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High precision integration for dynamic structural systems with holonomic constraints
Liu, Xiaojian,Begg, D.W.,Devane, M.A.,Zhong, Wanxie Techno-Press 1997 Structural Engineering and Mechanics, An Int'l Jou Vol.5 No.3
This paper presents a high precision integration method for the dynamic response analysis of structures with holonomic constraints. A detail recursive scheme suitable for algebraic and differential equations (ADEs) which incorporates generalized forces is established. The matrix exponential involved in the scheme is calculated precisely using $2^N$ algorithm. The Taylor expansions of the nonlinear term concerned with state variables of the structure and the generalized constraint forces of the ADEs are derived and consequently, their particular integrals are obtained. The accuracy and effectiveness of the present method is demonstrated by two numerical examples, a plane truss with circular slot at its tip point and a slewing flexible cantilever beam which is currently interesting in optimal control of robot manipulators.
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Caibao Jin,Xiaojian Zhu,Min Xiao,Songya Liu,Xian Liu,Jingjing Liu,Xiuwen Xu,Shujuan Yi,Li Meng 대한진단검사의학회 2018 Annals of Laboratory Medicine Vol.38 No.2
Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by a reciprocal translocation between the long arms of chromosomes 9 and 22, resulting in the formation of a Philadelphia (Ph) chromosome. Most chimeric BCR-ABL1 fusion transcripts are e13a2(b2a2) or e14a2(b3a2), encoding a 210-kDa protein, p210, but some are a e1a2 transcript or e19a2 transcript encoding a 190-kDa protein or a 230-kDa protein, respectively [1]
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Jiang, Changbo,Liu, Xiaojian,Yao, Yu,Deng, Bin The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.1
To improve our current understanding of tsunami-like solitary waves interacting with a row of vertical slotted piles on a sloping beach, a 3D numerical wave tank based on the CFD tool $OpenFOAM^{(R)}$ was developed in this study. The Navier-Stokes equations were employed to solve the two-phase incompressible flow, combining with an improved VOF method to track the free surface and a LES model to resolve the turbulence. The numerical model was firstly validated by our laboratory measurements of wave, flow and dynamic pressure around both a row of piles and a single pile on a slope subjected to solitary waves. Subsequently, a series of numerical experiments were conducted to analyze the breaking wave force in view of varying incident wave heights, offshore water depths, spaces between adjacent piles and beach slopes. Finally, a slamming coefficient was discussed to account for the breaking wave force impacting on the piles.
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Changbo Jiang,Xiaojian Liu,Yu Yao,Bin Deng 대한조선학회 2019 International Journal of Naval Architecture and Oc Vol.11 No.1
To improve our current understanding of tsunami-like solitary waves interacting with a row of vertical slotted piles on a sloping beach, a 3D numerical wave tank based on the CFD tool OpenFOAM® was developed in this study. The Navier-Stokes equations were employed to solve the two-phase incompressible flow, combining with an improved VOF method to track the free surface and a LES model to resolve the turbulence. The numerical model was firstly validated by our laboratory measurements of wave, flow and dynamic pressure around both a row of piles and a single pile on a slope subjected to solitary waves. Subsequently, a series of numerical experiments were conducted to analyze the breaking wave force in view of varying incident wave heights, offshore water depths, spaces between adjacent piles and beach slopes. Finally, a slamming coefficient was discussed to account for the breaking wave force impacting on the piles.
