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Appropriate diagnosis of biliary cystic tumors: comparison with atypical hepatic simple cysts
Seo, Jeong Kyun,Kim, Su Hyun,Lee, Sang Hyub,Park, Joo Kyung,Woo, Sang Myung,Jeong, Ji Bong,Hwang, Jin-Hyeok,Ryu, Ji Kon,Kim, Jin-Wook,Jeong, Sook-Hyang,Kim, Yong-Tae,Yoon, Yong Bum,Lee, Kuhn Uk,Kim, S Lippincott Williams Wilkins, Inc. 2010 European journal of gastroenterology & hepatology Vol.22 No.8
BACKGROUND: Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) are often confused with other intrahepatic cystic diseases. AIMS: The aims of this study were to investigate predictive factors of biliary cystic tumor (BCT) and clinical characteristic of BCAC. METHODS: We retrospectively reviewed preoperative diagnoses, overall characteristics and postoperative outcome of 20 BCTs and 19 cystadenoma-mimicking simple cysts that were pathologically confirmed. RESULTS: Comparing with atypical simple cysts, symptoms, left-lobe cyst, thick wall, septation, mural nodule, bile duct dilatation and an increase of serum alkaline phosphatase were associated with BCTs. However, on multivariate analysis, mural nodule, left-lobe cyst, and an increase of serum alkaline phosphatase were significantly frequent in BCTs with odds ratios of 75.5, 13.8, and 33.0, respectively. Among the 20 BCTs, seven BCACs were diagnosed. The characteristics of BCACs were mural nodule (P<0.01), intrahepatic cyst debris (P<0.01), and bile duct dilation (P=0.04). Cystic fluid analysis provided no significant differences between BCT and simple cyst. After fine needle aspiration cytology of BCTs, all except one BCAC with atypical cell showed nonspecific findings. After complete surgical excision (97.4% of patients), only one patient with BCAC had recurrence during 29 months of follow-up period. CONCLUSION: In hepatic cysts with mural nodule, left-lobe cyst or increment of serum alkaline phosphatase seem to be indicative of BCTs in the diagnosis of suspicious hepatic cyst. Intracystic debris, bile duct dilation, and mural nodule may be suggestive clinical features of malignancy in BCTs.
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Seo, Hyun Ook,Park, Eun Ji,Kim, Il Hee,Han, Sang Wook,Cha, Byeong Jun,Woo, Tae Gyun,Kim, Young Dok Elsevier 2017 CATALYSIS TODAY - Vol.295 No.-
<P><B>Abstract</B></P> <P>We have studied the influence of water vapors on the activity of the photo-catalytic oxidation of acetaldehyde on the surface of TiO<SUB>2</SUB> film under UV light (365nm) irradiation. Photo-catalysis experiments were performed at atmospheric conditions under various humidity levels (0, 16.8, and 33.6 relative humidity%) using a high vacuum chamber equipped with online gas-chromatography as a batch-type reactor. Acetaldehyde and H<SUB>2</SUB>O molecules competitively adsorbed on the surface of TiO<SUB>2</SUB> film and the increase in the humidity decreased both the acetaldehyde removal and CO<SUB>2</SUB> evolution rates. The rate of CO<SUB>2</SUB> evolution was even more influenced by the humidity level of the gas mixture compared to the acetaldehyde removal rate, particularly over the certain level of relative humidity. We evidenced that the total oxidation of acetaldehyde was majorly mediated by oxygen molecules rather than H<SUB>2</SUB>O vapor under our experimental conditions. It is suggested that photo-catalytic total oxidation of acetaldehyde was promoted by the presence of large active sites ensemble near the adsorbed acetaldehyde, which were available to oxygen. Increase of humidity level disturbed this large ensemble, resulting in the reduction of photo-catalytic degradation rate of acetaldehyde under UV light irradiation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Higher humidity level decreased the photo-catalytic mineralization of acetaldehyde. </LI> <LI> The total mineralization of acetaldehyde was majorly mediated by O<SUB>2</SUB>. </LI> <LI> Water vapor was competitively adsorbed on TiO<SUB>2</SUB> surface with acetaldehyde and O<SUB>2</SUB>. </LI> <LI> Water molecules inhibited the adsorption of the acetaldehyde and O<SUB>2</SUB>. </LI> <LI> Active sites ensemble promoted the total mineralization of acetaldehyde. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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( Sung Kyu Jung ),( Jae Beom Park ),( Byoung Joon So ),( Sang Geun Lee ),( Soo Hong Seo ),( Sang Wook Son ),( Il Hwan Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Erythema annulare centrifugum (EAC) is characterized by expanding erythematous rings. In most cases, underlying diseases such as infection, drug and pregnancy accompanied EAC. A previous study reported the pathogenesis of hypersensitivity reaction to fungal infection. In another study, fungal infection was evident in 48 of 66 patients with EAC. Objectives: The etiology and related disease in most cases of EAC is unknown. The purpose of this study was to analyze the relationship between EAC and underlying cutaneous fungal infections. Methods: In a retrospective study, 100 EAC patients confirmed by clinical or histopathological examination were enrolled. The patients` electronic medical records were reviewed. Results: 26 EAC patients had cutaneous fungal infection, such as tinea pedis and tinea unguium. Of them, 16 patients underwent fungal treatment. 9 of 16 patients showed improvement of EAC lesion with fungal treatment. 6 patients had history of other infections, 6 had endocrine disorders, 5 had drug history, 5 were pregnant and 1 had malignancy. Conclusion: EAC is thought to be associated with fungal infection. This study showed that the high prevalence of cutaneous fungal infection and the some response to fungal treatment in EAC patients. However, it was difficult to confirm a direct association in this study. In the future, there is a need for a larger cohort study including allergic confirmation test to prove causal association between EAC and fungal infection.
