A Novel Selenium- and Copper-Containing Peptide with Both Superoxide Dismutase and Glutathione Peroxidase Activities

Xian Feng Zou,Yue Tong Ji,Gui Gao,Xue Jun Zhu,Shao Wu Lv,Fei Yan,Si Ping Han,Xing Chen,Chang Cheng Gao,Jun Qiu Liu,Gui Min Luo 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.1

Clinical and Prognostic Significance of SOX11 in Breast Cancer

Liu, Dao-Tong,Peng-Zhao, Peng-Zhao,Han, Jing-Yan,Lin, Fan-Zhong,Bu, Xian-Min,Xu, Qing-Xia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Recently, the transcription factor SOX11 has gained extensive attention as a diagnostic marker in a series of cancers. However, to date, the possible roles of SOX11 in breast cancer has not been investigated. In this study, immunohistochemical staining for SOX11 was performed for 116 cases of breast cancer. Nuclear SOX11 was observed in 42 (36.2%) and cytoplasmic SOX11 in 52 (44.8%) of breast cancer samples. Moreover, high expression of cytoplasmic and nuclear SOX11 was associated with clinicopathological factors, including earlier tumor grade, absence of lymph node metastasis and smaller tumor size. Kaplan-Meier survival curves demonstrated high nuclear SOX11 expression to be associated with more prolonged overall survival than those with low expression and it could be an independent predictor of survival for breast cancer patients. It is worthwhile to note that cytoplasmic SOX11 was not correlated with prognosis of breast cancer patients. These data suggest the possibility that nuclear SOX11 could be as a potential target for breast cancer therapy.

Quality improvement effects of electrolyzed water on rice noodles prepared with semidry-milled rice flours

Rui Liu,Zhang-Long Yu,Yuan-Lin Sun,Li-Tao Tong,Li-Ya Liu,Li-Li Wang,Xian-Rong Zhou,Su-Mei Zhou 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.6

To investigate the effects of electrolyzed watertreatment on the qualities of rice noodles prepared withsemidry- milled rice flour, pasting properties and thermalproperties of rice flour, and the cooking and texturalproperties of rice noodles were determined. Higher peakviscosity and lower melting enthalpy were observed inelectrolyzed water (EW) treated rice flour. The hardness,gumminess and chewiness of rice noodle in slightly acidicelectrolyzed water treated rice noodles with availablechlorine concentration (ACC) 20.32 mg/L were increasedsignificantly (p\0.05). The cooking loss decreased significantlyin strong acidic electrolyzed water treated noodleswith ACC 10.09 mg/L treatment (p\0.05). Theresults indicated that EW could promote the gelatinizationof rice flour, and improve the textural qualities of ricenoodles. Therefore EW was appropriate to be used in ricenoodle production.

