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Soyeon Park,Yeojin Kim,Sunwoo Yoon,You Jin Nam,Sunhwa Hong,Yong Hyuk Cho,Sang Joon Son,Chang Hyung Hong,Jai Sung Noh,Hyun Woong Roh 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.3
Objective The impact of the government-initiated senior employment program (GSEP) on geriatric depressive symptoms is underexplored. Unearthing this connection could facilitate the planning of future senior employment programs and geriatric depression interventions. In the present study, we aimed to elucidate the possible association between geriatric depressive symptoms and GSEP in older adults.Methods This study employed data from 9,287 participants aged 65 or older, obtained from the 2020 Living Profiles of Older People Survey. We measured depressive symptoms using the Korean version of the 15-item Geriatric Depression Scale. The principal exposure of interest was employment status and GSEP involvement. Data analysis involved multiple linear regression.Results Employment, independent of income level, showed association with decreased depressive symptoms compared to unemployment (p<0.001). After adjustments for confounding variables, participation in GSEP jobs showed more significant reduction in depressive symptoms than non-GSEP jobs (β=-0.968, 95% confidence interval [CI]=-1.197 to -0.739, p<0.001 for GSEP jobs, β=-0.541, 95% CI=-0.681 to -0.401, p<0.001 for non-GSEP jobs). Notably, the lower income tertile in GSEP jobs showed a substantial reduction in depressive symptoms compared to all income tertiles in non-GSEP jobs.Conclusion The lower-income GSEP group experienced lower depressive symptoms and life dissatisfaction compared to non-GSEP groups regardless of income. These findings may provide essential insights for the implementation of government policies and community-based interventions.
Hong, Chanseok,An, Soyeon,Son, Mikwon,Hong, Soon Sun,Lee, Don Haeng,Lee, Chongmu Lippincott Williams Wilkins, Inc. 2012 Anti-cancer drugs Vol.23 No.5
To determine the appropriate surfactant to be added to TiO2 nanotubes (TNTs) for use in cancer photothermotherapy, this study measured the increase in temperature and examined the size distribution of TNT particles loaded with different surfactants during near-infrared irradiation. In addition, in-vitro cell (fluorescein isothiocyanate and MTT assay) tests were carried out to examine the cytotoxic effect of doxorubicin-loaded and polyvinyl alcohol-added TNTs (pTNTs). The mean particle size of the pTNTs was 151.8 nm with a particle size variation of less than 3 nm, which is low enough to flow through blood vessels without causing a blockage. The temperature of the pTNTs was ∼47°C, which is high enough to destroy cancer cells. Doxorubicin-loaded TNTs and pTNTs in combination with a near-infrared laser showed a cell viability of 4.5% – a sufficiently high cytotoxic effect.
딥스택 구조를 이용한 대형 함정의 단기 전력 부하 예측
홍창우(Chang Woo Hong),고민승(Min-Seung Ko),김홍렬(Hong-Ryeol Kim),김소연(Soyeon Kim),허견(Kyeon Hur) 대한전기학회 2020 전기학회논문지 Vol.69 No.4
The power load prediction in vessel is an important factor in determining the capacity and number of generators, and in particular the consumption of fuel oil which determines the number of days that can be sailed. In addition, short-term load forecasting is important for the capacity and scheduling of the ESS that will be applied in the future vessel. In this paper, we present a deep stack neural network for short-term load prediction in large vessels. The network is constructed using Convolutional Neural Network (CNN), Bidirectional Long-Short Term Memory (Bi-LSTM), and Long-Short Term Memory (LSTM). CNN is used for spatial feature extraction and Bi-LSTM is used to utilize information at both pre and post stages. Finally, LSTM is used to extract temporal characteristics. The voyage data of the Mokpo National Maritime University training ship was used for the short-term load prediction, and the predicted results are verified by the Mean Squared Error (MSE) and Mean Absolute Error (MAE).
