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      • KCI등재

        The Development of High-Current Power Supply System for Electrolytic Copper Foil

        An Luo,Fujun Ma,Qiaopo Xiong,Zhixing He 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2

        A 6.5 V/50 kA high-frequency switching power supply (HSPS) system composed of 10 power modules is developed to meet the requirements of copper-foil electrolysis. The power module is composed of a two-leg pulse width modulation (PWM) rectifier and a DC/DC converter. The DC/DC converter adopts two full-wave rectifiers in parallel to enhance the output. For the two-leg PWM rectifier, the ripple of the DC-link voltage is derived. A composite control method with a ripple filter is then proposed to effectively improve the performance of the rectifier. To meet the process demand of copper-foil electrolysis, the virtual impedance-based current-sharing control method with load current full feedforward is proposed for n-parallel DC/DC converters. The roles of load current feedforward and virtual impedance are analyzed, and the current-sharing control model of the HSPS system is derived. Virtual impedance is used to adjust the current-sharing impedance without changing the equivalent output impedance, which can effectively reduce current-sharing errors. Finally, simulation and experimental results verify the structure and control method.

      • KCI등재

        Influence of load on the recycling stability of nanospheres attached platinium ion for determination of glucose

        Elvan Hasanog˘lu O¨ zkan,Nurdan Kurnaz Yetim,Dilek Nartop,Nurs¸ en Sarı 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.25 No.-

        New nanospheres have been prepared with Pt2+ and Pt4+ for compare enzymatic properties of glucose oxidase enzyme (GOx). In this study nanoparticles, (aminomethyl)polystyrene (APS), 2-hydroxy-5- methylbenzaldehyde and Pt2+/Pt4+ have been synthesized by means of template and investigated the enzymatic properties of glucose oxidase enzyme (GOx) immobilized on there. The characteristics of the immobilized glucose oxidase (APS–Pt2+–GOx and APS–Pt4+–GOx) enzyme showed one optimum pH value. The influence of temperature, reusability and storage capacity on the free and immobilized glucose oxidase enzyme have been investigated. It is found that nanosphere including platinium atom exhibits excellent performance as the immobilized supporter of GOx, the immobilized enzyme demonstrates perfected storage and recycling stability. APS–Pt2+–GOx retains more than 30% of the initial activity after 32 successive cycles, which is a remarkable result.

      • KCI등재후보

        A New 5α,8α-Epidioxy Sterol from a Marine Sponge Psammocinia Species

        Hye Jin Park1,,Xuan Luo1,,Jongki Hong2,,Dong-kyoo Kim3,,Kwang Sik Im1, and,Jee H. Jung1* 한국생약학회 2005 Natural Product Sciences Vol.11 No.4

        An investigation of the MeOH soluble fractions of a marine sponge Psammocinia sp. (Order:Dictyoceratida) led to the isolation of a new epidioxy sterol (1) and four known sterols (2-5). Their planarstructures were defined by analyses of the spectroscopic data. The 27-nor-24-methylcholestan type side chain withan epidioxy nucleus (1) was unprecedented. Compounds 1-5 were isolated from a sponge Psammocinia sp. for the first time.

      • KCI등재

        Polymorphisms of Ionotropic Glutamate Receptor-Related Genes and the Risk of Autism Spectrum Disorder in a Chinese Population

        Xinyan Xie,Fang Hou,Li Li,Yanlin Chen,Lingfei Liu,Xiu Luo1,Huaiting Gu,Xin Li,Jiajia Zhang,Jianhua Gong,Ranran Song 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.5

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Objective: To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population. Methods: We performed spatio-temporal expression analysis of GRIK2 and NLGN1 in the developing prefrontal cortex, and examined the expression of the genes in ASD cases and healthy controls using the GSE38322 data set. Following, we performed a case-control study in a Chinese population. Results: The analysis using the publicly available expression data showed that GRIK2 and NLGN1 may have a role in the development of human brain and contribute to the risk of ASD. Later genetic analysis in the Chinese population showed that the GRIK2 rs6922753 for the T allele, TC genotype and dominant model played a significant protective role in ASD susceptibility (respectively: OR=0.840, p=0.023; OR=0.802, p=0.038; OR=0.791, p=0.020). The NLGN1 rs9855544 for the G allele and GG genotype played a significant protective role in ASD susceptibility (respectively: OR=0.844, p=0.019; OR=0.717, p=0.022). After adjusting p values, the statistical significance was lost (p>0.05). Conclusion: Our results suggested that GRIK2 rs6922753 and NLGN1 rs9855544 might not confer susceptibility to ASD in the Chinese population.

