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Peripheral Blood NK Cells Reflect Changes in Decidual NK Cells in Women With Recurrent Miscarriages
Park, Dong Wook,Lee, Hyun Joo,Park, Chan Woo,Hong, Sung Ran,Kwak-Kim, Joanne,Yang, Kwang Moon Blackwell Publishing Ltd 2010 American journal of reproductive immunology Vol.63 No.2
<P><B>Citation</B> Park DW, Lee HJ, Park CW, Hong SR, Kwak-Kim J, Yang KM. Peripheral blood NK cells reflect changes in decidual NK cells in women with recurrent miscarriages. Am J Reprod Immunol 2010; 63: 173–180</P><P>Problem </P><P>We aimed to investigate if peripheral blood natural killer (pNK) cell levels are correlated with decidual NK (dNK) cell levels, and if chemokine expression has any role in dNK cell regulation.</P><P>Method of study </P><P>Decidual tissues of women having two or more miscarriages with normal karyotype were collected after miscarriage and an immuno-histochemisty study was made. pNK cells were evaluated using flow cytometric analysis.</P><P>Results </P><P>The %CD3<SUP>−</SUP>/56<SUP>+</SUP> and %CD3<SUP>−</SUP>/56<SUP>+</SUP>/16<SUP>+</SUP> pNK cells showed a significant correlation with mean number of CD56<SUP>+</SUP> dNK cells. The number of decidual CD16<SUP>+</SUP> cells was significantly higher in women with elevated pNK (≥15%) than that of normal pNK (<15%). The %CD3<SUP>−</SUP>/56<SUP>+</SUP> and %CD3<SUP>−</SUP>/56<SUP>+</SUP>/16<SUP>+</SUP> pNK cells showed an inverse correlation with duration of gestation. The CCL3<SUP>+</SUP> and CXCL12<SUP>+</SUP> cells were present in the decidua; however, staining intensity was not correlated with number of dNK cells.</P><P>Conclusion </P><P>The pNK cell levels reflect changes in dNK cell levels. This implicates that pNK cell level is a clinically useful marker to predict pregnancy outcome. Further study is needed to examine if elevated pNK cells enhance recruitment of dNK cells in the decidua.</P>
[P178] Plaque-type blue nevus in a Korean woman
( Hyun-bin Kwak ),( Sang-woo Park ),( Su-kyung Park ),( Soo-han Woo ),( Jin Park ),( Seok-kweon Yun ),( Han-uk Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Plaque-type blue nevus is a rare variant of blue nevus, the precise prognostic significance of which is unknown. We report the unusual and rare case of an uncommon large, agminated blue nevus of the ``plaque type`` in a 23-year-old Korean female. She presented with a large blue plaque, 2.5 x 6cm in size, on the right lower flank. There were spots of various shades of blue on the plaque. The lesion had developed since birth and became more prominent over the past years. The patient had noticed subcutaneous nodules recently. On physical examination, subcutaneous nodules were found on palpation with no pain. No enlargement of the regional lymph nodules was found. Upon dermoscopic examination, the lesion was typified by areas of homogenous, unstructured blue pigmentation, brownish-blue in the center and blue at the periphery. At the periphery, tan pigmentation was noted. A biopsy was taken from the lesions. Elongated melanocytes in the interstices of the collagen with some melanophages were typical of a common blue nevus. No malignant features were found. A diagnosis of plaque-type blue nevus was made.
