집진용 세라믹 필터의 제조 및 공기 투과 특성

이승인,박재구,정재화 한양대학교 환경공학연구소 2000 環境科學論文集 Vol.21 No.-

슬러리발포 및 겔캐스팅법을 이용하여 세라믹 다공체를 제조하였다. 또한, 이를 분진제거용 여과재로 응용하기 위해 기공구조 및 공기 투과율에 관한 연구를 실시하였다. 기공률은 80% 정도이며, 100㎛와 200㎛, 두 종류의 기공크기를 갖는 다공체를 제조하였다. 기공들은 창(window)을 통해 연결된 연속성 기공구조를 갖는다. 미세분진을 제거하기 위해, 다공체의 한쪽 면은 표면여과층을 형성하였으며, 기공크기는 10 ㎛이하이다. 기공크기가 200㎛인 다공성지지체의 경우, 900∼1000×10-13 ㎥의 투과율은 나타내었으며,기공크기가 100㎛인 지지체의 투과율은 600∼700 × 10-13 ㎥로 각각 측정되었다. 표면여과층이 형성된 여과재의 투과율은 약 200 × 10-13 ㎥로서 지지체의 기공크기에 관계없이 거의 일정한 값을 나타냈다. 또한, Flyash 분진을 이용하여 측정한 여과재의 집진효율은 99.9% 이상인 것으로 나타났다. This study was carried out to evaluate the pore structure and air permeability of the foam ceramic filter prepared by using foam method. Two different types of agents, Benzethonium chloride(C27H42NO2Cl) and Sodium Lauryl Sulfate(CH3(CH2)11OSO3Na) were used for foaming slurry. Porosity of foam ceramics was about 80 % and pore sizes were differed as 200 and 100 ㎛ respectively according to types of agents. It was observed that foam ceramics had continuous pore structure that pores were connected each other by small pathways called windows. For collecting dust, one side of foam ceramic support was coated with fine particles that the size was 20∼50 ㎛. Pore size of the coating layer was under 10 ㎛. Permeability of foam ceramics is proportional to pore size. But coated ceramic filters have similar values without regard to pore size of supports. The permeability of supports was varied with pore size in the range of 600 × 10-13 ㎥ to 1000 × 10-13 ㎥. And for the case of the coated ceramic filter, it was about 200 × 10-13 ㎥. As a result of dust collection test with fly ash, the particle removal efficiency for the oeramic filter specimen was estimated over the 99.9%.

딜라트렌 정(카르베딜롤 25 mg)에 대한 카베롤 정의 생물학적 동등성

조혜영,이문석,박순철,임동구,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Carvedilol is an antihypertensive and antianginal compound that combines nonselective beta-adrenoceptor blocking and vasodilation properties and is devoid of intrinsic sympathomimetic activity. The purpose of the present study was to evaluate the bioequivalence of two carvedilol tablets, Dilatrend^TM (Chong Kun Dang Pharmaceutical Co., Ltd.) and Carvelol^TM (Dae Won Pharmaceutical Co., Ltd.), according to the prior and revised guidelines of Korea Food and Drug Administration (KFDA). The carvedilol release from the two carvedilol tablets in vitro was tested using KP ⅦI Apparatus Ⅱ method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB80 into water). Eighteen normal male volunteers, 24.22±1.86 years in age and 64.81±4.56㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 25㎎ of carvedilol was orally administered, blood was taken at predetermined time intervals and the concentrations of carvedilol in serum were determined using HPLC method with fluorescence detector. The dissolution profiles of two carvedilol tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters using non-transformed and logarithmically transformed AUC_t, and C_max. The results showed that the differences in AUC_t, C_max and T_max between two tablets based on the Dilatrend^TM were 2.23%, -2.00% and 0.00%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 13.55% and 17.61% for AUC_t and C_max respectively). The powers (1-β) at α=0.05, Δ=0.2 for AUC_t and C_max were 98.08% and 88.81%, respectively. The 90% confidence intervals were within ±20% (e.g., -5.69~10.16 and -12.30~8.30 for AUC_t and C_max, respectively). There were no sequence effect between two tablets in logarithmically transformed AUC_t and C_max. The 90% confidence intervals using logarithmically transformed were within the acceptance range of log(0.8) to log(l.25) (e.g., 0.95~1.11 and 0.89~1.09 for AUC_t and C_max, respectively). Two parameters met the criteria of prior and revised KFDA guideline for bioequivalence, indicating that Carvelol^TM tablet is bioequivalent to Dilatrend^TM tablet.

