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재발한 신경교종에서의 PCV 화학요법 : A Preliminary Report
장지수,송재욱,윤상민,이창훈,이승훈 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.11
Twelve patients with recurrent malignant glioma were treated with combination chemotherapy, consisting of procarbazlne(60㎎/㎡, 8th-21th day), CCNU(110㎎/㎡. 1st day), and vincristine(1.4㎎/㎡. 8th and 29th day) every 6 weeks. Most patients had undergone initial resection of primary tumor, postoperative radiotherapy, and another form of chemotherapy. Response or progression was defined as improvement or deterioration in MRI scan. Assessment of response followed evaluation of MRI obtained after the completion of each two cycles of chemotherapy, if possible. Partial(more than 50% reduction of tumor mass) response at 15+ to 47+ weeks after chemotherapy was noted in three(60%) of the five patients with recurrent oligodendrogliomas. But in patients with recurrent anaplastic astrocytoma or glioblastoma, partial response at 8+ weeks after chemotherapy was noted in one(14%) of the seven patients. It is suggested that PCV chemotherapy is more effective for patients with recurrent oligodendrogliomas than other recurrent gliomas.
Palladium-Catalyzed Asymmetric Nitrogen-Selective Addition Reaction of Indoles to Alkoxyallenes
Jang, Seok Hyeon,Kim, Hyun Woo,Jeong, Wook,Moon, Dohyun,Rhee, Young Ho THE AMERICAN CHEMICAL SOCIETY 2018 ORGANIC LETTERS Vol.20 No.4
<P>A new palladium-catalyzed asymmetric addition reaction of indoles to alkoxyallenes is reported. Remarkably, the reaction showed complete regioselectivity toward the nitrogen. A new mechanism distinct from that of conventional π-allyl chemistry is proposed to explain this unique selectivity. The utility of the reaction is demonstrated by highly efficient and flexible synthesis of <I>N</I>-glycosylindoles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2018/orlef7.2018.20.issue-4/acs.orglett.8b00191/production/images/medium/ol-2018-00191m_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol8b00191'>ACS Electronic Supporting Info</A></P>
장지수,송재욱,윤상민,이상형,이창훈,이승훈 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.3
A case of trigeminal neuralgia caused by a contralateral acoustic neurinoma is presented. After removal of the tumor, the neuralgic pain has completely disappeared. The pathophysiology of this entity is briefly reviewed. The neuralgic pain may be caused by the compression of the contralateral trigeminal nerve by the mass effect in this case.
Dental management of Lowe syndrome under general anesthesia in a child: A case report
Sophia Rhee,Ji-Soo Song,Teo Jeon Shin,Young-Jae Kim,Jung-Wook Kim,Ki-Taeg Jang,Sang-Hoon Lee,Hong-Keun Hyun Asia association of Disability and Oral health 2019 대한장애인치과학회지 Vol.15 No.2
Lowe syndrome, also known as oculocerebrorenal syndrome, is a rare X-linked recessive disorder characterized by a combination of abnormalities associated with ocular (congenital cataracts), nervous system (mental impairment and hypotonia), and renal dysfunction. Dental crowding, over-retained primary teeth, ectopic and delayed eruption of permanent dentition, and taurodontism have been reported as oral findings. Dental care for young patients with Lowe syndrome is complicated by difficulties in behavior management and other systemic conditions of these patients. General anesthesia may be an appropriate and effective option to eliminate the need for repeated visits to the hospital and to provide improved treatment quality for the patient. However, this approach should be used with caution because general anesthesia may induce malignant hyperthermia and metabolic acidosis in patients with Lowe syndrome. This case study reports the dental management of Lowe syndrome in a 4-yearold male patient who presented with multiple caries in his primary dentition under general anesthesia.
두개강내로 전이된 Adenoid Cystic Carcinoma 2례 : 증례보고 Report of Two Cases
송재욱,윤상민,이창훈,장지수,이승훈,조경자,강신광 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10
The authors describe two cases of unusual intracranial metastatic adenoid cystic carcinomas. A 42-year-old woman had a right pariental epidural metastatic mass. presumed hematogenous. spread from a primary tumor in the parotid gland. In second case, a 32-year-old man had a intracranial metastatic adenoid cystic carcinoma mimicking calcified psammomatous meningioma on CT scans. We present these unusual cases with a review of relevant literature and a discussion of possible pathogenesis.
