The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer

Pei Xu,Haibo Xiao,Qi Yang,Rui Hu,Lianyong Jiang,Rui Bi,Xueyan Jiang,Lei Wang,Ju Mei,Fangbao Ding,Jianbing Huang 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

Deubiquitinases (DUBs) and noncoding RNAs have been the subjects of recent extensive studies regarding their roles in lung cancer, but the mechanisms involved are largely unknown. In our study, we used The Cancer Genome Atlas data set and bioinformatics analyses and identified USP21, a DUB, as a potential contributor to oncogenesis in nonsmall-cell lung cancer (NSCLC). We further demonstrated that USP21 was highly expressed in NSCLCs. We then conducted a series of in vitro and in vivo assays to explore the effect of USP21 on NSCLC progression and the underlying mechanism involved. USP21 promoted NSCLC cell proliferation, migration, and invasion and in vivo tumor growth by stabilizing a well-known oncogene, Yin Yang-1 (YY1), via mediating its deubiquitination. Furthermore, YY1 transcriptionally regulates the expression of SNHG16. Moreover, StarBase bioinformatics analyses predicted that miR4500 targets SNHG16 and USP21. A series of in vitro experiments indicated that SNHG16 increased the expression of USP21 through miR-4500. In summary, the USP21/YY1/SNHG16 axis plays a role in promoting the progression of NSCLC. Therefore, the USP21/YY1/SNHG16/miR-4500 axis may be a potential therapeutic target in NSCLC treatment.

Improved Work Function of Preferentially Oriented Indium Oxide Films Induced by the Plasma Exposure Technique

Lei Yang,Shuai Guo,Qiuling Yang,Yuankun Zhu,Bing Dai,Hailing Yu,Pei Lei,Jiecai Han,Ying Hou,Jiaqi Zhu 대한금속·재료학회 2015 ELECTRONIC MATERIALS LETTERS Vol.11 No.6

The preferentially oriented In2O3 thin films were prepared on glass substrates by conventional magnetron sputtering with Ar+ plasma exposure at room temperature. Based on the x-ray diffraction, x-ray photoelectron spectroscopy, and UV photoelectron spectroscopy results, it was found that the Ar+ plasma exposure not only enhanced the low-temperature crystallization of In2O3 thin films, but also led to a dramatic improvement in the work function. Furthermore, it demonstrated that the shift mechanism of the work function in In2O3 thin films mainly combined with theelimination of oxygen defects and the change of the preferential orientation of In2O3 film surface.

Analysis and Design of Low Pass Filter using Unit Cell based on CRLH Transmission Line

Yang, Lei,Yang, Doo-Yeong The Korea Contents Association 2012 International Journal of Contents Vol.8 No.3

In this paper, a unit cell for low pass filter design by using composite right and left-handed transmission line in conductor-backed coplanar waveguide is proposed. The characteristics of the unit cell are analyzed in order to design a low pass filter in small sizes. By changing the sizes of the unit cell, the parameters of right-handed and left-handed immittance components are changed and the desired characteristics of the unit cell are achieved. The equivalent circuit of the unit cell is extracted and analyzed either. As a result, the simulation results of the unit cell and the equivalent circuit are almost identified. The movement and energy distributions of electromagnetic field are shown to confirm the property of the unit cell. In the end, a low pass filter is demonstrated by cascading three proposed unit cells, which shows cutoff frequency of 1.53GHz and deep attenuation from 2.23GHz to 4.49GHz lower than -50dB.

RECYCLING TREATMENT OF AQUACULTURE POND WATER BY AEROBIC BIOFILTRATION

( Lei Yang ) 한국물환경학회 1997 제6차 국제수질보전학회 아시아 태평양지역 학술회의 Vol.1 No.-

Estimation of Dynamic Behaviors of Bedrock Foundation Subjected to Seismic Loads Based on FEM and DEM Simulations

Lei Yang,Yujing Jiang,Bo Li,Shucai Li,Gang Wang 대한토목학회 2013 KSCE JOURNAL OF CIVIL ENGINEERING Vol.17 No.2

Seismic behavior of bedrock foundation remains as one of the most fundamental and important problems concerning the stability and safety of nuclear power plants. The dynamic FEM (Finite Element Method) is commonly utilized in analyzing the seismic responses of bedrock; while in recent decades, the DEM (Distinct Element Method) has attracted more and more attentions, which has a better capability of simulating the sliding and separation of discontinuities in dynamic simulations. In this study, the FEM and DEM were adopted to investigate the seismic behavior of the bedrock of a nuclear power plant located in Japan, and the differences between the two methods in dynamic simulations were illuminated. Simulation results using FEM and DEM models without discontinuities agree well with each other, exhibiting an amplification effect of intact bedrock on the seismic wave propagation. Numerical simulation results obtained from the models containing faults give similar responses of bedrock to the input seismic waves; however, the FEM model underestimates the weakening effect of discontinuities on the propagation of seismic waves due to that it cannot represent well the large deformational behavior of discontinuities. When large deformation happens due to large seismic loads, the DEM can be regarded as a better method in seismic response evaluations of bedrock with discontinuities.

Multi-path Routing Policy for Content Distribution in Content Network

( Lei Yang ),( Chaowei Tang ),( Heng Wang ),( Hui Tang ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.5

Content distribution technology, which routes content to the cache servers, is considered as an effective method to reduce the response time of the user requests. However, due to the exponential increases of content traffic, traditional content routing methods suffer from high delay and consequent inefficient delivery. In this paper, a content selection policy is proposed, which combines the histories of cache hit and cache hit rate to collaboratively determine the content popularity. Specifically, the CGM policy promotes the probability of possible superior paths considering the storage cost and transmission cost of content network. Then, the content routing table is updated with the proportion of the distribution on the paths. Extensive simulation results show that our proposed scheme improves the content routing and outperforms existing routing schemes in terms of Internet traffic and access latency.

