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Taufiq Ahmad,신영민,이진규,신혁준,Sajeesh Kumar Madhurakart Perikamana,신흥수 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.67 No.-
Here, we engineered spheroids by using ECM mimicking nano-fragments (NFs) with fibroblasts and investigated their effect on proliferation and cell/ECM interactions. NF incorporation resulted in formation of a stable spheroid, which improved proliferation and viability of cells by assisting oxygen transport confirmed by LOX-1 staining. In addition, hypoxic and apoptotic genes were significantly downregulated in spheroids with PD-NFs. Furthermore, ECM and cell junction proteins were highly expressed. Overall, our findings suggest that incorporation of NFs within spheroids for assembly with various cell types can be an alternative approach for 3D cell culture in many applications.
Taufiq Carnegie Dawood,Alamsyah Alwi,Rustam Effendi,Muhammad Abrar 대한산업공학회 2022 Industrial Engineeering & Management Systems Vol.21 No.2
Open economies’ banking systems are prone to financial stability issues and global crises. Most financing to the pri-vate sector is channeled through bank credit, and Islamic banking is expanding worldwide. This study’s novelty com-pared to previous studies is investigating whether the international bank lending channel, measured by foreign interest rate changes, and exchange rate dynamics influences domestic Islamic bank credit vis-à-vis conventional bank credit . In Islamic banking, transactions based on interest are prohibited and hence should not influence Islamic bank credit. Employing the NARDL framework, this study found that Islamic bank credit is negatively related to foreign interest rates. In addition, Islamic bank credit is found to be more significantly affected by the international bank lending channel than conventional bank credit. Furthermore, the exchange rate negatively influences domestic Islamic bank credit more significantly than conventional bank credit. The findings are in contrast with parts of the literature, which insinuates that Islamic banking is immune to weaknesses of conventional banking system. For recommendations, in formulating policies aimed at financial stability, authorities must consider the international bank lending channel, exchange rate dynamics and take into account the different relationships these variables have with Islamic, and conventional bank credit.
Ahmad, Taufiq,Parray, Shabir Ahmad,Ahmad, Naseem,Khan, Javed Ahmad,Zohaib, Sharique Cellmed Orthocellular Medicine and Pharmaceutical 2019 셀메드 (CellMed) Vol.9 No.1
Bronchial asthma is one of the most common chronic diseases globally and currently affects approximately 300 million people worldwide. As per scientific data, approximately 10-12% of adults; and 15% of children are affected by the disease. The increasing global prevalence of the disease imposes a high health care costs into its mechanisms and treatment. Unani system of medicine (USM) is a well known traditional therapy for number of diseases since ancient times. Time has proved that USM has a special role in treatment of chronic diseases, due its special Usooleillaj (Line of treatment). Dhiq al-Nafas (bronchial asthma) is also considered as a chronic disease. Since ancient times, the disease was cured by number of single as well as compound formulations by renowned Unani scholars. This review provides a comprehensive summary of medicinal plant throughout the world, with reference to renowned Unani scholars and physicians for treatment of Dhiq al-Nafas. A number of Unani single and compound drugs, highly efficacious and safe drugs are available for the asthma. The data were taken from classical literature of USM, Modern reference books & electronic journals. The recent information was collected from different authentic search engines. This review will provide the centuries therapeutic information's of classical literature and recent scientific studies of 12 herbal drugs mentioned in USM, which will help the academia, clinicians, research scholars and post graduate students from Unani Medicine, Traditional & Complementary Medicine and other related disciplines, having research interest or work in the Unani medicine.
