말라리아 환자 32예의 임상적 고찰

정용희,백일현,김태형,김영식,이우인,서환조 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 삼일열 말라리아는 국내에서 1986년 이후에는 박멸된 것으로 알려졌으나 1993년 이후 증가하는 양상을 보이고 있다. 이에 말라리아의 임상적 고찰을 통하여 이 질환을 이해함에 있다. 방법 : 1991년 1월부터 1999년 10월까지 반복적 고열과 오한을 주소로 본 병원에 내원하여 말초혈액 도말검사에 의해 말라리아 감염으로 확진된 32예의 환자에 대해서 후향적으로 조사하였다. 결과 : 1991년부터 1999년 10월까지 총 32명의 환자의 연도별 발생빈도는 각각 1991년에 1명, 1996년에 1명, 1997년에 3명, 1998년에 13명, 1999년에 14명이었다. 월별발생빈도는 7월과 8월에 집중적으로 발생하였다.(46.9%) 환자의 거주지는 경기 연천과 파주에 주로 분포되었다(53.1%). 성별발생분포는 32예의 환자중에 여자가 5명, 남자가 27명으로 남자가 더 많았다. 발병연령은 22세에서 87세까지 분포되었고 20-30대에 많이 발생하였으며 20대가 가장 많았다. 군인 및 제대자가 17명(59.4%)에 해당하였으며, 제대자의 평균 제대후의 기간은 10개월 정도였다. 가장 흔한 임상증상은 발열 및 오한이었다.(100%) 비장종대 및 간장종대는 각각 26명(81.3%), 3명(9.4%)에서 관찰되었다. 검사실 소견은 평균적으로 WBC 5.317/㎕, 혈색소 12.5±7.1g/㎗, 혈소판 78,906.3±68391.4㎕, GOT/GPT 43.7±26.7/49.6±57.3 IU/ℓ, Total bilirubin 1.6±0.9㎎/㎗를 보였다. 말초혈액 도말검사상 모두 P. vivax였다. 치료는 hydroxychloroquine과 primaquine의 치료에 잘 반응하였다. 결론 : 말라리아는 7월과 8월에 한국에서 호발하는 중요한 급성 열성 질환으로 조기 진단 및 치료에 보다 관심을 기울여야 할 것이다. Background : In Korea malaria has been rare, but since reemergence of indigenous vivax malaria in 1993, the number of cases of malaria have recently increased. We analyzed the cases of malaria who were treated in Kyung-Hee University College of Medicine with regard to define the clinical characteristics of malaria. Methods : We retrospectively analyzed of 32 cases of malaria admitted to Kyung-Hee University Hospital between 1991 and 1999. Malaria was diagnosed by peripheral blood smear. Results : Among a total of 32 cases, the number of yearly incidence of 1991, 1996. 1997, 1998 and 1999 were 1,1,3,13,14 respectively. It demonstrated the high incidence especially between July and August. The most patients (53.1%) resided in Yeonchon and Pajoo. Among them, 5 cases were female and 27 cases were male. The age distribution ranged from 22 to 76 year old. The high incidence of age was between 20's and 30's. Military solidiers and ex-soldiers are 17 cases(59.4 %). The most frequent symptom was fever and chills (100%). Splenomegaly and hepatomegaly were also observed in 81.3 %(26 of 32) and 9.4 %(3 of 32) respectively. The laboratory findings were WBC 5.317/㎕. Hb 12.5±2.1 g/dl. platelet 78,906±68,391.4/㎕. GOT/GPT 43.7±26.7/49.6±57.3 IU/L. LD 678.3±50.1 IU/L. total bilirubin 1.6±0.9mg/dl- The all cases were treated suscessfully with hydroxychloroquine and primaquine. There were no central nervous system complications and pulmonary edema. Conclusion : Malaria is one of the important acute febrile illness with the high incidence between July and August.

