http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Serum CA 19-9 Level Correlates CT Severity Score in Patients with NTM-PD
( Kangjoon Kim ),( Hye-jeong Lee ),( Seung Hyun Yong ),( Su Hwan Lee ),( Sang Hoon Lee ),( Song Yee Kim ),( Kyungsoo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Moo Suk Park ),( Young Sam Kim ),( Joon 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Until now, there is no validated clinical biomarker of nontuberculous mycobacterial pulmonary disease (NTM-PD) in terms of evaluating disease severity or treatment response. Limited data suggests that elevated serum carbohydrate antigen 19-9 (CA 19-9) is observed in the patients with NTM-PD, and the level decreases following the successful NTM-PD treatment. Methods This retrospective study examined 79 NTM-PD patients who conducted both measurement of serum CA 19-9 level and chest computed tomography (CT) scan, less than a month apart. The NTM-PD disease severity were rated by the scoring system based on CT images. Correlation between the CT score and the serum level of CA 19-9 were evaluated by using Spearman’s correlation coefficient and Spearman’s partial correlation coefficient, and the latter was controlled for the variables of age, sex and body mass index (BMI). Results Serum CA 19-9 levels had a positive correlation with the CT score, especially for the score of total (rs=.416, p<0.01), and the sub-score of bronchiectasis (rs=.251, p<0.05), bronchiolitis (rs=.289, p<0.01), cavity (rs=.221, p<0.05), and consolidation (rs=.303, p<0.01). Patients’ BMI had a negative correlation with the CT score (rs=-.358, p<0.01), but had no significant correlation with serum CA 19-9 level itself. After controlling for the variables of age, sex and BMI, partial correlation analysis showed statistically significant positive correlation between serum CA 19-9 level and the CT score of bronchiectasis, bronchiolitis, cavity, consolidation, and total sum (Table 1). Conclusion Serum CA 19-9 levels had a positive correlation with the CT severity score of NTM-PD. Serum CA 19-9 may be a useful biological marker for evaluating disease activity or therapeutic response in the patients with NTM-PD, and further study is warranted.
Brake Squeal Noise를 유발하는 Brake Contact Interface와 Rotor의 In-Plane Modes에 관한 연구Ⅱ
김경수(Kyungsoo Kim),조호준(Hojoon Cho),김두영(Dooyoung Kim),최원석(Wonseok Choe),박영준(Youngjoon Park),백봉범(Bongbum Back),김한규(Hankyu Kim),고승석(Seungseok Ko),정명구(Myoungkoo Chung) 한국자동차공학회 2010 한국자동차공학회 학술대회 및 전시회 Vol.2010 No.11
For many years, brake noise has been one of the top automotive brake warranty issues, and many studies have been conducted to reduce the squeal phenomenon by improving the rotor-pad contact interface or by decoupling modes inducing squeals. This is additional research of ‘A study of Brake Contact Interface and Rotor In-Plane Modes Induced Disc Brake Squeal noise’. This paper considers the different brake contact interfaces affecting high frequency brake squeal and introduce an effective way of reducing the problem by improving one of the brake secondary contacts. Furthermore, the reason of improving of brake secondary contact has a positive effect is investigated by modal analysis & squeal noise analysis.
Koh, Eun Sil,Lee, Kyungsoo,Kim, Su Hyun,Kim, Young Ok,Jin, Dong Chan,Song, Ho Chul,Choi, Euy Jin,Kim, Yong Lim,Kim, Yon Su,Kang, Shin Wook,Kim, Nam Ho,Yang, Chul Woo,Kim, Yong Kyun S. Karger AG 2015 American journal of nephrology Vol.42 No.2
<P>Abstract</P><P><B><I>Background/Aims:</I></B> β<SUB>2</SUB>-Microglobulin (β<SUB>2</SUB>-M) is a surrogate marker of middle-molecule uremic toxins and is associated with mortality in chronic hemodialysis patients. However, the impact of serum β<SUB>2</SUB>-M levels on mortality in peritoneal dialysis (PD) patients is uncertain. The purpose of this study was to examine the association of serum β<SUB>2</SUB>-M levels with all-cause mortality in PD patients. <B><I>Methods:</I></B> A total of 771 PD patients were selected from the Clinical Research Center registry for end-stage renal disease cohort in Korea. Patients were categorized into 3 groups by tertiles of serum β<SUB>2</SUB>-M levels. The primary outcome was all-cause mortality. <B><I>Results:</I></B> The median value of serum β<SUB>2</SUB>-M was 23.6 mg/l (interquartile range 14.8-33.4 mg/l), and the median follow-up period was 39 months. The Kaplan-Meier analysis showed that the all-cause mortality rate was significantly different according to tertiles of serum β<SUB>2</SUB>-M in PD patients (p = 0.03, log-rank). Multivariate Cox proportional analysis showed that the hazards ratio for all-cause mortality was 1.02 (95% CI 1.01-1.04, p = 0.006) per 1 mg/l increase in β<SUB>2</SUB>-M after adjustment for multiple confounding factors that relate to malnutrition and inflammation marker. However, serum β<SUB>2</SUB>-M was not associated with all-cause mortality after adjustment for residual renal clearance. <B><I>Conclusions:</I></B> These results are supportive of the potential role of the serum β<SUB>2</SUB>-M level as a predictor of mortality in PD patients.</P><P>© 2015 S. Karger AG, Basel</P>
Robustness of Whole Spine Reconstruction using Anterior-Posterior and Lateral Planar X-ray Images
Kim, Kyungsoo,Jargalsuren, Sainjargal,Khuyagbaatar, Batbayar,Park, Won Man,Lee, SuKyoung,Kim, Yoon Hyuk Korean Society for Precision Engineering 2018 International Journal of Precision Engineering and Vol.19 No.2
The X-ray-based reconstruction methods using anterior-posterior (AP) and lateral (LAT) images assumes that the angle between the AP and LAT images is perpendicular. However, it is difficult to maintain the perfect perpendicular angle between the AP and LAT images when taking those two images sequentially in real situations. In this study, the robustness of a three-dimensional (3D) whole spine reconstruction method using AP and LAT planar X-ray images was analyzed by investigating cases in which the AP and LAT images were not taken perpendicularly. 3D models of the patient-specific spine from five subjects were reconstructed using AP and LAT X-Ray images and the 3D template models of C1 to L5 vertebrae based on B-spline free-form deformation (FFD) technology. The shape error, projected area error, and relative error in length were quantified by comparing the reconstructed model (FFD model) to the reference model (CT model). The results indicated that the reconstruction method might be considered robust in case that there is a small angular error, such as <TEX>$5^{\circ}$</TEX>, between the AP and LAT images. This study suggested that simple technical indications to obtain the perpendicular AP and LAT images in real situations can improve accuracy of 3D spine reconstruction.