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Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression
Huiqin Feng,Xiaojian Liu 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.6
Purpose: Gastric cancer (GC) has a very poor prognosis when diagnosed at a late stage. Acyl-CoA thioesterase 7 (ACOT7) is a major isoform of the acyl coenzyme family that catalyzes the hydrolysis of fatty acyl-CoAs into unesterified free fatty acid and coenzyme A. The purpose of this study was to investigate the expression levels of ACOT7 in GC and mechanisms related therewith. Materials and Methods: Screening of systematic biology studies revealed ACOT7 as a key gene in GC, as well as involvement of the long non-coding RNA NMRAL2P in ACOT7 expression. In this study, GC tissues and adjacent tissue samples were obtained from 10 GC patients at the Department of Gastrointestinal Surgery. GES1 and SGC-7901 cells were collected and treated to silence ACOT7 and overexpress NMRAL2P. The expressions of ACOT7 and NMRAL2P were detected by real-time quantitative PCR and Western blot. Additionally, cell proliferation, apoptosis, migration, and invasion were examined. Results: ACOT7 was upregulated in gastric tumor tissues and GC cell lines. ACOT7 gene silencing induced a less malignant phenotype and was closely correlated to reduced cell proliferation and migration, altered cell cycle, and increased apoptosis. Furthermore, NMRAL2P was downregulated in tumor tissues and GC cell lines. NMRAL2P overexpression induced a more malignant phenotype and significantly inhibited the expression of ACOT7. Importantly, NMRAL2P indirectly methylated ACOT7 by binding to DNMT3b, thereby suppressing ACOT7 expression. Conclusion: NMRAL2P activation suppresses ACOT7 expression in GC. Thus, ACOT7 could be a promising target for the treatment of GC.
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Jun Wang,Weiqing Liu,Lu Wang,Xiaojian Han 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.56 No.6
In this paper, a new approach based on the continuum model is proposed to estimate the main cable tension force of suspension bridges from measured natural frequencies. This approach considered the vertical vibration of a main cable hinged at both towers and supported by an elastic girder and hangers along its entire length. The equation reflected the relationship between vibration frequency and horizontal tension force of a main cable was derived. To avoid to generate the additional cable tension force by sagextensibility, the analytical solution of characteristic equation for anti-symmetrical vibration mode of the main cable was calculated. Then, the estimation of main cable tension force was carried out by antisymmetric characteristic frequency vector. The errors of estimation due to characteristic frequency deviations were investigated through numerical analysis of the main cable of Taizhou Bridge. A field experiment was conducted to verify the proposed approach. Through measuring and analyzing the responses of a main cable of Taizhou Bridge under ambient excitation, the horizontal tension force of the main cable was identified from the first three odd frequencies. It is shown that the estimated results agree well with the designed values. The proposed approach can be used to conduct the long-term health monitoring of suspension bridges.
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Shuyou Zhang,Ci He,Xiaojian Liu,Jinghua Xu,Yanqiang Sun 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.12
This paper focuses on optimization of kinematic chain to reduce force-induced error in the scheme design phase of a fiveaxis machine tool. After conducting process planning on the machining target, local deformation of motion units in cutting positions is considered using a geometric way. A mathematical model is then established describing the influence of local deformation error on the general machining error through homogeneous transformation matrices. Conceptual model of the machine tool is constructed to obtain deformation distribution using static FEA. Error sensitivity coefficients are then calculated and compared among all alternative kinematic chains to select the optimized scheme. The proposed method is verified through a designing example of a fi ve-axis vertical machining center. The optimized kinematic chain could lower the magnitude of deformation sensitivities by 9.69% and increase error equalization variance by 71.25% compared to the conventional method.
