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Risk Reducing Surgery in Carriers with Double Heterozygosity for BRCA1 and BRCA2 Mutations
Hong, Woo-Sung,Kim, Ku-Sang,Jung, Yong-Sik,Kang, Seok-Yun,Kang, Doo-Kyoung,Kim, Tae-Hee,Yim, Hyunee,Chun, Mi-Son,Park, Myong-Chul,Chang, Suk-Joon Korean Society of Medical Genetics and Genomics 2012 대한의학유전학회지 Vol.9 No.1
Among the treatment options for BRCA mutation carriers, risk reducing surgery is the most effective. However, this procedure has been rarely performed in Korea. Interestingly, our case showed double heterozygosity for BRCA1 and BRCA2 mutations. The patient was diagnosed with left renal cancer and left breast cancer at 45-years-of-age, 4 years before risk reducing surgery. The patient received left radical nephrectomy and left partial mastectomy with axillary lymph node dissection. After pretest counseling, the patient underwent genetic testing that identified BRCA1 and BRCA2 mutations. After post-test counseling, the patient decided on intensive surveillance. At 49-years-of-age, the patient was newly diagnosed with contralateral breast cancer. Treatment options were discussed once again. We performed bilateral total mastectomy with immediate reconstruction and prophylactic bilateral salpingo-oophorectomy after multidisciplinary discussion. The patient has been satisfied with the results of surgery. We think this procedure is a recommendable treatment option for BRCA mutation carriers.
Young Joo Kim,Yun Jong Hyuk,Hong Sung Hoon,Song GeumJong,Lee Jong Eun,Son Myong Won,Han Sun Wook,Kim Sung Yong,Lee Moon-Soo 대한종양외과학회 2022 Korean Journal of Clinical Oncology Vol.18 No.2
Appendiceal mucocele is a rare mucin-producing neoplasm of appendiceal origin. Due to its location and imaging findings, appendiceal mucocele is easily confused with tumors of the right adnexa. We present a rare case of a patient initially misdiagnosed with an ovarian tumor intraoperatively diagnosed as an appendiceal mucocele and successfully treated. A 66-year-old postmenopausal woman was admitted to the gynecology department for an asymptomatic pelvic mass. Preoperative pelvic imaging showed an 8-cm cystic mass. Exploratory laparoscopy for the suspected epithelial borderline tumor from the right ovary revealed a cystic mass in the right pelvic area and normal uterus, fallopian tubes, and ovaries. Intraoperative consultation with the general surgery department confirmed the appendiceal origin. Laparoscopic appendectomy was performed. Histopathological examination confirmed a low-grade mucinous neoplasm of appendiceal origin. The patient was discharged on a postoperative day 5 without complications. The outpatient follow-up performed 1 month later showed no evidence of disease progression. Despite the use of advanced diagnostic tools, appendiceal mucocele may be confused for ovarian malignancies. Because the clinical features of appendiceal mucocele are nonspecific, clinicians and radiologists know the specific imaging findings. A multidisciplinary approach including general surgery, gynecology, and radiology is required for preoperative diagnosis and treatment.
임영우(Young-Woo Lim),서승호(Seung-Ho Seo),박성은(Seong-Eun Park),김은주(Eun-Ju Kim),권오철(Oh-Cheol Kweon),김기명(Ki-Myong Kim),손홍석(Hong-Seok Son) 한국식품영양과학회 2018 한국식품영양과학회지 Vol.47 No.2
본 연구에서는 비상품 토마토를 이용한 가공품의 개발 가능성을 알아보기 위해 토마토에 Lactobacillus plantarum을 접종하여 발효물을 제조하였으며, 발효 기간의 변화와 상품과 토마토와의 차이점을 분석하였다. 생균수 측정과 이화학적 분석을 통해 비상품과 여부에 관계없이 토마토의 발효는 다른 영양물질의 첨가 없이도 활발하게 이루어짐을 확인할 수 있었다. 비상품 토마토는 발효 후 더 높은 폴리페놀 함량으로 기인한 DPPH 라디칼 소거능이 상품과보다 높았다. GC-MS를 이용한 대사산물 분석에서는 발효 48시간까지 대사산물 패턴이 급격하게 변화하는 것으로 나타났으며, 상품과와 비상품과 사이에 초기 대사산물의 차이가 발효 후 유사해지는 것으로 확인되었다. 상품 토마토와 비상품 토마토 발효물은 일부 당과 유기산, 아미노산 함량에서 차이를 보였으며, 이는 초기 토마토의 성분이 다르기 때문으로 추정된다. 이상의 결과를 종합하면 비상품 토마토는 생과로서는 상품성이 떨어지더라도 유산균 발효를 통한 가공식품으로서의 개발 가치가 있을 것으로 생각된다. 또한, 이러한 결과는 채소와 과일의 발효 가공 연구에 있어서 대사산물의 변화를 실시간으로 모니터링하는 방법으로 GC-MS를 활용한 대사산물 분석이 활용될 수 있음을 시사한다. This study examined the quality characteristics of fermented tomato by Lactobacillus plantarum. A gas chromatography-mass spectrometry dataset coupled with multivariate statistical analysis was used to investigate the metabolic changes in tomato during fermentation and to assess the possibility of its development as a processed product using non-marketable (immature and overripe) tomatoes. Non-marketable tomatoes exhibited higher 1,1-diphenyl- 2-picrylhydrazyl regent radical scavenging ability than the control tomatoes due to the higher polyphenol contents after fermentation. The metabolites of tomato changed rapidly until 48 hours after fermentation. Although the contents of some sugars, organic acids, and amino acids were different, the metabolite patterns between the non-marketable and control tomatoes were similar after fermentation. These results suggest that non-marketable tomatoes have development value as processed foods through fermentation by lactic acid bacteria, despite their inferior commercial value as a raw material.
갑상샘의 미만성 경화아형 유두상암의 1예 보고: 초음파와 컴퓨터 단층촬영 영상
김흥철,남궁숙,홍명선,황임경,김한준<SUP>1<.SUP>,최영희<SUP>2<.SUP>,Heung Cheol Kim,M.D.,Sook Namkung,M.D.,Myong Son Hong,M.D.,Im Kyung Hwang,M.D.,Han Joon Kim,M.D.<SUP>1<.SUP> and Young Hee Choi,M.D.<SUP>2<.SUP> 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.1
We report here on a case of diffuse sclerosing papillary carcinoma (DSPC), which is a subtype of papillary carcinoma of thyroid, in a 27-year-old female. The ultrasound images showed diffuse enlargement of the thyroid lobes and this was associated with underlying diffuse scattered microcalcifications and a heterogeneous hypoechoic background parenchyma that was without any masses. The CT image showeddiffuse scattered dot-like hyperdensities with bilateral multiple metastastic lymph nodes. Because making the cytological diagnosis of DSPC is still challenging, the radiological findings that show this disease's characteristic features may be important clues for making the correct diagnosis. <B>(Ko</B><B></B><B>rean J Endocrine Surg 2008;8:43-47)</B>