Aortic Stenosis: New Insights in Diagnosis, Treatment, and Prevention

Saki Ito,Jae K. Oh 대한심장학회 2022 Korean Circulation Journal Vol.52 No.10

Aortic stenosis (AS) is one of the most common valvular heart diseases and the number of patients with AS is expected to increase globally as the older population is growing fast. Since the majority of patients are elderly, AS is no longer a simple valvular heart disease of left ventricular outflow obstruction but is accompanied by other cardiac and comorbid conditions. Because of the significant variations of the disease, identifying patients at high risk and even earlier detection of patients with AS before developing symptomatic severe AS is becoming increasingly important. With the proven of efficacy and safety of transcatheter aortic valve replacement (TAVR) in the severe AS population, there is a growing interest in applying TAVR in those with less than severe AS. A medical therapy to reduce or prevent the progression in AS is actively investigated by several randomized control trials. In this review, we will summarize the most recent findings in AS and discuss potential future management strategies of patients with AS.

Color Recommendation for Text Based on Colors Associated with Words

Saki liba,Tetsuaki Nakamura,Maki Sakamoto 한국산업정보학회 2012 한국산업정보학회논문지 Vol.17 No.1

In this paper, we propose a new method to select colors representing the meaning of text contents based on the cognitive relation between words and colors. Our method is designed on the previous study revealing the existence of crucial words to estimate the colors associated with the meaning of text contents. Using the associative probability of each color with a given word and the strength of color association of the word, we estimate the probability of colors associated with a given text. The goal of this study is to propose a system to recommend the cognitively plausible colors for the meaning of the input text. To build a versatile and efficient database used by our system, two psychological experiments were conducted by using news site articles. In experiment 1, we collected 498 words which were chosen by the participants as having the strong association with color. Subsequently, we investigated which color was associated with each word in experiment 2. In addition to those data, we employed the estimated values of the strength of color association and the colors associated with the words included in a very large corpus of newspapers (approximately 130,000 words) based on the similarity between the words obtained by Latent Semantic Analysis (LSA). Therefore our method allows us to select colors for a large variety of words or sentences. Finally, we verified that our system cognitively succeeded in proposing the colors associated with the meaning of the input tort comparing the correct colors answered by participants with the estimated colors by our method. Our system is expected to be of use in various types of situations such as the data visualization, the information retrieval, the art or web pages design, and so on.

The Effects of RGB Wavelength of Polychromatic LED Light Sources on Melatonin Suppression

Saki Tanaka,Akira Yasukouchi 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5

Amino Acids and Protein Digestibility and Metabolizable Energy Availability of Barley Ration in Response to Grind^® Enzyme in Broiler Chickens

Saki, Ali Asghar,Mirzayi, S.,Ghazi, Sh.,Moini, M.M.,Naseri Harsini, R. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.5

Increasing accuracy of broiler diet formulation based on amino acid digestibility in comparison to application of total amino acids could lead to more feed efficiency and productivity. This experiment was conducted for determination of sampling site (excreta and ileum) and recognition of the effects of a commercial enzyme ($Grind^{(R)}$ Danisco, Finland) on metabolizable energy, protein and amino acid digestibility of barley. This study was modulated by a marker in 21-day old Arbor Acres chickens. Corn-soybean meal was used as a control diet and, in the other two treatments, barley (at a level of 40%) with and without enzyme as the test ingredient were supplemented to the basal diet. Chromic oxide was included in all diets (0.5%) as an indigestible marker. Apparent metabolizable energy (AME), corrected by nitrogen (AMEn) and apparent digestibility of aspartic acid, glutamic acid, serine, glycine, alanine, tyrosine, valine and methionine were significantly (p<0.05) higher in feces than ileum. Protein digestibility of diet and barley was significantly (p<0.05) higher in the ileum than in feces. Apparent digestibility of tryptophan, proline, methionine, phenylalanine and lysine was increased significantly (p<0.05) by enzyme supplementation. In contrast, no response was observed in AME, AMEn, and protein digestibility of the diet and barley by enzyme supplementation. The results of this study have shown that AME and amino acid digestibility were increased in feces, in contrast an adverse effect was observed for protein digestibility of the diet and barley.

The Availability of Energy and Protein, with Respect to Uric Acid, of Yellow-seeded Rapeseed Meal in Broiler Diets

Saki, A.A.,Mahmoudi, H.,Tabatabaei, M.M.,Ahmadi, A. Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.11

Experiments were conducted to evaluate the nutritional value of yellow-seeded rapeseed meal (YRSM). In the first experiment nutrient retention was recorded by 48 Arbor Acres-broiler chickens (28-d old) to determine AMEn (nitrogen-corrected apparent metabolizable energy), coefficient of apparent protein digestibility based on ileal digesta nitrogen, excreta nitrogen and uric acid nitrogen. The second experiment was carried out with 304 Arbor Acres-broiler chickens to compare effects of SBM (soybean meal) and YRSM on performance, carcass and digestive tract status. In the control treatment, SBM was replaced by graded levels of YRSM at 15, 22.5 and 30% of diet. Digestibility of YRSM protein was significantly lower (p<0.001) than SBM protein. The protein digestibility based on ileal measurement was significantly higher (p<0.001) than protein digestibility from excreta samples. There was no significant difference (p>0.001) between ileal and excreta digestibility of protein based on uric acid. AMEn as a fraction of gross energy was 0.54 in SBM and 0.45 in YRSM. With the exception of 30% YRSM, other YRSM treatments resulted in major effects on length and weight of the gastrointestinal tract. The results of this study have shown no adverse effect on performance as well as protein digestibility and energy value in response to replacement of SBM by YRSM with the exception of 22.5 and 30% YRSM.

