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Kim, Sejin,Park, Eujin,Min, Sang-il,Yi, Nam-Joon,Ha, Jongwon,Ha, Il-Soo,Cheong, Hae Il,Kang, Hee Gyung KOREAN ACADEMY OF MEDICAL SCIENCE 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.1
<P><B>Background</B></P><P>Atypical hemolytic uremic syndrome (aHUS) is a rare disease that is often associated with genetic defects. Mutations of complement factor H (<I>CFH</I>) are the most common genetic defects that cause aHUS and often result in end-stage renal disease. Since <I>CFH</I> is mainly produced in the liver, liver transplantation (LT) has been performed in patients with defective <I>CFH</I>.</P><P><B>Methods</B></P><P>The clinical courses of four kidney allograft recipients who lost their native kidney functions due to aHUS associated with a <I>CFH</I> mutation were reviewed.</P><P><B>Results</B></P><P>Subject A underwent kidney transplantation (KT) twice, aHUS recurred and the allograft kidney failed within a few years. Subject B received a KT and soon experienced a recurrence of aHUS coinciding with infection. Her allograft kidney function has worsened, and she remains on plasma infusion therapy. Subject C underwent LT followed by KT. She is doing well without plasma infusion therapy after combined LT-KT for 3 years. Subject D received KT following LT and is now recurrence-free from aHUS.</P><P><B>Conclusion</B></P><P>In patients with aHUS associated with a <I>CFH</I> mutation, KT without LT was complicated with a recurrence of aHUS, which might lead to allograft loss. Conversely, LT was successful in preventing the recurrence of aHUS and thus might be another option for a recurrence-free life for aHUS patients associated with <I>CFH</I> mutation.</P>
Identification of molecular markers for the oncogenicdifferentiation of hepatocellular carcinoma
Gyung-Ran Yu,Seong-Hun Kim,Seon-Hwa Park,Xiang-Dan Cui,Dong-Yuan Xu,Hee-Chul Yu,Baik-Hwan Cho,Young-Il Yeom,Sang-Soo Kim,Sang-Bae Kim,추인선,김대곤 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.5
The aim of this study was to identify molecular markers associated with oncogenic differentiation in hep-atocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene expression profiles and corresponding non-tu-tal 217 genes, 72 were expressed preferentialy in HCC tissues. Among 186 diferentialy regulated genes, there were molecular chaperone and tumor sup-pressor gene clusters in the Edmondson grades I and I (GI/I) subclass compared with the liver cirrhosis (LC) subclass. The Edmondson grades III and IV (GIII/IV) subclass with a poor survival (P = 0.0133) contained 122 diferentialy regulated genes with a cluster containing pared with the GI/II subclass. Imunohistochemical analysis revealed that ANXA2, one of the 72 genes pref-erentially expressed in HCC, was over-expressed in the sinusoidal endothelium and in malignant hepatocytes in HCC. The genes identified in the HCC subclasses wil be useful molecular markers for the genesis and pro-gresion of HCC. In addition, ANXA2 might be a novel marker for tumor angiogenesis in HCC.
Longitudinal Changes in Resting-State Brain Activity in a Capsular Infarct Model
Kim, Donghyeon,Kim, Ra Gyung,Kim, Hyung-Sun,Kim, Jin-Myung,Jun, Sung Chan,Lee, Boreom,Jo, Hang Joon,Neto, Pedro R,Lee, Min-Cheol,Kim, Hyoung-Ihl SAGE Publications 2015 Journal of cerebral blood flow and metabolism Vol.35 No.5
Longitudinal Changes in Resting-State Brain Activity in a Capsular Infarct Model
Kim, Donghyeon,Kim, Ra Gyung,Kim, Hyung-Sun,Kim, Jin-Myung,Jun, Sung Chan,Lee, Boreom,Jo, Hang Joon,Neto, Pedro R,Lee, Min-Cheol,Kim, Hyoung-Ihl SAGE Publications 2015 Journal of cerebral blood flow and metabolism Vol.35 No.1