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Wang Caicheng,Wang Zili,Zhang Shuyou,Liu Xiaojian,Tan Jianrong 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.3
With light weight, high strength, and high performance, metal bent tubes have attracted increasing applications in aeronautics. However, the growing demand for customized tubular parts has led to a significant increase in the cost of conventional tube-bending processes, as they can only process tubes of a specific diameter. To this end, this paper proposes a variable diameter die (VDD) scheme which can bend tubes with a specific range of diameters. To investigate the formability of VDD-processed tubes for practical VDD applications, an accurate and reliable prediction method of cross-sectional distortion is imperative. Hence, we pioneer a novel intelligent model based on quantum-behaved particle swarm optimization (QPSO)-optimized back-propagation neural network (BPNN) to predict a rational cross-sectional distortion characterization index: average distortion rate. The adaptive adjustment of coefficients and the Gaussian distributed random vector are introduced to QPSO, which balance the search and enhance the diversity of the population, respectively. For further improvement in optimization performance, the informed initialization strategy is applied to QPSO. The efficiency of the proposed reinforced QPSO (RQPSO)-optimized BPNN model is evaluated by comparing the results with those of the BPNN, BPNN with Xavier initialization, several different particle swarm optimization variants-optimized BPNN models, and variants of popular machine learning models. The results indicated the superiority of RQPSO over other methods in terms of the coefficient of determination (${R}^2$), variance account for, root mean square error (MSE), mean absolute error, and standard deviation of MSE. Thus, the proposed novel algorithm could be employed as a reliable and accurate technique to predict the cross-sectional distortion of VDD-processed tubes.
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Ci He,Shuyou Zhang,Lemiao Qiu,Zili Wang,Xiaojian Liu 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.11
Virtual prototypes have been appealing in the early design stage of computer aided tolerancing, because it is less expensive to evaluate and modify tolerances numerically. Derived from the machining processes, form uncertainties are simulated, controlled and analyzed in virtual prototypes using parametric and intuitive surface patches. The generation of a complete virtual prototype often involves combining surface patches with different patterns to one complete model. To overcome possible geometric defects in this process, a surface merging method is proposed in this paper. Skin Model Shapes is first introduced as the geometric foundation. The whole part surface is segmented based on the geometric shape and machining type. Then point-based patches are generated accordingly. Interpolation implicit surfaces based on radial basis function networks are constructed in patch boundaries based on spatial-constrained homogeneous transformation matrices. A feature augmentation process is then introduced to preserve processing features after resampling the blend patch. The proposed method is proved to be efficient in feature retaining as well as surface smoothing, through numerical experiments and analysis on an example mechanical part. The results show that the generated virtual prototype would become 62.5% more smooth while retaining a 91.6% feature similarity after using the proposed method. Moreover, the proposed method could preserve 174% more features at a cost of 9.0% smoothness than using a conventional modified trimmed filtering method.
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Wen Zhang,Ruizhu Lin,Zhikun Lu,Huiying Sheng,Yi Xu,Xiuzhen Li,Jing Cheng,Yanna Cai,Xiaojian Mao,Li Liu 대한소아소화기영양학회 2020 Pediatric gastroenterology, hepatology & nutrition Vol.23 No.6
Purpose: Progressive familial intrahepatic cholestasis (PFIC) is a rare genetic autosomal recessive disease caused by mutations in ATP8B1, ABCB11 or ABCB4. Mutational analysis of these genes is a reliable approach to identify the disorder. Methods: We collected and analyzed relevant data related to clinical diagnosis, biological investigation, and molecular determination in nine children carrying these gene mutations, who were from unrelated families in South China. Results: Of the nine patients (five males, four females) with PFIC, one case of PFIC1, four cases of PFIC2, and four cases of PFIC3 were diagnosed. Except in patient no. 8, jaundice and severe pruritus were the major clinical signs in all forms. γ-glutamyl transpeptidase was low in patients with PFIC1/PFIC2, and remained mildly elevated in patients with PFIC3. We identified 15 different mutations, including nine novel mutations (p.R470HfsX8, p.Q794X and p.I1170T of ABCB11 gene mutations, p.G319R, p.A1047P, p.G1074R, p.T830NfsX11, p.A1047PfsX8 and p.N1048TfsX of ABCB4 gene mutations) and six known mutations (p.G446R and p.F529del of ATP8B1 gene mutations, p.A588V, p.G1004D and p.R1057X of ABCB11 gene mutations, p.P479L of ABCB4 gene mutations). The results showed that compared with other regions, these three types of PFIC genes had different mutational spectrum in China. Conclusion: The study expands the genotypic spectrum of PFIC. We identified nine novel mutations of PFIC and our findings could help in the diagnosis and treatment of this disease.
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