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Sung-Gi Lee, Bo-Yeon Lee, Minwoo Hwang, Hyun Cho, Hee-Chol Kim, Honglae Sohn 조선대학교 기초과학연구원 2011 조선자연과학논문집 Vol.4 No.4
We describe the synthesis and characterization of silicon nanoparticles prepared by the solution reduction of silicon tetrachloride by lithium naphthalenide and subsequently with n-butyllithium at room temperature. These reactions produce silicon nanoparticles with surfaces that are covalently terminated with butyl group. Reaction with lithium aluminium hydride instead of n-butyllithium produces hydride-terminated silicon nanoparticles. The butyl or hydride terminated silicon nanoparticles can be suspended in hexane and their optical behavior have been characterized by photoluminescence spectroscopy. Stabilization of silicon nanoparticles were investigated upon illumination, indicating that as-prepared silicon nanoparticles are very stable at room temperature for several days.
Lee, Sung-Gi,Lee, Bo-Yeon,Hwang, Minwoo,Cho, Hyun,Kim, Hee-Chol,Sohn, Honglae The Basic Science Institute Chosun University 2011 조선자연과학논문집 Vol.4 No.4
We describe the synthesis and characterization of silicon nanoparticles prepared by the solution reduction of silicon tetrachloride by lithium naphthalenide and subsequently with n-butyllithium at room temperature. These reactions produce silicon nanoparticles with surfaces that are covalently terminated with butyl group. Reaction with lithium aluminium hydride instead of n-butyllithium produces hydride-terminated silicon nanoparticles. The butyl or hydride terminated silicon nanoparticles can be suspended in hexane and their optical behavior have been characterized by photoluminescence spectroscopy. Stabilization of silicon nanoparticles were investigated upon illumination, indicating that as-prepared silicon nanoparticles are very stable at room temperature for several days.
Gallbladder paraganglioma with hemorrhage: A case report and literature review
Sang Hwa Song,Chol Kyoon Cho,Eun Kyu Park,Hee Joon Kim,Young Hoe Hur,Yang Seok Koh,Yun Ho Lee 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.4
Gallbladder paraganglioma (GP) is a rare tumor, with only 12 cases reported in the literature to date. Due to its rarity, clinical information of GP is insufficient. We present a case of GP in a 48-year-old female along with a literature review of all GP cases described to date. A 48-year-old female presented with intermittent right upper abdominal pain. Preoperative imaging revealed a hematoma in the gallbladder lumen without any definite etiology. Laparoscopic cholecystectomy was performed. Gross examination of the gallbladder revealed multiple small stones and a large hematoma as well as a 1.6-cm-sized polypoid mass at the gallbladder fundus. Microscopic study of the polypoid mass showed a zellballen appearance. Immunohistochemical analysis revealed that the mass was positive for synaptophysin, CD56, and chromogranin, suggesting GP. GP is difficult to diagnose because of non-specific clinical findings. Almost all GP cases are diagnosed based on histologic findings after cholecystectomy. Simple cholecystectomy was performed as a treatment in all reported cases of GP, including our case. There was no postoperative tumor recurrence or metastasis after surgery.
Flame retardant epoxy complex produced by addition of montmorillonite and carbon nanotube
Sung Kyu Lee,Byong Chol Bai,임지선,Se Jin In,이영석 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.6
Flame retardant additives of montmorillonite (MMT) and multi-walled carbon nanotube (MWCNT) were embedded in epoxy resin to improve the resin’s resistance to oxidation. The MWCNTs reduced the degradation rate of the epoxy complex and increased the char yield, and also increased the limiting oxygen index in a first order relationship with char yield. MMT acted as an energy storage medium to hinder thermal transfer within the epoxy complex. The thermal activation energy increased upon addition ofMMT/MWCNT. Addition ofMMT andMWCNT significantly improved the flame retardant and anti-oxidation properties of the epoxy complex. 2010 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
The inhibitory effects of rebamipide on cigarette smoke-induced airway mucin production
Lee, Sung Yong,Kang, Eun Joo,Hur, Gyu Young,Jung, Ki Hwan,Jung, Hye Cheol,Lee, Sang Yeub,Kim, Je Hyeong,Shin, Chol,In, Kwang Ho,Kang, Kyung Ho,Yoo, Se Hwa,Shim, Jae Jeong Elsevier 2006 Respiratory medicine Vol.100 No.3
