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동일한 국제예후지표(International Prognostic Index)를 나타내는 미만성 대형 B-세포 림프종에서 Bcl-2와 p16의 임상적 중요성
박상은,박수진,곽승근,박남숙,천재민,윤환중,조덕연,김삼용,김진만 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2
In Korea, malignant lymphoma is a common cancer, comprising about 2.7% of all malignant neoplasm. Diffuse large B cell lymphoma is the most common lymphoma, representing about 50% of all Non-Hodgkin's lymphoma. Diffuse large B-cell lymphoma is usually considered as heterogeneous group of neoplasms rather than a single clinicopathological entity. Clinical prognostic systems, including the International Prognostic Index (IPI), although useful to assess overall prognosis, embrace patients with heterogeneous prognoses. But International Prognostic Index scoring system is not sufficiently predict the prognosis. It is likely that the prognostic assessment of patients with diffuse large B-cell lymphomamight be improved by using biological features. Bcl-2 protein and p16 protein expression is recognized as useful biologic markers predicting the prognosis of patients with diffuse large B-cell lymphoma. To determine the clinical significance and prognostic value of bcl-2 and p16 proteins expression patterns, we studied 18 patients with de novo DLBL, whose archival pathology specimen were available for immunohistochemistry studies, atChungnam National University Hospital from September 1992 to December 2000. Archival specimens from each patient were immunostained with respective antibodies for bcl-2, p16. The results are as follows; 1) The median age was 54(rage : 37-69). There were 12 male patients(66.7%) and 6 female patients(33.3%) The 'B' symptom was abscentin all patients. The stages were as follows : Ⅰ, 2 patient(11.1%), Ⅱ, 10 patient(55.6%), Ⅲ, 4patient(22.2%) and Ⅳ, 2patient(11.1%). 3 patients(16.8%) had the elevated LDH level, 14 patients(77.8%) had the normal LDH level and 1 patients(5.6%) was not identified the LDH level. 2 patients(11.1%) had the bulky disease and 16 patients(88.7%) had no bulky diease. The distribution of ECOG status were O, 2 patients(11.1%c), 1, 14patients(77.8%) and 2, 2patients(11.1%). 2) Theimmunohistochemistry results are as follows bcl-2:+,10 patients(55.6%), bcl-2:-, 8patinets(44.4%), p16:+,3 patients(16.7%), p16:-, 15patients(83.3%) 3) After a median follow UP durations of 67 months, the median survival time was 57 months with a rage of 7-100+ months. 5-years overall survival rates was 44% by Kaplan-Meier method. 4) Reduced overall survival was demonstrated in the patients who expressed bcl-2 protein(P=0.0174). 5-year overall survivial rate was 12%(bcl-2 expression) versus 88%(no bcl-2 expression) 5) Among diffuse large B-cell lymphoma patients with IPI score 0-1, reduced overall survival was demonstrated with bcl-2 expression(P=0.023). 5-year overall survival rate was 18%(bcl-2 expression group) versus 100%(no bcl-2 expressiongroup) 6) Median survival durtation of diffuse large B-cell lymphoma patients negative for p16 expression was 57 months whereas p16 postive patients' median survival duration was not reached(P=0.4478). In diffuse large B-cell lymphoma patients with identical IPI scores, bcl-2 expression had additional prognostic value.
에너지 모니터링 시스템 구축을 통한 편의점의 에너지 성능에 관한 연구
박경순(Park, Kyung-Soon),윤대원(Yoon, Dae-Won),천정길(Chun, Jung-Gil),이건호(Lee, Keon-Ho),손원득(Son, Won-Tug) 한국건축친환경설비학회 2015 한국건축친환경설비학회 논문집 Vol.9 No.3
This study reviews the status of building area, energy consumption and energy cost in convenience store and evaluates the current energy performance in the small retail and is analysed energy consumption of 80,242kWh and energy cost of 7,258,063Won by energy simulation of EnergyPlus. It is offered energy conservation component technology of window thermal performance, air tightness, LED lighting, high performance system air conditioner, building energy management system and mist spray outdoor unit in which the characteristics of the convenience stores operated by small retail. energy performance analysis of energy conservation component technology is showed energy consumption of 56,481kWh, energy saving rate of 29.6% and energy cost of 2,263,589Won. Building energy monitoring system is aimed to verify the performance of the application of energy saving technology between energy simulation and energy monitoring and is evaluated by error rate of 9.3%. With the above results, it is proven to save energy through energy savings element technology for small retail and to try effort of energy savings through the application of retail and wholesale stores across the country.