      • PO-009: Effect of Baseline Resistance-associated Variants on SVR with the 3D Regimen with and without RBV in GT1a and GT1b-infected Patients

        ( Christoph Sarrazin ),( Mark S. Sulkowski ),( Preethi Krishnan ),( Rakesh Tripathi ),( Gretja Schnell ),( Yan Xie ),( Daniel E. Cohen ),( Roger Trinh ),( Lino Rodrigues-jr. ),( Yan Luo3,Nancy S. Shul 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

        Aims: The 3 direct-acting antiviral (3-DAA) regimen of ombitasvir, ritonavir-boosted paritaprevir and dasabuvir ± RBV is approved in the US and EU for treatment of hepatitis C virus (HCV) genotype (GT) 1 infection. Baseline resistance associated variants (RAVs) in HCV NS3 or NS5A can impact response to other DAA regimens; we assessed the prevalence and impact of RAVs on response to the 3-DAA regimen. Methods: Next-generation sequencing (Illumina MiSeq) assessed baseline samples from treatment-naive (PEARL-IV), -experienced (SAPPHIRE- II), or cirrhotic (TURQUOISE-II) GT1a patients who received 3-DAA + RBV, and treatment-experienced (PEARL-II) or cirrhotic (TURQUOISE-III) GT1b patients who received 3-DAA alone. Thresholds of 1 and 15%, respectively, detected the prevalence and impact of baseline RAVs; impact of RAVs conferring ≥ 5-fold resistance to components of the 3-DAA regimen on response was determined by com- paring SVR rates in patients with or without RAVs. Results: SVR rates were 96% and 100% in patients with GT1a and GT1b, respectively. One or more NS5A RAVs were present in 11% of treatment-experienced or cirrhotic GT1a patients, whereas NS5A RAVs were found in 19% of GT1b patients (15% threshold). Similar SVR rates were seen in GT1a patients with or without NS5A RAVs. All GT1b patients with NS5A RAVs, including at position Y93, achieved SVR. NS3 RAVs were uncommon (≤2%). NS3 RAVs were not seen in any of the 14 virologic failures and an NS5B RAV was seen in 1 virologic failure. The presence of the GT1a NS3 Q80K polymorphism had no impact on SVR. Conclusions: Understanding impact of baseline NS5A RAVs on treatment outcomes is important for relevant HCV therapies. Patients with HCV GT1a-infection treated with the 3-DAA regimen + RBV achieved high SVR rates, regardless of the presence of baseline RAVs. All GT1b patients treated with the 3-DAA regimen alone achieved SVR.