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Application of expert system for smart livestock production management: A review
Sung Wook Lee,Md Nasim Reza,Sun-Ok Chung,Ho-Sung An,Ye Rin Lee,Sung Soo Kim,Hye Won Seo,Chang Uk Cheon 사단법인 한국정밀농업학회 2023 정밀농업과학기술지 Vol.5 No.1
Globally, the population is expanding, whereas the agricultural labor population is decreasing due to the population aging. In addition, as a result of the liberalization of trade restrictions, prices for food and livestock are becoming less competitive, and the effects of climate change are becoming more pronounced. As a result, there is a growing expectation for the livestock industry to adopt cutting-edge technologies in order to maximize efficiency and output. This paper reviewed the current livestock industry based on the livestock environment management, feeding management, disease prediction and management, and the field of manure treatment. Applications and justifications for expert systems in the livestock sector were also discussed, as were examples and justifications for effective mechanization and automation systems. The paper also covered the anticipated future applications of the expert system and conducts an analysis of the current use cases.
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Radioresponse of Hepatocellular Carcinoma-Treatment of Lymph Node Metastasis
Sang Min Yoon,Jong Hoon Kim,Eun Kyung Choi,Seung Do Ahn,Sang-wook Lee,Byong Yong Yi,Young Wha Chung,Young Sang Lee,Dong Jin Seo 대한암학회 2004 Cancer Research and Treatment Vol.36 No.1
PURPOSE: To analyze the radioresponse of hepatocellular carcinomas (HCC), using accurate measurements of the tumor size in extrahepatic lymph node metastasis, and to obtain information for the future treatment of primary intrahepatic lesions. MATERIALS AND METHODS: Fifty-one extrahepatic lymph node metastases from primary HCCs, which could be treated by external radiotherapy alone, were included in this study. The radiation dose ranged from 30 to 51 Gy with fraction sizes of 2.0~3.0 Gy. Responses were determined by measuring the areas on CT scans 0, 1 and 3 months after the completion of radiotherapy. The median follow-up period of the surviving patients was 10 months. RESULTS: The overall response rate was 76%, and the important factors were; total dose of radiation, time dose fractionation (TDF) value and the biologically effective dose (BED). A dose of 45 Gy or higher showed an objective response rate of 93%, and if the TDF value was higher than 90, a similar result was observed. In about half (47%) of the patients the maximum response was observed at 3 months or later. The response duration was observable in 14 patients surviving 12 months or longer. Regrowth of irradiated lesions were observed in 4 (66.7%) patients among those who received less than 45 Gy, and in 4 (50%) among those who were treated with 45 Gy or more. There was a statistically significant difference in the survivals between the responders and non-responders (p=0.008). Gastrointestinal bleeding or ulceration was observed in 8 patients, including 3 with NCI common toxicity criteria grade III or higher. CONCLUSION: Radiotherapy was an effective palliative modality for extrahepatic metastasis in HCCs. A radiation dose of 45 Gy or higher (or a TDF value 〉90), was required for a major response. (Cancer Res Treat. 2004;36:79-84)
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Sang-Hoon Lee,June-Hyuk Kim,Whan-Seong Cho,Sung-Wook Seo,Sung-Kyu Kim,Joo-Han Oh 한국식품영양과학회 2005 Preventive Nutrition and Food Science Vol.10 No.3
In this double-blind, placebo-controlled trial, we assessed the efficacy and safety of beef tallow extract (BTE) including Cis-9-cetylmyristoleate in patients with arthritis. Between May and December 2003, we selected 80 patients (n=80) who showed/manifested arthritic symptoms and whose radiological findings were suggestive of arthritis, and randomly assigned them to placebo-controlled (n=40) and treatment group (n=40). The placebo (corn starch 350 mg) and BTE (208 mg) were orally administered to placebo-controlled and treatment group three times a day, respectively. We assessed the efficacy and safety based on the visual analogue scale (VAS) and modified knee society knee scores (MKSKS) at baseline and endpoint, respectively. To assess the safety, we monitored the adverse effects noted in liver, kidney, cardiovascular and gastrointestinal system for 3 weeks. Then, we performed not only a questionnaire study but also laboratory tests (e.g., liver function test, kidney function test, urinalysis, electrocardiography [EKG], complete blood cell counts [CBC] and chest X-ray). For statistical analysis, Student t-test and paired t-test were done using SPSS^® Version 11.0. Statistical significance was set at p<0.05. The scores between VAS and MKSKS showed statistical significance (p<0.05) with an improvement of 69.2% (27/39) and 3.8% (21/39) of treatment-group patients, respectively. Abnormal laboratory findings were noted in neither placebo-controlled nor treatment group. In conclusion, our results indicate that the administration of BTE was a safe and effective treatment regimen for patients with arthritis. In addition, the efficacy of BTE was more remarkable in alleviating the symptoms rather than improving the function.