Kyungsoo Kim,DAVAASAMBUU BAYASGALAN,Ruoyu Wei,Yoon Hyuk Kim 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.2
The anterior cruciate ligament (ACL) is part of the knee joint injured during taekwondo kicking. However, few studies have investigated the ACL injury mechanism and its inherent risk factors. In this study, we compared the knee joint kinematics in the pivoting leg during eight typical taekwondo kicks (back, roundhouse, turning-back, hook, side, push, axe, and front kicks) to investigate the possible risk of ACL injury. Standard inverse dynamics analyses were used to calculate axial tibial rotation and knee joint varus-valgus moment using a musculoskeletal model of the lower extremity and a motion analysis system with six high-speed digital cameras and a force plate. The maximum values of internal tibial rotation and valgus moment in the pivot leg were investigated. In addition, the time interval when the internal rotation and/or valgus moment exceeded the upper limit of the safe region during the kicking was analyzed. The results revealed that most kicks had time intervals of excessive amounts of internal tibial rotation and/or knee valgus moment, which are related to the risk of ACL injury. Moreover, one particular kicking motion, the hook kick, has a relatively high ACL injury risk in the pivot leg compared to other kicking motions. We suggest that athletes and coaches be aware of these risky kicks.
Unbalanced Growth in a Small Economy with Open Capital Markets
Kyungsoo Kim,송의영 한국계량경제학회 2019 계량경제학보 Vol.30 No.4
This paper shows that in an economy with open capital markets, there exists a force toward unbalanced growth driven by intertemporal substitution of consumption and trade imbalance. We construct a two-sector Ramsey economy composed of a technologically progressive tradable sector and a technologically stagnant nontradable sector. We show that a capital account liberalization in the economy will drive the long-run share of the tradable sector toward one or zero, depending on whether the autarky interest rate is higher or lower than the world interest rate. The difference between the autarky interest rate and the world interest rate ultimately dictates the direction of structural transformation regardless of the progression of the Baumol's disease that pushes up the relative price and the share of nontradables. Because the autarky interest rate is increasing in the rate of technological progress, our result suggests that cross-country differences in the rate of technological progress may be an important factor in accounting for the diverse patterns of structural change in a financially integrated world.
Kim, Jeong Tae,Barua, Sonia,Kim, Hyeongmin,Hong, Seong-Chul,Yoo, Seung-Yup,Jeon, Hyojin,Cho, Yeongjin,Gil, Sangwon,Oh, Kyungsoo,Lee, Jaehwi The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.4
In this study, the effect of particle size of genistein-loaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability was investigated. Genistein-loaded solid lipid microparticles and nanoparticles were prepared with glyceryl palmitostearate. Except for the particle size, other properties of genistein-loaded solid lipid microparticles and nanoparticles such as particle composition and drug loading efficiency and amount were similarly controlled to mainly evaluate the effect of different particle sizes of the solid lipid particulate systems on drug dissolution behavior and oral bioavailability. The results showed that genistein-loaded solid lipid microparticles and nanoparticles exhibited a considerably increased drug dissolution rate compared to that of genistein bulk powder and suspension. The microparticles gradually released genistein as a function of time while the nanoparticles exhibited a biphasic drug release pattern, showing an initial burst drug release, followed by a sustained release. The oral bioavailability of genistein loaded in solid lipid microparticles and nanoparticles in rats was also significantly enhanced compared to that in bulk powders and the suspension. However, the bioavailability from the microparticles increased more than that from the nanoparticles mainly because the rapid drug dissolution rate and rapid absorption of genistein because of the large surface area of the genistein-solid lipid nanoparticles cleared the drug to a greater extent than the genistein-solid lipid microparticles did. Therefore, the findings of this study suggest that controlling the particle size of solid-lipid particulate systems at a micro-scale would be a promising strategy to increase the oral bioavailability of genistein.