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Muranaka, Tetsuhito,Yuki, Satoshi,Komatsu, Yoshito,Sawada, Kentaro,Harada, Kazuaki,Kawamoto, Yasuyuki,Nakatsumi, Hiroshi,Sakamoto, Naoya The Korean Gastric Cancer Association 2016 Journal of gastric cancer Vol.16 No.3
Purpose: The International Organization for Standardization-5fluorouracil (FU) 10 trial found that bolus 5-FU and l-leucovorin was not inferior to S-1 in the treatment of gastric cancer (GC). Continuous 5-FU and the rapid injection of 5-FU have different anti-cancer effects. Thus, bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. Materials and Methods: We retrospectively analyzed the medical records of all patients with S-1 or capecitabine-resistant, unresectable, or recurrent GC treated with bolus 5-FU and l-leucovorin between January 2010 and December 2015 at Hokkaido University Hospital. The bolus 5-FU and l-leucovorin regimen consisted of intravenous l-leucovorin ($250mg/m^2/2h$) and bolus 5-FU ($600mg/m^2$) administered once weekly followed by a 2-week rest period; each cycle was repeated every 8 weeks. Results: A total of 14 patients were identified. The disease control rate was 35.7%. The median progression-free survival was 1.6 months (95% confidence interval [CI], 1.3~2.0 months), and the median overall survival was 6.3 months (95% CI, 4.7~7.9 months). No patient died from treatment-related causes. The most common severe adverse event associated with bolus 5-FU and l-leucovorin was neutropenia, which occurred in 21.4% of patients. Conclusions: Bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. We are planning a multi-center prospective phase II trial to evaluate the efficacy and safety of bolus 5-FU and l-leucovorin treatment for pre-treated unresectable or recurrent GC to confirm the results of this limited, retrospective study.
Tetsuhito Muranaka,Yoshito Komatsu,Satoshi Yuki,Kentaro Sawada,Kazuaki Harada,Yasuyuki Kawamoto,Hiroshi Nakatsumi,Naoya Sakamoto 대한위암학회 2016 Journal of gastric cancer Vol.16 No.3
Purpose: The International Organization for Standardization-5fluorouracil (FU) 10 trial found that bolus 5-FU and l-leucovorin was not inferior to S-1 in the treatment of gastric cancer (GC). Continuous 5-FU and the rapid injection of 5-FU have different anti-cancer effects. Thus, bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. Materials and Methods: We retrospectively analyzed the medical records of all patients with S-1 or capecitabine-resistant, unresectable, or recurrent GC treated with bolus 5-FU and l-leucovorin between January 2010 and December 2015 at Hokkaido University Hospital. The bolus 5-FU and l-leucovorin regimen consisted of intravenous l-leucovorin (250 mg/m2/2 h) and bolus 5-FU (600 mg/m2) administered once weekly followed by a 2-week rest period; each cycle was repeated every 8 weeks. Results: A total of 14 patients were identified. The disease control rate was 35.7%. The median progression-free survival was 1.6 months (95% confidence interval [CI], 1.3~2.0 months), and the median overall survival was 6.3 months (95% CI, 4.7~7.9 months). No patient died from treatment-related causes. The most common severe adverse event associated with bolus 5-FU and lleucovorin was neutropenia, which occurred in 21.4% of patients. Conclusions: Bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. We are planning a multi-center prospective phase II trial to evaluate the efficacy and safety of bolus 5-FU and l-leucovorin treatment for pre-treated unresectable or recurrent GC to confirm the results of this limited, retrospective study.