<P><B>Summary</B></P><P>Cigarette smoke may be the main cause of chronic bronchitis. Exposure of cigarette smoke induces the recruitment of inflammatory cells in the airway epithelium, and release of the tumor necrosis factor <I>α</I> (TNF<I>α</I>) from airways. Previous reports have shown that cigarette smoke induces goblet cell metaplasia by activating an epidermal growth factor receptor (EGFR) cascade, and that this results in mucin production. Rebamipide (2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl] propionic acid, OPC-12759) directly inhibits the production of superoxide (O<SUB>2</SUB><SUP>−</SUP>) and inhibits proinflammatory cytokines (such as TNF<I>α</I> and IL-8). In the present study, we aimed to analyze the inhibitory effects of rebamipide on TNF<I>α</I> and EGFR activation after cigarette smoke treatment in vitro and in vivo.</P><P>NCl-H292 cells and Sprague-Dawley rats were used for in vitro and in vivo studies. In vitro studies, cigarette smoke solution was found to increase TNF<I>α</I> secretion, and EGFR-specific tyrosine phosphorylation, and to elevate MUC5AC production. These effects were inhibited dose-dependently by pretreatment with rebamipide (MUC5AC protein levels were inhibited from 44% to 17%, P<0.05). In vivo studies, cigarette smoke was found to cause inflammatory cell recruitment and to increase the secretion of TNF<I>α</I> in bronchoalveolar lavage (BAL) fluids (from 198±78 to 2270±158pg/ml, P<0.01). Moreover, the pretreatment of rats with rebamipide inhibited goblet cell metaplasia and TNF<I>α</I> secretion, dose-dependently (from 2270±158 to 1377±112pg/ml, P<0.05).</P><P>In conclusion, the exposure of airway epithelium to cigarette smoke-induced TNF<I>α</I> production, neutrophil recruitment, activated EGFR, and caused MUC5AC mucin synthesis. Moreover, rebamipide was found to prevent this cigarette smoke-induced TNF<I>α</I> release, and mucin production.</P>
Measuring sleep quality after adenotonsillectomy in pediatric sleep apnea.
Lee, Seung Hoon,Choi, Ji Ho,Park, Il Ho,Lee, Sang Hag,Kim, Tae Hoon,Lee, Heung Man,Park, Hee-Kwon,Thomas, Robert J,Shin, Chol,Yun, Chang-Ho Triological Foundation [etc.] 2012 The Laryngoscope Vol.122 No.9
<P>The aim of this study was to demonstrate postoperative changes in sleep quality in children with obstructive sleep apnea (OSA), using both conventional sleep staging and electrocardiogram-based cardiopulmonary coupling (CPC) analysis. The hypothesis is that being electroencephalography (EEG)-independent, CPC may detect changes in sleep quality that traditional sleep architecture analysis cannot.</P>
Lee, Seung-Pyo,Park, Sung-Ji,Kim, Yong-Jin,Chang, Sung-A,Park, Eun-Ah,Kim, Hyung-Kwan,Lee, Whal,Lee, Sang-Chol,Park, Seung Woo,Sohn, Dae-Won,Choe, Yeon-Hyeon BioMed Central 2013 Journal of cardiovascular magnetic resonance Vol.15 No.-
<P><B>Background</B></P><P>Severe aortic stenosis (AS) patients with late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) or left ventricular (LV) systolic dysfunction are known to have worse outcome. We aimed to investigate whether LGE on CMR would be useful in early detection of subclinical LV structural and functional derangements in AS patients.</P><P><B>Methods</B></P><P>118 patients with moderate to severe AS were prospectively enrolled. Echocardiography and CMR images were taken and the patients were divided into groups according to the presence/absence of LGE and of LV systolic dysfunction (LV ejection fraction (EF) <50%). The stiffness of LV was calculated based on Doppler and CMR measurements.</P><P><B>Results</B></P><P>Patients were grouped into either group 1, no LGE and normal LVEF, group 2, LGE but normal LVEF and group 3, LGE with depressed LVEF. There was a significant trend towards increasing LV volumes, worsening of LV diastolic function (E/e’, diastolic elastance), systolic function (end-systolic elastance) and LV hypertrophy between the three groups, which coincided with worsening functional capacity (all p-value < 0.001 for trend). Also, significant differences in the above parameters were noted between group 1 and 2 (E/e’, 14.6 ± 4.3 (mean ± standard deviation) in group 1 vs. 18.2 ± 9.4 in group 2; end-systolic elastance, 3.24 ± 2.31 in group 1 vs. 2.38 ± 1.16 in group 2, all p-value < 0.05). The amount of myocardial fibrosis on CMR correlated with parameters of diastolic (diastolic elastance, Spearman’s ρ = 0.256, p-value = 0.005) and systolic function (end-systolic elastance, Spearman’s ρ = -0.359, p-value < 0.001).</P><P><B>Conclusions</B></P><P>These findings demonstrate the usefulness of CMR for early detection of subclinical LV structural and functional deterioration in AS patients.</P>