바세도우(Basedow)病의 診斷과 治療

Takasu Novuyuki 藥業新聞社 1986 (月刊) 醫藥情報 Vol.1986 No.1

No Effect of High Fat Diet-Induced Obesity on Spontaneous Reporter Gene Mutations in gpt Delta Mice

Takasu, Shinji,Ishii, Yuji,Matsushita, Kohei,Kuroda, Ken,Kijima, Aki,Kodama, Yukio,Ogawa, Kumiko,Umemura, Takashi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

A large number of epidemiological studies have demonstrated that obesity is a risk factor for several human cancers. Several animal studies using rodents with diet-induced or genetic obesity have also demonstrated that obesity can promote tumor development. However, the effects of obesity on the early stages of carcinogenesis, and especially on the spontaneous occurrence of somatic gene mutations, remain unclear. To investigate the effects of obesity on the rate of spontaneous gene mutations, we performed reporter gene mutation assays in liver, kidney, and colon, organs in which obesity appears to be associated with cancer development on the basis of epidemiological or animal studies, in mice with high fat diet (HFD)-induced obesity. Six-week-old male and female C57BL/6 gpt delta mice were fed HFD or standard diet (STD) for 13 or 26 weeks. At the end of the experiments, reporter gene mutation assays of liver, kidney, and colon were performed. Final body weights and serum leptin levels of male and female mice fed HFD for 13 or 26 weeks were significantly increased compared with corresponding STD-fed groups. Reporter gene mutation assays of liver, kidney, and colon revealed that there were no significant differences in gpt or $Spi^-$ mutant frequencies between STD- and HFD-fed mice in either the 13-week or 26-week groups. These results indicate that HFD treatment and consequent obesity does not appear to influence the spontaneous occurrence of somatic gene mutations.

Oviposition by the larval parasitoid Microplitis croceipes into conspecific adults

K. Takasu,K. H. Le 한국응용곤충학회 2005 한국응용곤충학회 학술대회논문집 Vol.2005 No.05

Improvement of Robustness of the Dual Floor Image Tracking Odometry Measurement

Takahiro TAKASU,Makoto MIZUKAWA,Yoshinobu ANDO 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

Dual Floor Image Tracking (DFIT) is a dead reckoning component, which acquires optical flows of ground images from two cameras. The robot that is equipped with the DFIT can measure its position and rotation without being affected by slip or drift. Noncontact feature of the DFIT enables to add-on robots with an arbitrary driving mechanism. This paper presents the design principle of the DFIT and the features of RT component with experimental evaluation.

Comparison of conventional and new endoscopic band ligation devices for colonic diverticular bleeding

Ayaka Takasu,Takashi Ikeya,Yasutoshi Shiratori 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.3

Background/Aims: Endoscopic band ligation (EBL) is used to treat colonic diverticular bleeding (CDB). An endoscopic variceal ligationdevice for esophageal varices is used as a conventional EBL device (C-EBL). A new EBL device (N-EBL) was developed by SumitomoBakelite Co. in August 2018. We aimed to evaluate the clinical outcomes of N-EBL compared with those of C-EBL. Methods: Seventy-nine patients who underwent EBL for CDB at St. Luke’s International Hospital, Japan, between 2017 and 2020 wereincluded in this retrospective study. Patients were divided into the C-EBL and N-EBL groups. Their clinical outcomes, includingachieving initial hemostasis, early rebleeding, procedure time, and EBL-associated adverse events, were evaluated. Results: Of the 79 patients, 36 (45.6%) were in the C-EBL group and 43 (54.4%) were in the N-EBL group. The rate of achieving initialhemostasis was 100% in the C-EBL group and 93.0% in the N-EBL group. No significant difference was noted in the early rebleedingrate between the groups (p=0.24). The N-EBL group achieved a shorter median EBL procedure time than the C-EBL group (14.2 minutesvs. 18.2 minutes, p=0.02). No adverse events were observed in either group. Conclusions: The N-EBL device is safe and useful and may reduce EBL procedure time.

Conservative Loan Loss Allowance and Bank Lending

Yusuke TAKASU,Makoto NAKANO 한국유통과학회 2019 The Journal of Asian Finance, Economics and Busine Vol.6 No.3

The purpose of this study is to investigate the relation between conservative loan loss accounting practice of banks, defined as accounting behavior that increases loan loss allowances against expected credit losses, and bank lending. Furthermore, we specify the macroeconomic conditions reflecting debtors’ borrowing environments and analyze how these conditions affect the relation between conservative loan loss allowances and bank lending. Although existing literature reports that accounting conservatism has a direct effect on non-financial firms’ investment behavior, there is little evidence about an effect of conservatism on banks’ lending behavior. By exploiting data showing the links between individual Japanese firms and their individual lenders to control both loan demand and supply, we estimate OLS regressions to test the relationships among conservative loan loss allowance, bank lending, and macroeconomic conditions using a unique dataset containing bank–firm–year observations between 2001 and 2013. We find banks that have conservative loan loss allowances tend to provide fewer loans to firms with financing needs when macroeconomic conditions are good and these conservative banks are likely to provide more loans to firms when macroeconomic conditions are bad. Our findings suggest that reflecting expected credit loss into loan loss allowances can mitigate the procyclical behavior of banks.

