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Chun, Yoon-Keun,Ha, Joo-hun,Hong-Jung-Woo,Oh, Soo-Myung,Kim, Sung-Soo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1
Yoon-Keun Chun¹,Joohun Ha□Hong-Jung Woo□, Soo Myung Oh□,Sung Soo Kim□ ¹Department of Molecular Biology, College of Medicine,²Department of Surgery, college of Medicine,³Department of Internal Medicine, College of Oriental Medicine,and ⁴East-Weat Medical Reserch Institute,Kyung Hee University, Seoul, Korea. The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection. Proceedings of International Symposium on East-West Medicine, Seoul. 212-230, 1999. -Hepatitis B is caused by hepadnavirus. Hepatitis B virus replicates through 3.5kb pregenomic RNA intermediate which is regulated by core promoter. Pathogenesis of hepatitis B virus has been bilieved the result of host immune response. But recently many studies have reported that high level of viral replication caused by mutation in core promoter might result in severs hepatitis. But these studies were performed in vitro, not in vivo. So there is yet debate about which factor, viral of host factor, is more important in pathogenesis of hepatitis B virus. So we measured real viral replication level in 204 chronic hepatitis B patients by quantifying HBV DNA from sera by our novel PCR-based more sensitive method, and compared these results with ALT level measured from same sera, which indicates liver cell damage. Surprisingly there are no significant correlation between HBV DNA quantity and ALT level. Then we cloned core promoter region. In SSCP, we found that many viral mutants coexist in one patient. Base on SSCP result, we chose main viral core promoter type in each patients, which is thought to determine overall viral replication level in this patient. Main type of core promoter region of each 41 patients were directly sequenced. And with these we measured promoter activity by luciferase assay system and compared promoter activity with on another. We found tha there were some differences in promoter activity according to core promoter sequences. And we constructed replication-competent viral constructs with core promoter from 41 patients and Transfected these into HepG2 cell and measured HBV DNA by southern blot. There were also differences in HBV DNA quantity according to core promoter sequences. On these all results we investigated correlation between the effect of HBV core promoter on viral replication in vitro and HBN DNA quantity, ALT level from sera of each patients. We found there is no significant correlation among them. As a result, we concluded that in determining severity chronic hepatitis B patients, host factors of each patient is more important rather than replicative activity of virus itself.
Sung Ho Song,Soo Yeun Park,Jun Seok Park,Hye Jin Kim,Chun-Seok Yang,Gyu-Seog Choi 대한외과학회 2015 Annals of Surgical Treatment and Research Vol.90 No.1
Purpose: Treatment of patients with para-aortic lymph node metastasis from colorectal cancer is controversial. The goal of this study was to investigate the technical feasibility of laparoscopic intrarenal para-aortic lymph node dissection in patients with colorectal cancer and clinically suspected para-aortic lymph node dissection. Methods: The inclusion criteria for the laparoscopic approach were patients with infrarenal para-aortic lymph node metastasis from colorectal cancer. Patients who had any other distant metastatic lesion or metachronous para-aortic lymph node metastasis were excluded from this study. Perioperative outcomes and survival outcomes were analyzed. Results: Between November 2004 and October 2013, 40 patients underwent laparoscopic para-aortic lymph node dissection. The mean operating time was 192.3 ± 68.8 minutes (range, 100–400 minutes) and the mean estimated blood loss was 65.6 ± 52.6 mL (range, 20–210 mL). No patient required open conversion. The postoperative complication rate was 15.0%. Sixteen patients (40.0%) had pathologically positive lymph nodes. In patients with metastatic para-aortic lymph nodes, the 3-year overall survival rate and disease-free survival rate were 65.7% and 40.2%, respectively. Conclusion: The results of our study suggest that a laparoscopic approach for patients with colorectal cancer with metastatic para-aortic lymph nodes can be a reasonable option for selected patients.
Mode Identification in the Design of Wideband Cylindrical Monopole Antenna
Chun, Joong-Chang,Kim, Sang-Youl,Jeung, Deuk-Soo The Korea Institute of Information and Commucation 2009 Journal of information and communication convergen Vol.7 No.3
Cylindrical monopole antenna is one of most promising candidates for multi-band applications such as PCS, WLAN, DMB, and UWB wireless services. In this research, we demonstrate that there exist two types of current distributions according to the exciting frequency in a double band cylindrical monopole antenna, in which double resonance is achieved by adjusting the coupling structure of the antenna base. The operating modes of current distributions are identified from CST software simulations, the standing wave mode in a lower band and the traveling wave mode in a higher band. Also it is noticed that the mode behavior is quite similar to a helical antenna, a standing-wave (resonance) mode and a traveling-wave (non-resonance) mode according to the electrical dimensions of antenna. The effective ranges for operating modes and design formulas of the double band antenna are derived from simulation and measured results.
Implementation of 3-D Medical Imaging Analysis Software
Sang Joon Park,Sung Chun Kang,Byung Gi Lee,Yong Soo Kim,Jong Hyo Kim 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7
A three-dimensional segmentation of the trachea-bronchial tree of the lungs is notoriously difficult. This is due to the fact that some small anatomical structures are subject to partial volume effects from computed tomography (CT) scans. Furthermore, the limited intensity contrast between the participating materials (air, blood, and tissues) in medical imaging increases the segmentation difficulties. In this paper, we qualitatively compared and analyzed several segmentation methods to extract the lower airways of the bronchi. In addition, we have developed a fully automated PC-based software on windows platform. Using CT scans of human cases, we present results showing that this novel approach is convenient, accurate, automatic and well-visual in estimating airway. Our proposed method can provide pre-operative planning of the intervention for lung surgery as a complementary tool.