질소산화물 제거를 위한 V₂O_5/TiO₂촉매 코팅된 다공성 실리카 필터의 제조 및 특성

한요섭,고재철,박영구,김승호,박재구 三陟大學校 2005 論文集 Vol.38 No.-

The prepared porous support from silica coated with TiO₂ and V₂O_(5) catalysts were studied by selective catalytic reduction of NOx with NH₃ The effects of V₂O_(5) loading, reaction temperature, space velocity and filter-type(disk and sphere) on the characteristics of NOx reduction with NH₃ were mainly investigated. At space velocity 6000h^(-1), reaction temp rature 350℃, V₂O_(5) loading 6.Owt.% and oxygen content 5%, the NOx reduction was higher to about 91%. The efficiency of porous silica on V₂O_(5)/TiO₂ catalytic disk-filter was higher than that of the V₂O_(5)/TiO₂ catalytic sphere-filter. It has been experimentally observed that the V₂O_(5)/TiO₂ catalytic disk-filter has strong resistance of gas flow.

무기질 담체에 대한 폐수중 미생물의 흡착 메카니즘

이상훈,정기택,박재구,류경근 漢陽大學校 環境工學硏究所 1997 環境科學論文集 Vol.18 No.-

무기질 담채에 대한 폐수증 미생물의 흡착 메카니즘에 대하여 두 입자간의 물리화학적 상호작용을 설명하는 DLVO이론을 도입하여 검토하였다. 실험에 사용된 흡착제는 평균입도가 약40㎛ 정도인 규석, 고령토, 석회석질의 입자 및 다공성의 벌크상 소재를 이용하였다. 시간에 따른 미생물 흡착량(biofilm mass)은 반응전후의 담체(carrier)의 질량차로 구하였으며, 이에따른 폐수중의 COD제거율을 측정·평가하였다. 실험결과 폐수중의 COD제거율은 석회석, 고령토, 담체의 순으로 높게 나타났으며, 이는 담체의 표면전위(ζ-potential) 및 표면구조에따른 미생물 흡착량 변화에 기인 하는 것으로 생각된다. The mechanisms of adsorption of microorganisms to inorganic solid surfaces are studied with DLVO theory of describing physico-chemical interaction between two particles. Average size of 40㎛ of silica, kaolin, limestone powders and porous materials are utilized as adsorbent. Biofilm mass is estimated by the weight difference of carrier before and after the interaction with microorganisms. Also, COD removal rates in wastewater based on biofilm mss are discussed. As a result COD removal rate is higher in order of limestone, kaolin, and silica. This fact is considered that 5-potentials and surface structures of carriers cause change in adsorption capacity of microorganisms.

딜라트렌정(카르베딜롤 25mg)에 대한 카베롤 정의 생물학적 동등성

조혜영,이문석,박순철,임동구,문재동,이용복 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.4

Carvedilol is an antihypertensive and antianginal compound that combines nonselective beta-adrenoceptor blocking and vasodilation properties and is devoid of intrinsic sympathomimetic activity. The purpose of the present study was to evaluate the bioequivalence of two carvedilol tablets, Dilatrend^TM (Chong Kun Dang Pharmaceutical Co., Ltd.) and Carvelol^TM (Dae Won Pharmaceutical Co., Ltd.), according to the prior and revised guidelines of Korea Food and Drug Administration (KFDA). The carvedilol release from the two carvedilol tablets in vitro was tested using KP VII Apparatus Ⅱ method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB80 into water). Eighteen normal male volunteers, 24.22±1.86 years in age and 64.81±4.56 kg in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 25 mg of carvedilol was orally administered, blood was taken at predetermined time intervals and the concentrations of carvedilol in serum were determined using HPLC method with fluorescence detector. The dissolution profiles of two carvedilol tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_t C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters using non-transformed and logarithmically transformed AUC_t and C_max The results showed that the differences in AUC_t C_max and T_max between two tablets based on the Dilatrend^TM were 2.23%, -2.00% and 0.00%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=8 were less than 20% (e.g., 13.55% and 17.61% for AUC_t and C_max respectively). The powers (1-β) at α=0.05, Δ=0.2 for AUC_t and C_max were 98.08% and 88.81%, respectively. The 90% confidence intervals were within 20% (e.g., -5.69∼10.16 and -12.30∼8.30 for AUC_t and C_max, respectively). There were no sequence effect between two tablets in logarithmically transformed AUC_t and C_max, The 90% confidence intervals using logarithmically transformed were within the acceptance range of log(0.8) to log(1.25) (e.g., 0.95∼1.11 and 0.89∼1.09 for AUC_t and C_max respectively). Two parameters met the criteria of prior and revised KFDA guideline for bioequivalence, indicating that Carvelol^TM tablet is bioequivalent to Dilatrend^TM tablet.