      • KCI등재

        韓愈와 柳宗元의 작문 경쟁

        羅聯添(Lian-Tian Luo),金智英(번역자) 중국어문논역학회 2017 中國語文論譯叢刊 Vol.0 No.41

        본고는 羅联添이 1992년에 발표한 <論韓愈古文幾個問題>의 제4장 “韓愈와 柳宗元이 고문으로 서로 경쟁함(韓柳爲文相角)” 부분을 번역한 것이다. 한유와 유종원의 글이 유사하다거나 경쟁적이라는 견해는 예전부터 있어왔다. 이런 주장은 송대의 羅大經, 명대의 孫礦, 청대의 林云銘, 근대의 錢基博이 제기한 바 있다. 필자는 한유와 유종원의 작문 경쟁에 대한 이전의 정황을 검토하고, 이전에 언급되지 않았던 다른 작품들을 예로 들어 한유와 유종원의 글쓰기에 확실히 경쟁심리가 있었음을 증명하였다. 즉 한유와 유종원의 작품 가운데 서로의 작품을 의식하면서 경쟁적으로 쓴 29조의 작품을 예로 들며, 창작 연대와 주요 내용을 설명하고 그 증거를 제시하였다. 경쟁했던 작품을 종합해 보니 두 사람의 작품 중 시기를 확정할 수 있는 작품 가운데 한유가 유종원 보다 앞서 지은 작품이 월등히 많았다. 이로써 유종원이 고문 창작에 있어 한유와 경쟁하려는 의도가 많았고, 한유가 유종원과 경쟁하려 한 것은 적었음을 알 수 있다. 이 점은 또한 한유가 고문 창작에서 주도적인 지위를 차지하고 있었음을 분명히 보여준다. 후인들이 한유를 당송고문운동의 으뜸으로 추앙하는 데에는 그만한 까닭이 있는 것이다. This paper is a translation of Han-Yu and Liu Zong-yuan’s writing competition in Chapter 4 of Luo Lian-tian’s <論韓愈古文的幾個問題>. The view that Han-Yu and Liu Zong-yuan’s writings are similar or competitive has been around for a long time. These claims were made by Luo Da-jing of Song Dynasty, Sun-Kuang of Ming Dynasty, Lin Yun-ming of Qing Dynasty, and Qian Ji-bo of modern times. I reviewed the previous context of Han-Yu and Liu Zong-yuan’s writing competition and proved that there was a clear competition in their writings by taking other works not mentioned before. I took examples the twenty - nine articles which compete with each other while conscious of their works among the works of Han-Yu and Liu Zong-yuan, in a chronological order Among the works that we can confirm the timing of the works of two people, Han-Yu had much more works than Liu Zong-yuan. This shows that Liu Zong-yuan intends to compete with Han-Yu for the Composition of the ancient writing, and that Han-Yu did not try to compete with Liu Zong-yuan. This also clearly shows that Han-Yu was in a leading position in the Composition of the ancient writing. There is a clear reason why the posterity pay reverence to Han-Yu as the forerunner of the Composition of the ancient writing movement.

      • Autophagy Inhibition Promotes Gambogic Acid-induced Suppression of Growth and Apoptosis in Glioblastoma Cells

        Luo, Guo-Xuan,Cai, Jun,Lin, Jing-Zhi,Luo, Wei-Shi,Luo, Heng-Shan,Jiang, Yu-Yang,Zhang, Yong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

        Objective: To investigate the effects of gambogic acid (GA) on the growth of human malignant glioma cells. Methods: U251MG and U87MG human glioma cell lines were treated with GA and growth and proliferation were investigated by MTT and colony formation assays. Cell apoptosis was analyzed by annexin V FITC/PI flow cytometry, mitochondrial membrane potential assays and DAPI nuclear staining. Monodansylcadaverine (MDC) staining and GFP-LC3 localisation were used to detect autophagy. Western blotting was used to investigate the molecular changes that occurred in the course of GA treatment. Results: GA treatment significantly suppressed cell proliferation and colony formation, induced apoptosis in U251 and U87MG glioblastoma cells in a time- and dose-dependent manner. GA treatment also lead to the accumulation of monodansylcadaverine (MDC) in autophagic vacuoles, upregulated expressions of Atg5, Beclin 1 and LC3-II, and the increase of punctate fluorescent signals in glioblastoma cells pre-transfected with GFP-tagged LC3 plasmid. After the combination treatment of autophagy inhitors and GA, GA mediated growth inhibition and apoptotic cell death was further potentiated. Conclusion: Our results suggested that autophagic responses play roles as a self-protective mechanism in GA-treated glioblastoma cells, and autophagy inhibition could be a novel adjunctive strategy for enhancing chemotherapeutic effect of GA as an anti-malignant glioma agent.

