티미디어논문지 Vol.9 No.2

        COVID-19 laid the groundwork for the transition from traditional to digital classrooms during its peak period. In the digital classroom, various technologies enhance teachings, such as hardware (PCs, laptops, tablets, and smartphones) and software (social media sites, videos, slides, sounds, and narrations). To illustrate how digital technologies enhance, innovate, and keep up with tourism education, this paper describes how convergences of digital technologies enhance, innovate, and update tourism education. The author selected a hybrid classroom setting as a case study for International Tourism and Culture, a course offered during the Fall 2021 semester. In designing and implementing the course, the facilitator employed content, pedagogical, and technological knowledge. As part of the course management plan, both the facilitator and students will utilize technology. The study concludes that incorporating multimedia technology in teaching tourism courses provides numerous advantages, such as 1) time and space flexibility, 2) development and practice of technical competencies, 3) positive effect on students' engagement, and 4) promotion of soft skills development. Integrating multimedia technology into the teaching of courses and throughout the curriculum contributes to the development of strategies for transforming Tourism Education.

      • SCOPUSKCI등재

        Accessory mental foramen: A rare anatomical variation detected by cone-beam computed tomography

        Torres, Marianna Guanaes Gomes,Valverde, Ludmila De Faro,Vidal, Manuela Torres Andion,Crusoe-Rebello, Ieda Margarida Korean Academy of Oral and Maxillofacial Radiology 2015 Imaging Science in Dentistry Vol.45 No.1

        The mental foramen is a bilateral opening in the vestibular portion of the mandible through which nerve endings, such as the mental nerve, emerge. In general, the mental foramen is located between the lower premolars. This region is a common area for the placement of dental implants. It is very important to identify anatomical variations in presurgical imaging exams since damage to neurovascular bundles may have a direct influence on treatment success. In the hemimandible, the mental foramen normally appears as a single structure, but there are some rare reports on the presence and number of anatomical variations; these variations may include accessory foramina. The present report describes the presence of accessory mental foramina in the right mandible, as detected by cone-beam computed tomography before dental implant placement.

      • DOMESTIC INTEGRATION OF RICE MARKETS IN THE PHILIPPINES AND ITS DETERMINANTS

        Torres, Maria Angelica C.,Bacud, Eva Salve,Delos Reyes, Julieta 한국무역학회 2019 한국무역학회 국제학술대회 Vol.2019 No.08

        Due to the high political significance of rice, government has been putting efforts in order to address rice insufficiency in the Philippines. Provisioning of trade reforms and policies is one of the interventions to improve the availability and affordability of rice in the country, and to protect the welfare of the local rice farmers. Government intervention and support services would not be fully effective if markets are not integrated, since price signals would not be transmitted efficiently and gains from trade will not be fully grasped. This paper examined integration between domestic rice markets across 16 regions in the Philippines using Johansen co-integration approach with 18-year period monthly retail price series of regular-milled rice from January 2000 to December 2017. Determinants of market integration were also identified. It was found out that 63% of the regional rice markets are integrated. Volume of production, distance and shock affected areas have significantly influenced integration among regional rice markets.

      • Analyzing corrosion rates of TiO<sub>2</sub> nanotubes/titanium separation passive layer under surface and crystallization changes

        Torres, I. Zamudio,Dominguez, A. Sosa,Bueno, J.J. Perez,Meas, Y.,Lopez, M.L. Mendoza,Dector, A. Techno-Press 2021 Advances in nano research Vol.10 No.3

        The evaluation of the corrosion resistance of titanium with a TiO2 nanotubes top layer was carried out (TiO2 NT). These nanostructures were evolved into anatase nanoparticles without heat treatment in an aqueous medium, which is a novel phenomenon. This work analyzes the layer between the nanotube bottom and the substrate, which is thin and still susceptible to corrosion. The bottom of TiO2 nanotubes having Fluor resulting from the synthesis process changed between amorphous to crystalline anatase with a crystallite size of about 4 nm, which influenced the corrosion rates. Four kinds of samples were evaluated. A) NT by Ti anodizing; B) NTSB for Ti plates, either modifying its surface or anodizing the modified surface; C) NT-480 for anodized Ti and heat-treated (480℃) for reaching the anatase phase; D) NTSB-480 for Ti plates, first, modifying its surface using sandblast, after that, anodizing the modified surface, and finally, heat-treated to 480℃ to compare with samples having induced crystallization and passivation. Four electrochemical techniques were used to evaluate the corrosion rates. The surfaces having TiO2 nanotubes with a sandblast pre-treatment had the highest resistance to corrosion.