Nitric oxide-induced immune switching in experimental inflammatory autoimmune diseases
Kwak, Hyun-Jeong,Kim, Hyung-Jin,Park, Jae-Sung,Jun, Chang-Duk,Lee, Mun-Young,Shin, Tae-Kyun,Chung, Hun-Taeg The Korean Association of Immunobiologists 2001 Immune Network Vol.1 No.2
Background: Nitric oxide (NO) production has been described as a double-edged sword eliciting both pro- and anti-inflammatory effects in different immune reactions. This work was undertaken to investigate the immunoregulatory role of NO in experimental allergic encephalomyelitis (EAE) and experimental allergic uveitis (EAU). Method: We examined whether molsidomine (MSDM), a NO donor, administration to the myelin basic protein (MBP)- or interphotoreceptor retinoid binding protein (IRBP)-immunized rats could suppress EAE development by shifting toward the Th2 cytokine response. In the EAE experiments, the rats were treated orally with MSDM (10 mg/kg/day) at the early stage (-1~4 days) or throughout the experimental period (-1~15 days). Results: This resulted in significant amelioration of the disease and mild clinical symptoms, while MBP-immunization without MSDM administration showed severe EAE development. A marked reduction in inflammation was also observed in the spinal cord, indicating the crucial role of NO in the pathogenesis of EAE in in vivo. In the EAU experiments, a 24 h pre-treatment with MSDM prior to IRBP immunization resulted in significant inhibition of the disease. Furthermore, MSDM administration for 2 1 days completely reduced the incidence and severity of EAU. To investigate whether MSDM could modulate cytokine switching from Th 1 to Th2, culture supernatants of MBP- or IRBP-stimulated inguinal lymphocytes were analyzed. MSDM treatment enhanced IL-10 secretion but decreased IFN-${\gamma}$. IL-4 was undetectable in all groups. In contrast, the MBP-or IRBP-immunized rats without MSDM secreted high concentrations of IFN-${\gamma}$, but low concentrations of IL-10. Conclusion: In conclusion, NO administation suppresses EAE and EAU by modulating the Th1/Th2 balance during inflammatory immune responses. This work further suggests that NO may be useful in the therapeutic control of autoimmune disease.
( Sung Heon Song ),( Young Jin Jun ),( Seung Sam Paik ),( Hyun Jung Kwak,),( Sang Heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Dong Ho Shin ),( Sung Soo Park ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.6
Non small cell lung cancer (NSCLC) frequently metastasizes to brain, bone, liver, and adrenal glands. While an autopsy of NSCLC reveals some cases of metastasis to the kidney, clinical detection of renal metastases is extremely rare. Furthermore, metastases to the kidney usually present as multifocal or bilateral lesions and solitary renal metastases are usually suspected to be renal cell carcinoma. We now report a case of asymptomatic solitary renal metastasis from a primary squamous cell carcinoma, which was detected by routine surveillance with abdominal CT after curative surgery.
( Sang-woo Park ),( Hyun-bin Kwak ),( Seok-kweon Yun ),( Han-uk Kim ),( Jin Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Discoid lupus erythematosus (DLE) and actinic keratosis (AK) usually present as erythematous plaque on the face and are often indistinguishable each other. However, differentiation of these two skin conditions is important, because they are treated differently. Objectives: We aimed to know the diagnostic usefulness of dermoscopy for differentiating between facial DLE and AK. Methods: We retrospectively evaluated dermoscopic features of 109 histopathologically-proven DLE and AK (29 DLE and 80 AK patients) on the face. Results: Mean age of the DLE and AK patients was 55.2±8.4 years (M:F=37.9%:62.1%) and 70.0±7.8 years (M:F=30.0%:70.0%), respectively. Follicular keratotic plug (48.3% vs 25.0%), perifollicular whitish halo (55.2% vs 23.8%), follicular red dot (17.2% vs 1.3%), blue-gray granular pigmentation (82.8% vs 17.5%), and hairpin vessel (13.8% vs 2.5%) were significantly higher in DLE, while AK was characterized by reticular pigmentation (17.2% vs 56.3%), superficial brown pigmentation (13.7% vs 61.3%), pseudofollicular opening (6.9% vs 30.0%), and black-brown dot (27.6% vs 51.3%). There was no significant difference of scale (24.1% vs 17.5%) and telangiectatic vessel (48.3% vs 32.6%) between two groups. Conclusion: The distinct dermoscopic patterns observed in this study could be a useful clue for the differential diagnosis between DLE and AK. Further studies are needed to confirm our preliminary observations.