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한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
우성일,강동우,서한길,김봉조,이인상,정근화,박소영,정치영,이환철,정경천,손진욱,Woo, Sung-Il,Kang, Dong-Woo,Seo, Han-Gil,Kim, Bong-Jo,Lee, In-Sang,Jeong, Geun-Hoa,Park, So-Young,Jung, Chi-Yeong,Lee, Hwan-Cheol,Jeong, Kyeong-Cheon,Sohn, 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2
P450 CYP2D6 enzyme(=debrisoquine hydroxylase) is known to metabolize many neuroleptics and some genetic polymorphisms in the CYP2D6 gene were reported to be associated with tardive dyskinesia(TD). We investigeted the association of two genetic polymorphisms in the CYP2D6 gene, $CYP2D6^*4$ and $CYP2D6^*10$, with TD in Korean schizophrenic subjects. Subjects consisted of 71 Korean schizophrenics and TD was evaluated using the Abnormal Involuntary Movement Scale (AIMS). There were no statistically significant differences in the demographic variables of age, male to female percentage and the current antipsychotic(CPZ equivalent) dose between the group with TD and the group without TD. But the duration of antipsychotic drug exposure was significantly higher in the group without TD(p=0.000, by independent t-test). The mean AIMS score in the group with TD was $11.2{\pm}6.6$(S.D.). Genotypings for the presence of $CYP2D6^*4$ and $CYP2D6^*10$ were done using PCR amplifications and endonuclease digestions. There were no statistically significant genotypic and alleleic associations between TD and $CYP2D6^*4$(by chisquare tests), and between TD and $CYP2D6^*10$(by chi-square tests). These results indicate that the $CYP2D6^*4$ and $CYP2D6^*10$ polymorphisms have no significant roles in the causation of TD.
A Case of Renal-limited Lupus-like Nephritis
Chi Young Park,Ji-su Kim,Suk pyo Shin,Won-Jung Hong,Yoon Hee Lee,Sang Ho Cho,Dong-Ho Yang,Jin Jung Choi 순천향의학연구소 2013 Journal of Soonchunhyang Medical Science Vol.19 No.2
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is clinically heterogeneous and affects multiple organs particularly the kidney. Lupus nephritis is a common and severe manifestation of SLE in which immune-mediated inflammation can lead to permanent damage within the kidney, resulting in end stage renal failure. Recently a renal biopsy showed lupus nephritis on a 40-year old female without any other features of SLE such as clinical symptoms and autoantibodies including antinuclear antibody and anti-dsDNA. The renal biopsy showed that histopathological change of global and segmental sclerosis of glomeluri, diffuse proliferative nephritis with crescent formation compatible with class IV lupus nephritis. She was treated with systemic corticosteroids and pulse cyclophosphamide, followed by mycofenolate mofetil. During two years of follow-up, there have been no clinical or laboratory findings to meet the diagnostic criteria of SLE, suggesting that isolated lupus nephritis could occur without SLE.
Sang Won Jeon,Changsu Han,Young-Hoon Ko,Seo Young Yoon,Chi-Un Pae,Joonho Choi,Yong Chon Park,Jong-Woo Kim,Ho-Kyoung Yoon,Seung-Duk Ko,Ashwin A. Patkar,Mark Zimmerman 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.1
Objective: This study was aimed at evaluating the diagnostic validity of the Korean version of the Clinically Useful Depression Outcome Scale (CUDOS) with varying follow-up in a typical clinical setting in multiple centers. Methods: In total, 891 psychiatric outpatients were enrolled at the time of their intake appointment. Current diagnostic character-istics were examined using the Structured Clinical Interview for DSM-IV (41% major depressive disorder). The CUDOS was meas-ured and compared with three clinician rating scales and four self-report scales. Results: The CUDOS showed excellent results for internal consistency (Cronbach’s α ,0.91), test-retest reliability (patients at intake, r =0.81; depressed patients in ongoing treatment, r =0.89), and convergent and discriminant validity (measures of depres-sion, r =0.80; measures of anxiety and somatization, r =0.42). The CUDOS had a high ability to discriminate between different levels of depression severity based on the rating of Clinical Global Impression for depression severity and the diagnostic classi-fication of major depression, minor depression, and non-depression. The ability of the CUDOS to identify patients with major depression was high (area under the receiver operating characteristic curve=0.867). A score of 20 as the optimal cutoff point was suggested when screening for major depression using the CUDOS (sensitivity=89.9%, specificity=69.5%). The CUDOS was sensitive to change after antidepressant treatment: patients with greater improvement showed a greater decrease in CUDOS scores ( p <0.001). Conclusion: The results of this multi-site outpatient study found that the Korean version of the CUDOS is a very useful measure-ment for research and for clinical practice.