中国证券法上短线交易的法律规制

李鲜花 ( Li Xian-hua ),刘秋彤 ( Liu Qiu-tong ) 건국대학교 법학연구소 2020 一鑑法學 Vol.0 No.46

자본시장의 발전에 따라 증권거래상의 부당거래행위도 증가하고 있는데, 회사 내부자의 미공개 중요정보이용행위를 규제하기 위하여 중국 증권법 상에서는 단기매매차익회수제도를 도입하고 있다. 이와 같은 제도는 증권시장의 건전한 발전과 투자자보호를 위하여 긍정적인 역할을 하고 있다. 중국 2019년 신 증권법에서는 단기매매차익회수규정에 대하여 비교적 큰 개정을 하였는데, 본 고에서는 신 증권법상의 해당 규정과 결부하여 아래와 같은 내용을 살펴보기로 한다. 첫째, 신구 증권법 상의 해당 규정을 비교하면서 단기매매차익반환의 규제대상·객체·객관요건·귀책사유 등과 결부하여 중국의 단기매매차익 회수요건에 대한 법적 및 이론적 요건들을 분석하였다. 둘째, 단기매매 차익회수권의 행사에 관한 현재 여러 가지 수익확정방식과 행사기간에 관한 주장들을 정리하고 이에 대한 저자의 주장을 제시하고 있다. 또한 이 부분에서는 중국 입법상 단기매매차익의 행사절차와 관련하여 최근의 “전국 법원 민상사재판업무회의개요” 제25조 주주대표소송의 해당 규정과 결부하여 단기매매차익회수절차에 관한 여러가지 문제점과 최근의 입법동향을 분석하고 있다. 셋째, 중국 신 증권법상 단기매매차익회수의 적용예외에 관한 규정을 살펴보았다. 2019년 신 증권법 제44조에서는 “국무원 증권감독관리기구에서 규정한 기타 상황”에 적용예외를 둔다고 처음으로 명확히 규정하였다. 이와 같은 규정은 실무 상의 요구를 반영하였고, 나중에 구체적인 규정에 두는데 전제를 마련하였다. 본 고에서는 중국의 실제 상황과 입법을 분석하고 미국의 실무경험과 입법을 참고한 기초 상에서 단기거래차익반환의 예외 규정을 구체화할 것을 제안하고 있다. 마지막으로 본 고에서는 중국의 단기거래 법적규제에 관하여 총괄적인 평가를 하고 그 중 보완할 부분과 대책을 제시하고 있다. Due to the rapid development of the capital market economy, the internal personnel of the company are often affected by various factors such as interest driven, short-term trading phenomenon occurs frequently and is extremely harmful. Countries around the world have regulated this short-term trading behavior in succession, and the securities law of China has also carried out detailed regulations. The legal regulating of the short-term trading is a kind of deterrence insider to comply with the requirements of the law is forbidden to use the means of the position and damage the interest of the company, through the way of establishing deter mechanism to the legislative purpose of maintaining a fair and just market, enhance the confidence of investors, to guard against insider trading, promote the company’s business management and construct a green financial environment. This paper tries to compare the old and new “securities law” as the Angle of view, on the short-term trading in system as the research object, first introduced the related regulation of short-term trading legislation development, clear the relevant provisions of the new “securities law” for short-term trading to make major changes, and in the existing legal system, it puts forward the elements of the identification of short-term transactions, and defines short-term transactions from the subject, object, objective elements and the principle of liability. Second through the introduction of short-term trading in right to determine the trading behavior of yield calculation and compare different calculation during exercise way to select the most suitable one, can make our short-term trading regulation to mature, is conducive to protect the interests of the company is the most basic is to protect the basic rights of a company investors, combined with a new “securities law” the relevant provisions of, again to further in the exercise of right of procedure, including the national work conference on court in civil and commercial trial summary article 25 more detailed prepositional procedure of shareholder representative litigation rules, drawn to the trial practice of unity. In 2019 the new “securities law” the 44th increased “other circumstances stipulated by the securities regulatory agency under the State Council”, reflect the need of judicial practice, for our country specific reserved space saving type is determined, at the same time in the study and analysis of relevant legal system, on the basis of using the experience of the mature market in the United States put forward the perfect our short-term trading in saving Suggestions and countermeasures. In the last part, the author makes an analysis on the system of short-term trading earnings in China, points out the deficiencies and puts forward some Suggestions to improve the law in order to look forward to a more harmonious and fair market environment.

Significance of Caveolin-1 Regulators in Pancreatic Cancer

Chen, Tao,Liu, Liang,Xu, Hua-Xiang,Wang, Wen-Quan,Wu, Chun-Tao,Yao, Wan-Tong,Yu, Xian-Jun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Caveolin-1 is a scaffold protein on the cell membrane. As the main component of caveolae, caveolin-1 is involved in many biological processes that include substance uptake and transmembrane signaling. Many of these processes and thus caveolin-1 contribute to cell transformation, tumorigenesis, and metastasis. Of particular interest are the dual rolesof tumor suppressor and oncogene that caveolin-1 appear to play in different malignancies, including pancreatic cancer. Therefore, analyzing caveolin-1 regulators and understanding their mechanisms of actionis key to identifying novel diagnostic and therapeutic tools for pancreatic cancer. This review details the mechanisms of action of caveolin-1 regulators and the potential significance for pancreatic cancer treatment.