Solution-based fabrication of ZnO/ZnSe heterostructure nanowire arrays for solar energy conversion
Cho, Seungho,Jang, Ji-Wook,Lim, Sang-Hoon,Kang, Hyun Joon,Rhee, Shi-Woo,Lee, Jae Sung,Lee, Kun-Hong Royal Society of Chemistry 2011 Journal of materials chemistry Vol.21 No.44
<P>We report a method for synthesizing ZnO/ZnSe heterostructure nanowire arrays for use in photoelectrochemical (PEC) water splitting. The surfaces of ZnO nanowires immobilized on a conducting glass substrate were modified to form ZnO/ZnSe heterostructure nanowire arrays through a reaction with an aqueous sodium selenite and hydrazine solution. ZnO/ZnSe heterostructure nanowires with different morphologies were synthesized by varying solution concentrations and reaction times. The ZnO nanowire/ZnSe nanoparticle heterostructures (ZS1) were synthesized by a dissolution–recrystallization mechanism. At longer reaction times and higher solution concentrations, the nanostructure arrays transformed into ZnO nanowire/ZnSe nanosphere heterostructure arrays (ZS2) <I>via</I> Ostwald ripening. ZnO/ZnSe heterostructure arrays (ZS1 and ZS2) yielded higher photocurrents than the pristine ZnO nanowire arrays in a PEC water splitting test under AM 1.5G simulated solar light. The ZnO/ZnSe heterostructure array photoanodes exhibited absorption in the visible spectrum (<550 nm in wavelength) with a high incident-photon-to-current-conversion efficiency (IPCE) of up to 47% (ZS1) or 57% (ZS2) at 0.0 V <I>vs.</I> Ag/AgCl. The photoanode yielded a relatively high photocurrent density of 1.67 mA cm<SUP>−2</SUP> (ZS1) or 2.35 mA cm<SUP>−2</SUP> (ZS2) at 0.3 V compared to the ZnO nanowire arrays (0.125 mA cm<SUP>−2</SUP>). Structural differences between ZS1 and ZS2 yielded different PEC performances. A comparison to ZS2 revealed that ZS1 exhibited a higher photocurrent density under a low applied potential (from −0.78 V to −0.07 V) and a lower photocurrent density under a high applied potential (above −0.07 V).</P> <P>Graphic Abstract</P><P>Through a simple surface modification reaction, ZnO/ZnSe heterostructure nanowire arrays were fabricated for use in photoelectrochemical water splitting. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1jm14014k'> </P>
김상욱,김준호,서도원,이장희 충북대학교 산업경영연구소 1997 産業과 經營 Vol.10 No.1
이 논문은 중소기업의 육성발전과 효율적인 경영관리를 통한 경쟁력 제고를 위해 충북지역에 위치한 중소기업의 경영특성에 관한 연구이다. 지역적 특성과 산업구조를 바탕으로 우리 지역 중소기업의 경영일반, 인사노무·조직관리, 생산관리, 마아케팅, 재무관리, 회계, 경영정보화등에 관한 실태를 분석하기 위해 실증적 자료와 분석을 이용하였다. 기업내부의 문제점을 분석하여 기업의 자생력과 정책지원 방향을 제시하고 중소기업 경영의 안정과 활성화에도 기여할 수 있을 것이다.
Microbial Risk Assessment using E. coli in UV Disinfected Wastewater Irrigation on Paddy
Han Pil Rhee,Chun G. Yoon,Kwang Wook Lung,Jang Won Son 대한환경공학회 2009 Environmental Engineering Research Vol.14 No.2
Water stress has become a major concern in agriculture. Korea suffers from limited agricultural water supply, and wastewater reuse has been recommended as an alternative solution. A study was performed to examine the effects of microorganism concentration in the ponded-water of a paddy rice field with reclaimed-water irrigation for evaluating the microbial risk to farmers and neighborhood children. Most epidemiological studies were performed based on an upland field, and they may not directly applicable to paddy fields. Beta-Poisson model was used to estimate the microbial risk of pathogen ingestion. Their risk value increased significantly high level after irrigation and precipitation. It implies that agricultural activities such as plowing, and fertilizing, and precipitation need be practiced a few days after irrigation considering health risks. The results about field application of the microbial risk assessment using E. coli showed difference according to monitoring time and treatment plot. Result of the microbial risk assessment showed that risk values of ground-water and reclaimed secondary wastewater irrigation were lower than directly use of wastewater treatment plants` effluent. This paper should be viewed as a first step in the application of quantitative microbial risk assessment of E. coli to wastewater reuse in a paddy rice farming.
토끼 모델에서 탈미네랄화된 골분을 함유한 PLGA 지지체를 이용한 조직공학적 골 재생
장지욱 ( Ji Wook Jang ),박기숙 ( Ki Suk Park ),김순희 ( Soon Hee Kim ),박종수 ( Chong Soo Park ),김문석 ( Moon Suk Kim ),한창환 ( Chang Whan Han ),이종문 ( John M. Rhee ),강길선 ( Gil Son Khang ),이해방 ( Hai Bang Lee ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.1
Demineralized bone particle (DBP), one of the significant natural bioactive materials, has a powerful inducer of new bone growth. It has been recognized that DBP contains many kinds of osteogenic and chondrogenic cytokines as bone morphogenic protein (BMP). BMP acts as local mitogen to stimulate proliferation of mesenchymal stem cell. Bone marrow stromal cell (BMSCs) can be differentiated in culture into osteoblasts, chondrocytes, and myoblasts with controlling of the environment of cell growth. In this study, we developed the DBP loaded poly(L-lactide-co-glycolide) (PLGA) scaffolds for the possibility of the application of the tissue engineered bone. PLGA/DBP scaffolds were prepared by solvent casting/salt leaching method and characterized by porosimeter, scanning electron microscopy, and differential scanning calorimetry. BMSCs were isolated from femur of New Zealand white rabbit and cultured with osteo-medium for osteogenic differentiation. DBP impregnated PLGA scaffolds with BMSCs were implanted into the head and femur of New Zealand white rabbit to observe the effect of DBP on the osteoinduction compared with control scaffolds. Thin sections were cut from paraffin embedded tissues and histological sections were stained hematoxylin & eosin and safranin-O. It can be observed that the porosity was above 94.6% and the pore size was above 69.8 ?m. In vivo study, we could observe that similar to bone tissue region in PLGA/BMSCs and PLGA/BMSCs/DBP groups, but bone tissue region did not occur almost in control scaffolds. From these results, it seems that DBP play an important role for bone induction on BMSCs.