기분석 정보에 기반한 색인어 추출에 관한 연구

진정환,김태완 인제대학교기초과학연구소 2001 자연과학 Vol.5 No.-

본 논문에서는 기분석 사전정보를 이용한 색인어 추출 시스템을 제안한다. 일반적으로 형태소 분석 방법은 실행시에 어절마다 코드변환, 형태소분리, 원형복원 규칙을 통한 분석후보의 여과 등의 과정을 거쳐 형태소 분석을 수행하므로 실행 효율의 관점에서 효율적이지 못하다. 이러한 문제점을 완화하기 위하여 어절 단위의 기분석 사전에 의한 분석을 실시하여 색인어로 추출함으로써 실행효율을 개선할 수 있다. 또한 사전 미등록 어휘를 포함한 복합명사의 분해를 위하여 각각의 어절의 음절 패턴에 따라 분해를 실시하여 단위 명사를 추출하였으며 복합 명사 분리시 통계정보와 MNPR을 이용하여 분해모호성 문제를 해결하였다. 본 논문에서 제시한 색인어 추출시스템은 문서분류, 문서용약, 정보추출 등의 분야에서 유용하게 사용할 수 있다. In the paper, we propose an index term abstract system based on pre-Analysis information. Most morphological analysis methods require repetitive procedures of input character segmentation and lemmatization of constitument morphemes, filtering of candidate results through looking up lexicons, which causes run-time inefficiency. To alleviate such problem of run-time inefficiency, we extract index term use a method of morphological analysis based on pre-analysis of partial words, so as to enhance the run time performance of the system. Moreover, we proposed a method of using statistical information and MNPR(Minimal Noun Preference Rule)in order to segment compound nouns include unregistered noun. Proposed index term abstract system is used usefully document classification, document summarization, information retrieval.

Methotrexate 치료를 받고 있는 활동성 류마티스 관절염 환자에서 etanercept의 유효성과 안전성에 관한 연구

최병렬,강태영,정청일,이혜순,엄완식,김태환,전재범,유대현,배상철 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 류마티스 관절염을 앓고 있는 한국인 중에 기존 DMARDs로 치료 실패하였고, 고정용량의 MTX를 복용하고 있는 환자들에 있어서 etanercept의 유효성과 안전성을 평가하고자 하였다. 방법 : 기존 DMARDs로 치료 실패한 활동성 류마티스 관절염 환자 76명을 대상으로 하여 단일군, 공개시험을 하였다. 대상 환자들은 고정용량의 MTX를 복용하면서 etanercept 25 mg을 1주일에 두 번 피하 주사하였으며 12주간 투여하였다. 유효성은 ACR 20, ACR 50,조조강직 시간으로 평가하였고, 약제의 안전성은 이상반응 등으로 평가하였다. 결과 : 대상 환자는 총 76명으로 평균 연령은 45.2세, 남자 5명, 여자 71명이었다. 84.4%인 54명이 12주째에 ACR 20을 만족하였고, 53.1%인 34명이 12주째에 ACR 50을 만족하였다. 조조 강직 시간은 치료 전 203.3분에서 치료 12주째 42.6분을 평균 74.5% 호전되었다. 가장 흔한 이상반응은 주사부위 반응이었다. 이외에도 상기도 감염, 오심, 안면부종 등이 발생하였으나 심각한 부작용은 없었다. 결론 : etanercept는 효과적이고, 안전한 류마티스 관절염 치료 방법이며 특히 MTX치료에도 불구하고 활동성인 류마티스 관절염에 기대되는 치료라고 할 수 있다. Background : This study was performed to investigate the efficacy and safety of etanercept in active rheumatoid arthritis patients with stable dose of methotrexate in Korean. Methods : In a 12 week, single arm, open trial, we assigned 76 patients with active rheumatoid arthritis who had an inadequate response to disease-modifying antirheumatic drugs. Patients received twice-weekly subcutaneous injections of etanercept 25 ㎎ while containing to receive methotrexate at a stable dose of 7.5~25 ㎎ per week. The clinical response was defined as the percent improvement in disease activity according to the criteria of the American Collage of Rheumatology (ACR) at 12 weeks. Results : Etanrecept led to significant improvements in disease activity and was safe and well tolerated. At 12 week, 84.4% of the patients receiving 25 ㎎ of etanercept achieved a 20% ACR response, and 53.1% of those receiving etanercept achieved a 50% ACR response. The most common adverse event was injection-site reaction. Other advanse events were upper respiratory infection, nausea, and facial edema, but there were no serious adverse events associated with etanercept. Conclusion : In active rheumatoid arthritis patients, etanercept was safe, well tolerated, and provided rapid clinical improvements.