시클러 캡슐(세파클러 250㎎)에 대한 경보세파클러 캡슐의 생물학적동등성

조혜영,강현아,김세미,박찬호,오인준,임동구,문재동,이용복 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

The purpose of the present study was to evaluate the bioequivalence of two cefaclor capsules, Ceclor (Lilly Korea Co., Ltd.) and Kyongbocefaclor (Kyongbo Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of cefaclor from the two cefaclor formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media (pH 1.2. 4.0. 6.8 buffer solution and water). Twenty four healthy male subjects. 22.96±1.52 years in age and 67.03±7.90 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After one capsule containing 250 mg of cefaclor was orally administered, blood was taken at pre-determined time intervals and the concentrations of cefaclor in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition. the pharmacokinetic parameters such as AUC_(t), C_(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t). C_(max) and untransformed Tmaa. The results showed that the differences between two formulations based on the reference drug, Ceclor. were -1.90%, 2.68% and -7.60% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.91-log 1.06 and log 0.92-log 1.18 for AU', and C_(max), respectively). Thus. the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kyongbocefaclor capsule was bioequivalent to Ceclor capsule.

Enhanced Clopidogrel Responsiveness in Smokers : Smokers' Paradox Is Dependent on Cytochrome P450 <i>CYP1A2</i> Status

Park, Kyung Woo,Park, Jin Joo,Jeon, Ki-Hyun,Kang, Si-Hyuk,Oh, Il-Young,Yang, Han-Mo,Cho, Hyun-Jai,Lee, Hae-Young,Kang, Hyun-Jae,Koo, Bon-Kwon,Oh, Byung-Hee,Park, Young-Bae,Kim, Hyo-Soo Ovid Technologies Wolters Kluwer -American Heart A 2011 Arteriosclerosis, thrombosis, and vascular biology Vol.31 No.3

Grinding Time for Control of the Size Fraction of Products in the Attrition Milling

Park, Jai Koo,Jeong, Young,Yang, Jeong Il,Jung, Moon Young 한국화학공학회 1998 Korean Journal of Chemical Engineering Vol.15 No.4

Grinding tests for garnet were carried out by using an attrition mill under wet processes. Effects of feed filling ratios and a chemical agent (sodium hexametaphosphate, SHP) were investigated on the grinding, time of the garnet. The progeny particles obtained were screened into various particle size intervals, which were 100 mesh over, 100/400 mesh and 400 mesh under. In order to estimate the mass fraction of the particles in a given particle size interval, mathematical models were derived from the first-order reaction model, then compared to experimental data. It was observed that variation of the feed filling ratio did not show a significant effect on the mash fraction of the product. The chemical agent was, however, effective so that the mass fraction could be controlled by adjusting the content. of SHP.

알루미늄 폐드로스를 활용한 다공성 세라믹스의 제조 및 응용

박재구 ( Jai Koo Park ),박형규 ( Hyoung Kyu Park ) 대한금속재료학회 ( 구 대한금속학회 ) 2005 재료마당 Vol.18 No.4

무기계 다공성 환경소재의 제조 및 응용

박재구(Park Jai-Koo) 한국지반환경공학회 2000 한국지반환경공학회 학술발표회논문집 Vol.2000 No.-