보건소 건강증진사업 수행과정의 질 평가

서영준,정애숙,박태선,김주경,박남수,이희원 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1

This study purports to assess the process quality of health promotion programs at public health centers. The sample used in this study consisted of 242 public health centers in South Korea. Data was collected with self-administered questionnaires between September. 3rd to September. 23rd in 2002. The 95 returned questionnaires were analyzed by SPSS 11.0 version. The major findings are as follows; There is a need to improve (1) a procedure for reviewing and analyzing strategic planning, (2) the quality of the staff in charge of program management, (3) the function of planning and training for monitoring and evaluation, (4) the ability of program managers in advising and consulting with clients, and (5) a procedure for organizing resources and information. In conclusion, in order to improve the process quality of health promotion programs at public health centers, integrated support from various institutions such as public health centers, community, regional and national health authorities and administrative departments is required.

기능성 고등어 Fillet 제조 및 저장 중 품질 변화

신석우,장미순,권미애,서호준 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2004 한국식품저장유통학회지 Vol.11 No.1

고등어 fillet 제품의 저장 중 항산화의 기능성을 부여하고 고등어 특유의 비린내를 제거하기 위해 식염 외에 녹차, dillweed, 키토산, 올리고당, 생강을 첨가하여 진공포장한 후 5℃, 0℃, -20℃에 80일간 저장하면서 제품 특성을 조사하였다. 5℃에 저장한 고등어 fillet의 휘발성 염기질소 측정 결과는 이들 첨가물을 단독 또는 복합적으로 첨가한 시제품에서 2주 이내에 초기부패에 도달했고, 0℃에서는 4∼7주, -20℃에서는 저장 80일간 모든 시제품에서 신선도를 유지할 수 있었다. 이들 첨가물 가운데서도 키토산과 올리고당을 첨가한 시제품이 가장 신선도가 양호함을 알 수 있었다. 항산화성은 초기 과산화물가가 5.4∼7.8 meq/kg 이었던 것이 5℃ 저장시 35일째 15.7∼20.4 meq.kg, 0℃저장시 49일째 13.9∼18.4 meq/kg, -20℃저장시 80일째 11.6∼20.2 meq/kg으로 저온 일수록 산화속도가 늦었고 각각의 저장온도에서도 녹차, dillweed, 생강, 키토산, 올리고당을 첨가한 시제품에서 가장 산화속도가 늦었다. 친유성 갈색도는 -20℃에서 80일간 저장기간동안 거의 변화가 보이지 않았고 5℃와 0℃에서는 저장기간이 연장됨에 따라 갈색도는 증가하는 경향을 나타내었다. 저장 중 생균수 변화는 5℃와 0℃에서는 저장 80일째까지 생균수 변화는 보이지 않아 신선도 유지가 가능하였다. 관능검사 결과는 5℃저장시 14∼21일, 0℃저장시 28∼49일 점질물이나 산패취가 발생하여 상품적 가치를 상실하였고, -20℃에서는 80일간 저장기간 동안에 이들 변화는 나타나지 않았다. In oredr to endow mackerel fillet with antioxidant effect, functionality and remove fishy smell, chitosan, oligosaccaide, extracts of green tea, dill weed and ginger was used as soaking solution additives. Quality characteristics of soaked mackerel fillet(SMF) was investigated during storage temperature and time after vacuum packing with polyvinyl chloride film. From the results of VBN measurement, initial spoilage was showed within 2 or 3 weeks in SMF soaked with brine including extracts of green tea, herb and ginger at 5℃. In case of adding chitosan and oligosaccarides to the solution mentioned above, initial spoilage was found from 4 to 7 weeks, oxidation was reduced remarkably and SMF stored at -20℃ maintained the freshness during 80 days. Viable cell counts were reached to 108 for 3 weeks storage at 5 and 0℃. But no change of viable cell counts was founded at -20℃. The shelf-lifes of SMF according to 5, 0 and -20℃ storage temperatures were 2 to 3, 4 to 7 weeks and about 3 months, respectively.

Docetaxel and epirubicin salvage regimen in relapsed anthracycline-sensitive metastatic breast cancer patients after anthracycline-containing adjuvant therapy

Seo, Jae Hong,Sung, Hwa Jung,Park, Kyong Hwa,Choi, In Keun,Oh, Sang Cheul,Shin, Sang Won,Kim, Yeul Hong,Kim, Jun Suk,Kim, Ae-Ree,Lee, Jae-Bok,Koo, Bum Hwan Springer-Verlag 2009 Investigational new drugs Vol.27 No.1

Apolipoprotein A1 Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition of Alveolar Epithelial Cells

( Ae Rin Baek ),( Ji Min Lee ),( Hyun Jung Seo ),( Jong Sook Park ),( June Hyuk Lee ),( Sung Woo Park ),( An Soo Jang ),( Do Jin Kim ),( Eun Suk Koh ),( Soo Taek Uh ),( Yong Hoon Kim ),( Choon Sik Par 대한결핵 및 호흡기학회 2016 Tuberculosis and Respiratory Diseases Vol.79 No.3