Numerical Study on Roughness Effect for Axi-symmetry Submerged Body in High Reynolds Number

Tae-Hwan Joung,Hyung-Do Song,Jong-Gil Yum,Seongjin Song,Sunho Park 해양환경안전학회 2018 海洋環境安全學會誌 Vol.24 No.2

본 논문은 3차원 축대칭 몰수체에 대해 소스 코드가 공개된 OpenFOAM 4.0을 이용하여 첫 번째 격자의 높이와 레이놀즈 수에 따른 마찰저항 변화에 대해 연구하였다. 마찰저항 계산을 위해 경계조건, 수치조건을 정립하였다. 축대칭 물체의 3차원 효과로 인해 거칠 기가 매우 작은 12 μΜ에서도 부드러운 표면과 비교해 마찰저항이 다르게 계산되었다. 레이놀즈 수가 커질수록 경계층의 두께 증가가 감소되었으며 이로 인해 마찰저항의 증가량이 감소되었다. 첫 번째 격자의 크기인 y+에 대한 영향에 대해서도 검토하였다. 첫 번째 격자가 log layer에 위치하고 있지 않으면 마찰저항과 표면의 전단력이 과도하게 예측되는 것을 확인하였다. 이는 경계층이 두껍게 예측되어 난류 에너지가 과도하게 예측되었기 때문으로 판단된다. 표면의 거칠기가 커질수록 경계층이 두꺼워지고 표면의 난류에너지가 증가되는 것을 확인하였다. 마찰저항을 정확하게 예측하기 위해서는 y+ 값, 거칠기 및 벽함수가 적절한 영역에 위치해야 함을 알 수 있었다. In this paper, the friction drag force of 3D submerged body is investigated by considering the surface roughness, the first grid height, and the Reynolds number using open CFD source code, OpenFOAM 4.0. A procedure for estimating drag components by CFD code is set up and suggested in this study. In the 3D submerged body, because of the form factor in the 3D computations, the friction resistance with the small roughness of 12  obtains different result with the smooth wall. As the Reynolds number increased, the boundary layer becomes thinner and the fiction resistance tends to decrease. In the computations for the effect of y+, the friction resistance and wall shear stress are excessively predicted when the y+ value deviates from the log layer. This is presumably because the boundary layer becomes thicker and the turbulence energy is excessively predicted in the nose due to the increase in y+ value. As the roughness increases, the boundary layer becomes thicker and the turbulence kinetic energy on the surface increases. From this study, the drag estimation method, considering the roughness by numerical analysis for ships or offshore structures, can be provided by using the suggested the y+ value and surface roughness with wall function.

Shape optimization of an autonomous underwater vehicle with a ducted propeller using computational fluid dynamics analysis

Tae-Hwan Joung,Karl Sammut,Fangpo He,이승건 대한조선학회 2012 International Journal of Naval Architecture and Oc Vol.4 No.1

Autonomous Underwater Vehicles (AUVs) provide a useful means of collecting detailed oceano-graphic information. The hull resistance of an AUV is an important factor in determining the power requirements and range of the vehicle. This paper describes a procedure using Computational Fluid Dynamics (CFD) for determining the hull resistance of an AUV under development, for a given propeller rotation speed and within a given range of AUV velocities. The CFD analysis results reveal the distribution of the hydrodynamic values (velocity, pressure, etc.) around the AUV hull and its ducted propeller. The paper then proceeds to present a methodology for optimizing the AUV profile in order to reduce the total resistance. This paper demonstrates that shape optimization of conceptual designs is possible using the commercial CFD package contained in Ansys™. The optimum design to minimize the drag force of the AUV was identified for a given object function and a set of constrained design parameters.

Verification of CFD analysis methods for predicting the drag force and thrust power of an underwater disk robot

Joung, Tae-Hwan,Choi, Hyeung-Sik,Jung, Sang-Ki,Sammut, Karl,He, Fangpo The Society of Naval Architects of Korea 2014 International Journal of Naval Architecture and Oc Vol.6 No.2

This paper examines the suitability of using the Computational Fluid Dynamics (CFD) tools, ANSYS-CFX, as an initial analysis tool for predicting the drag and propulsion performance (thrust and torque) of a concept underwater vehicle design. In order to select an appropriate thruster that will achieve the required speed of the Underwater Disk Robot (UDR), the ANSYS-CFX tools were used to predict the drag force of the UDR. Vertical Planar Motion Mechanism (VPMM) test simulations (i.e. pure heaving and pure pitching motion) by CFD motion analysis were carried out with the CFD software. The CFD results reveal the distribution of hydrodynamic values (velocity, pressure, etc.) of the UDR for these motion studies. Finally, CFD bollard pull test simulations were performed and compared with the experimental bollard pull test results conducted in a model basin. The experimental results confirm the suitability of using the ANSYS-CFX tools for predicting the behavior of concept vehicles early on in their design process.

