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P064 : Treatment of genital wart by bleomycin intralesional injection
( Sang Seok Kim ),( So Eun Park ),( Jin Yong Lee ),( Soo Jung Shin ),( Chang Sun Yoo ),( Chul Woo Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: The success of treating genital wart is widely variable. Although many treatment modalities have been described, choosing an appropriate treatment can be difficult when the genital wart is large or occurs in surgically inaccessible areas. Objectives: The purpose of this study is to assess the efficacy and safety of bleomycin intralesional injection in treating genital warts. Methods: We performed bleomycin intralesional injections in 15 patients with 164 genital warts. These injections were performed as an in-office procedure and repeated every 2 weeks, if needed. Changes in lesions and adverse reactions were recorded, and therapeutic efficacy was evaluated. Results: Treatment was beneficial in 11 (73.3%) patients. Complete resolution of the warts was observed after 1-7 treatment sessions (mean, 3.6). Recurrences were observed in 2 patients, and 2 patients did not respond well to treatment. Pain, dyspigmentation, crusts and mild scar formation were the main adverse effects. Conclusion: Intralesional bleomycin injection is a safe and effective alternative treatment modality for genital wart not only in small lesions but also in large and surgically inaccessible lesions.
P164 : Treatment of digital mucous cysts by sodium tetradecyl sulfate sclerotherapy
( Chul Woo Kim ),( So Eun Park ),( Jin Yong Lee ),( Soo Jung Shin ),( Chang Sun Yoo ),( Sang Seok Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: There are various treatment modalities for digital mucous cysts(DMCs), among which sclerotherapy has been reported as an effective alternative treatment. Here, we report our experience of intralesional sclerotherapy with sodium tetradecyl sulfate(STS) for treatment of DMCs. Objectives: The purpose of this study is to assess the efficacy and safety of sclerotherapy with STS in treating DMCs. Methods: We performed the treatment for 15 patients(2 patients with multiple lesions) with 18 DMCs.(one patient with 3 lesions and the other with 2 lesions). 1%-3% STS 0.2-0.5ml was injected into a lesion at each session, and repeated every 4 weeks if necessary. Changes in lesions and adverse reactions were recorded, and the therapeutic efficacy was evaluated. Results: The treatment was beneficial in 14(77.8%) of 18 lesions. Lesions exhibited complete resolution after a mean of 2.4 injections. Recurrences were observed in 2 patients(one patient in toe and the other in finger), and 2 patients(all in fingers) did not respond well to treatment. No patient reported any major adverse effects. However, 3 patients experienced transient pain and 5 patients experienced erosions and superficial skin necrosis at the injection site, which resolved within a few days. Conclusion: Based on the results of our study, treatment was well tolerated with few side effects, and resulted in high cure rate. Therefore, we believe that sclerotherapy with STS is a promising alternative treatment for DMCs.
Calcineurin is expressed and plays a critical role in inflammatory arthritis.
Yoo, Seung-Ah,Park, Bo-Hyoung,Park, Gyeong-Sin,Koh, Hae-Seok,Lee, Mi-Sook,Ryu, Sung Ho,Miyazawa, Keiji,Park, Sung-Hwan,Cho, Chul-Soo,Kim, Wan-Uk Williams Wilkins 2006 JOURNAL OF IMMUNOLOGY Vol.177 No.4
<P>Calcineurin is a calcium-activated phosphatase to mediate lymphocyte activation and neuron signaling, but its role in inflammatory arthritis remains largely unknown. In this study, we demonstrate that calcineurin was highly expressed in the lining layer, infiltrating leukocytes, and endothelial cells of rheumatoid synovium. The basal expression levels of calcineurin were higher in the cultured synoviocytes of rheumatoid arthritis patients than those of osteoarthritis patients. The calcineurin activity in the synoviocytes was increased by the stimulation with proinflammatory cytokines such as IL-1beta and TNF-alpha. Moreover, rheumatoid arthritis synoviocytes had an enlarged intracellular Ca(2+) store and showed a higher degree of [Ca(2+)](i) release for calcineurin activity than osteoarthritis synoviocytes when stimulated with either TNF-alpha or phorbol myristate acetate. IL-10, an anti-inflammatory cytokine, failed to increase the Ca(2+) and calcineurin activity. The targeted inhibition of calcineurin by the overexpression of calcineurin-binding protein 1, a natural calcineurin antagonist, inhibited the production of IL-6 and matrix metalloproteinase-2 by rheumatoid synoviocytes in a similar manner to the calcineurin inhibitor, cyclosporin A. Moreover, the abundant calcineurin expression was found in the invading pannus in the joints of mice with collagen-induced arthritis. In these mice, calcineurin activity in the cultured synovial and lymph node cells correlated well with the severity of arthritis, but which was suppressed by cyclosporin A treatment. Taken together, our data suggest that the abnormal activation of Ca(2+) and calcineurin in the synoviocytes may contribute to the pathogenesis of chronic arthritis and thus provide a potential target for controlling inflammatory arthritis.</P>
