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Kazuaki Yamagiwa,Yuji Tanabe,Shuji Harada,Tadaaki Shimizu,Tetsuo Oka 한국공학교육학회 2012 공학교육연구 Vol.15 No.5
Faculty of engineering, Niigata University has been executing start-up engineering education programs for the first-year students to educate his or her ability to solve engineering problems. They are divided into teams and tackle a task that they expect to easily accomplish. The expected results are hardly obtained. Then they try to seek the gap between the results and their knowledge. They analyze the phenomena and improve the approach. They evaluate the results of second trial and the effectiveness of the measures. That is, the project requires so-called PDCA cycles for students to solve engineering problems. The start-up engineering project is one of the compulsory subjects and seven departments have given the students several tasks based on their technicality. The students exchange their knowledge, ideas and learn how to use knowledge to solve the problems. Their reports and questionnaire survey proved that the projects are highly effective to improve his or her ability to solve engineering problems and give them strong motivation to learn engineering. We introduce the some tasks and the outcomes of the projects set by seven departments; mechanical and production engineering, electrical and electronic engineering, information engineering, biocybernetics, chemistry and chemical engineering, civil engineering and architecture, and material science and engineering.
Yamagiwa, Kazuaki,Tanabe, Yuji,Harada Shuji,Shimizu Tadaaki,Oka Tetsuo 한국공학교육학회 2012 공학교육연구 Vol.15 No.5
Faculty of engineering, Niigata University has been executing start-up engineering education programs for the first-year students to educate his or her ability to solve engineering problems. They are divided into teams and tackle a task that they expect to easily accomplish. The expected results are hardly obtained. Then they try to seek the gap between the results and their knowledge. They analyze the phenomena and improve the approach. They evaluate the results of second trial and the effectiveness of the measures. That is, the project requires so-called PDCA cycles for students to solve engineering problems. The start-up engineering project is one of the compulsory subjects and seven departments have given the students several tasks based on their technicality. The students exchange their knowledge, ideas and learn how to use knowledge to solve the problems. Their reports and questionnaire survey proved that the projects are highly effective to improve his or her ability to solve engineering problems and give them strong motivation to learn engineering. We introduce the some tasks and the outcomes of the projects set by seven departments; mechanical and production engineering, electrical and electronic engineering, information engineering, biocybernetics, chemistry and chemical engineering, civil engineering and architecture, and material science and engineering.
Seunghee Hong,Seiya Harada,Kazuaki Onoue,Byungchan Min,Keisuke Suzuki,Shun'ichi Doi 대한인간공학회 2012 대한인간공학회 학술대회논문집 Vol.2012 No.5
A major cause of traffic accidents has been found in the human factors involved in driver's awareness during driving, and the effect of alarm was reported as the increase of awareness and the improving effect for property of perception, cognition and judgment of the driver. The arousal stimulus for driver by auditory-visual alert also affects to the physiological condition and the autonomic nervous system (ANS). Recent developments in multi near-infrared spectroscopy (MNIRS) have enabled the arousal level apparent with brain activity by measurement of hemoglobin concentrations as cerebral blood volume, as well as the ordinary biological signals like heart beats, finger plethysmogram and pulsation waves. In this study, the three kinds of auditory alert as pre-information, sound alert and voice guidance were used for adaptive assisting systems for the elderly driver and the influence of these alerts on the driver's psychosomatic state was examined using driving simulator for 30 minutes driving. Experiment was conducted with the subjects in a driving position as they were partially awakened by auditory-visual alert, repeatedly and measured their biological properties. As the results, after taking the effects of the adaptive assisting alert systems, the effect of arousal and awareness improvement was recognized in the subjects and the activation of cerebral blood volume was observed according to the amount of the stimulus and combination of awareness modal as auditory alert system.