Shape optimization of an autonomous underwater vehicle with a ducted propeller using computational fluid dynamics analysis

Joung, Tae-Hwan,Sammut, Karl,He, Fangpo,Lee, Seung-Keon The Society of Naval Architects of Korea 2012 International Journal of Naval Architecture and Oc Vol.4 No.1

Autonomous Underwater Vehicles (AUVs) provide a useful means of collecting detailed oceano-graphic information. The hull resistance of an AUV is an important factor in determining the power requirements and range of the vehicle. This paper describes a procedure using Computational Fluid Dynamics (CFD) for determining the hull resistance of an AUV under development, for a given propeller rotation speed and within a given range of AUV velocities. The CFD analysis results reveal the distribution of the hydrodynamic values (velocity, pressure, etc.) around the AUV hull and its ducted propeller. The paper then proceeds to present a methodology for optimizing the AUV profile in order to reduce the total resistance. This paper demonstrates that shape optimization of conceptual designs is possible using the commercial CFD package contained in Ansys$^{TM}$. The optimum design to minimize the drag force of the AUV was identified for a given object function and a set of constrained design parameters.

A Study on the Structural Design and Analysis of a Deep-sea Unmanned Underwater Vehicle

TAE-HWAN JOUNG,JAE-HWAN LEE,IN-SIK NHO,JONG-MOO LEE,PAN-MOOK LEE 한국해양공학회 2006 韓國海洋工學會誌 Vol.20 No.3

This paper discusses the structural design and analysis of a 6,000 meters depth-rated capable deep-sea unmanned underwater vehicle (UUV) system. The UUV system is currently under development by Maritime and Ocean Engimeeimg Rereauch Institute(MOERI), Korea Ocean Research and Development Institute (KORDI). The UUV system is composed of three vehicles - α Remotely Operated Vehicle (ROV), an Autonomous Underwater Vehicle (AUV) and a Launcher - which include underwater equipment. The dry weight of the system exceeds 3 tons hence it is necessary to carry out the optimal design of structural system to ensure the minimum weight and sufficient space within the frame for the convenient use of the embedded equipments. In this paper, therefore, the structural design and analysis of the ROV and launcher frame system were carried out, using the optimizing process. The cylindrical pressure vessels for the ROV were designed to resist the extreme pressure of 600 bars, based on the finite element analysis. The collapse pressure for the cylindrical pressure vessels was also checked through a theoretical analysis.

Anthocyanins in Cowpea [Vigna unguiculata (L.) Walp. ssp. unguiculata]

Tae Joung Ha,Myoung-Hee Lee,Yu Na Jeong,Jin Hwan Lee,Sang-Ik Han,Chang-Hwan Park,Suk-Bok Pae,Chung-Dong Hwang,In-Youl Baek,Keum-Yong Park 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.3

The aim of this study was to isolate and identify the anthocyanins in the black seed coated cowpea [Vigna unguiculata (L.) Walp. ssp. unguiculata] using reverse phase C-18 open column chromatography and high performance liquid chromatography (HPLC) with diode array detection and electro spray ionization/mass spectrometry (DAD-ESI/MS) analysis, respectively. Anthocyanins were extracted from the coat of black cowpea with 1%trifluoroacetic acid (TFA) in methanol, isolated by RP-C-18 column chromatography, and their structures elucidated by 1D and 2D nuclear magnetic resonance (NMR)spectroscopy. The isolated anthocyanins were characterized as delphinidin-3-O-glucoside (2) and cyanidin-3-Oglucoside (4). Furthermore, 5 minor anthocyanins were detected and identified as delphinidin-3-O-galactoside (1),cyanidin-3-O-galactoside (3), petunidin-3-O-glucoside (5),peonidin-3-O-glucoside (7), and malvidin-3-O-glucoside (8) based on the fragmentation patterns of HPLC-DADESI/MS analysis.

CFD 해석을 이용한 덕트형 자율무인잠수정의 운동해석 및 설계 최적화에 관한 연구

정태환(Tae-Hwan Joung),Karl Sammut,Fangpo He,이승건(Seung-Keon Lee) 한국해양공학회 2009 韓國海洋工學會誌 Vol.23 No.1

Autonomous Underwater Vehicles (AUV's) provide an important means for collecting detailed scientific information from the ocean depths. The hull resistance of an AUV is an important factor in detennining the power requirements and range of the vehicle. This paper describe a design method that uses Computational Fluid Dynamics (CFD) to determine the hull resistance of an AUV under development. The CFD results reveal the distribution of the hydrodynamic values (velocity, pressure, etc.) of an AUV with a ducted propeller. This paper also discusses the optimization of the AUV hull profile to reduce the total resistance. This paper demonstrates that shape optimization in a conceptual design is possible by using a commercial CFD package. Optimum design work to minimize the drag force of an AUV was carried out, for a given object function and constraints.