Experience from Managing Private PlanetLab Korea
박천종(Chun Jong Park),장건(Keon Jang),문수복(Sue Moon) 한국정보과학회 2009 한국정보과학회 학술발표논문집 Vol.36 No.2B
Private PlanetLab Korea is a PlanetLab based testbed for KOREN to create a better environment for Future Internet research in Korea. Beginning with the general introduction of PlanetLab, this paper discusses on the issues has been raised during six months of managing Private PlanetLab Korea. As a conclusion, it proposes the measures to address the issues and fully utilize PPK as a Future Internet testbed.
유제춘(Je-Chun Yu),손경국(Kyeong-Kook Son),이혜경(Hye-Kyeong Lee),김사리(Sah-Ri Kim),박보아(Bo-Ah Park),강건자(Keon-Ja Kang),이창화(Chang-Hwa Lee) 대한사회정신의학회 2004 사회정신의학 Vol.9 No.2
연구목적: 복지를 위한 가용자원이 제한되어 있는 우리나라의 상황에서 효율적인 지역사회 정신보건사업 수행을 위해 지역에 대한 정확한 인식과 지역 주민들의 요구에 대한 이해는 매우 중요하다. 이를 위해 저소득 도시지역을 대상으로 정신보건과 관련된 지역의 특성, 정신보건에 대한 인식과 요구도를 조사하고자 하였다. 방법: 대덕구 정신보건센터에 도보로 접근이 가능한 지역의 전체 가구인 7278가구를 대상으로 하여 경기도 의왕시 정신보건센터에서 지역사회 정신보건요구 조사를 위해 사용한 설문지를 이용해서 우편을 통한 설문조사를 하였고, 635개의 회신을 받아 분석 하였다. 결과: 조사 대상 지역은 의료보장 형태나 세대별 월수입 등 여러 측면에서 사회 안전망이 부실하고 사회경제적으로 여건이 열악한 편이었다. 그로인해 지역 주민들은 정신보건 문제의 시급성은 많이 인식하고 있는 반면 치료는 충분히 받지 못하는 경우가 많고 도움을 받을 수 있는 정신보건센터에 대해서도 모르고 있는 경우가 많았다. 정신보건 서비스 중에서 청소년비행, 치매, 알콜문제 등에 대한 위기개입 프로그램이 가장 필요한 것으로 평가하였다. 결론: 정신보건센터의 역할에 대한 홍보와 함께 위기개입에 대한 정신보건 요구를 충족시킬 수 있는 적절한 프로그램의 개발과 시행이 시급하게 필요하다고 생각된다.
Process Development for Mass Production of Biocontrol agent Using Filamentous Microorganisms
Hae Woong Park,Sang Il Lee,Keon Jin Lee,Sanghyun Ha,Hyun Jung Gwak,Ae Ri Han,Young Bae Chung,Ho Hyun Chun,Hyeyeon Song 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
Biological control has been tried for integrated pest management. It is often comparable, safe, and environment-friendly, making itself an alternative for chemical agents. Filamentous microorganisms, i.e., fungi and streptomystes, produce many kinds of useful metabolites, and some of them have been developed as a biocontrol agent. However, they still have a long way because of the concern of manufacturing cost. Therefore, process development was intensively studied to meet cost-effectiveness. Operating conditions of bioreactor, e.g., agitation and aeration, had an effect on biological and physiological responses such as mycelial morphology, oxygen and nutrient transfer. Understanding relationship between operating parameters and microbial responses in terms of growth, substrate and oxygen consumption, and production yield was critical for process development. This study dedicated to build strategies for mass production of biological control agent using aerobic filamentous microorganisms.