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Seo, Jong-Bae,Choe, Sung-Sik,Jeong, Hyun-Woo,Park, Sang-Wook,Shin, Hyun-Jung,Choi, Sun-Mi,Park, Jae-Young,Choi, Eun-Wook,Kim, Jae-Bum,Seen, Dong-Seung,Jeong, Jae-Yeon,Lee, Tae-Gyu Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.4
$Lysimachia$ $foenum-graecum$ has been used as an oriental medicine with anti-inflammatory effect. The anti-obesity effect of $L.$ $foenum-graecum$ extract (LFE) was first discovered in our screening of natural product extract library against adipogenesis. To characterize its anti-obesity effects and to evaluate its potential as an anti-obesity drug, we performed various obesity- related experiments $in$ $vitro$ and $in$ $vivo$. In adipogenesis assay, LFE blocked the differentiation of 3T3-L1 preadipocyte in a dose-dependent manner with an IC50 of $2.5{\mu}g/ml$. In addition, LFE suppressed the expression of lipogenic genes, while increasing the expression of lipolytic genes $in$ $vitro$ at $10{\mu}g/ml$ and $in$ $vivo$ at 100 mg/kg/day. The anti-adipogenic and anti- lipogenic effect of LFE seems to be mediated by the inhibition of PPAR${\gamma}$ and C/EBP${\alpha}$ expression as shown in $in$ $vitro$ and $in$ $vivo$, and the suppression of PPAR${\gamma}$ activity $in$ $vitro$. Moreover, LFE stimulated fatty acid oxidation in an AMPK-dependent manner. In high-fat diet (HFD)-induced obese mice (n = 8/group), oral administration of LFE at 30, 100, and 300 mg/kg/day decreased total body weight gain significantly in all doses tested. No difference in food intake was observed between vehicle- and LFE-treated HFD mice. The weight of white adipose tissues including abdominal subcutaneous, epididymal, and perirenal adipose tissue was reduced markedly in LFE-treated HFD mice in a dose-dependent manner. Treatment of LFE also greatly improved serum levels of obesity-related biomarkers such as glucose, triglycerides, and adipocytokines leptin, adiponectin, and resistin. All together, these results showed anti-obesity effects of LFE on adipogenesis and lipid metabolism $in$ $vitro$ and $in$ $vivo$ and raised a possibility of developing LFE as anti-obesity therapeutics.
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Seo, Hyun Ook,Woo, Tae Gyun,Park, Eun Ji,Cha, Byeong Jun,Kim, Il Hee,Han, Sang Wook,Kim, Young Dok Elsevier 2017 APPLIED SURFACE SCIENCE - Vol.420 No.-
<P><B>Abstract</B></P> <P>We have studied the photo-catalytic degradation of acetaldehyde over the surface of TiO<SUB>2</SUB> films under UV light (365nm) irradiation both at dry and humid air conditions using a high vacuum chamber equipped with on-line gas-chromatography as a batch-type reactor. Changes of TiO<SUB>2</SUB> surfaces upon the photo-catalysis experiments were studied by X-ray photoelectron spectroscopy. The competitive adsorption of water and acetaldehyde resulted in the reduction of reaction rate of photo-catalytic degradation of acetaldehyde under the UV light irradiation. The photo-catalytic reaction rate of TiO<SUB>2</SUB> films towards acetaldehyde mineralization increased when the photo-catalysis experiments were performed repeatedly and it was much more pronounced under humid conditions. Our XPS analysis revealed that carbon impurities on the surface of TiO<SUB>2</SUB> films were removed by UV-light driven photo-catalytic mineralization under humid conditions. Water vapor facilitated the photo-catalytic removal of carbon impurities from TiO<SUB>2</SUB> surface generating additional active sites of TiO<SUB>2</SUB> which resulted in the enhanced photo-catalytic activity of TiO<SUB>2</SUB> films.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Changes of TiO<SUB>2</SUB> surfaces during photo-catalysis were studied by XPS. </LI> <LI> Role of humidity for photo-catalytic decomposition of acetaldehyde was studied. </LI> <LI> Competitive adsorption of water and acetaldehyde resulted in the reduction of reaction rate. </LI> <LI> Water vapor facilitated the photo-catalytic removal of carbon impurities from TiO<SUB>2</SUB>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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