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Diagnostic Role of Survivin in Urinary Bladder Cancer
Srivastava, Anupam Kumar,Singh, Pankaj Kumar,Srivastava, Kirti,Singh, Dhramveer,Dalela, Divakar,Rath, Srikanta Kumar,Goel, Madhu Mati,Bhatt, Madan Lal Brahma Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: Early diagnosis of carcinoma of bladder remains a challenge. Survivin, a member of the inhibitor of apoptosis (IAP) protein family, is frequently activated in bladder carcinoma. The objective of this study was to investigate urinary survivin as a marker for diagnosis of urinary bladder. Materials and Methods: We examined urinary survivin concentration in 28 healthy individuals, 46 positive controls and 117 cases of histologically proven TCC prior to transurethral resection, using ELISA, and compared values with findings for urinary cytology. Results: Survivin was found to be significantly higher in the cancer group (P<0.05). A cut off value of 17.7 pg/ml was proposed, with an approximate sensitivity of 82.9% and specificity of 81.1% (P<0.0001), whereas urine cytology had a sensitivity of 66.7% and a specificity of 96.0%. Conclusions: Urinary survivin can be used as a non-invasive diagnostic biomarker for TCC bladder, both for primary and recurrent disease.
A HYBRID ALGORITHM FOR LUNG CANCER CLASSIFICATION USING SVM AND NEURAL NETWORKS
Pankaj Nanglia,Sumit Kumar,Aparna N. Mahajan,Paramjit Singh,Davinder Rathee 한국통신학회 2021 ICT Express Vol.7 No.3
The present research article focused on the factual findings of the potential usage of the combinational Feed-Forward Back Propagation Neural Network as a judgment making for lung cancer. In this context, Support Vector Machine is integrated with Feed-Forward Back Propagation Neural Network to create a hybrid algorithm that further helps in reducing the computation complexity of the classification. A set of 500 images are utilized in which 75% data is used for the training purpose and the rest 25% is used to achieve the classification. In the view of forgoing, a three-block mechanism is proposed for the classification in which the first block preprocesses the dataset, the second block extracts the features via the SURF technique followed by the optimization using Genetic Algorithm and the terminal block is for the classification via FFBPNN. The hybrid classification algorithm is named as Kernel Attribute Selected Classifier and the overall classification accuracy of the proposed algorithm is 98.08%. Herein, the objective of the study is to enhance the classification accuracy by applying a hybrid classification algorithm.
Pankaj Raizada,Abhinandan Kumar,Vasudha Hasija,Pardeep Singh,Vijay Kumar Thakur,Aftab Aslam Parwaz Khan 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-
Considering the current scenario of rising environmental and energy concerns, engineering of Z-schemephotocatalytic systems is in the spotlight. The prime reason for this includes efficient redox abilities andeffective space separation along with the migration of photoinduced charge carriers over conventionalheterojunction systems. Herein we foreground the stumbling blocks of traditional heterojunctionsystems and enlighten the generations of Z-scheme photocatalysis originating from liquid-phase todirect Z-scheme photocatalytic systems. We provide substantial criteria and selection aspects ofchoosing reductive type photocatalysts as a potential aspirant for the Z-scheme photocatalytic system. AsZ-scheme photocatalytic systems render effective space separation of photogenerated carriers, activespecies generation, wide optical absorption and amended redox ability. We focus on comprehensiveillustration of all solid-state and direct Z-scheme photocatalysts by coupling reductive typephotocatalysts with other semiconductor material and explored their potential for efficacious conversionof solar energy into functional energy. Herein, we aim to provide in-depth and updated criteria forselecting Z-scheme photocatalysts for CO2 reduction, water splitting, and nitrogenfixation. Lastly, thearticle compiles with a conclusive note about future perspectives and challenges accompanying all solidstateand direct Z-scheme Z photocatalysts and their energy conversion applications.
Pankaj Kumar Sagar,Poonam Sharma,Rambir Singh 대한약침학회 2022 Journal of pharmacopuncture Vol.25 No.1
Objectives: The quorum-sensing–inhibitory and anti-biofilm activities of the methanol extract of E. globulus leaves were determined against clinically isolated multidrug-resistant Pseudomonas aeruginosa. Methods: The preliminary anti-quorum–sensing (AQS) activity of eucalyptus was investigated against a biosensor strain Chromobacterium violaceum ATCC 12472 (CV12472) by using the agar well diffusion method. The effect of sub-minimum inhibitory concentrations (sub-MICs) of the methanol extract of eucalyptus on different quorum-sensing–regulated virulence factors, such as swarming motility, pyocyanin pigment, exopolysaccharide (EPS), and biofilm formation, against clinical isolates (CIs 2, 3, and 4) and reference PA01 of Pseudomonas aeruginosa were determined using the swarm diameter (mm)-measurement method, chloroform extraction method, phenol (5%)-sulphuric acid (concentrated) method, and the microtiter plate assay respectively, and the inhibition (%) in formation were calculated. Results: The preliminary AQS activity (violacein pigment inhibition) of eucalyptus was confirmed against Chromobacterium violaceum ATCC 12472 (CV12472). The eucalyptus extract also showed concentration-dependent inhibition (%) of swarming motility, pyocyanin pigment, EPS, and biofilm formation in different CIs and PA01 of P. aeruginosa. Conclusion: Our results revealed the effectiveness of the E. globulus extract for the regulation of quorum-sensing–dependent virulence factors and biofilm formation at a reduced dose (sub-MICs) and suggest that E. globulus may be a therapeutic agent for curing and controlling bacterial infection and thereby reducing the possibility of resistance development in pathogenic strains.