Micrografting and Heat Treatment Combination for Eliminating Virus of CTV-infected Citrus
Chi Won Chae(채치원),Su Hyun Yun(윤수현),Jae Ho Park(박재호),Jae Wook Hyun(현재욱),Sang Wook Koh(고상욱),Dong Hoon Lee(이동훈) 한국생명과학회 2013 생명과학회지 Vol.23 No.2
본 연구는 바이러스에 감염된 감귤나무로부터 열처리와 경정접목을 병행 처리하여 바이러스를 제거코자 수행하였다. ‘세토카’ 교잡종을 포함한 6품종을 재료로서 사용하였으며 이를 조사된 모든 개체에서는 외관적으로 바이러스 감염 증상이 관찰되지 않았으나 TAS?ELISA 검정을 통해 전원 CTV에 감염되어 있음이 확인되었다. ‘세토카’를 대상으로 특정 온도 시험을 수행한 결과, 주?야간 40℃ 온도 조건에서 높은 비율로 바이러스가 제거되었다. 항혈청법으로 할 수 있었으며, 그 처리에서 획득된 무균의 신초를 이용하여 기내 파종된 탱자 대목에 경정접목하였다. 경정 접목된 모든 개체에서는 바이러스 병징이 발견되지 않았고 TAS-ELISA와 SDV 크로마토법에 의해서도 무균이 확인되었다. CTV, SDV와 CTLV를 대상으로 한 RT-PCR 검사를 통해서도 극소량의 바이러스조차 발견되지 않았다. 따라서, 열처리와 경정접목을 통해 ‘세토카’, ‘삼다조생’, ‘풍광’, ‘부지화’ 및 ‘에히메카시 다이28고’ 품종에서 총 11개의 무균의 식물체를 획득하였다. This study was conducted to eliminate viruses from citrus-infected plants using micrografting and thermotherapy. Six citrus cultivars including a ‘Setoka’ hybrid were used as plant sources. The TAS-ELISA technique demonstrated that several plants were CTV positive. However, no CTV symptoms were detected in plants obtained from shoots and treated at a high temperature of 40°C during the day and night and micrografted for two weeks with old trifoliate orange rootstock in vitro. Indexing of CTV, SDV, and CTLV for RT-PCR analysis of the eleven citrus seedlings, including ‘Setoka’, ‘Samdajosang’, ‘Pungkwang’, ‘Shiranuhi’, and ‘Ehimekashi dai28go’ was virus free following the micrografting and thermal therapy.
