Factors affecting outpatient bowel preparation for colonoscopy

Saloni A. Shah,Elinor Zhou,Neil D. Parikh 소화기인터벤션의학회 2019 Gastrointestinal Intervention Vol.8 No.2

Background: Colonoscopy remains one of the most effective methods to screen for colorectal cancer. However, the detection of colorectal polyps is dependent on the cleanliness of the colonic tract. The purpose of our retrospective chart review was to identify clinical factors that were associ-ated with a lower Boston Bowel Preparation Scale (BBPS). Knowledge of these factors could identify which patients may benefit from increased pre-procedure guidance or more rigorous bowel preparation.Methods: The charts of consecutive patients undergoing screening or surveillance colonoscopies over a one-year period were reviewed. Cases were defined as BBPS ≤ 5 while controls were patients with BBPS ≥ 6. For each included patient, multiple characteristics were extracted. The chi-square analysis was performed for univariate analysis and a binomial logistic regression model for the multivariable analysis.Results: One thousand and fifty-five colonoscopy reports with BBPS scores were retrieved with 189 cases (BBPS ≤ 5) and 866 controls (BBPS ≥ 6). Cases and controls were similar in age, sex, ethnicity, employment status, and marital status. Compared to patients with adequate bowel prepara-tions, significantly more patients with inadequate bowel preparation had the following characteristics: diabetes, psychiatric illness, American Society of Anesthesiologists class ≥ 3, history of inadequate bowel preparation, active smoker, opioid user, insulin user and Medicaid coverage. On multivari-able logistic regression analyses, predictive factors of an inadequate bowel preparation were diabetes, psychiatric illness, opioid use, active tobacco use, history of inadequate bowel preparation, and Medicaid coverage.Conclusion: This large retrospective case-control study identified independent predictive factors of an inadequate bowel preparation. Knowledge of these characteristics may aid both primary care providers and gastroenterologists in identifying patients who could benefit from an extended bowel preparation as well as enhanced education prior to their colonoscopy.

Raiding the Miniature Tradition

Saloni Mathur 한국근현대미술사학회 2007 한국근현대미술사학 Vol.18 No.-

Factors affecting outpatient bowel preparation for colonoscopy

Saloni A. Shah,Elinor Zhou,Neil D. Parikh 소화기인터벤션의학회 2019 International journal of gastrointestinal interven Vol.8 No.2

Background: Colonoscopy remains one of the most effective methods to screen for colorectal cancer. However, the detection of colorectal polyps is dependent on the cleanliness of the colonic tract. The purpose of our retrospective chart review was to identify clinical factors that were associ-ated with a lower Boston Bowel Preparation Scale (BBPS). Knowledge of these factors could identify which patients may benefit from increased pre-procedure guidance or more rigorous bowel preparation.Methods: The charts of consecutive patients undergoing screening or surveillance colonoscopies over a one-year period were reviewed. Cases were defined as BBPS ≤ 5 while controls were patients with BBPS ≥ 6. For each included patient, multiple characteristics were extracted. The chi-square analysis was performed for univariate analysis and a binomial logistic regression model for the multivariable analysis.Results: One thousand and fifty-five colonoscopy reports with BBPS scores were retrieved with 189 cases (BBPS ≤ 5) and 866 controls (BBPS ≥ 6). Cases and controls were similar in age, sex, ethnicity, employment status, and marital status. Compared to patients with adequate bowel prepara-tions, significantly more patients with inadequate bowel preparation had the following characteristics: diabetes, psychiatric illness, American Society of Anesthesiologists class ≥ 3, history of inadequate bowel preparation, active smoker, opioid user, insulin user and Medicaid coverage. On multivari-able logistic regression analyses, predictive factors of an inadequate bowel preparation were diabetes, psychiatric illness, opioid use, active tobacco use, history of inadequate bowel preparation, and Medicaid coverage.Conclusion: This large retrospective case-control study identified independent predictive factors of an inadequate bowel preparation. Knowledge of these characteristics may aid both primary care providers and gastroenterologists in identifying patients who could benefit from an extended bowel preparation as well as enhanced education prior to their colonoscopy.