T. Muranaka,T. Uehara,T. Sakano,Y. Nabetani,T. Akitsu,T. Kato,T. Matsumoto,S. Hagihara,O. Abe,S. Hiraki,Y. Fujikawa 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5
Ga-doped zinc-oxide (GZO) films grown at various Ga/Zn supply ratios were prepared on glass substrates by using plasma-assisted molecular beam deposition. The films were carefully characterized by using Hall, X-ray diffraction (XRD) and transmission electron microscopy (TEM) measurements. At low Ga/Zn supply ratios, the carrier density systematically increased with increasing Ga/Zn supply ratio. However, a saturation of the carrier density near 4 − 6 × 1020 cm−3 was observed when the Ga/Zn supply ratio was in the range from 5 × 10−5 % to 0.5 %. From TEM observations, uniform crystal grains were observed to grow with low-angle tilt grain boundaries in GZO films with low doping. On the other hand, high-angle tilt grain boundaries were observed in the highly-doped GZO films. A detailed selected area electron diffraction (SAED) analysis revealed that such non-uniformity in the highly-doped GZO films appears during the initial growth stage.
T. Muranaka,A. Nisii,T. Uehara,T. Sakano,Y. Nabetani,T. Akitsu,T. Kato and T. Matsumoto,T. Matsumoto,S. Hagihara,O. Abe,S. Hiraki,Y. Fujikawa 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5
Ga-doped zinc-oxide (GZO) films grown under various Ga/Zn supply ratios were carefully characterized by using Hall measurements and optical transmittance measurements to investigate the electrical and the optical properties of the GZO films on glass, polyethylene terephthalate (PET), and polycarbonate (PC) substrates. The resistivity of the GZO films grown at 290 ℃ on glass substrates ranged from 4 × 10-2 cm to 3 × 10-4 cm for Ga/Zn supply ratios from 0 % to 0.5 %. The growth of the GZO films at a low temperature of 90 ℃ was also performed on glass, PET, and PC substrates. When the Ga/Zn supply ratios were 0.05 - 0.1 %, the 90 ℃-grown GZO films on glass substrates showed resistivities similar to those of 290 ℃-grown GZO films. The 90 ℃-grown GZO films on PET and PC substrates showed resistivities of 1 × 10-3 cm and 4 × 10-4 cm, respectively. The Hall carrier density was 8 × 1020 cm-3, which was almost the same value as that of the 90 ℃-grown GZO films on glass substrates. The GZO films on PET and PC substrates also showed visible transparency as good as that of the GZO films on glass substrates, and the average transmittance in the visible region was higher than 85 %.
Influence of work and family environments on burnout among emergency medical technicians
Haruna Junpei,Uemura Shuji,Taguchi Yukiko,Muranaka Saori,Niiyama Sachi,Inamura Hirotoshi,Sawamoto Keigo,Mizuno Hirotoshi,Narimatsu Eichi 대한응급의학회 2023 Clinical and Experimental Emergency Medicine Vol.10 No.3
Objective: Burnout among emergency medical technicians is a serious problem affecting delivery of quality emergency medical services. Although the repetitive nature of the job and lower education level requirements for technicians have been reported as risk factors, little is known about the influence of burden of responsibility, degree of supervisor support, and home environment on burnout among emergency medical technicians. This study aimed to test the hypothesis that burden of responsibility, degree of supervisor support, and home environment increase burnout probability. Methods: A web-based survey was conducted among emergency medical technicians in Hokkaido, Japan from July 26, 2021 to September 13, 2021. A total of 21 facilities were randomly selected from 42 fire stations. Prevalence of burnout was measured using the Maslach Burnout-Human Services Survey Inventory (MBI-HSS). Burden of responsibility was measured using a visual analog scale. Occupational background was also measured. Supervisor support was measured using the Brief Job Stress Questionnaire (BJSQ). Family-work negative spillover was measured using the Japanese version of Survey Work–Home Interaction–NijmeGen (SWING). The cutoff value for burnout syndrome was defined as emotional exhaustion≥27 and/or depersonalization≥10. Results: A total of 700 survey respondents were included, and 27 surveys with missing data were excluded. The suspected burnout frequency was 25.6%. Covariates were adjusted using multilevel logistic regression model analysis. Low supervisor support (odds ratio, 1.421; 95% confidence interval, 1.136–1.406; P<0.001) and high family-work negative spillover (odds ratio, 1.264; 95% confidence interval, 1.285–1.571; P<0.001) were independent factors associated with higher probability of burnout. Conclusion: This study indicated that focusing on improvement of supervisor support for emergency medical technicians and creating supportive home environments may assist in reducing burnout frequency.
