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Choi, E Ryoung,Park, Sung-Ji,Choe, Yeon Hyeon,Ryu, Dong Ryeol,Chang, Sung-A,Choi, Jin-Oh,Lee, Sang-Chol,Park, Seung Woo,Kim, Byoung Joon,Kim, Duk-Kyung,Oh, Jae K BioMed Central 2010 Journal of cardiovascular magnetic resonance Vol.12 No.-
<P><B>Background</B></P><P>Miyoshi myopathy (MM) is an autosomal recessive distal myopathy characterized by early adult onset. Cardiomyopathy is a major clinical manifestation in other muscular dystrophies and an important prognostic factor. Although dysferlin is highly expressed in cardiac muscle, the effect of dysferlin deficiency in cardiac muscle has not been studied. We hypothesized that early myocardial dysfunction could be detected by 2D strain echocardiography and late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR).</P><P><B>Method</B></P><P>Five consecutive MM patients (3 male) in whom we detected the DYSF gene mutation and age-matched healthy control subjects were included. None of the patients had history of cardiac disease or signs and symptoms of overt heart failure. Patients were studied using 2D strain echocardiography and CMR, with 2D strain being obtained using the Automated Function Imaging technique.</P><P><B>Results</B></P><P>All patients had preserved left ventricular systolic function. However, segmental Peak Systolic Longitudinal Strain (PSLS) was decreased in 3 patients. Global PSLS was significantly lower in patients with MM than in control subjects (p = 0.005). Basal anterior septum, basal inferior septum, mid anterior, and mid inferior septum PSLS were significantly lower in patients with MM than in control subjects (P < 0.0001, < 0.0001, 0.038 and 0.003, respectively). Four patients showed fibrosis by LGE. The reduced PSLS lesion detected by 2D strain tended to be in the same area as that which showed fibrosis by LGE.</P><P><B>Conclusions</B></P><P>Patients with MM showed subclinical involvement of the heart. 2D strain and LGE are sensitive methods for detecting myocardial dysfunction prior to the development of cardiovascular symptoms. The prognostic significance of these findings warrants further longitudinal follow-up.</P>
Anti-oxidative and Anti-inflammatory Effects of Protulaca Oleracea on the LPS-stimulated AGS Cells
Kim, Chae-Hyun,Park, Pyeong-Beom,Choe, Seung-Ryeol,Kim, Tae-Heon,Jeong, Jong-Kil,Lee, Kwang-Gyu,Lee, Chang-Hyun,Jeong, Han-Sol The Physiological Society of Korean Medicine and T 2009 동의생리병리학회지 Vol.23 No.2
Protulaca oleracea, a widely distributed weed, has been reported to exhibit different health promoting effects. The objective of this study was to evaluate the anti-oxidative and anti-inflammatory effects of P. oleracea on LPS-stimulated AGS cells. The cytotoxicity of P. oleracea in AGS cells was examined by MTT assay. The anti-oxidative effects of P. oleracea were examined by DPPH assay. RT-PCR was carried out to examine the effect of P. oleracea in the mRNA expression of different inflammatory mediators. MTT assay revealed that P. oleracea have almost no cytotoxity in AGS cells. DPPH radical scavenging activities were better than butylated hydroxyl toluene (BHT). The mRNA expression of different endogenous anti-oxidative enzymes (SOD2, GPx3 and catalase) were preserved by P. oleracea in AGS cells. The nitric oxide production and expression of iNOS in LPS stimulated RAW264.7 were suppressed in P. oleracea treated groups. Based on these findings, P. oleracea has protective anti-oxidant and anti-inflammatory effects.
이상연,조승진,최승렬,김순희,엄진영,장현오,유형관,Lee, Sang-Yeon,Jo, Seung-Jin,Choe, Seung-Ryeol,Kim, Sun-Hui,Eom, Jin-Yeong,Jang, Hyeon-O,Yu, Hyeong-Gwan 한국건강관리협회 2006 한국건강관리협회지 Vol.4 No.1
Background: This survey has focused on Client-Satissfaction for health examination services of Korean Association of Health Promotion, This research will help final weak point and promote the qualify of the services provided. Methods: This survey was done on 400 visitors of the clinic. Between Jan. 2 and May 3l, 2005 Questionaires were distributed to the visitors with a informed consent. Results: The visitㅐrs for health examination at Daegu chapter of Korean Association of Health promotion had high-school or higher level education(79.8%) and were self-employed persons with an average monthly income of 3~4 million won(27.7%), and housewives(33.0%). The most frequent complaints of the visitors was the difficulty in access to the center. The motives for taking health examination were cheap cost of examination(32.7%) and recommendation by fami1y members and friends(42.0%). The possitive attitude of the employees of KAHP were kind reponses to phone calls(85.3%) and kind explanations to questions(68.5%). Regarding the merits of the examination at KAHP, appropriate equipments(68.0%) and quality of equipments(66.0%) and they expressed their desire for further use revisit to the KAHP(85.3%).Conclusions. It is concluded that this KAHP is providing services meeting their demands in cost and qualitatively of health examination. However, it is noted that there are several weak points in own system that make own clients uneasy in taking health examination. They have to be solved by providing transporting for accession, kind attitudes and comfortable facilities.