A Hybrid Static Compensator for Dynamic Reactive Power Compensation and Harmonic Suppression

Yang, Jia-qiang,Yang, Lei,Su, Zi-peng The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.3

This paper presents a combined system of a small-capacity inverter and multigroup delta-connected thyristor switched capacitors (TSCs). The system is referred to as a hybrid static compensator (HSC) and has the functions of dynamic reactive power compensation and harmonic suppression. In the proposed topology, the load reactive power is mainly compensated by the TSCs. Meanwhile the inverter is meant to cooperate with TSCs to achieve continuous reactive power compensation, and to filter the harmonics generated by nonlinear loads and the TSCs. First, the structure and mathematical model of the HSC are discussed Then the control method of the HSC is presented. An improved reduced order generalized integrator (ROGI)-based selective current control method is adopted in the inverter to achieve high-performance reactive and harmonic current compensation. Meanwhile, a switch control strategy is proposed to implement precise and fast switching of the TSCs and to avoid changing the time delay needed by the conventional switch strategy. Experiments are implemented on a 20 KVA HSC prototype and the obtained results verify the validity of the proposed HSC system.

Improvement of comprehensive performance of compound green soil in sponge city

Lei Zhang,Zhicheng Li,Tianliang Yang,Ping Yang 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.5

Large-scale constructions of urbanization increase the impervious areas of city, leading to the urban hydrological effects such as urban waterlogging and rainwater runoff pollution. To this end, China proposed to adopt the measure to build sponge cities. However, the existing green soil cannot meet the comprehensive needs of sponge city. In order to quickly evaluate the comprehensive performance of the soil in sponge city, a comprehensive evaluation criterion was designed, which is related to the characteristics of greening soil permeability, porosity, pH, salinity and fertility. Based on the criterion, a new type of composite green soil was obtained with the silt soil: medium sand: sawdust ratio of 72.5%: 20%: 7.5%. Finally, compared with the existing soil, the new green soil not only meets the comprehensive performance requirements of the green soil’s fertility, pH, permeability and other factors, but also has higher permeability and water retention. It was proved that the new green soil has apparent advantages in the control of rainwater.

Synthesis of Porous Carbon Supported Palladium Nanoparticle Catalysts by Atomic Layer Deposition: Application for Rechargeable Lithium–O₂ Battery

Lei, Yu,Lu, Jun,Luo, Xiangyi,Wu, Tianpin,Du, Peng,Zhang, Xiaoyi,Ren, Yang,Wen, Jianguo,Miller, Dean J.,Miller, Jeffrey T.,Sun, Yang-Kook,Elam, Jeffrey W.,Amine, Khalil American Chemical Society 2013 Nano letters Vol.13 No.9

<P>In this study, atomic layer deposition (ALD) was used to deposit nanostructured palladium on porous carbon as the cathode material for Li–O<SUB>2</SUB> cells. Scanning transmission electron microscopy showed discrete crystalline nanoparticles decorating the surface of the porous carbon support, where the size could be controlled in the range of 2–8 nm and depended on the number of Pd ALD cycles performed. X-ray absorption spectroscopy at the Pd K-edge revealed that the carbon supported Pd existed in a mixed phase of metallic palladium and palladium oxide. The conformality of ALD allowed us to uniformly disperse the Pd catalyst onto the carbon support while preserving the initial porous structure. As a result, the charging and discharging performance of the oxygen cathode in a Li–O<SUB>2</SUB> cell was improved. Our results suggest that ALD is a promising technique for tailoring the surface composition and structure of nanoporous supports in energy storage devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2013/nalefd.2013.13.issue-9/nl401833p/production/images/medium/nl-2013-01833p_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl401833p'>ACS Electronic Supporting Info</A></P>

1-(2-Pyridylazo)-2-naphthol as a synergistic additive for improving throwing power of through hole copper electronic electroplating

Lei Jin,Zhao-Yun Wang,Zhuan-Yun Cai,Jia-Qiang Yang,An-Ni Zheng,Fang-Zu Yang,De-Yin Wu,Dongping Zhan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-

In this work, we develop a novel 1-(2-Pyridylazo)-2-naphthol (PAN)-based acidic sulfate copper electronicelectroplating process for compact, homogeneous and conformal copper thickening of throughhole (TH). The adsorption characteristics, electrochemical properties and the interaction mechanismsof three additives (PEG, SPS and PAN) are studied in detail. Scanning electron microscope (SEM) and opticalmicroscope (OM) reveal that PAN can make the copper coating in fine grains and high throwing powerof 90.35% in TH without an overhang phenomenon. Theoretical calculations illustrate that the bindingenergies between additive molecules and copper surface decrease in the order: PAN > SPS > PEG. Cyclic voltammetry experiments at rotating rates of 1200 and 200 r/min prove that PAN itself can accelerateand weakly suppress copper electrodeposition at the center and mouth of TH, respectively. PANbehaves respectively the synergistic and antagonistic effects with PEG at the mouth and center of TH,and the weakly synergistic effects with SPS both at the mouth and center of TH. The addition of PANto the virgin make-up solution (VMS) containing PEG and SPS causes decreasing the relative electriccharge (DQ) at high and low rotating rates from 18.52 ± 0.08% to 8.25 ± 0.05%, which satisfies the closercopper electronic electroplating rate at the center and mouth of TH. The effective and complicated synergisticeffects of the additives PEG, SPS and PAN can achieve compact, homogeneous and conformal copperthickening of TH.