Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis

Wang, Tingyu,Li, Jun,Jin, Zhigui,Wu, Feihua,Li, Yunwu,Wang, Xiaohua,Zhou, Hong,Zhou, Qian The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2

CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) have been shown to play a regulatory or suppressive role in the immune response and are possibly relevant to the pathogenesis of autoimmune diseases. In the present study, we attempted to investigate the frequency of CD4+CD25+ Tregs in peripheral blood (PB) of collagen-induced arthritis (CIA) rats during the development of arthritis, to determine whether their frequency is involved in the immunoregulation of this disease. The results showed that normal rats had similar frequencies of CD4+CD25+ Tregs in PB during the experiment time, expressed as a percentage of CD4+CD25+Foxp3+ T cells among the CD4+ T lymphocyte population. In contrast, the frequency of CD4+CD25+Foxp3+ T cells in CIA rats was found to change during the development of arthritis. In CIA rats, there is a significant negative correlation between the frequency of CD4+CD25+Foxp3+ T cells and paw swelling (r=-0.786, p< 0.01). The relationship between the frequency of CD4+CD25+Foxp3+ T and immune activation was not found in normal rats. During the time course, the frequency of CD4+CD25+Foxp3+ T was lower in CIA rats than in normal ones. The data suggest that the frequency of PB CD4+CD25+ Tregs may be a promising marker for arthritis activity.

Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis

Tingyu Wang,Jun Li,Zhigui Jin,Feihua Wu,Yunwu Li,Xiaohua Wang,Hong Zhou,Qian Zhou 대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2

CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) have been shown to play a regulatory orsuppressive role in the immune response and are possibly relevant to the pathogenesis of autoimmunediseases. In the present study, we attempted to investigate the frequency of CD4+CD25+ Tregs inperipheral blood (PB) of collagen-induced arthritis (CIA) rats during the development of arthritis, todetermine whether their frequency is involved in the immunoregulation of this disease. The resultsshowed that normal rats had similar frequencies of CD4+CD25+ Tregs in PB during the experimenttime, expressed as a percentage of CD4+CD25+Foxp3+ T cells among the CD4+ T lymphocyte population. In contrast, the frequency of CD4+CD25+Foxp3+ T cells in CIA rats was found to change duringthe development of arthritis. In CIA rats, there is a significant negative correlation betweenthe frequency of CD4+CD25+Foxp3+ T cells and paw swelling (r=−0.786, p< 0.01). The relationshipbetween the frequency of CD4+CD25+Foxp3+ T and immune activation was not found in normal rats. During the time course, the frequency of CD4+CD25+Foxp3+ T was lower in CIA rats than in normalones. The data suggest that the frequency of PB CD4+CD25+ Tregs may be a promising marker forarthritis activity.

Testing independence and goodness-of-fit jointly for functional linear models

Tingyu Lai,Zhongzhan Zhang,Wang Yafei 한국통계학회 2021 Journal of the Korean Statistical Society Vol.50 No.2

A conventional regression model for functional data involves expressing a response variable in terms of the predictor function. Two assumptions, that (i) the predictor function and the error are independent and (ii) the relationship between the response variable and the predictor function takes functional linear model, are usually added to the model. Checking the validation of these two assumptions is fundamental to statistic inference and practical applications. We develop a test procedure to check these assumptions simultaneously based on generalized distance covariance. We establish the asymptotic theory for the proposed test under null and alternative hypotheses, and provide a bootstrap procedure to obtain the critical value of the test. The proposed test is consistent against all alternatives provided that the semimetrics related to the generalized distance are strong negative, and can be readily generalized to other functional regression models. We explore the finite sample performance of the proposed test by using both simulations and real data examples. The results illustrate that the proposed method has favorable performance compared with the competing method.