히다(Hida) 변성대의 북동부에 위치하는 가따까이가와(片貝川) 유역 히다 변성암류에 대한 변성암석학적인 연구

전은영,Takasu. A 대한지질학회 1992 대한지질학회 학술대회 Vol.1992 No.

Genetic association of swine leukocyte antigen class II haplotypes and body weight in Microminipigs

Tatsuya Matsubara,Masaki Takasu,Noriaki Imaeda,Naohito Nishii,Satoshi Takashima,Takashi Nishimura,Toshiaki Nishimura,Takashi Shiina,Asako Ando,Hitoshi Kitagawa 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.2

Objective: Microminipigs are a novel animal model with extensive applications in laboratory studies owing, in part, to their extremely small body sizes. In this study, the relationship between swine leukocyte antigen (SLA) class II haplotype and body weight was evaluated in the Microminipig population. Methods: A total of 1,900 haplotypes, covering SLA class II haplotypes Lr-0.7, Lr-0.23, Lr-0.17, Lr-0.37, Lr-0.16, Lr-0.11, Lr-0.13, and Lr-0.18, were analyzed in 950 piglets. Birth weights and weights on postnatal day 50 were examined in piglets with eight different SLA class II haplotypes. Results: The mean birth weight of piglets with the Lr-0.23 haplotype (0.415 kg, n = 702) was significantly lower than that of piglets with Lr-0.17 (0.445 kg, n = 328) and Lr-0.37 (0.438 kg, n = 383) haplotypes. At postnatal day 50, the mean body weight of piglets with the Lr-0.23 haplotype (3.14 kg) was significantly lower than that of piglets with the Lr-0.13 haplotype (3.46 kg, p<0.01). There were no significant differences in daily gains (DGs) among the eight haplotypes. However, piglets with the Lr-0.11 and -0.18 haplotype combination or any heterozygous haplotype combinations containing Lr-0.23 had significantly lower DGs than those of piglets with the Lr-0.18, 0.37 haplotype combination. Conclusion: Piglets with the Lr-0.23 haplotype had relatively low body weights at birth and on postnatal day 50 and slightly lower DGs than those of piglets with other haplotypes. Therefore, the Lr-0.23 SLA class II haplotype may be a suitable marker for the selective breeding of Microminipigs with small body sizes.

Effects of the combination of SGLT2 selective inhibitor ipragliflozin and various antidiabetic drugs in type 2 diabetic mice

Atsuo Tahara,Toshiyuki Takasu,Masanori Yokono,Masakazu Imamura,Eiji Kurosaki 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.2

The sodium-glucose cotransporter 2 (SGLT2) is responsible for most glucose reabsorption in the kidney and has been proposed as a novel therapeutic target for the treatment of type 2 diabetes. In the present study, the combinatory effects of SGLT2 selective inhibitor ipragliflozin and various antidiabetic drugs in high-fat diet and streptozotocin-nicotinamide-induced type 2 diabetic mice were investigated. Ipragliflozin dose-dependently increased urinary glucose excretion and improved glucose tolerance. In addition, each antidiabetic drug (mitiglinide, glibenclamide, sitagliptin, insulin, metformin, voglibose, or rosiglitazone) also significantly improved glucose tolerance without affecting urinary glucose excretion. Combination treatment of ipragliflozin with each antidiabetic drug additively improved glucose tolerance. In these experiments, ipragliflozin-induced increases in urinary glucose excretion were not influenced by combination treatment with antidiabetic drugs. Further, ipragliflozin did not affect antidiabetic drug-induced insulinotropic action (mitiglinide and glibenclamide), increases in plasma glucagon-like peptide-1 and insulin levels via inhibition of dipeptidyl peptidase 4 activity (sitagliptin), increases in plasma insulin level (insulin), decreases in hepatic phosphoenolpyruvate carboxykinase activity (metformin), inhibition of small intestinal disaccharidase activity (voglibose), or improvement of impaired insulin secretion (rosiglitazone). These results suggest that combination treatment of ipragliflozin with various antidiabetic drugs additively enhances the improvement in glucose tolerance without affecting each drug’s unique pharmacological effects. Ipragliflozin may therefore be expected to be effective when administered as part of a combination regimen in the treatment of type 2 diabetes.

Learning of narcotic odors by a parasitoid

Bui, Lan Huong,Takasu, Keiji Institute of Agricultural Science 2009 Korean Journal of Agricultural Science Vol.36 No.1

When the parasitic wasp Microplitis croceipes experiences odors while feeding on sugar water, it learns to associate the odors with sugar and thereafter exhibits typical food searching behavior in response to the odors. Previous studies have shown that this wasp can be used for detection of the small amount of explosives or other volatile chemicals. In the present study, we examined if this wasp can learn and report narcotic odors. Males of M. croceipes were trained to link sugar water with pseudo-narcotic scents that have been used for training narcotic detection dogs, and their behavioral response to the trained odors was observed. The males that had been given either an odor or sugar water did not show any positive response to the odors. However, when the wasps were given a combination of sugar water and either the pseudo-Cocaine, Heroin, LSD or Marihuana, they quickly learned to associate the odors with sugar, and thereafter positively responded to those odors. Our results suggest that this wasp can be used for detection of these narcotics.