Magneto-Optical Properties of ZnMnSe-ZnSe-ZnCdSe Quantum Structures
T. Kato and T. Matsumoto,M. Ito,M. Tajima,K. Omori,T. Muranaka,Y. Nabetani,T. Matsumoto 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5
We have studied the circularly polarized photoluminescence (PL) and reflectance properties of a series of ZnSe/ZnCdSe/ZnSe/ZnMnSe single quantum wells (SQWs) and ZnSe/ZnCdSe/ ZnSe/ZnCdMnSe /ZnSe coupled double quantum wells (DQWs). The degree of circular polarization of the exciton luminescence from the ZnCdSe non-magnetic semiconductor (NMS) well was studied as a function of the spacer layer thickness and the exciton energies in the NMS and the diluted magnetic semiconductor (DMS) regions. The polarization degree became larger as the spacer thickness became smaller. The polarization also depended on the excito n energies in the NMS and the DMS regions and became larger as the exciton energy in the nCdSe well became closer to that in the DMS layer or the DMS well.
Choi, Hyunju,Ohyama, Kiyoshi,Kim, Yu-Young,Jin, Jun-Young,Lee, Saet Buyl,Yamaoka, Yasuyo,Muranaka, Toshiya,Suh, Mi Chung,Fujioka, Shozo,Lee, Youngsook American Society of Plant Biologists 2014 The Plant cell Vol.26 No.1
<P>This work identified two ABC transporters important for normal pollen coat deposition and, thus, critical for pollen fitness. The transporters are probably involved in the transfer of pollen coat material from maternal tissues to the pollen surface.</P>
Identification of marneral synthase, which is critical for growth and development in Arabidopsis
Go, Young S.,Lee, Saet B.,Kim, Hae J.,Kim, Jungmook,Park, Hyo‐,Young,Kim, Jeong‐,Kook,Shibata, Kyomi,Yokota, Takao,Ohyama, Kiyoshi,Muranaka, Toshiya,Arseniyadis, Simé,on,Suh, Mi C. Blackwell Publishing Ltd 2012 The Plant journal Vol.72 No.5
<P><B>Summary</B></P><P>Plants produce structurally diverse triterpenoids, which are important for their life and survival. Most triterpenoids and sterols share a common biosynthetic intermediate, 2,3‐oxidosqualene (OS), which is cyclized by 2,3‐oxidosqualene cyclase (OSC). To investigate the role of an OSC, marneral synthase 1 (MRN1), <I>in planta</I>, we characterized a Arabidopsis <I>mrn1</I> knock‐out mutant displaying round‐shaped leaves, late flowering, and delayed embryogenesis. Reduced growth of <I>mrn1</I> was caused by inhibition of cell expansion and elongation. Marnerol, a reduced form of marneral, was detected in Arabidopsis overexpressing <I>MRN</I>1, but not in the wild type or <I>mrn1</I>. Alterations in the levels of sterols and triterpenols and defects in membrane integrity and permeability were observed in the <I>mrn1</I>. In addition, GUS expression, under the control of the <I>MRN1</I> gene promoter, was specifically detected in shoot and root apical meristems, which are responsible for primary growth, and the mRNA expression of Arabidopsis clade II OSCs was preferentially observed in roots and siliques containing developing seeds. The eGFP:MRN1 was localized to the endoplasmic reticulum in tobacco protoplasts. Taken together, this report provides evidence that the unusual triterpenoid pathway via marneral synthase is important for the growth and development of Arabidopsis.</P>