The Effects of RGB Wavelength of Polychromatic LED Light Sources on Melatonin Suppression

( Saki Tanaka ),( Akira Yasukouchi ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-

The purpose of this study was to examine how the composition of red, green and blue energy in the polychromatic light affected melatonin suppression and to consider the appropriate wavelength configuration which suitable for interior lighting with less impact on the non-visual effects. We used the light-emitting diode (LED) as a light source which consisted of three monochromatic lights (red, green and blue). The polychromatic light (300lx with 5000K) was employed as a reference condition, which included the least blue part of energy with Ra (color rendering index) kept more than 80. There were four lighting conditions; two of four consisted of red and blue each combined with constant green which have the same total energy as the reference condition, the other two were non blue and blue each combined with the same energy of red and green as that of reference condition. The number of conditions was five including the reference condition. Subjects were 8 university students (age of 20 - 25) who didn`t have a problem of health. They were instructed to keep a regular sleep-wake schedule 5-7days prior to the experiment. They were exposed to all of lighting conditions in a different day between 24:00 and 26:00 followed by exposure to dim light (under 10 lx) from 19:00 to 24:00. Saliva samples were collected every 60 minutes between 20:00 and 24:00 and every 30 minutes between 24:00 and 26:00.

Real-world efficacy and safety of bevacizumab single-maintenance therapy following platinum-paclitaxel chemotherapy plus bevacizumab in patients with advanced cervical cancer

Saki Kotaka,Eiji Kondo,Yosuke Kawai,Kota Okamoto,Yasuyuki Kishigami,Takaharu Yamawaki,Kenji Nagao,Toru Hirata,Shiro Suzuki 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.5

Objective: Bevacizumab maintenance therapy following platinum-based combination chemotherapy for metastatic, recurrent, or persistent cervical cancer is not recommended as standard therapy. This pilot study aimed to evaluate the efficacy and safety of bevacizumab maintenance therapy and the contribution of the platinum-free interval to the efficacy of subsequent chemotherapy for advanced cervical cancer. Methods: We retrospectively identified 115 patients with metastatic, recurrent, or persistent cervical cancer treated with platinum-paclitaxel chemotherapy plus bevacizumab at 7 institutions between 2015 and 2020. The primary endpoints were overall survival (OS) and progression-free survival (PFS) in patients who received bevacizumab maintenance therapy and those who did not. We also analyzed the adverse events associated with bevacizumab and survival time from the start of subsequent chemotherapy in both groups. Results: Following platinum-paclitaxel plus bevacizumab chemotherapy, 34 patients received bevacizumab maintenance therapy and 81 patients did not. Of the 115 patients, 56 received chemotherapy for subsequent relapse. Although bevacizumab maintenance therapy prolonged PFS (median of 16.0 months vs. 9.0 months, p=0.041), significant differences were not observed in OS (p=0.374). Furthermore, bevacizumab maintenance therapy did not prolong OS and PFS after the start of subsequent chemotherapy (p=0.663 and p=0.136, respectively). Bevacizumab maintenance therapy significantly increased hypertension (p=0.035) and proteinuria (p=0.005) but did not cause complications leading to death. Conclusion: Bevacizumab single-maintenance therapy for advanced cervical cancer can be considered in selected cases, such as those with acceptable bevacizumab-related side effects. The outcomes of our study will likely contribute to decision-making regarding practical treatment strategies.

A note on split simple Lie algebras

MIN,SAKI 崇實大學校 1987 論文集 Vol.17 No.-

Let L be a 3-dimensional Lie algebra over a field K, and let L'=[L, L] be the derived algebra of L. Assume that L=L'. For a given non-zero element k of K, there exists an element H of L such that [H, E] = kE, namely, E is the characteristic vector of the adjoint representation of L and k is the characteristic value, then L is called split, by definition. It is known that such L is simple.

On a Certain Type of 3-dimensional Lie Algebras

Min,SaKi 朝鮮大學校 師範大學 1970 師大論文集 Vol.1 No.-

Let L be a 3-dimensional Lie algebras over a field K, and let L’=[LL] be the derived algebra of L.Assume that L=L/For any given non-zero element k of K, if there existsan element H of L such that[EH]=kE, namely, Eis the characteristic vector of the adjoint representation of L and k is the characteristic value, then L is called split, by definition. It is known that such L is simple. The split 3-dimensional simple Lie algebra plays important roles in the theory of Lie algebra. Let (e_1, e_2, e_3)be a basis for L. N. Jacobson shows that there exists a basis (E_1, E_2, E_3)for L such that

統監府,朝鮮總督府による風俗習慣調査の史的變遷 -調査資料の機關別,時期別整理を中心に-

( Miyauchi Saki ) 동서대학교 일본연구센터 2014 次世代 人文社會硏究 Vol.10 No.-