Identification of candidate odorant‐degrading enzyme genes in the antennal transcriptome of Aphidius gifuensis

Kang Zhi‐Wei,Liu Fang‐Hua,Xu Yong‐Yu,Cheng Jia‐Hui,Lin Xiao‐Li,Jing Xiang‐Feng,Tian Hong‐Gang,Liu Tong‐Xian 한국곤충학회 2021 Entomological Research Vol.51 No.1

Odorant‐degrading enzymes (ODEs) have been found in insect antennae and play a critical role in signal chemical degradation once the message is conveyed. Significant progress has been made in characterizing ODEs in a variety of pests but very little is known in their natural enemies. We have carried out an antennae‐ and sex‐specific transcriptome of Aphidius gifuensis, a natural enemy of aphid, to identify the candidate ODEs. Based on the antennae‐ and sex‐specific transcriptome, a total of 100 putative ODEs were identified including one aldehyde oxidase (AOX), four alcohol dehydrogenases (ADs), eight UDP‐glucuronosyltransferases (UGTs), 45 cytochrome P450 (P450s), nine glutathione S‐transferases (GSTs) and 40 carboxylesterases (CCEs or CXEs). Additionally, we used RT‐qPCR to determine the expression profiles of these genes in tissues of both sexes. Based on the phylogenic analysis and tissue‐expression patterns, AgifEstE4, AgifCXE3, AgifCCE4, AgifCCE7, and AgifCCE18 were suggested as key ODEs in A. gifuensis. In addition, the female or male specifically enriched genes, such as AgifCCE17, AgifEstB1, AgifCYP18a1, AgifUGT2C2, were also considered to involve in the chemosensory processing in A. gifuensis. This study not only identified the candidate ODEs in A. gifuensis but also provided source for further exploration of the molecular mechanisms of chemical signal transductions in A. gifuensis, as well as other hymenopteran species.

Refining and Validating a Two-stage and Web-based Cancer Risk Assessment Tool for Village Doctors in China

Shen, Xing-Rong,Chai, Jing,Feng, Rui,Liu, Tong-Zhu,Tong, Gui-Xian,Cheng, Jing,Li, Kai-Chun,Xie, Shao-Yu,Shi, Yong,Wang, De-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

The big gap between efficacy of population level prevention and expectations due to heterogeneity and complexity of cancer etiologic factors calls for selective yet personalized interventions based on effective risk assessment. This paper documents our research protocol aimed at refining and validating a two-stage and web-based cancer risk assessment tool, from a tentative one in use by an ongoing project, capable of identifying individuals at elevated risk for one or more types of the 80% leading cancers in rural China with adequate sensitivity and specificity and featuring low cost, easy application and cultural and technical sensitivity for farmers and village doctors. The protocol adopted a modified population-based case control design using 72, 000 non-patients as controls, 2, 200 cancer patients as cases, and another 600 patients as cases for external validation. Factors taken into account comprised 8 domains including diet and nutrition, risk behaviors, family history, precancerous diseases, related medical procedures, exposure to environment hazards, mood and feelings, physical activities and anthropologic and biologic factors. Modeling stresses explored various methodologies like empirical analysis, logistic regression, neuro-network analysis, decision theory and both internal and external validation using concordance statistics, predictive values, etc..

Cues of intraguild predators (Harmonia axyridis) and different temperatures alter foraging and oviposition strategies of the parasitoid Aphidius gifuensis

Yu Xing-Lin,Feng Yi,Liu Tong-Xian,Qiu Bao-Li 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.2