Nanocrack-regulated self-humidifying membranes
Park, Chi Hoon,Lee, So Young,Hwang, Doo Sung,Shin, Dong Won,Cho, Doo Hee,Lee, Kang Hyuck,Kim, Tae-Woo,Kim, Tae-Wuk,Lee, Mokwon,Kim, Deok-Soo,Doherty, Cara M.,Thornton, Aaron W.,Hill, Anita J.,Guiver, Nature Publishing Group, a division of Macmillan P 2016 Nature Vol.532 No.7600
<P>The regulation of water content in polymeric membranes is important in a number of applications, such as reverse electrodialysis and proton-exchange fuel-cell membranes. External thermal and water management systems add both mass and size to systems, and so intrinsic mechanisms of retaining water and maintaining ionic transport(1-3) in such membranes are particularly important for applications where small system size is important. For example, in proton-exchange membrane fuel cells, where water retention in the membrane is crucial for efficient transport of hydrated ions(1,4-7), by operating the cells at higher temperatures without external humidification, the membrane is self-humidified with water generated by electrochemical reactions(5,8). Here we report an alternative solution that does not rely on external regulation of water supply or high temperatures. Water content in hydrocarbon polymer membranes is regulated through nanometre-scale cracks ('nanocracks') in a hydrophobic surface coating. These cracks work as nanoscale valves to retard water desorption and to maintain ion conductivity in the membrane on dehumidification. Hydrocarbon fuel-cell membranes with surface nanocrack coatings operated at intermediate temperatures show improved electrochemical performance, and coated reverse-electrodialysis membranes show enhanced ionic selectivity with low bulk resistance.</P>
( Chi Young Jung ),( Yeoung Hun Choe ),( Sang Yeub Lee ),( Woo Jin Kim ),( Jong Deog Lee ),( Seung Won Ra ),( Eu Gene Choi ),( Jae Seung Lee ),( Myung Jae Park ),( Ju Ock Na ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.5
Background/Aims: To use serological and multiplex polymerase chain reaction (PCR) assays to examine sputum samples from patients experiencing acute exacerbation of chronic obstructive pulmonary disease (AECOPD) for the presence of atypical pathogens, including Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila. Methods: From September 2012 to February 2014, 341 patients with AECOPD attending outpatient clinics were enrolled as part of a randomized, double-blind, multicenter study. A commercial enzyme-linked immunosorbent assay was used to measure serum immunoglobulin M (IgM) and IgG antibody titers on the first day of the study and at 36 days post-enrollment. Multiplex PCR was used to test sputum samples for the presence of atypical pathogens. A urinary antigen test for L. pneumophila was performed on the first day. Results: Nineteen patients (5.6%) showed serological evidence of acute infection with M. pneumoniae. Also, one and seven patients (2%) showed serological evidence of acute infection with C. pneumoniae and L. pneumophila, respectively. All DNA samples were negative for M. pneumoniae, C. pneumoniae, and L. pneumophila according to PCR. Only one urine sample was positive for L. pneumophila antigen, but serologic evidence was lacking. Conclusions: Serological testing suggested that infection by atypical pathogens during AECOPD was relatively uncommon. In addition, PCR provided no direct evidence of infection by atypical pathogens. Thus, atypical pathogens may not be a major cause of AECOPD in South Korea.
Using Mobile Phones in EFL Classes
Sung, Tae-Soo,Park, Kab-Yong,Joo, Chi-Woon Korean Society of Computer Information 2017 韓國컴퓨터情報學會論文誌 Vol.22 No.6
This article is to investigate the possibility that project-based classes introducing mobile phones can replace the monotony of traditional classes led by teachers as well as they can encourage students to take active part in the classes to some extent. The students in groups choose a genre for their own video projects (e.g., movie, drama, news, documentary, and commercial) and produce the video contents using a mobile phone for presentation made at the end of a semester. In the sense that the students are allowed to do video-based mobile phone projects, they can work independently outside of class, where time and space are more flexible and students are free from the anxiety of speaking or acting in front of an audience. A mobile phone project consists of around five stages done both in and outside of the classroom. All of these stages can be graded independently, including genre selection, drafting of scripts, peer review and revision, rehearsals, and presentation of the video. Feedback is given to students. After the presentation, students filled out a survey questionnaire sheet devised to analyze students' responses toward preferences and level of difficulty of the project activity. Finally, proposals are made for introduction of a better mobile phone-based project classes.
Park, Sang-Ho,Lee, Dong-Hun,Oh, Kye-Heon,Kim, Chi-Kyung The Microbiological Society of Korea 2000 The journal of microbiology Vol.38 No.3
Several types of bioluminescent reporter strains have been developed for the detection and monitoring of pollutant aromatics contaminating the environment. In this study, a bioluminescent reporter strain, E. coli SHP3, was constructed by fusing the luc gene of firefly luciferase with the promoter of pcbC responsible for the meta-cleavage of aromatic hydrocarbons. the bioluminescence expressed by the luc gene in the reporter was well triggered by the promoter when it was exposed to 2,3-dihydroxybiphenyI (2,3-DHBP) at 0.5 to 1 mM concentrations. The bioluminescent response was more extensive when the reporter strain was exposed to 5 mM catechol and 2 mM 4-chlorocatechol. These different types of bioluminescent responses by E. coli SHP3 appeared to be characterized by the nature of the aromatics to stress. Since E. coli SHP3 responded to 2,3-DHBP quite sensitively, this reporter strain could be applied for detecting some catecholic pollutants.