Singh Divya,Ramniwas Seema,Tyagi Pankaj Kumar,Kumar Girish,Gola Deepak 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.1
Drosophila (Sophophora) kikkawai, Burla, 1954 and Drosophila (Sophophora) leontia, Tsacas & David 1978 are closely related sibling species, the former being cosmopolitan and the latter is restricted to tropical localities. We investigated the influence of introgressive hybridization on phenotypic diversity of the two sibling species in the present study. How hybridization supports the relative abundance of pure species according to latitudinal cline is the aim of this study because hybrids show a tendency to acquire geographical location of their parent species in equal or greater abundance. How hybridization supports the plasticity for melanization of hybrids is not explored yet. The two species can cross and generate hybrids. For this, we crossed true breeding strains of both species to obtain the hybrids i.e. dark female (♀) of D. kikkawai (D. k) with males (♂) of D. leontia (D. l) in cross I and light ♀ of D. k with ♂ of D. l in cross II along with their reciprocal crosses. Finally, we studied the plasticity of both species and their hybrids at 6 growth temperatures (14, 17, 21, 25, 28 and 31 ◦ C). We found that there is no plasticity for melanization in true breeding darker and lighter strain of D. kikkawai as well as D. leontia whereas hybrids of both species showed high phenotypic plasticity. Significant differences in slope values across tem peratures in parental and hybrid lines suggest plastic effects. Phenotypic variation in abdominal melanization in hybrids can be interpreted as a result of gene introgression with D. kikkawai. We conclude that introgressive hybridization might be an important, although underestimated, mechanism shaping species distribution and adaptation.
( Binit Kumar Singh ),( Rohini Sharma ),( Parul Kodan ),( Manish Soneja ),( Pankaj Jorwal ),( Neeraj Nischal ),( Ashutosh Biswas ),( Sanjay Sarin ),( Ranjani Ramachandran ),( Naveet Wig ) 대한결핵 및 호흡기학회 2020 Tuberculosis and Respiratory Diseases Vol.83 No.4
Background: Line probe assay (LPA) is standard diagnostic tool to detect multidrug resistant tuberculosis. Noninterpretable (NI) results in LPA (complete missing or light wild-type 3 and 8 bands with no mutation band in rpoB gene region) poses a diagnostic challenge. Methods: Sputum samples obtained between October 2016 and July 2017 at the Intermediate Reference Laboratory, All India Institute of Medical Sciences Hospital, New Delhi, India were screened. Smear-positive and smear-negative culturepositive specimens were subjected to LPA Genotype MTBDRplus Ver 2.0. Smear-negative with culture-negative and culture contamination were excluded. LPA NI samples were subjected to phenotypic drug susceptibility testing (pDST) using MGIT-960 and sequencing. Results: A total of 1,614 sputum specimens were screened and 1,340 were included for the study (smear-positive [n=1,188] and smear-negative culture-positive [n=152]). LPA demonstrated 1,306 (97.5%) valid results with TUB (Mycobacterium tuberculosis) band, 24 (1.8%) NI, three (0.2%) valid results without TUB band, and seven (0.5%) invalid results. Among the NI results, 22 isolates (91.7%) were found to be rifampicin (RIF) resistant and two (8.3%) were RIF sensitive in the pDST. Sequencing revealed that rpoB mutations were noted in all 22 cases with RIF resistance, whereas the remaining two cases had wild-type strains. Of the 22 cases with rpoB mutations, the most frequent mutation was S531W (n=10, 45.5%), followed by S531F (n=6, 27.2%), L530P (n=2, 9.1%), A532V (n=2, 9.1%), and L533P (n=2, 9.1%). Conclusion: The present study showed that the results of the Genotype MTBDRplus assay were NI in a small proportion of isolates. pDST and rpoB sequencing were useful in elucidating the cause and clinical meaning of the NI results.
Rohit Kumar,Anita Sudhaik,Aftab Aslam Parwaz Khan,Pankaj Raizada,Abdullah M. Asiri,Satyabrata Mohapatra,Sourbh Thakur,Vijay Kumar Thakur,Pardeep Singh 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.106 No.-
Growing pollution and high energy demand are some of the major issues against humans. Waterpollution is one of the main problems created due to industrial waste and irresponsible human activities. Nowadays, photocatalysis is rising as an efficient alternative to overcome the energy requirement andwater purification, as it can use solar light as a source of energy. Due to some limitations of photocatalysts,such as photocarriers recombination, low surface area, and limited light absorption, modificationssuch as defect modifications, heterojunction can be employed. Out of all, Z-scheme heterojunction is aproficient way to overwhelm the limitation of pristine photocatalysts. To enhance the activity of Zschemephotocatalyst, even more, a dual Z-scheme photocatalytic scheme has been developed in whichtwo Z-scheme based charge transfer occur simultaneously on a ternary photocatalyst. In this review, wehave discussed the different types of dual Z-schemes along with their application in water purificationand finally, we have discussed the future prospects for further research.
JHADE, PANKAJ KUMAR,SALUJA, AMARJEET SINGH Department of Mathematics 2015 Kyungpook mathematical journal Vol.55 No.3
The aim of this paper is to prove strong convergence theorem by a modified three step iterative process with errors for three nonexpansive mappings in the frame work of uniformly smooth Banach spaces. The main feature of this scheme is that its special cases can handle both strong convergence like Halpern type and weak convergence like Ishikawa type iteration schemes. Our result extend and generalize the result of S. H. Khan, Kim and Xu and many other authors.