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Kim, Hee Kyung,Kim, Sun Young,Lee, Su Jin,Kang, Mihyeon,Kim, Seung Tae,Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Lee, Dong Woo,Park, Woong Yang,Kim, Sung Joo,Park, Se Hoon,Lee, Jeeyun Neoplasia Press 2016 Translational oncology Vol.9 No.3
<P><I>BACKGROUND:</I> Although pazopanib treatment has become the standard chemotherapy in salvage setting for metastatic sarcoma patients, most patients progress after pazopanib treatment in 4 to 6 months. After failure to pazopanib, patients have limited options for treatment. Therefore, subsequent therapy in patients who failed to pazopanib is urgently needed and the use of patient derived cells or patient derived tumors for accompanying testing with various pharmacological inhibitors could offer additional treatment options for these patients. <I>METHODS:</I> Patient derived tumor cells were collected from ascites at the time of progression to pazopanib and a 13-drug panel was tested for drug sensitivity. We confirmed the results using <I>in vitro</I> cell viability assay and immunoblot assay. We also performed the genomic profiling of PDX model. <I>RESULTS:</I> The growth of patient derived tumor cells was significantly reduced by exposure to 1.0 μM AZD2014 compared with control (control versus AZD2014, mean growth = 100.0% vs 16.04%, difference = 83.96%, 95% CI = 70.01% to 97.92%, <I>P</I> = .0435). Similarly, 1.0 μM BEZ235 profoundly inhibited tumor cell growth <I>in vitro</I> when compared to control (control versus BEZ235, mean growth = 100.0% vs 7.308%, difference = 92.69%, 95% CI = 78.87% to 106.5%, <I>P</I> < .0001). Despite the presence of CDK4 amplification in the patient-derived tumor cells, LEE011 did not considerably inhibit cell proliferation when compared with control (control vs LEE011, mean growth = 100.0% vs 80.23%, difference = 19.77%, 95% CI = 1.828% to 37.72%, <I>P</I> = .0377). The immunoblot analysis showed that BEZ235 treatment decreased pAKT, pmTOR and pERK whereas AZD2014 decreased only pmTOR. <I>CONCLUSION:</I> Taken together, upregulation of mTOR/AKT pathway in sarcoma patient derived cells was considerably inhibited by the treatment of AZD2014 and BEZ235 with downregulation of AKT pathway (greater extent for BEZ235). These molecules may be considered as treatment option in STS patient who have failed to pazopanib in the context of clinical trials.</P>
이재도,양승복,정수웅 대구보건대학 1994 대구보건대학 論文集 Vol.14 No.-
In this paper, Using a Fuzzy theory an On-Line phoneme recognition procedure of Korean characters is studied. The recognition method is performed by reading the pixel coordinates, finding the feature points, recognizing the stroke, recognizing the phoneme in order. In the course of recognizing the stroke, first the feature points of an inputed stroke is characterized by starting point, end point, and bending point. and then, based on 0, 5, 6, 7, 8, 9, and 10 stroke code among the recognized stroke the distance or direction between base stroke and the next input stroke is used for recognizing the phoneme
김수령,서은영,이웅희,이증훈,이충식 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2
A search for the genes expressed only in gastric cancer may help to define molecular alterations or aid in diagnosis of gastric cancer. Recently, suppression subtractive hybridization (SSH) has been used as an effective technique for detection of differentially expressed genes. We discovered a noble gene which belongs to the Reg family in stomach cancer tissue using the SSH technique. We identified and named the Reg Ⅳ gene that is highly expressed only in gastric tumor tissue. The Reg family gene has a lot of functions of the growth factor and gene regulation. The cathepsin L-12 gene, which is known to exhibit increased expression in breast cancer and some inflammatory conditions, is also expressed in stomach cancer. Expressions were verified by reverse Northern blot analysis and Northern blot analysis. We expect these genes to be used as an important tool for the diagnosis and/or understanding of the pathogenesis of gastric cancer.
임수진,이웅빈 용인대학교 자연과학연구소 2008 自然科學硏究所論文誌 Vol.13 No.1
Abstract - Mt. Mugap is located 37°23′00″~37°25′00″N in latitude at 127°19′00″~127° 21′30″E in longitude in Gyeonggi-do. The investigated vascular plants consist of total 173 taxa: 3 forms, 21 varieties, 149 species, 133 genera, 63 families, 28 orders, 4 classes. Twelve special plants designated by Environment Ministry were investigated: 4th grade for 4 taxa, 3rd grade for 4 taxa, 2nd grade for 2 taxa, and 1st grade for 2 taxa. As for the useful plants, there were 79 taxa of edible ones(45.7%), 42 taxa of medicinal ones(24.2%), 11 taxa of ornamental ones(6.4%), 41 taxa of industrial ones(23.7%), and 4 taxa of poisonous ones(2.3%) respectively.
영숫자 그림이 혼용된 한글문서에서 문자 분리에 관한 연구
정수웅,이갑래 김천과학대학 1998 김천과학대학 논문집 Vol.24 No.-
In this paper, we propose a new method for segmenting characters in hangul document mixed with alphanumeric characters and picture. Since hangul has structural characteristics different from those of alphanumeric characters, structural characteristics of hangul characters are also different from those of alphanumeric ones. If hangul and alphanumeric characters are both written in a document, it is difficult to know whether the touching characters are hangul or not. The proposed segmentation method uses an MLP to generate candidate cutting points. The MLP-based segment lea군 cutting points from training samples which are composed of features extracted from touching character images and correct cutting point of those images. It generates five candidate cutting points per a touching character image and each candidate has a value that is regarded as cutting possibility at that position.
정수웅;이갑래 김천과학대학 2009 김천과학대학 논문집 Vol.35 No.-
The organizational costs which result from losing an employee are very high. Recently, Many researchers focused on not how people quit their jobs but why they don't leave them. Reflecting the idea of people's being "situated or connected in a social web, " embeddedness has several key aspects: the extent to which people have links to other people or activities, the extent to which their jobs and communities fit other aspects in their "life spaces," and the ease with which links could be broken-what they would give up if they left their present settings. As a result, one way to improve the embeddedness of travel agency in the organization is to form a unity among the employees through enforcement of consistent management policies, concern and consideration of each employee, activation of horizontal communication among the employees, and employees' participation in decision making and sharing employees' values.