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The selective induction of leelamine on hepatic CYP 2B activity in ICR mice
Ju Hee Sim(심주희),Woongsik Nam(남웅식),Hungchan O(오흥찬),Suyoun Lee(이수연),Doohyun Lee(이두현),Kwang-Hyeon Liu(류광현),Taeho Lee(이태호),Jae Yun Han(한재윤),Sung Hwan Ki(기성환),Tae Cheon Jeong(정태천),Sangkyu Lee(이상규) 환경독성보건학회 2014 한국독성학회 심포지움 및 학술발표회 Vol.2014 No.5
Cellular growth and fatty acid content of Arctic chlamydomonadalean
Jung, Woongsic,Kim, Eun Jae,Lim, Suyoun,Sim, Hyunji,Han, Se Jong,Kim, Sanghee,Kang, Sung-Ho,Choi, Han-Gu The Korean Society of Phycology 2016 ALGAE Vol.31 No.1
Arctic microalgae thrive and support primary production in extremely cold environment. Three Arctic green microalgal strains collected from freshwater near Dasan Station in Ny-Alesund, Svalbard, Arctic, were analyzed to evaluate the optimal growth conditions and contents of fatty acids. The optimal growth temperature for KNF0022, KNF0024, and KNF0032 was between 4 and 8℃. Among the three microalgal strains, KNF0032 showed the maximal cell number of 1.6 × 107 cells mL<sup>-1</sup> at 4℃. The contents of fatty acids in microalgae biomass of KNF0022, KNF0024, and KNF0032 cultured for 75 days were 37.34, 73.25, and 144.35 mg g<sup>-1</sup> dry cell weight, respectively. The common fatty acid methyl esters (FAMEs) analyzed from Arctic green microalgae consisted of palmitic acid methyl ester (C16:0), 5,8,11-heptadecatrienoic acid methyl ester (C17:3), oleic acid methyl ester (C18:1), linoleic acid methyl ester (C18:2), and α-linolenic acid methyl ester (C18:3). KNF0022 had high levels of heptadecanoic acid methyl ester (26.58%) and heptadecatrienoic acid methyl ester (22.17% of the total FAMEs). In KNF0024 and KNF0032, more than 72.09% of the total FAMEs consisted of mono- and polyunsaturated fatty acids. Oleic acid methyl ester from KNF0032 was detected at a high level of 20.13% of the FAMEs. Arctic freshwater microalgae are able to increase the levels of polyunsaturated fatty acids under a wide range of growth temperatures and can also be used to produce valuable industrial materials.
Na Hyun Kim,Jong Soo Han,Woo Kyung Bae,Joo Young Kim,Kiheon Lee,이혜진,Kee Hyuck Lee,Se Young Jung,HanKyung Lee,Hee-Yeong Jeong,Young A Kim,Suyoun Sim,Ji-Won Kang 대한가정의학회 2022 Korean Journal of Family Medicine Vol.43 No.4
Background: Since the era of “thyroid cancer epidemic,” many Korean academic societies discouraged the use of ultrasonography in healthy individuals and revised the Korean Thyroid Imaging Reporting and Data System to ad-dress the overscreening and overdiagnosis issues. This study aimed to evaluate the change in the diagnostic effec-tiveness of thyroid cancer screening over the last decade.Methods: This single-center, retrospective observational study analyzed the data of 125,962 thyroid nodules ob-tained during cancer screening at the health promotion center of Seoul National University Bundang Hospital from 2010 to 2019. Only 327 thyroid cancer cases pathologically confirmed by fine-needle aspiration (FNA) were includ-ed in the study. The strength of the association between the number of FNA and (1) the number of thyroid cancer diagnoses, (2) the positive predictive values (PPVs), and (3) the difference in PPV from the previous year were eval-uated using Pearson’s correlation analysis.Results: The number of thyroid FNA biopsies as well as the thyroid cancer diagnoses decreased from 2010 to 2019 (166 to 48 [-71.1%] vs. 43 to 22 [-48.8%]). The PPV of FNA biopsies increased from 25.9% to 45.8% (+76.8%) and was negatively correlated with the number of FNA biopsies performed (R=-0.87, P<0.001). The difference in PPV from the previous year increased similarly but without statistical significance (R=-0.59, P=0.09).Conclusion: The diagnostic efficiency of thyroid cancer screening has increased over the last decade, as evidenced by the increasing PPV of FNA biopsies.