Kepler, Ryan M.,Sung, Gi-Ho,Harada, Yukio,Tanaka, Kazuaki,Tanaka, Eiji,Hosoya, Tsuyoshi,Bischoff, Joseph F.,Spatafora, Joseph W. Wiley (John WileySons) 2012 American journal of botany Vol.99 No.3
<P>This research seeks to advance understanding of conditions allowing movement of fungal pathogens among hosts. The family Clavicipitaceae contains fungal pathogens exploiting hosts across three kingdoms of life in a pattern that features multiple interkingdom host shifts among plants, animals, and fungi. The tribe Ustilaginoideae potentially represents a third origin of plant pathogenesis, although these species remain understudied. Fungal pathogens that cause ergot are linked morphologically with Clavicipitaceae, but are not yet included in phylogenetic studies. The placement of Ustilaginoideae and ergot pathogens will allow differentiation between the host habitat and host relatedness hypotheses as mechanisms of phylogenetic diversification of Clavicipitaceae.</P>
Yoshihide Kanno,Tetsuya Ohira,Yoshihiro Harada,Shinsuke Koshita,Takahisa Ogawa,Hiroaki Kusunose,Yoshiki Koike,Taku Yamagata,Toshitaka Sakai,Kaori Masu,Keisuke Yonamine,Kazuaki Miyamoto,Megumi Tanaka,T 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.3
Background/Aims: The aim of this study was to evaluate the safety of sedation with propofol as an alternative to benzodiazepinedrugs in outpatient endoscopy. Methods: In this prospective study, examinees who underwent outpatient endoscopy under propofol sedation and submitted a nextdayquestionnaire with providing informed consent were evaluated. Periprocedural acute responses, late adverse events within 24hours, and examinee satisfaction were evaluated. Results: Among the 4,122 patients who received propofol in the 17,978 outpatient-based endoscopic examinations performedbetween November 2016 and March 2018, 2,305 eligible examinees (esophagogastroduodenoscopy for 1,340, endoscopicultrasonography for 945, and total colonoscopy for 20) were enrolled, and their responses to a questionnaire were analyzed. Themean propofol dose was 69.6±24.4 mg (range, 20–200 mg). Diazepam, midazolam, and/or pentazocine in combination withpropofol was administered to 146 examinees. Mild oxygen desaturation was observed in 59 examinees (2.6%); and mild bradycardia,in 2 (0.09%). Other severe reactions or late events did not occur. After eliminating 181 invalid responses, 97.7% (2,065/2,124) of thepatients desired propofol sedation in future examinations. Conclusions: Propofol sedation was found to be safe-without severe adverse events or accidents-for outpatient endoscopy on thebasis of the patients’ next-day self-evaluation. Given the high satisfaction level, propofol sedation might be an ideal tool for painlessendoscopic screening.
Tetsuhito Muranaka,Yoshito Komatsu,Satoshi Yuki,Kentaro Sawada,Kazuaki Harada,Yasuyuki Kawamoto,Hiroshi Nakatsumi,Naoya Sakamoto 대한위암학회 2016 Journal of gastric cancer Vol.16 No.3
Purpose: The International Organization for Standardization-5fluorouracil (FU) 10 trial found that bolus 5-FU and l-leucovorin was not inferior to S-1 in the treatment of gastric cancer (GC). Continuous 5-FU and the rapid injection of 5-FU have different anti-cancer effects. Thus, bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. Materials and Methods: We retrospectively analyzed the medical records of all patients with S-1 or capecitabine-resistant, unresectable, or recurrent GC treated with bolus 5-FU and l-leucovorin between January 2010 and December 2015 at Hokkaido University Hospital. The bolus 5-FU and l-leucovorin regimen consisted of intravenous l-leucovorin (250 mg/m2/2 h) and bolus 5-FU (600 mg/m2) administered once weekly followed by a 2-week rest period; each cycle was repeated every 8 weeks. Results: A total of 14 patients were identified. The disease control rate was 35.7%. The median progression-free survival was 1.6 months (95% confidence interval [CI], 1.3~2.0 months), and the median overall survival was 6.3 months (95% CI, 4.7~7.9 months). No patient died from treatment-related causes. The most common severe adverse event associated with bolus 5-FU and lleucovorin was neutropenia, which occurred in 21.4% of patients. Conclusions: Bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. We are planning a multi-center prospective phase II trial to evaluate the efficacy and safety of bolus 5-FU and l-leucovorin treatment for pre-treated unresectable or recurrent GC to confirm the results of this limited, retrospective study.
Muranaka, Tetsuhito,Yuki, Satoshi,Komatsu, Yoshito,Sawada, Kentaro,Harada, Kazuaki,Kawamoto, Yasuyuki,Nakatsumi, Hiroshi,Sakamoto, Naoya The Korean Gastric Cancer Association 2016 Journal of gastric cancer Vol.16 No.3
Purpose: The International Organization for Standardization-5fluorouracil (FU) 10 trial found that bolus 5-FU and l-leucovorin was not inferior to S-1 in the treatment of gastric cancer (GC). Continuous 5-FU and the rapid injection of 5-FU have different anti-cancer effects. Thus, bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. Materials and Methods: We retrospectively analyzed the medical records of all patients with S-1 or capecitabine-resistant, unresectable, or recurrent GC treated with bolus 5-FU and l-leucovorin between January 2010 and December 2015 at Hokkaido University Hospital. The bolus 5-FU and l-leucovorin regimen consisted of intravenous l-leucovorin ($250mg/m^2/2h$) and bolus 5-FU ($600mg/m^2$) administered once weekly followed by a 2-week rest period; each cycle was repeated every 8 weeks. Results: A total of 14 patients were identified. The disease control rate was 35.7%. The median progression-free survival was 1.6 months (95% confidence interval [CI], 1.3~2.0 months), and the median overall survival was 6.3 months (95% CI, 4.7~7.9 months). No patient died from treatment-related causes. The most common severe adverse event associated with bolus 5-FU and l-leucovorin was neutropenia, which occurred in 21.4% of patients. Conclusions: Bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. We are planning a multi-center prospective phase II trial to evaluate the efficacy and safety of bolus 5-FU and l-leucovorin treatment for pre-treated unresectable or recurrent GC to confirm the results of this limited, retrospective study.