Yoo, Joh Yeong,Lee, Han Seung,Tae, Sung Ho,Chul, Moon Byung Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.348 No.-
<P>As concrete is a type of porous materials, water or air freely permeates concrete. Therefore the durability of concrete decreases. However, porous material with a rust inhibitor may allow permeation of water into concrete. In addition, there may be permeation of water through the rust inhibitor at the location of steel frames. The objective of the study is to investigate the penetration depth of concrete under water forced conditions with pressure.</P>
Yoo, Hyuk Sang,Mazda, Osam,Lee, Hyeon Yong,Kim, Jin Chul,Kwon, Seok Min,Lee, Jung Eun,Kwon, Ick Chan,Jeong, Hesson,Jeong, Yu Seok,Jeong, Seo Young Elsevier 2006 Journal of controlled release Vol.112 No.1
<P><B>Abstract</B></P><P>A cationic emulsion containing an insulin expression plasmid was prepared for the treatment of type 1 diabetic mellitus (DM) in vivo. A rat proinsulin-1 gene was inserted to EBV-based plasmid vectors containing CAG promoter. Cationic emulsion composed of DOTAP and squalene was complexed with the plasmid DNA. An intravenous injection of cationic emulsion containing proinsulin gene decreased blood glucose levels for 7 days within normal range. The cationic emulsion exerted more profound effect on blood glucose levels compared to naked DNA. RT-PCR results confirmed that the proinsulin was expressed in several organs containing liver, lung, spleen, and kidney. The refractory response was invoked by multiple injections of naked DNA or cationic emulsion/DNA complex, which was later proven to be an immune response against expressed proinsulin. Therefore, the cationic emulsion showed a promising result as a novel insulin gene therapy vehicle by decreasing blood glucose level for a month.</P>
결합조직형성 악성중피종 1예 A Case of Desmoplastic Malignant Mesothelioma (DMM)
( Sang Woo Park ),( Tae Ok Kim ),( Hyun Wook Kang ),( Hee Jung Ban ),( In Jae Oh ),( Young Chul Kim ),( Yoo Duk Choi ),( Sang Yun Song ),( Soo Ok Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Abstract Malignant mesothelioma (MM) is a rare tumor that associated with asbestos exposure. For the reliable diagnosis, the adequate representative tissue samples are essential for the histology and immunohistochemical staining. We report a case of desmoplastic malignant mesothelioma (DMM), accounting for only 5-10% of all MM and having poor prognosis. A 76-year-old male visited emergency room presenting with chest pain. Chest computed tomography showed focal lobulated pleural enhancing mass in posterior aspect of left upper lobe. After video-assisted thoracoscopic surgery and several immunohistochemical stains, we could diagnose as DMM. The patient refused chemotherapy, but received analgesics and palliative radiation for the painful back area. Subsequently, he was dead after 17 months from appearance of the initial symptom.
Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia
Yoo, Hyeon Gyeong,Kim, Jin Sook,Lee, Se Rah,Pyo, Hyun Keol,Moon, Hyung In,Lee, Jong Hee,Kwon, Oh Sang,Chung, Jin Ho,Kim, Kyu Han,Eun, Hee Chul,Cho, Kwang Hyun Pharmaceutical Society of Japan 2006 Biological & pharmaceutical bulletin Vol.29 No.6
<P>Androgenetic alopecia (AGA) is a dihydrotestosterone (DHT)-mediated process, characterized by continuous miniaturization of androgen reactive hair follicles and accompanied by perifollicular fibrosis of follicular units in histological examination. Testosterone (T: 10<SUP>−9</SUP>—10<SUP>−7</SUP> <SMALL>M</SMALL>) treatment increased the expression of type I procollagen at mRNA and protein level. Pretreatment of finasteride (10<SUP>−8</SUP> <SMALL>M</SMALL>) inhibited the T-induced type I procollagen expression at mRNA (40.2%) and protein levels (24.9%). T treatment increased the expression of transforming growth factor-beta 1 (TGF-β1) at protein levels by 81.9% in the human scalp dermal fibroblasts (DFs). Pretreatment of finasteride decreased the expression of TGF-β1 protein induced by an average of T (30.4%). The type I procollagen expression after pretreatment of neutralizing TGF-β1 antibody (10 μg/ml) was inhibited by an average of 54.3%. Our findings suggest that T-induced TGF-β1 and type I procollagen expression may contribute to the development of perifollicular fibrosis in the AGA, and the inhibitory effects on T-induced procollagen and TGF-β1 expression may explain another possible mechanism how finasteride works in AGA.</P>