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Nguyen Thi Minh Hong,Nguyen Ba Doan,Nguyen Huy Tiep,Le Viet Cuong,Bui Nguyen Quoc Trinh,Pham Duc Thang,김동현 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
In this work, we study the magnetic properties of a CoFe/NiFe/PZT heterostructured nanocompositethat is affected by the strain in the PZT substrate when a voltage in the range from –250to 250 V is applied. An interesting electric-voltage-controlled magnetic anisotropy, with a relativeincrease in magnetization up to above 100%, is observed. This brings a new challenge to operate alow-power-consuming spin electronic device. We also utilize a theoretical model based on interfacecharge-mediated and strain-mediated magnetic-electric coupling to understand the change in themagnetic properties of the investigated material.
서민수(Min-Su Seo),조성대(Sung-Dae Cho),안남식(Nam-Shik Ahn),정지원(Ji-Won Jung),양세란(Se-Ran Yang),박준석(Joon-Suk Park),박기수(Ki-Su Park),홍인선(In-Sun Hong),조은혜(Eun-Hye Jo),Nguyen Ba Tiep(Nguyen Ba Tiep),이영순(Yong-Soon L 한국독성학회 2003 Toxicological Research Vol.19 No.2
A nonspecific immunostimulator BARODON® was tested for mutagenicity using Ames Salmonella tester strains TA98, TA100, TA102, TA1535 and TA1537 with or without metabolic activation<br/> (S9 mix). None of the fresh species showed mutagenicity. In the reverse mutation test using Salmonella typhimurium TA98, TA100, TA102, TA1535 and TA1537 did not increase the number of revertants at all doses tested (5, 2.5 or 1.25 mg/ml). Chromosome aberration test was carried out in Chinese hamster lung (CHL) cell line. The cells were treated with BARODON® (1, 0.5 or 0.25 mg/ml), while positive control group was treated with Mitomycin C (0.1 mg/ml). The results show that there is no statistically significant difference between positive control and treatment groups. In mouse micronucleus test, there was significant increase in the ratio of micronucleated polychromatic erythrocyte (MNPCE) in the high dose group (10% BARODON®), while there is no significance between control and low (2.5% BARODON®) or middle (5% BARODON®) dose groups. Taken togather, this results suggest that below 5% BARODON® might not have mutagenic potential in vitro and vivo systems.
비특이 면역증강제 BARODON®의 안점막 및 피부에 대한 국소자극시험
조은혜,조성대,안남식,정지원,양세란,박준석,Nguyen Ba Tiep,박기수,홍인선,서민수,이영순,강경선 한국독성학회 2003 Toxicological Research Vol.19 No.1
Two local irritation and skin sensitization studies of nonspecific immunostimulator, BARODON® were carried out with New Zealand White rabbits and Hartley guinea pigs. In skin irritation test of male New Zealand White rabbits, body weights were not significantly changed and there were no responses after treatment for 24 or 72 hours and the Primary irritation index (P.I.I.) was ''0''. And, in the eye irritation test, there were chemosis in some of rabbits. One of 3 rabbits in washing group was detected chemosis after 24 and 72 h following treatment and 2 of 6 rabbits in non-washing group were detected chemosis after 24h and 7 days following treatment. Therfore, total score is ''4'' after 24 h and ''2'' after 72 h following treatment by conforming article "some blood vessel are clearly hyperemic". However evaluation value is non-irritant because M.O.I. (Mean ocular irritation index) score is below during the all experimental period and no significance through individuals and exposure time. In skin sensitization, the score of skin reaction was graded I with 0% sensitization rate. Taken together, these results indicate that BARODON® may be non-irritant material.
랫드에서 방풍, Saposhnikovia divaricata (Turcz.) Schischk의 피하투여 독성에 대한 연구
이영순,조성대,안남식,정지원,양세란,박준석,박기수,홍인선,서민수,조은혜,Nguyen Ba Tiep,강경선 한국독성학회 2003 Toxicological Research Vol.19 No.1
To evaluate influence of Saposhnikovia divaricata ( Turcz.) Schischk extract on rat, Saposhnikovia divaricata ( Turcz.) Schischk extract was diluted with 0.9% saline (100 mg/ml/kg, 10 mg/ml/kg, and 1 mg/ml/kg, respectively), and each of diluted test material extract was daily treated subcutaneously for 4 weeks and single-treated subcutaneously for 2 weeks. There were no significances in body weight analysis, urinary analysis, and ophthalmological test. However, in serum biochemical analysis and hematological analysis, we found some significances in high and middle dose group compared with control group. These significances in serum biochemical analysis and hematological analysis may be not induced by test material, because it was not found to be significant from control group in histopathological examination. Therefore, it was concluded that NOEL (No Observed Effect Level) of test material extract may be higher than all treatment doses used in this study, and Saposhnikovia divaricata ( Turcz.) Schischk extract may be a non-toxic material
봉독 추출물(F1, F3)의 랫드에 대한 단회 및 4주 반복 피하 투여 독성시험
박기수,조성대,안남식,정지원,양세란,박준석,홍인선,서민수,조은혜,Nguyen Ba Tiep,이영순,강경선 한국독성학회 2003 Toxicological Research Vol.19 No.1
This study was performed to evaluate single and repeated-dose toxicities of Bee Venom Extracts (F1, F3) in Spraque-Dawley. F1 was injected subcutaneously to rat at dose levels of 0, 0.0002, 0.002, 0.02 mg/kg/day for single-dose toxicity study and repeated-dose toxicity study. F3 was injected subcutaneously to rat at dose level of 0, 0.003, 0.03, 0.3 mg/kg/day for single-dose toxicity study and repeated-dose toxicity study. In both studies, there were no dose related changes in mortality, clinical sign, body weight change, food and water consumption, opthalmoscopy, organ weights, urine analysis, biochemical examination, and hematological findings of all animals treated with Bee Venom (F1, F3). Gross and histopathological findings revealed no evidence of specific toxicity related to Bee Venom (F1, F3). These results suggest that the subcutaneous NOEL (No Observed Effect Level) of Bee Venom (F1, F3) may be over F1 - 0.02 mg/kg, F3 - 0.3 mg/kg.
