A Memory-efficient Hand Segmentation Architecture for Hand Gesture Recognition in Low-power Mobile Devices

Sungpill Choi,Seongwook Park,Hoi-Jun Yoo 대한전자공학회 2017 Journal of semiconductor technology and science Vol.17 No.3

Hand gesture recognition is regarded as new Human Computer Interaction (HCI) technologies for the next generation of mobile devices. Previous hand gesture implementation requires a large memory and computation power for hand segmentation, which fails to give real-time interaction with mobile devices to users. Therefore, in this paper, we presents a low latency and memory-efficient hand segmentation architecture for natural hand gesture recognition. To obtain both high memory-efficiency and low latency, we propose a streaming hand contour tracing unit and a fast contour filling unit. As a result, it achieves 7.14 ㎳ latency with only 34.8 KB on-chip memory, which are 1.65 times less latency and 1.68 times less on-chip memory, respectively, compare to the best-in-class.

A Memory-efficient Hand Segmentation Architecture for Hand Gesture Recognition in Low-power Mobile Devices

Choi, Sungpill,Park, Seongwook,Yoo, Hoi-Jun The Institute of Electronics and Information Engin 2017 Journal of semiconductor technology and science Vol.17 No.3

Hand gesture recognition is regarded as new Human Computer Interaction (HCI) technologies for the next generation of mobile devices. Previous hand gesture implementation requires a large memory and computation power for hand segmentation, which fails to give real-time interaction with mobile devices to users. Therefore, in this paper, we presents a low latency and memory-efficient hand segmentation architecture for natural hand gesture recognition. To obtain both high memory-efficiency and low latency, we propose a streaming hand contour tracing unit and a fast contour filling unit. As a result, it achieves 7.14 ms latency with only 34.8 KB on-chip memory, which are 1.65 times less latency and 1.68 times less on-chip memory, respectively, compare to the best-in-class.

A 9.52 ms Latency, and Low-power Streaming Depth-estimation Processor with Shifter-based Pipelined Architecture for Smart Mobile Devices

Sungpill Choi,Kyuho Jason Lee,Youngwoo Kim,Hoi-Jun Yoo 대한전자공학회 2020 Journal of semiconductor technology and science Vol.20 No.3

The 3D hand gesture interface (HGI) for virtual reality and mixed reality on smart mobile devices is strongly dependent upon the robust depth-estimation with low latency and power consumption. However, the conventional depth-estimation hardware such as active depth sensors and stereo matching accelerators cannot realize the always-on and natural 3D HGI on mobile platform due to their large power consumption from active depth sensors and computations as well as the massive external memory bandwidth, respectively. To resolve the limit, we propose a depth-estimation processor that realizes the always-on and natural 3D HGI with algorithm and hardware co-optimization. The processor features: 1) shifter-based adaptive support weight aggregation that replaces complex floating-point operations with integer operations to reduce power and bandwidth by 92.2% and 69.1%; 2) line streaming 7-stage pipeline architecture with aggregation pipeline reordering optimization to realize 94% utilization and 43.9% memory reduction; and 3) shifting register-based pipeline buffer optimization to reduce 29.8% area. The proposed depth-estimation processor realizes a real-time 3D HGI with 9.52 ms of latency under QVGA stereo inputs. It achieves external memory bandwidth reduction to 18.93 MB/s with 15.56 mW power and 2.8 mm2 area, which are 4.1x and 6.9x more efficient than state-of-the-arts [9, 10], respectively.

혼합 커널을 활용한 과학기술분야 용어간 관계 추출 (pp.82-83)

최성필(SungPil Choi),최윤수(Yoonsu Choi),정창후(Chang-Hoo Jeong),맹성현(Sung-Hyun Myaeng) 한국정보과학회 2009 한국정보과학회 학술발표논문집 Vol.36 No.1

Selenate specifically sensitizes drug-resistant cancer cells by increasing apoptosis via G2 phase cell cycle arrest without P-GP inhibition

Choi, Ae-Ran,Jee Jo, Min,Jung, Myung-Ji,Sik Kim, Hyung,Yoon, Sungpil Elsevier 2015 european journal of pharmacology Vol.764 No.-