Effect of ultra-fine slag on mechanical and permeability properties of Metakaolin-based sustainable geopolymer concrete

Parveen, Parveen,Mehta, Ankur,Saloni, Saloni Techno-Press 2019 Advances in concrete construction Vol.7 No.4

The present study deals with the development of metakaolin-based geopolymer concrete (GPC) and thereafter studying the effects of adding ultra-fine slag on its mechanical and permeability characteristics. The mechanical characteristics including compressive, split tensile, flexural strengths and elastic modulus were studied. In addition, permeability characteristics including water absorption, porosity, sorptivity and chloride permeability were studied up to 90 days. The results showed the effective utilization of metakaolin for the development of elevated temperature cured geopolymer concrete having high 3-day compressive strength of 42.6 MPa. The addition of ultra-fine slag up to 15%, as partial replacement of metakaolin resulted in an increase in strength characteristics. Similar improvement in durability properties was also observed with the inclusion of ultra-fine slag up to 15%. Beyond this optimum content of 15%, further increase in ultra-fine slag content affected the mechanical as well as permeability parameters in a negative way. In addition, the relationship between various properties of GPC was also derived.

Mechanical and microstructural study of rice husk ash geopolymer paste with ultrafine slag

Parveen, Parveen,Jindal, Bharat Bhushan,Junaid, M. Talha,Saloni, Saloni Techno-Press 2019 Advances in concrete construction Vol.8 No.3

This paper presents the mechanical and microstructural properties of the geopolymer paste which was developed by utilizing the industrial by-products, rice husk ash (RHA) and ultra-fine slag. Ultra-fine slag particles with average particle size in the range of 4 to 5 microns. RHA is partially replaced with ultra-fine slag at different levels of 0 to 50%. Sodium silicate to sodium hydroxide ratio of 1.0 and alkaline liquid to binder (AL/B) ratio of 0.60 is taken. Setting time, compressive, flexural strengths were studied up to the age of 90 days with different concentrations of NaOH. The microstructure of the hybrid geopolymer paste was studied by performing the SEM, EDS, and XRD on the broken samples. RHA based geopolymer paste blended with ultrafine slag resulted in high compressive and flexural strengths and increased setting times of the paste. Strength increased with the increase in NaOH concentration at all ages. The ultra-small particles of the slag acted as a micro-filler into the paste and enhanced the properties by improving the CASH, NASH, and CSH. The maximum compressive strength of 70MPa was achieved at 30% slag content with 16M NaOH. The results of XRD, SEM, and EDS at 30% replacement of RHA with ultra-fine slag densified the paste microstructure.

Novel SIRT1 inhibitor 15-deoxy-Δ ^12,14 -prostaglandin J ₂ and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells

Tae, In Hwan,Park, Eun Young,Dey, Prasanta,Son, Ji Yeon,Lee, Seok-Yong,Jung, Jee h.,Saloni, Saloni,Kim, Mi-Hyun,Kim, Hyung Sik D.A. Spandidos 2018 International journal of oncology Vol.53 No.6

<P>Clinically relevant sirtuin (SIRT) inhibitors may possess antitumor activities. A previous study indicated that 15-deoxy-Δ<SUP>12,14</SUP>-prostaglandin J<SUB>2</SUB> (15d-PGJ<SUB>2</SUB>) exhibited potent anticancer activity by SIRT1 inhibition. Therefore, the aim of the present study was to investigate whether its derivatives (J11-C1 and J19) exhibited anticancer activity against ovarian cancer SKOV3 cells. Cell viability was determined using an MTT assay. Cell cycle arrest, apoptosis and autophagy were determined using flow cytometry or western blot analysis. J11-Cl and J19 were less cytotoxic to SKOV3 cells compared with 15d-PGJ<SUB>2</SUB>. Molecular docking studies supported the interactions of 15d-PGJ<SUB>2</SUB>, J11-Cl and J19 with various amino acids in SIRT1 proteins. Similar to 15d-PGJ<SUB>2</SUB>, J11-C1 and J19 inhibited SIRT1 enzymatic activity and decreased SIRT1 expression levels in a concentration-dependent manner. J11-C1 induced apoptotic cell death more effectively compared with J19, which was associated with markedly decreased expression of the anti-apoptotic molecule B-cell lymphoma 2 (Bcl-2). Furthermore, the levels of light chain 3-II (LC3-II) and beclin-1 were clearly induced in SKOV3 cells treated with J11-Cl. Thus, 15d-PGJ<SUB>2</SUB> and its derivatives exhibited anticancer activity possibly by inducing apoptotic or autophagic cell death pathways. Collectively, the results of the present study suggest that 15d-PGJ<SUB>2</SUB> and its derivatives exerted antitumor activity by selectively modulating the expression of genes associated with cell cycle arrest, apoptosis and autophagy. Notably, J11-C1 is a novel candidate SIRT1 inhibitor with anticancer activity.</P>