      • KCI등재

        Genetic evaluation of sheep for resistance to gastrointestinal nematodes and body size including genomic information

        Torres Tatiana Saraiva,Sena Luciano Silva,Santos Gleyson Vieira dos,Figueiredo Filho Luiz Antonio Silva,Barbosa Bruna Lima,Júnior Antônio de Sousa,Britto Fábio Barros,Sarmento José Lindenberg Rocha 아세아·태평양축산학회 2021 Animal Bioscience Vol.34 No.4

        Objective: The genetic evaluation of Santa Inês sheep was performed for resistance to gastrointestinal nematode infection (RGNI) and body size using different relationship matrices to assess the efficiency of including genomic information in the analyses. Methods: There were 1,637 animals in the pedigree and 500, 980, and 980 records of RGNI, thoracic depth (TD), and rump height (RH), respectively. The genomic data consisted of 42,748 SNPs and 388 samples genotyped with the OvineSNP50 BeadChip. The (co)variance components were estimated in single- and multi-trait analyses using the numerator relationship matrix (A) and the hybrid matrix H, which blends A with the genomic relationship matrix (G). The BLUP and single-step genomic BLUP methods were used. The accuracies of estimated breeding values and Spearman rank correlation were also used to assess the feasibility of incorporating genomic information in the analyses. Results: The heritability estimates ranged from 0.11±0.07, for TD (in single-trait analysis using the A matrix), to 0.38±0.08, for RH (using the H matrix in multi-trait analysis). The estimates of genetic correlation ranged from –0.65±0.31 to 0.59±0.19, using A, and from –0.42±0.30 to 0.57±0.16 using H. The gains in accuracy of estimated breeding values ranged from 2.22% to 75.00% with the inclusion of genomic information in the analyses. Conclusion: The inclusion of genomic information will benefit the direct selection for the traits in this study, especially RGNI and TD. More information is necessary to improve the understanding on the genetic relationship between resistance to nematode infection and body size in Santa Inês sheep. The genetic evaluation for the evaluated traits was more efficient when genomic information was included in the analyses. Objective: The genetic evaluation of Santa Inês sheep was performed for resistance to gastrointestinal nematode infection (RGNI) and body size using different relationship matrices to assess the efficiency of including genomic information in the analyses.Methods: There were 1,637 animals in the pedigree and 500, 980, and 980 records of RGNI, thoracic depth (TD), and rump height (RH), respectively. The genomic data consisted of 42,748 SNPs and 388 samples genotyped with the OvineSNP50 BeadChip. The (co)variance components were estimated in single- and multi-trait analyses using the numerator relationship matrix (A) and the hybrid matrix H, which blends A with the genomic relationship matrix (G). The BLUP and single-step genomic BLUP methods were used. The accuracies of estimated breeding values and Spearman rank correlation were also used to assess the feasibility of incorporating genomic information in the analyses.Results: The heritability estimates ranged from 0.11±0.07, for TD (in single-trait analysis using the A matrix), to 0.38±0.08, for RH (using the H matrix in multi-trait analysis). The estimates of genetic correlation ranged from –0.65±0.31 to 0.59±0.19, using A, and from –0.42±0.30 to 0.57±0.16 using H. The gains in accuracy of estimated breeding values ranged from 2.22% to 75.00% with the inclusion of genomic information in the analyses.Conclusion: The inclusion of genomic information will benefit the direct selection for the traits in this study, especially RGNI and TD. More information is necessary to improve the understanding on the genetic relationship between resistance to nematode infection and body size in Santa Inês sheep. The genetic evaluation for the evaluated traits was more efficient when genomic information was included in the analyses.

      • Mass transfer analysis for CO<sub>2</sub> bubble absorption in methanol/Al<sub>2</sub>O<sub>3</sub> nanoabsorbents

        Torres Pineda, Israel,Kim, Dongmin,Kang, Yong Tae Elsevier 2017 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.114 No.-

        <P><B>Abstract</B></P> <P>In this paper computational fluid dynamics (CFD) analysis is carried out to investigate CO<SUB>2</SUB> bubble absorption characteristics in methanol/Al₂O<SUB>3</SUB> nanoabsorbents. Bubble size, rising velocity and mass transfer rate are compared to the previous experimental results for validation. It is found that the distance traveled for each CO<SUB>2</SUB> bubble increases as the concentration of Al<SUB>2</SUB>O<SUB>3</SUB> increases, which, in consequence, increases the residence time between liquid and gas phases resulting in higher interfacial mass transfer rates. For the case of a bubble rising in the gap between walls, the wall shear stress has a major effect on the bubble diameter and rising velocity which in consequence affects the mass transfer coefficient. It is concluded that the mass transfer coefficient enhances by about 40% by adding Al₂O<SUB>3</SUB> nanoparticles (0.01vol%) compared with pure methanol absorbent from the experimental and simulation results. It is also concluded that the use of nanoparticles has a higher impact on mass transfer rate than it does on mass transfer amount, which depends on the residence time and travel distance of CO<SUB>2</SUB> bubbles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mass transfer analysis is carried out for CO<SUB>2</SUB> bubble absorption in nanoabsorbents. </LI> <LI> CO<SUB>2</SUB> absorption enhancement by nanoabsorbents is evaluated. </LI> <LI> Mass transfer coefficient enhances by about 40% by adding Al₂O<SUB>3</SUB> nanoparticles (0.01vol%). </LI> <LI> The use of nanoparticles has a higher impact on mass transfer rate than it does on mass transfer amount. </LI> </UL> </P>

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