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by the accumulation of excessive fibroblasts and myofibroblasts in the extracellular matrix. The transforming growth factor β1 (TGF-β1).induced epithelial-to-mesenchymal transition (EMT) is thought to be a possible source of fibroblasts/ myofibroblasts in IPF lungs. We have previously reported that apolipoprotein A1 (ApoA1) has anti-fibrotic activity in experimental lung fibrosis. In this study, we determine whether ApoA1 modulates TGF-β1.induced EMT in experimental lung fibrosis and clarify its mechanism of action. Methods: The A549 alveolar epithelial cell line was treated with TGF-β1 with or without ApoA1. Morphological changes and expression of EMT-related markers, including E-cadherin, N-cadherin, and α-smooth muscle actin were evaluated. Expressions of Smad and non-Smad mediators and TGF-β1 receptor type 1 (TβRI) and type 2 (TβRII) were measured. The silica-induced lung fibrosis model was established using ApoA1 overexpressing transgenic mice. Results: TGF-β1.treated A549 cells were changed to the mesenchymal morphology with less E-cadherin and more N-cadherin expression. The addition of ApoA1 inhibited the TGF-β1.induced change of the EMT phenotype. ApoA1 inhibited the TGF-β1.induced increase in the phosphorylation of Smad2 and 3 as well as that of ERK and p38 mitogenactivated protein kinase mediators. In addition, ApoA1 reduced the TGF-β1.induced increase in TβRI and TβRII expression. In a mouse model of silica-induced lung fibrosis, ApoA1 overexpression reduced the silica-mediated effects, which were increased N-cadherin and decreased E-cadherin expression in the alveolar epithelium. Conclusion: Our data demonstrate that ApoA1 inhibits TGF-β1.induced EMT in experimental lung fibrosis.

가을철 열성 질환의 감별진단에서 혈청 ADA의 진단적 의의

서병기,홍애라,용석중,안강현,김도훈,송광선,신계철 대한감염학회 1996 감염 Vol.28 No.6

목적 : 혈청 ADA는 대식세포계를 활성화시키는 감염성 질환에서 증가하는 것으로 알려져 있다. 이에 저자들은 가을철 열성질환의 원인 질환으로 흔히 발생하는 쯔쯔가무시병, 렙토스피라증, 신증후 출혈열 환자들의 혈청 ADA 를 측정하므로해서 이 질환들의 조기 감별진단에 도움을 줄 수 있는 지에 대하여 알아보고자 하였다. 방법 : 대상은 혈청학적 검사로 확인된 쯔쯔가무시병 15예, 신증후 출열열9예, 렙토스피라증 7예로 모두 31예였으며 이들의 혈청학적 진단은 간접면역형광법 및 particle agglutination법을 사용하였다. 혈청 ADA는 colorimetry법으로 측정하였다. 결과 : 1) 쯔쯔가무시병군이 렙토스피라증군과 신증후 출혈열군에서보다 유의하게 혈청 ADA의 활성이 높았다(p<0.01). 2) 기존의 보고들과 큰 차이없이 신증후 출혈열군이 쯔쯔가무시군보다 유의하게 신병증의 소견이 현저하였으며, 혈소판 수가 유의하게 적었다. 결론 : 열성 질환의 조기감별에서 혈청 ADA측정이 쯔쯔가무시병을 진단하는데 도움을 줄 것으로 생각된다. Objectives : Serum adenosine deaminase(ADA) activity is increased in various diseases such as liver diseases, tuberculosis, typhoid fever and certain hematopoietic malignancies. Serum ADA seems to originate exclusively from the monocyte/macrophage lineage in such diseases. So we investigated the value of serum ADA determination for the early differential diagnosis of serologically verified scrub typhus, hemorrhagic fever with renal syndrome(HERS) and leptospirosis. Methods : Serum ADA values were determined by colorimetry methods. Fifteen cases of serologically confimed scrub typhus were compared with 9 cases of HERS and 7 cases of leptospirosis. Indirect immunofluorescence assay was performed for scrub typhus and leptospirosis, while HERS was diagnosed by particle agglutination test. Results : Serum ADA values were significantly higher in scrub typhus(85.55 ±20.7U/L) than in hemorrhagic fever with renal syndrome(39.6 ±26U/L)or leptospirosis(38.3 ±15.1U/L)(p<0.01). Proteinuria and thrombocytopenia were significantly more common in patients with HERS than in scrub typhus or leptospirosis. Conclusion : Serum ADA measurement may he useful in early differentiation of scrub typhus from hemorrhagic fever with renal syndrome and leptospirosis before serological confirmation.