      • KCI등재

        DC 마그네트론 Co-sputtering 시스템을 이용하여 증착한 GAZO 박막의 전기적 및 구조적 특성

        Luo Jie(Jie Luo),박세훈(Se-hun Park),송풍근(Pung-keun Song) 한국표면공학회 2009 한국표면공학회지 Vol.42 No.3

        Ga/Al doped ZnO (GAZO) thin films were prepared on non-alkali glass substrate by co-sputtering system using two DC cathodes equipped with AZO (Al2O3:2.0 wt%) target and GZO (Ga₂O₃:6.65 wt%) target. This study examined the influence of Al/Ga concentration and substrate temperature on the electrical, structural and optical properties of GAZO films. The lowest resistivity 1.95×10<SUP>?3</SUP> Ω㎝ was obtained at room temperature. With increasing substrate temperature, resistivity of GAZO film decreased to a minimum value of 7.47×10<SUP>?4</SUP>Ω㎝ at below 300℃. Futhermore, when 0.05% H₂ gas was introduced, resistivity of GAZO film decreased to 6.69×10<SUP>?4</SUP>Ω㎝. All the films had a preferred orientation along the (002) direction, indicating that the deposited films have hexagonal wurtzite structure formed by the textured growth along the c-axis. The average transmittance of the films was more than 85% in the visible light range.

      • KCI등재

        Expression and Regulation of Transcription Factor FoxA2 in Chronic Rhinosinusitis With and Without Nasal Polyps

        Qing Luo,Jia Zhang,Hongtian Wang,Fenghong Chen,Xi Luo,Beiping Miao,Xingmei Wu,Renqiang Ma,Xiangqian Luo,Geng Xu,Jianbo Shi,Huabin Li 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.5

        Purpose: Chronic rhinosinusitis (CRS) is characterized by the excessive production of mucus. However, the molecular mechanism underlying mucin overproduction in CRS with or without nasal polyps (CRSwNP and CRSsNP, respectively) is poorly understood. This study was conducted to assess the importance of the transcription factor FoxA2 in mucin production and to investigate the targeting of FoxA2 as a potential therapeutic strategy for mucus hypersecretion in CRS patients. Methods: We enrolled 15 CRSwNP patients, 15 CRSsNP patients, and 10 normal controls in this study. The expression levels of FoxA2, MUC5AC, and MUC5B in inflamed and healthy nasal tissues were examined via immunohistochemistry and quantitative reverse transcription-polymerase chain reaction, and the levels of several proinflammatory cytokines in nasal secretions were measured via FlowCytomix analysis. In addition, the expression of MUC5AC and FoxA2 was determined in polyp-derived epithelial cells and NCI-H292 cells after in vitro stimulation. Results: FoxA2 was significantly down-regulated, and MUC5AC and MUC5B were significantly up-regulated in both the CRSwNP and CRSsNP patients compared to the controls (P<0.05), and the protein level of FoxA2 was negatively associated with the IL-6 level in the CRS patients (P<0.05). IL-6 significantly increased MUC5AC expression but inhibited FoxA2 expression in vitro (P<0.05). Transfection with a FoxA2 expression plasmid significantly decreased MUC5AC promoter activity (P<0.05) and inhibited IL-6-induced MUC5AC production (P<0.05). In addition, clarithromycin significantly alleviated IL-6-induced FoxA2 suppression and decreased MUC5AC expression in vitro (P<0.05). Conclusions: Our findings suggest that FoxA2 may be considered a therapeutic target for the modulation of mucus hypersecretion in CRS patients.

      • Wavelength switchable flat-top all-fiber comb filter based on a double-loop Mach-Zehnder interferometer

        Luo, Ai-Ping,Luo, Zhi-Chao,Xu, Wen-Cheng,Cui, Hu The Optical Society 2010 Optics express Vol.18 No.6

        <P>A wavelength switchable all-fiber comb filter with flat-top spectral response based on a double-loop Mach-Zehnder (M-Z) interferometer is proposed and demonstrated. The proposed flat-top filter consists of a rotatable polarizer and a double-loop M-Z interferometer composed of two fiber couplers with a polarization controller (PC) in the first loop. In the theoretical analysis, when the second coupler of the M-Z interferometer is a non-3dB one, with proper settings of the polarization state of the input light and the PC, the wavelength switchable comb filter with flat-top passband can be obtained. Theoretical prediction was verified by experimental demonstration. The measured 1 dB bandwidth was 0.51 nm with a channel spacing of 0.98 nm, indicating that the flat-top passband of 1 dB bandwidth extends to about 50% of the comb spacing.</P>

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