<P> Strokes attributable to subcortical infarcts have been increasing recently in elderly patients. To gain insight how this lesion influences the motor outcome and responds to rehabilitative training, we used circumscribed photothrombotic capsular infarct models on 36 Sprague-Dawley rats (24 experimental and 12 sham-operated). We used 2-deoxy-2-[<SUP>18</SUP>F]-fluoro-D-glucose-micro positron emission tomography (FDG-microPET) to assess longitudinal changes in resting-state brain activity (rs-BA) and daily single-pellet reaching task (SPRT) trainings to evaluate motor recovery. Longitudinal FDG-microPET results showed that capsular infarct resulted in a persistent decrease in rs-BA in bilateral sensory and auditory cortices, and ipsilesional motor cortex, thalamus, and inferior colliculus ( P<0.0025, false discovery rate (FDR) q<0.05). The decreased rs-BA is compatible with diaschisis and contributes to manifest the malfunctions of lesion-specific functional connectivity. In contrast, capsular infarct resulted in increase of rs-BA in the ipsilesional internal capsule, and contralesional red nucleus and ventral hippocampus in recovery group ( P<0.0025, FDR q<0.05), implying that remaining subcortical structures have an important role in conducting the recovery process in capsular infarct. The SPRT training facilitated motor recovery only in rats with an incomplete destruction of the posterior limb of the internal capsule (PLIC) (Pearson's correlation, P<0.05). Alternative therapeutic interventions are required to enhance the potential for recovery in capsular infarct with complete destruction of PLIC. </P>
Kim, Shi Hyoung,Park, Jae Gwang,Lee, Jongsung,Yang, Woo Seok,Park, Gye Won,Kim, Han Gyung,Yi, Young-Su,Baek, Kwang-Soo,Sung, Nak Yoon,Hossen, Muhammad Jahangir,Lee, Mi-nam,Kim, Jong-Hoon,Cho, Jae Youl Hindawi Publishing Corporation 2015 MEDIATORS OF INFLAMMATION Vol.2015 No.-
<P>Even though a lot of reports have suggested the anti-inflammatory activity of kaempferol (KF) in macrophages, little is known about its exact anti-inflammatory mode of action and its immunopharmacological target molecules. In this study, we explored anti-inflammatory activity of KF in LPS-treated macrophages. In particular, molecular targets for KF action were identified by using biochemical and molecular biological analyses. KF suppressed the release of nitric oxide (NO) and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>), downregulated the cellular adhesion of U937 cells to fibronectin (FN), neutralized the generation of radicals, and diminished mRNA expression levels of inflammatory genes encoding inducible NO synthase (iNOS), TNF-<I>α</I>, and cyclooxygenase- (COX-) 2 in lipopolysaccharide- (LPS-) and sodium nitroprusside- (SNP-) treated RAW264.7 cells and peritoneal macrophages. KF reduced NF-<I>κ</I>B (p65 and p50) and AP-1 (c-Jun and c-Fos) levels in the nucleus and their transcriptional activity. Interestingly, it was found that Src, Syk, IRAK1, and IRAK4 responsible for NF-<I>κ</I>B and AP-1 activation were identified as the direct molecular targets of KF by kinase enzyme assays and by measuring their phosphorylation patterns. KF was revealed to have <I>in vitro</I> and <I>in vivo</I> anti-inflammatory activity by the direct suppression of Src, Syk, IRAK1, and IRAK4, involved in the activation of NF-<I>κ</I>B and AP-1.</P>
Kim Si Hyun,Sung Gyung-Hye,Park Eun Hee,Hwang In Yeong,Kim Gyu Ri,송새암,Lee Hae Kyung,Uh Young,Kim Young Ah,Jeong Seok Hoon,Shin Jong Hee,Shin Kyeong Seob,Lee Jaehyeon,Jeong Joseph,Kim Young Ree,Yong Do 대한진단검사의학회 2022 Annals of Laboratory Medicine Vol.42 No.2
Salmonella is one of the major causes of food-borne infections. We investigated the serotype distribution and antimicrobial resistance of Salmonella isolates collected in Korea between January 2016 and December 2017. In total, 669 Salmonella isolates were collected from clinical specimens at 19 university hospitals. Serotyping was performed according to the Kauffmann–White scheme, and antimicrobial susceptibility was tested using Sensititre EUVSEC plates or disk diffusion. Among the strains, C (39.8%) and B (36.6%) were the most prevalent serogroups. In total, 51 serotypes were identified, and common serotypes were S. enterica serovar I 4,[5],12:i:- (16.7%), S. Enteritidis (16.1%), S. Bareilly (14.6%), S. Typhimurium (9.9%), and S. Infantis (6.9%). The resistance rates to ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole were 32.6%, 12.1%, and 8.4%, respectively. The resistance rates to cefotaxime and ciprofloxacin were 8.1% and 3.0%, respectively, while 5.4% were multidrug-resistant. S. enterica serovar I 4,[5],12:i:- and S. Enteritidis were highly prevalent, and there was an increase in rare serotypes. Multidrug resistance and ciprofloxacin resistance were highly prevalent. Periodic investigations of Salmonella serotypes and antimicrobial resistance are needed.