Effects of Household Washing and Cooking Methods on Removal of Listeria monocytogenes from Enoki Mushroom

Seo Young Chung,Sun Ae Kim,Min Suk Rhee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Listeria monocytogenes, a foodborne pathogen that provokes listeriosis, has been responsible for outbreaks caused by various foods including enoki mushroom (EM). The aim of this study was to establish standard protocols for home food preparation methods (washing and cooking) which could completely remove L. monocytogenes in EM. Three types of washing method (WM) using distilled water (rinsing under running water, dipping in 22℃ or 40℃ water), 2 types of WM using NaCl and vinegar solution, and 9 types of cooking methods (CM) including boiling, blanching, frying and steaming were selected. In case of WMs, washing with 40℃ water or immersing in 10% NaCl solution both induced < 1 log reduction. WM with the highest removal rate was immersing in 5% vinegar for 20 min, which resulted in 1.4 log reduction. In all CMs, including boiling in water at 70℃ for 3 min, L. monocytogenes was reduced by more than 4 log CFU/g and no L. monocytogenes was detected in any of the samples after enrichment procedure. Our findings suggest that consumers could be advised to immerse EMs in 5% vinegar solution when eating them raw or cook with a sufficient heating process for safe consumption in home.

Phase II study of vinorelbine monotherapy in anthracycline and taxane pre-treated metastatic breast cancer

Seo, Hee Yeon,Lee, Hyun Joo,Woo, Ok Hee,Park, Kyong Hwa,Woo, Sang Uk,Yang, Dae Sik,Kim, Ae-Ree,Lee, Jae-Bok,Lee, Eun Sook,Kim, Yeul Hong,Kim, Jun Suk,Seo, Jae Hong Springer-Verlag 2011 Investigational new drugs Vol.29 No.2

Predictive Model for Growth Kinetics of Listeria monocytogenes on Enoki Mushroom as a Function of Distribution and Storage Temperature

Seo Young Chung,Sun Ae Kim,Min Suk Rhee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Listeria monocytogenes is a food poisoning pathogen that causes listeriosis. Since it is a psychrophilic pathogen, it can grow under cold environment. The aim of this study was to develop a predictive model to describe the growth of L. monocytogenes in enoki mushroom, a recent causative food of L. monocytogenes outbreak. Growth of L. monocytogenes was observed at selected temperatures (5, 15, 25, 30 and 35℃) of which L. monocytogenes could be exposed during the distribution and storage process. The R² values of the growth parameters (lag time, LT; specific growth rate, SGR) were 0.964-0.989 using the Baranyi primary model. The polynomial model was found to be an appropriate secondary model based on the correlation of determination of 0.995 for SGR and LT. The polynomial equation has bias factors of 1.014 for SGR, 1.225 for LT and accuracy factors of 1.092 for SGR and LT, which suggested the predictions of the models were in a safe and acceptable range. The predictive model developed in this study will be useful for estimating the growth of L. monocytogenes in enoki mushroom, when it is exposed to various temperature and time conditions during the processing.

Association of Metformin Use With Cancer-Specific Mortality in Hepatocellular Carcinoma After Curative Resection: A Nationwide Population-Based Study

Seo, Young-Seok,Kim, Yun-Jung,Kim, Mi-Sook,Suh, Kyung-Suk,Kim, Sang Bum,Han, Chul Ju,Kim, Youn Joo,Jang, Won Il,Kang, Shin Hee,Tchoe, Ha Jin,Park, Chan Mi,Jo, Ae Jung,Kim, Hyo Jeong,Choi, Jin A,Choi, Wolters Kluwer Health, Inc. All rights reserved. 2016 Medicine Vol.95 No.17

<P>Many preclinical reports and retrospective population studies have shown an anticancer effect of metformin in patients with several types of cancer and comorbid type 2 diabetes mellitus (T2DM). In this work, the anticancer effect of metformin was assessed in hepatocellular carcinoma (HCC) patients with T2DM who underwent curative resection. A population-based retrospective cohort design was used. Data were obtained from the National Health Insurance Service and Korea Center Cancer Registry in the Republic of Korea, identifying 5494 patients with newly diagnosed HCC who underwent curative resection between 2005 and 2011. Crude and adjusted hazard ratios (HRs) were calculated using Cox proportional hazard models to estimate effects. In the sensitivity analysis, we excluded patients who started metformin or other oral hypoglycemic agents (OHAs) after HCC diagnosis to control for immortal time bias. From the patient cohort, 751 diabetic patients who were prescribed an OHA were analyzed for HCC-specific mortality and retreatment upon recurrence, comparing 533 patients treated with metformin to 218 patients treated without metformin. In the fully adjusted analyses, metformin users showed a significantly lower risk of HCC-specific mortality (HR 0.38, 95% confidence interval [CI] 0.30-0.49) and retreatment events (HR 0.41, 95% CI 0.33-0.52) compared with metformin nonusers. Risks for HCC-specific mortality were consistently lower among metformin-using groups, excluding patients who started metformin or OHAs after diagnosis. In this large population-based cohort of patients with comorbid HCC and T2DM, treated with curative hepatic resection, metformin use was associated with improvement of HCC-specific mortality and reduced occurrence of retreatment events.</P>

2009년도 장마 분석 및 특성

서애숙,Seo, Ae-Suk 한국수자원학회 2009 물과 미래(한국수자원학회지) Vol.42 No.8