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Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis
Wang, Tingyu,Li, Jun,Jin, Zhigui,Wu, Feihua,Li, Yunwu,Wang, Xiaohua,Zhou, Hong,Zhou, Qian The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2
CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) have been shown to play a regulatory or suppressive role in the immune response and are possibly relevant to the pathogenesis of autoimmune diseases. In the present study, we attempted to investigate the frequency of CD4+CD25+ Tregs in peripheral blood (PB) of collagen-induced arthritis (CIA) rats during the development of arthritis, to determine whether their frequency is involved in the immunoregulation of this disease. The results showed that normal rats had similar frequencies of CD4+CD25+ Tregs in PB during the experiment time, expressed as a percentage of CD4+CD25+Foxp3+ T cells among the CD4+ T lymphocyte population. In contrast, the frequency of CD4+CD25+Foxp3+ T cells in CIA rats was found to change during the development of arthritis. In CIA rats, there is a significant negative correlation between the frequency of CD4+CD25+Foxp3+ T cells and paw swelling (r=-0.786, p< 0.01). The relationship between the frequency of CD4+CD25+Foxp3+ T and immune activation was not found in normal rats. During the time course, the frequency of CD4+CD25+Foxp3+ T was lower in CIA rats than in normal ones. The data suggest that the frequency of PB CD4+CD25+ Tregs may be a promising marker for arthritis activity.
Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis
Tingyu Wang,Jun Li,Zhigui Jin,Feihua Wu,Yunwu Li,Xiaohua Wang,Hong Zhou,Qian Zhou 대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2
CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) have been shown to play a regulatory orsuppressive role in the immune response and are possibly relevant to the pathogenesis of autoimmunediseases. In the present study, we attempted to investigate the frequency of CD4+CD25+ Tregs inperipheral blood (PB) of collagen-induced arthritis (CIA) rats during the development of arthritis, todetermine whether their frequency is involved in the immunoregulation of this disease. The resultsshowed that normal rats had similar frequencies of CD4+CD25+ Tregs in PB during the experimenttime, expressed as a percentage of CD4+CD25+Foxp3+ T cells among the CD4+ T lymphocyte population. In contrast, the frequency of CD4+CD25+Foxp3+ T cells in CIA rats was found to change duringthe development of arthritis. In CIA rats, there is a significant negative correlation betweenthe frequency of CD4+CD25+Foxp3+ T cells and paw swelling (r=−0.786, p< 0.01). The relationshipbetween the frequency of CD4+CD25+Foxp3+ T and immune activation was not found in normal rats. During the time course, the frequency of CD4+CD25+Foxp3+ T was lower in CIA rats than in normalones. The data suggest that the frequency of PB CD4+CD25+ Tregs may be a promising marker forarthritis activity.