Ahmad Taufiq,Yuanita Amalia Hariyanto,Sunaryono,Siriwat Soontaranon 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.75 No.9
Hydroxyapatite, which has been widely used in the medical eld in the last couple of years, is a superior biomaterial due to its biocompatibility and nontoxicity. Hydroxyapatite requires highly magnetic materials to perform maximally in specic medical elds. In this study, hydroxyap- atite/magnetite composites mainly composed of limestone and natural iron sand were synthesized through a coprecipitation method, and composites having different hydroxyapatite-to-magnetite mass ratios were compared. The crystal structure, particle size, fractal dimension, morphology, functional group, and energy gap were characterized using X-ray diffraction (XRD), synchrotron X-ray scattering (SAXS), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, and ultraviolent-visible (UV-Vis) spectroscopy. The research results showed that the hydroxyapatite and magnetite phases had a hexagonal structure and cubic structure, respectively. In general, from the FTIR data analysis, the hydroxyapatite and magnetite particles were iden- tied from the functional groups of phosphate, iron-oxygen, carbonate, and hydroxyl. Moreover, depending on particle size, the samples consisting of 3.7-nm primary particles formed a cluster with a massive three-dimensional structure. Meanwhile, the energy gap showed various values ranging between 3.25 and 3.86 eV.
Ahmad, Taufiq,Lee, Jinkyu,Shin, Young Min,Shin, Hyeok Jun,Madhurakat Perikamana, Sajeesh Kumar,Park, Sun Hwa,Kim, Sung Won,Shin, Heungsoo Elsevier 2017 ACTA BIOMATERIALIA Vol.64 No.-
<P><B>Abstract</B></P> <P>Extracellular matrix (ECM) microenvironment is critical for the viability, stemness, and differentiation of stem cells. In this study, we developed hybrid-spheroids of human turbinate mesenchymal stem cells (hTMSCs) by using extracellular matrix (ECM) mimicking fragmented fibers (FFs) for improvement of the viability and functions of hTMSCs. We prepared FFs with average size of 68.26 µm by partial aminolysis of poly L-lactide (PLLA) fibrous sheet (FS), which was coated with polydopamine for improved cell adhesion. The proliferation of hTMSCs within the hybrid-spheroids mixed with fragmented fibers was significantly increased as compared to that from the cell-only group. Cells and fragmented fibers were homogenously distributed with the presence of pore like empty spaces in the structure. LOX-1 staining revealed that the hybrid-spheroids improved the cell viability, which was potentially due to enhanced transport of oxygen through void space generated by engineered ECM. Transmission electron microscopy (TEM) analysis confirmed that cells within the hybrid-spheroid formed strong cell junctions and contacts with fragmented fibers. The expression of cell junction proteins including connexin 43 and E-cadherin was significantly upregulated in hybrid-spheroids by 16.53 ± 0.04 and 28.26 ± 0.11-fold greater than that from cell-only group. Similarly, expression of integrin α<SUB>2,</SUB> α<SUB>5</SUB>, and β<SUB>1</SUB> was significantly enhanced at the same group by 25.72 ± 0.13, 27.48 ± 0.49, and 592.78 ± 0.06-fold, respectively. In addition, stemness markers including Oct-4, Nanog, and Sox2 were significantly upregulated in hybrid-spheroids by 96.56 ± 0.06, 158.95 ± 0.06, and 115.46 ± 0.47-fold, respectively, relative to the cell-only group. Additionally, hTMSCs within the hybrid-spheroids showed significantly greater osteogenic differentiation under osteogenic media conditions. Taken together, our hybrid-spheroids can be an ideal approach for stem cell expansion and serve as a potential carrier for bone regeneration.</P> <P><B>Statement of Significance</B></P> <P>Cells are spatially arranged within extracellular matrix (ECM) and cell/ECM interactions are crucial for cellular functions. Here, we developed a hybrid-spheroid system incorporating engineered ECM prepared from fragmented electrospun fibers to tune stem cell functions. Conventionally prepared cell spheroids with large diameters (>200 µm) is often prone to hypoxia. In contrast, the hybrid-spheroids significantly enhanced viability and proliferation of human turbinate mesenchymal stem cells (hTMSCs) as compared to spheroid prepared from cell only. Under these conditions, the presence of fragmented fibers also improved maintenance of stemness of hTMSCs for longer time cultured in growth media and demonstrated significantly greater osteogenic differentiation under osteogenic media conditions. Thus, the hybrid-spheroids can be used as a delivery carrier for stem cell based therapy or a 3D culture model for <I>in vitro</I> assay.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>