Simultaneous removal of NOx and SO2 using two-stage O3 oxidation combined with Ca(OH)2 absorption

Yang Zou,Yan Wang,Xiaolong Liu,Tingyu Zhu,Mengkui Tian,Maoyu Cai 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.11

This paper proposes two-stage O3 oxidation combined with Ca(OH)2 for simultaneous removal of NOx and SO2 (NOx: Nitrogen oxides including NO, NO2 and N2O5). In two-stage oxidation, NO was first oxidized to NO2 in an oxidation tube, and NO2 was further oxidized into N2O5 in the spray tower. NOx and SO2 were simultaneously removed in the spray tower. This method can effectively reduce the extra waste of O3 caused by the decomposition of N2O5, especially at high temperature. Effects of various factors on denitrification efficiency were investigated. The results showed that the NOx removal efficiency decreased and O3 extra consumption ratio increased with the increase of oxidation temperature or oxidation reaction time. When the O3/NO molar ratio was 1.8, one-stage O3 oxidation at 150 oC extra wasted 33.3% of O3. With the increase of O3 concentration at site 2, the NOx removal efficiency first increased and then stabilized. Compared with the one-stage O3 oxidation-absorption, the two-stage oxidation-absorption improved NOx removal efficiency from 62.5% to 89%. In addition, the increase of CaSO3 slurry concentration had little effect on the denitrification efficiency.

Cyclic Behavior of Sand under Traffic Loading with ‘Inclined’ Consolidation

Lin Guo,Yuan Fang,Tingyu Wu,Jun Wang,Hongxu Jin,Li Shi 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.5

To investigate the vertical strain development of sand under traffic loading after the process of ‘inclined’ consolidation, a series of cyclic drained tests were carried out by using a hollow cylinder apparatus. Three parameters were considered in this paper: initial consolidation angle, vertical cyclic stress ratio and cyclic torsional stress ratio. Test results show that the vertical strain under traffic loading path is larger than that of specimens whose cyclic torsional stress ratio is equal to 0 in the same situation. Furthermore, the vertical stain will decrease with the increase of consolidating inclination in the situation of same values of vertical cyclic stress ratio and cyclic torsional stress ratio. When initial consolidation angle is equal to 0o and 22.5o, the vertical strain will increase with increasing value of cyclic torsional stress ratio, while the effect of cyclic torsional stress ratio on vertical strain will be less significant when initial consolidation angle is equal to 45o. Moreover the trend that vertical strain increases with increasing value of cyclic torsional stress ratio will be more significant for a larger value of vertical cyclic stress ratio.

Ab initio calculations of electronic structures of SrMoO4 crystals containing F and F+ color centers

Jigang Yin,Qiren Zhang,Tingyu Liu,Xiaofeng guo,Min Song,Xien Wang,Haiyan Zhang 한국물리학회 2009 Current Applied Physics Vol.9 No.6

The electronic structures of SrMoO4 crystals containing F and F+ color centers with the lattice structure optimized are studied within the framework of the fully relativistic self-consistent Dirac–Slater theory, using a numerically discrete variational (DV-Xα) method. From the calculation, it is concluded that F and F+ color centers have donor energy level in the forbidden band. The electronic transition energies from the donor level to the bottom of the conduction band are 1.855 eV and 2.161 eV, respectively, which correspond to the 670 nm and 575 nm absorption bands. It is predicted that the 670 nm and 575 nm absorption bands originate from the F and F+ centers in SrMoO4 crystals. The electronic structures of SrMoO4 crystals containing F and F+ color centers with the lattice structure optimized are studied within the framework of the fully relativistic self-consistent Dirac–Slater theory, using a numerically discrete variational (DV-Xα) method. From the calculation, it is concluded that F and F+ color centers have donor energy level in the forbidden band. The electronic transition energies from the donor level to the bottom of the conduction band are 1.855 eV and 2.161 eV, respectively, which correspond to the 670 nm and 575 nm absorption bands. It is predicted that the 670 nm and 575 nm absorption bands originate from the F and F+ centers in SrMoO4 crystals.

First-principles study on electronic states of SrWO4 crystals containing F-type color centers

Min Song,Qiren Zhang,Tingyu Liu,Jigang Yin,Xiaofeng Guo,Haiyan Zhang,Xi’en Wang 한국물리학회 2009 Current Applied Physics Vol.9 No.4

The electronic structures of the SrWO4 crystals containing F-type color centers are studied within the framework of the fully relativistic self-consistent Dirac–Slater theory using a numerically discrete variational (DV-Xα) method. The calculations indicate that either F or F+ center has donor energy level within the forbidden band. The electronic transition energies from the two donor levels to the bottom of the conduction band are 1.82 eV and 2.28 eV corresponding to the 685 nm and 545 nm absorption bands, respectively. It is, therefore, concluded that the 545–685 nm absorption bands are originated from the F and F+ center in SrWO4 crystal respectively. The electronic structures of the SrWO4 crystals containing F-type color centers are studied within the framework of the fully relativistic self-consistent Dirac–Slater theory using a numerically discrete variational (DV-Xα) method. The calculations indicate that either F or F+ center has donor energy level within the forbidden band. The electronic transition energies from the two donor levels to the bottom of the conduction band are 1.82 eV and 2.28 eV corresponding to the 685 nm and 545 nm absorption bands, respectively. It is, therefore, concluded that the 545–685 nm absorption bands are originated from the F and F+ center in SrWO4 crystal respectively.