인체 구강암 세포주에서 Docosahexaenoic acid에 의한 세포독성 기전
홍태화(Tae-hwa Hong),김훈(Hoon Kim),신소연(Soyeon Shin),Kaipeng Jing,정소연(Soyeon Jeong),임현(Hyun Lim),윤동혁(Donghyuk Yun),정기은(Ki-Eun Jeong),이명렬(Myung-Ryul Lee),박종일(Jong-Il Park),권기량(Gi-Ryang Kweon),박승길(Seung Kiel 한국생명과학회 2013 생명과학회지 Vol.23 No.5
오메가-3 지방산은 많은 암에서 세포독성을 나타낸다고 보고 되어 왔으나 구강암에 대한 연구는 전혀 없다. 이에 본 연구에서는 구강암세포에서 오메가-3 지방산 중 DHA의 세포독성 기전을 규명하여 다음과 같은 결과를 얻었다. DHA는 구강암 세포주 SCC-4 및 SCC-9의 증식을 농도 의존적으로 억제하였으며, FACS 분석, TUNEL assay 및 PARP cleavage 등에 의해 자가사멸을 유도함이 확인 되었다. 또한 DHA는 LC-3II 단백증가, GFP-LC-3 dot 형성 및 autophagic flux assay 등에 의해 자가포식도 유도됨이 규명되었다. SCC-9 세포에서 AMPK의 인산화는 DHA 에 의해 증가 하였으나, p-AKT<sup>Thr308</sup>, p-AKT<sup>Ser473</sup> 및 mTOR단백양은 감소하였다. 이상의 결과로 DHA는 구강암세포에서 AMPK 활성증가 및 AKT 억제에 통한 mTOR 신호경로 차단에 따른 자가사멸 및 자가포식에 의해 세포독성을 나타낼 수 있음을 시사하며, 따라서 DHA는 구강암의 예방 및 치료에 유용하게 사용될 수 있으리라 생각된다. In the United States, about 40,000 new cases of oral cancer are diagnosed each year and nearly 7,800 patients died from it in 2012. Omega-3 polyunsaturated fatty acids have been found to have anticancer effects in a variety of cancer cell lines and animal models, but their effect in oral cancer remains unclear. This study was designed to examine the effect of docosahexaenoic acid (DHA, a kind of omega- 3 fatty acid) on oral cancer cells and the molecular mechanism of its action. We found that exposure of squamous cell carcinoma-4 (SCC-4) and squamous cell carcinoma-9 (SCC-9) human oral cancer cells to DHA induced growth inhibition in a dose- and time-dependent manner. Meanwhile, in addition to the elevated levels of apoptotic markers, such as cleaved PARP, subG1 portion and TUNEL-positive nuclei, DHA led to autophagic vesicle formation and an increase in autophagic flux, indicating the involvement of both apoptosis and autophagy in the inhibitory effects of DHA on oral cancer cells. Further experiments revealed that the apoptosis and autophagy induced by DHA were linked to inhibition of mammalian target of rapamycin (mTOR) signaling by AKT inhibition and AMP-activated protein kinase (AMPK) activation in SCC-9 cells. Together, our results suggest that DHA induces apoptosis- and autophagy-associated cell death through the AMPK/AKT/mTOR signaling pathway in oral cancer cells. Thus, utilization of omega-3 fatty acids may represent a promising therapeutic approach for chemoprevention and treatment of human oral cancer.
Development of Cellulose Hydrogel Microspheres for Lipase Immobilization
Soyeon Jo,Sae-Rom Park,Yujin Oh,Jiyeon Hong,Hyung Joo Kim,Kwang Jin Kim,Kyeong Keun Oh,이상현 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.1
Cellulose hydrogel microspheres were prepared by sol-gel transition using an ionic liquid-in-oil emulsion. Factors that influenced the formation of these microspheres, including the ratio of ionic liquid to oil, surfactant concentration, and stirring speed, were optimized for lipase immobilization. Using the optimized method, Candida rugosa lipase was efficiently immobilized on the microspheres by physical adsorption. As compared with the free lipase, the specific activity of the immobilized lipase was 1.4 times higher, its half-life at 45°C was 41 times longer, and it showed an enhanced stability over a wide pH range. The lipase immobilized on cellulose microspheres showed a much higher loading efficiency, immobilization yield, and specificity constant than lipase immobilized on microcrystalline cellulose or millimeter-sized hydrogel beads. To increase the reusability of cellulose microspheres as an enzyme support material, magnetic cellulose microspheres were also prepared by adding Fe3O4. The lipase immobilized on magnetic cellulose microspheres was simply recovered using a magnet and continuously reused with a minimal loss of activity.
Soyeon Kim,Sun Mi Kim,Da Seul Kim,Seunga Han,Ji Sun Hong,Jeong Seok Seo 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.1
Objective Menopause symptoms can vary in type, duration, and severity. The purpose of this study was to investigate the key factors predicting severe symptoms among Korean perimenopausal women with various demographic data, obstetric and psychiatric histories, and menopausal symptoms screening scale scores. Methods Data were collected from 1,060 women, and 4 latent classes were identified using latent profile analysis, with 6 major categories of menopausal complaints. Among the 4 classes, we selectively used data from the “all unimpaired” and “all impaired” groups.Menopause rating scale (MRS), sociodemographic, obstetric, and psychiatric factors were assessed, and hierarchical logistic regression analyses were conducted with the “all impaired” group as a dependent variable. Results Marital status and scores on the psychological and somatic subscales of the MRS were statistically related to being in the “all impaired” group. Otherwise, family history of menopausal symptoms, menarche age, and history of other psychiatric disorders were not statistically significant predictors of being in the “all impaired” group. Conclusion The psychological and somatic subscales of the MRS predict the severity of perimenopausal syndrome better than obstetric and psychiatric history do among Korean perimenopausal women. Psychological and somatic symptoms as well as genitourinary symptoms in menopausal patients should be closely evaluated.