Organisms live in complex systems where they simultaneously balance responses to multiple factors. Insects are dealing with indirect pressures from predators under the influence of temperature. Currently, little is known about how they balance these factors. Under laboratory conditions, we investigated the effects of the predator Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae) cues and temperature (23, 28, and 33 ◦ C) on the foraging and oviposition behavior of the parasitoid Aphidius gifuensis Ashmead (Hymenoptera: Braconidae) using the aphid Myzus persicae (Sulzer) (Hemiptera: Aphididae) as a host. In all trials, the frequency and duration of stinging, walking, or stationary behavior of A. gifuensis were not influenced by H. axyridis cues. However, in trials with predator cues, A. gifuensis produced less offspring than trials without predator cues. On the other hand, the frequency of A. gifuensis stinging, walking, or stationary behavior, and the number of A. gifuensis larvae increased with rising temperature. Specially, when the predator cues were present, parasitoid responded to rising tem peratures by increasing frequency of each behavior and an increase in offspring number. Our findings indicate that A. gifuensis might show flexible foraging and oviposition behavior in response to H. axyridis associated cues and different temperatures. Thus, the effects of both temperature and H. axyridis cues should be considered when assessing the foraging outcomes of A. gifuensis prior to combining these two enemies in aphid management practice.

Influence of selected host plants on biology of castor whitefly, Trialeurodes ricini (Hemiptera: Aleyrodidae)

Hong Huang,Hui Zhao,Yong-Mei Zhang,Shi-Ze Zhang,Tong-Xian Liu 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.4

The development time, immature survivorship, immature size, tertiary sex ratio, pre-oviposition period, fecundity,and preferences of the castor whitefly, Trialeurodes ricini on four host plant species (castor, eggplant, cottonand green bean) were evaluated under laboratory conditions. Development time from egg to adult emergencewas the longest on cotton (33.3 days), the shortest on green bean (25.4 days), and intermediate on eggplant(28.5 days) and castor (28.3 days). The survival rate was the highest on castor (92.5%), followed by those ongreen bean (80.2%) and eggplant (73.8%), and the lowest on cotton (42.6%). The sex ratio was the highest on cotton(♀:♂ = 2.45:1.00), the lowest on eggplant (♀:♂ = 0.75:1.00), and intermediate on castor and green bean(♀:♂= 1.04:1.00). T. ricini immatures and adultswere generally largerwhen reared on castor and eggplant thanon other plants. The net reproduction rate (R0) was 57.656 females per female per generation, the generationtime(T) was 35.9 days, the intrinsic rate of increase (rm)was 0.1128 eggs per female per day, the gross reproductionrate (GRR) was 108.04 eggs per female per generation, the finite rate of increase (λ) was 1.1194 females perfemale per day, and the doubling time (DT) was 6.1149 days. In both no-choice and two-choice tests, T. riciniadults preferred castor for feeding and oviposition

Synthesis, Crystal Structure and Characterization of Cu(II) and Cd(II) Coordination Compounds Based on Ligand 2-(3-(Pyridin-2-yl)-1H-pyrazol-1-yl)acetic Acid

Zhang, Ya-Jun,Wang, Cui-Juan,Mao, Kai-Li,Liu, Xiao-Lei,Huang, Shuai,Tong, Yan,Zhou, Xian-Li Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.7

Two novel coordination compounds $[Cu_2(pypya)_3(H_2O)_2]{\cdot}Cl{\cdot}(H_2O)_5$ (1) and $\{[Cd(pypya)(ta)_{1/2}]{\cdot}H_2O\}_n$ (2) (Hpypya=2-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)acetic acid, $H_2ta$=terephthalic acid) were synthesized and characterized by single X-ray diffraction. Structure determination reveals that complex 1 and complex 2 crystallize in the triclinic system, with the P-1 space group. The asymmetric unit of 1 contains two Cu(II) ions, and their coordination modes are different. These units of complex 1 are linked together via hydrogen bonds and ${\pi}-{\pi}$ interactions, and the 3D structure of complex 1 was formed. Complex 2, a mononuclear Cd(II) coordination compound, has a 2D structure which was constructed via coordination bonds. TGA and fluorescence spectra analysis of complex 1 and complex 2 have also been studied. In addition, the geometry parameters of complex 1 have been optimized with the B3LYP method of density functional theory (DFT) to explain its coordination behavior. The electronic properties of the complex 1 and ligand Hpypya have been investigated based on the nature bond orbital (NBO) analysis at the B3LYP level of theory. The result verifies that the synergistic effect have occurred in the compound.