Study on the Stability of Accumulated Layer Landslide under the Coupling Action of Earthquake and Rainfall

Xiaohui Yang,Xianfeng Diao,Tingyu Zhou,Fei Hu,Sihan Wang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.1

Tectonic movement, heavy rainfall and other environmental factors are important factors causing the slope instability of accumulation body. Aiming at jiangdingya H1 landslide in Bailong River Basin, Zhouqu County, Gansu Province, the deformation law and stability of accumulation landslide under the coupling condition of earthquake and rainfall were systematically analyzed by means of laboratory physical model test, numerical simulation and theoretical derivation. The results show that: 1) The crack development law of landslide model test under the coupling effect of earthquake and rainfall is analyzed, and the stability characteristics of landslide deformation and failure in three stages are obtained. 2) According to the model test and numerical simulation results, it is found that the coupling effect has the greatest influence on the stability of the slope toe of the accumulation landslide, and the failure mode of the accumulation landslide changes from “pull-shear” failure to “compression-shear” failure, and the failure of the accumulation landslide occurs in a local location. 3) Based on the unbalanced thrust method and GA model, a landslide stability calculation model of loose accumulation body under the coupling effect of earthquake and rainfall was improved by comprehensively considering the effects of complex factors such as seismic inertia force and seepage force.The research results can provide reference for landslide prevention, monitoring and early warning in Zhouqu area of Gansu Province.

Study on surface physical and chemical mechanism of nanobubble enhanced flotation of fine graphite

Tang Chongliang,Ma Fangyuan,Wu Tingyu,Zhang Di,Wang Ye,Zhao Tonglin,Fan Zhaolin,Liu Xinyue 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.122 No.-

It has been concluded in a recently published investigation that the nanobubble flotation process significantlyreduces the number of fine flake graphite flotation stages and improves the flotation performance. The present study was conducted to explore the mechanisms of surface nanobubbles enhancing flake graphiteflotation by investigating effects of nanobubbles on surface properties of graphite and interactionsbetween particles and bubbles by use of contact angle analyzer, zeta potential analyzer, FourierTransform Infrared Spectroscopy (FTIR), and X-ray Photoelectron Spectroscopy (XPS). The study resultsshow that nanobubbles can improve the surface properties of graphite and enhance the adsorption effectof collector, which increased the contact angle of the graphite surface by 11.93 compared with conventionalflotation. Infrared spectroscopy and potential analysis showed that the nanobubbles could enhancethe hydrophobic attraction and reduce the electrostatic repulsion between the collector and the graphitesurface, which was beneficial to enhance the hydrophobic surface of the graphite and enhance theagglomeration of fine graphite particles. XPS analysis showed that the nanobubbles covered polar hydrophilicgroups (such as CAO, C@O, COOH) on the graphite surface, which enhanced the adsorption of collectorto improve the hydrophobicity of graphite surface.

Study on the doping mechanism and electronic structure for Nb5+ doping PbWO4 crystals

Teng Chen,Kaiyu Xu,Dongli Shi,Mingjie Wang,Tingyu Liu 한국물리학회 2010 Current Applied Physics Vol.10 No.1

The existing forms of the impurity Nb5+ in the Nb5+:PbWO4 (PWO) crystals are simulated by computer technology. The possible various kinds of defects in the Nb5+:PWO crystals are also simulated. By analyzing the calculation results of defect formation energies and binding energies, the optimal substitution positions of the Nb5+ ions and the charge compensating mechanism [Nb-w+V2+ o +Nb-w] in the Nb5+:PWO crystals were obtained. The electronic structures for Nb5+:PWO were calculated with density functional theory code CASTEP. It shows that the doping of Nb5+ ions could suppress the 350 nm absorption band.