<P><B>Abstract</B></P> <P>The purpose of this study was to identify conditions that will increase the sensitivity of drug-resistant cancer cells. Selenium derivatives have been shown to present anti-cancer properties in the clinic. Currently, selenate, selenite, selenomethionine (SeMet), methyl-selenocysteine (MSC), and methaneselenic acid (MSA) are the most common selenium derivatives used as drugs in humans. Herein, we tested whether these selenium derivatives can sensitize KBV20C cancer cells, which are highly resistant to anti-cancer drugs such as vincristine. All five drugs could sensitize KBV20C cells to the same extent as they sensitized the sensitive parent KB cells, suggesting that selenium-derived drugs can be used for drug-resistant cancer cells. We also observed that these drugs did not inhibit the P-glycoprotein (P-gp) pumping-out ability, suggesting that the sensitization by selenium-derived drugs does not depend on P-gp activity in resistant KBV20C cells. Interestingly, using a cell viability assay, microscopic observation, and Hoechst staining, we found that selenate highly sensitized drug-resistant KBV20C cells by activating the apoptotic pathway, when compared to sensitive KB cells.</P> <P>Furthermore, we investigated why selenate sensitizes resistant KBV20C cells. Selenate-induced toxicity was associated with an increase in G2-phase cell cycle arrest in KBV20C cells, suggesting that the selenate-induced increase in apoptosis resulted from cell cycle arrest in resistant KBV20C cells. Our findings may contribute to the development of selenate-based therapies for patients resistant to cancer drugs.</P>

농작업 재해예방 E-learning 프로그램의 사용성 평가

Sungpill Jo,Kyeong-Hee Choi,Yong-Ku Kong,Hye Seon Chae,Inseok Lee(이인석) 대한인간공학회 2015 대한인간공학회 학술대회논문집 Vol.2015 No.10

Objective: 고령 농업인을 대상으로 효과적인 E-learning 프로그램을 제공하기 위해 체계적인 연구 방법 및 절차를 수립하여 E-learning 프로그램을 개발하였고, 이에 대해 사용성 평가를 실시하였다. Background: 선행 농작업 관련 재해 예방 교육 자료들은 책자 위주의 단방향 접근방법으로 교육의 흥미를 떨어뜨리며 동기부여 및 이해도가 낮아 학습 효과를 기대하기 어렵다. 따라서 사용자 인터페이스가 간결하고 이해하기 쉬우며 양방향 상호작용하여 필요한 안전 지식을 습득할 수 있는 프로그램이 필요하다. Method: 7명의 농촌지도사와 14명의 농업인들이 e-러닝 프로그램의 사용성을 평가하였다. 두 그룹은 프로그램을 시청한 후 효율성, 학습(교육)용이성, 만족도에 대하여 5점 척도로 평가하였다. 설문평가 후 프로그램의 대한 자유로운 토의를 진행하였다. Results: 연구 결과 e-러닝 프로그램의 전반적인 효율성, 학습용이성, 만족도는 높았으며, 고령 농업인이 쉽게 조작할 수 있었으며, 농업지도사의 교육용으로 적합한 것으로 평가되었다. Conclusion: 고령농업인의 흥미를 갖고 농작업 안전 관련 정보를 접할 수 있는 e-러닝 프로그램을 통하여 농업의 안전문화 형성에 도움이 될 것으로 기대된다.

Sensitization of Cancer Cells through Reduction of Total Akt and Downregulation of Salinomycin-Induced pAkt, pGSk3 <i>β</i> , pTSC2, and p4EBP1 by Cotreatment with MK-2206

Choi, Ae-Ran,Kim, Ju-Hwa,Yoon, Sungpil Hindawi Publishing Corporation 2014 BioMed research international Vol.2014 No.-

<P>MK-2206 is an inhibitor of Akt activation. It has been investigated as an anticancer drug in clinical trials assessing the potential of pAkt targeting therapy. The purpose of this study was to identify conditions that increase the sensitivity of cancer cells to MK-2206. We found that the treatment of cancer cells with a high concentration of salinomycin (Sal) reduced total Akt protein levels but increased activated Akt levels. When cancer cells were cotreated with MK-2206 and Sal, both pAkt and total Akt levels were reduced. Using microscopic observation, an assessment of cleaved PARP, FACS analysis of pre-G1 region, and Hoechst staining, we found that Sal increased apoptosis of MK-2206-treated cancer cells. These results suggest that cotreatment with MK-2206 and Sal sensitizes cancer cells via reduction of both pAkt and total Akt. Furthermore, cotreatment of cancer cells with Sal and MK-2206 reduced pp70S6K, pmTOR, and pPDK1 levels. In addition, Sal-induced activation of GSK3<I>β</I>, TSC2, and 4EBP1 was abolished by MK-2206 cotreatment. These results suggest that cotreatment using MK-2206 and Sal could be used as a therapeutic method to sensitize cancer cells through targeting of the PI3K/Akt/mTOR pathway. Our findings may contribute to the development of MK-2206-based sensitization therapies for cancer patients.</P>