Performance Enhancement in Hill-Climbing Approach for Test Case Prioritization using Functional Dependency Technique

Sarabjit Kaur,Saloni Ghai 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.11

Test case prioritization is basically the process of prioritizing the execution order of test cases in order to increase the fault detection rate. If fault detection rate is being gradually improved during regression testing then it will provide faster feedback to system developers which ultimately deliver the software earlier. Many of the existing test case prioritization techniques illustrated that test cases can be executed in any order but the concept of functional dependency plays an important role between test cases. In this paper we have described about testing, its types, test case prioritization and its techniques. Regression testing is normally being used to retest the component of a system that verifies that defects are removed or not from the effected part of the software after modifications. This paper enhances the hill climbing approach for test case prioritization by using functional dependency technique. This prioritization approach schedules test cases based upon functional dependency technique .Our approach is quiet efficient as compare to any other technique. Regression testing is quite popular as it helps to make the system error free after modifications.

Understanding Indian Mediation: Comparison of Indian and Korean Mediation Programs

( Yonghwan Choung ),( Byungdo Park ),( Saloni Kumari ) 건국대학교 법학연구소 2021 一鑑法學 Vol.- No.49

Our societies are in constant state of dispute. We need a mechanism of dispute resolution, which is less formal, fast, flexible, cheaper, voluntary, and devoid of lengthy procedures. Mediation is one such method, which is operational in India as well as in Korea. Although the process of dispute resolution through mediation has existed since ages, it has not been able to gain the popularity that it needs. There are several issues responsible for the same and through this research we aim to identify all such problems and try to reach desirable outcome. The purpose and objective of the research is to draw a comparative analysis of contemporary mediation program in India and Korea. The focus is upon the working techniques of court-connected/court- led mediation. The comparative approach of India and Korea would help in understanding the basic concept of mediation, functioning in both the jurisdiction. In the midst of Pandemic, when countries were under lockdown we managed to use empirical method of data collection by conducting interviews with several experts/professionals (mostly working mediators at India and Korea). We found that, although, the rationale behind adoption of mediation in India and in Korea varies but, there exist a common need of enhancement and regularizing the status of mediation program. Both the countries lack mediation culture and awareness among the lawyers, judges and the parties. We found, Indian mediation program is similar to US mediation program. Both have similar way of appointment of mediators and enforcement of settlement agreement. Whilst, the mediation program in Korea is a hybrid/ combination of both India and US, with its distinct features.

Isolated Unilateral Tessier Cleft 10 with Anterior Staphyloma

Deepsekhar Das,Aishwarya Rathod,Saloni Gupta,Sujeeth Modaboyina,Sahil Agrawal 대한안과학회 2021 Korean Journal of Ophthalmology Vol.35 No.3

Studies of the benzopyran class of selective COX-2 inhibitors using 3D-QSAR and molecular docking

Dharmendra K. Yadav,Saloni,Praveen Sharma,Sanjeev Misra,Harpreet Singh,Ricardo L. Mancera,김강,장청연,김미현,Horacio Pe´rez-Sa´nchez,최은화,수렌드라 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12

The Gaussian-based 3D-QSAR studies for 58 selective COX-2 (cyclooxygenase-2) inhibitors belonging to benzopyran chemical class were performed. Partial least squares analysis produced statistically significant model with (R training 2 = 0.866) and predictability (Q training 2 = 0.66, Q test 2 = 0.846). The 3D-QSAR model includes steric, electrostatic, hydrophobic, and hydrogen bond acceptor field indicators, whereas the potential field contributions indicate that the steric and hydrophobic features of the molecules play an important role in governing their biological activity. A molecular docking simulation and protein–ligand interaction pattern analysis reveal the importance of Tyr-361 and Ser-516 of the COX-2 active site for X-ray crystal structures and this class of molecules. Thus the combined approach of ligand-based and structure-based models provided an improved understanding in the interaction between benzopyran chemical class and COX-2 inhibition, which will guide the future identification of more potent anti-inflammatory drugs.