Differential Expressions of Gap Junction Proteins during Differentiation of Rat Neuronal Stem Cells
Se-Ran Yang,Sung-Dae Cho,Nam-Shik Ahn,Ji-Won Jung,Joon-Suk Park,Nguyen Ba Tiep,Ki-Su Park,In-Sun Hong,Eun-Hye Jo,Min-Su Seo,Byong-Su Yoon,Yong-Soon Lee,Kyung-Sun Kang 한국환경성돌연변이발암원학회 2003 한국환경성돌연변이·발암원학회지 Vol.23 No.1
Gap junctional intercellular communication (GJIC) plays a key role during development, process of tissue differentiation, and in maintenance of adult tissue homeostasis. Neural stem cells leading to formation of cell clusters termed “neurospheres”, can differentiate into neurons, oligodendrocytes, and astrocytes. We investigated the expression levels and distribution of connexin43 (Cx43) and connexin32 (Cx32), abundant gap junctional protein in neural cells and in neurospheres isolated from rat fetus embryonic day (ED) 17. During differentiation of neurospheres, expression of Cx43 and 32 were increased time-dependently within 72 h, and then decreased at 7 day in western blot analysis. TPA-induced inhibition<br/> of GJIC was confirmed by decreased fluorescence by SL/DT assay, and induced hyperphosphorylation of Cx43 while no changes in Cx32 levels in western blot assay. Our results indicate that GJIC may be a crucial role in the differentiation of neuronal stem cell. And this GJIC can be inhibited by TPA through the hyperphosphorylation of Cx43.
Differential Expressions of Gap Junction Proteins during Differentiation of Rat Neuronal Stem Cells
Yang, Se-Ran,Cho, Sung-Dae,Ahn, Nam-Shik,Jung, Ji-Won,Park, Joon-Suk,Tiep, Nguyen Ba,Park, Ki-Su,Hong, In-Sun,Jo, Eun-Hye,Seo, Min-Seo,Yoon, Byong-Su,Lee, Yong-Soon,Kang, Kyung-Sun Korean Environmental Mutagen Society 2003 한국환경성돌연변이·발암원학회지 Vol.23 No.1
Gap junctional intercellular communication (GJIC) plays a key role during development, process of tissue differentiation, and in maintenance of adult tissue homeostasis. Neural stem cells leading to formation of cell clusters termed 'neurospheres', can differentiate into neurons, oligodendrocytes, and astrocytes. We investigated the expression levels and distribution of connexin43 (Cx43) and connexin32 (Cx32), abundant gap junctional protein in neural cells and in neurospheres isolated from rat fetus embryonic day (ED) 17. During differentiation of neurospheres, expression of Cx43 and 32 were increased time-dependently within 72 h, and then decreased at 7 day in western blot analysis. TPA-induced inhibition of GJIC was confirmed by decreased fluorescence by SL/DT assay, and induced hyperphosphorylation of Cx43 while no changes in Cx32 levels in western blot assay. Our results indicate that GJIC may be a crucial role in the differentiation of neuronal stem cell. And this GJIC can be inhibited by TPA through the hyperphosphorylation of Cx43.
랫드와 비글에서 GC-100X 세정제의 독성에 대한 연구
강경선,조성대,안남식,정지원,양세란,박준석,박기수,홍인선,서민수,조은혜,이영순,Kang, Kyung-Sun,Cho, Sung-Dae,Ahn, Nam-Shik,Jung, Ji-Won,Yang, Se-Ran,Park, Joon-Suk,Park, Ki-Soo,Hong, In-Sun,Seo, Min-Soo,Jo, Eun-Hye,Nguyen, Ba Tiep,Lee, 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.1
Because cleaning products are part of our everyday lives, it is essential that they should not present significant risks to health. However, many petrochemicals in most soaps and detergents can be absorbed through the scalp and skin and, over time, accumulate in the organs and tissues. This accumulation may result in brain, nerve, and liver damage. Therefore, it is interested in developing non-harmful detergent. According to Korea Research Institute of Chemical Technology, GC-100X may be non-harmful and non-corrosive alkaline ionic water (pH 12). It is composed of hydroxyl radicals and supplemented with xylitol. To evaluate influence of GC-100X on rats and beagles, GC-100X was diluted with distilled water (25%, 50%, and 100% solution respectively). Each of diluted GC-100X was daily treated per oral. In body weight analysis, urinary analysis, ophthalmological test and autopsy, we did not find any significance, but in serum biochemical analysis and hematological analysis, we found some significances in middle dose group compared with control group. These significances in serum biochemical analysis and hematological analysis may be not induced by GC-100X, because it was not found to be significant from control group in histopathological examination. Thus, it is concluded that NOEL(No Observed Effect Level) of GC-100X may be higher than all treatment doses used in this study, and GC-100X may be a non-toxic detergent.