Co-treatment of LY294002 or MK-2206 with AZD5363 Attenuates AZD5363-induced Increase in the Level of Phosphorylated AKT

CHOI, AE-RAN,KIM, JU-HWA,WOO, YEON HWA,CHEON, JI HYUN,KIM, HYUNG SIK,YOON, SUNGPIL Potamitis Press 2016 Anticancer research Vol.36 No.11

<P>Clinical trials are in progress on AZD5363, an inhibitor of protein kinase B (AKT), to assess its effects on the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Cells treated with AKT inhibitors have been reported to activate alternative pathways in order to escape growth inhibition. AZD5363-sensitized Hs578T breast cancer cells displayed reduced levels of phosphorylated glycogen synthase kinase 3 beta (pGSK3 beta). Interestingly, in AZD5363-treated cells, the level of phosphorylated (activated) AKT (pAKT) increased. Since pAKT positively correlates with cancer growth and survival, we aimed to identify conditions that could reduce AZD5363-induction of pAKT. We examined whether AZD5363 induction of pAKT could be reduced by co-treatment with inhibitors of the PI3K/AKT/mTOR pathway (LY294002, MK-2206, wortmannin, perifosine, rapamycin, everolimus, and temsirolimus). We observed that co-treatment of LY294002 or MK-2206 with AZD5363 reduced the level of pAKT. Since MK-2206 is clinically used, we propose that co-treatment using MK-2206 with AZD5363 would prove beneficial in blocking the AZD5363-induced pAKT signaling pathway. Our findings contribute to the development of AZD5363-based sensitization therapies for patients with cancer.</P>

Attenuation of Colchicine Toxicity in Drug-resistant Cancer Cells by Co-treatment with Anti-malarial Drugs

CHOI, AE-RAN,KIM, JU-HWA,CHEON, JI HYUN,KIM, HYUNG SIK,YOON, SUNGPIL Potamitis Press 2016 Anticancer research Vol.36 No.11

<P>Background/Aim: Colchicine (COL) is a wellknown and potent microtubule targeting anticancer agent. The purpose of our study was to identify conditions that increase sensitization of COL-resistant cancer cells that overexpress P-glycoprotein (P-gp). Materials and Methods: The anti-malarial drugs chloroquine (CHL), mefloquine (MEF) and primaquine (PRI) have been shown to increase sensitization in drug-resistant KBV20C cells via P-gp inhibition. Therefore, we tested whether co-treatment of COL with PRI, CHL or MEF increases sensitivity in COL-resistant KBV20C cells over that of cells treated with COL alone and whether these effects are attributable to P-gp activity. Results: Interestingly, we found that both CHL and PRI, but not MEF, reduced cytotoxicity in KBV20C cells receiving high concentrations of COL, suggesting that the effects of CHL and PRI have specific mechanisms among the anti-malarial drugs. The effects of CHL and PRI were specific to COL-resistant cells, since we did not detect a reduction in cytotoxicity in drug-sensitive parent KB cells. These data suggest that CHL and PRI inhibit the signaling pathways of COL-treated-resistant cells without P-gp inhibition. Furthermore, we studied the molecular mechanisms underlying the effects of COL-CHL co-treatment in KBV20C cells. FACS analysis, annexin V staining and western blot analysis revealed that G(2) arrest and apoptosis were lower in cells co-treated with COL and CHL than in cells treated with COL alone. We also found that pH2AX, pHistone H3 and pRb expression was highly reduced in COL-CHL co-treated cells but not in COL-VIB co-treated cells. In addition, expression of the p21 protein, which correlates with drug-resistant phenotypes, increased in cells receiving COL-CHL co-treatment over that of COL-treated cells. Conclusion: These results suggest that reduced G(2) arrest and apoptosis resulting from COL-CHL co-treatment was attributable to DNA damage and reduced cell cycle progression. These findings provide important information regarding the prevention of COL toxicity in COL-resistant cells and indicate that CHL, PRI and MEF may contribute to sensitization in COL-resistant cells.</P>

안드로이드 환경의 다중생체인식 기술을 응용한 인증 성능 개선 연구

최성필(Sungpil Choi),정강훈(Kanghun Jeong),문현준(Hyeonjoon Moon) 한국멀티미디어학회 2013 멀티미디어학회논문지 Vol.16 No.3