生體血의 保存環境과 腐敗産物에 依한 血中알콜濃度變化에 關한 硏究

張成吉,金英雲,柳在薰,吳世珍,權五星,朴世延 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

韓國人의 各 臟器組織中 靑酸鹽의 微量分布에 關한 硏究(Ⅱ)

張成吉,金恩浩,金英雲,李鎭勳,柳在薰,權五星,金明德,吳世珍,金由那 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

요와 농 검체에서의 Vancomycin 내성 장구균 분리 2예

김성규,김문정,권오헌,김준명,정석훈,정윤섭,이경원,전세일 대한감염학회 1996 감염 Vol.28 No.4

65세 여자 환자의 요 검체에서 vancomycin 내성 E. faecalis를, 욕창의 농에서 vancomycin 내성 E. faecium을 분리하였는데, 환자의 병력으로 미루어 미국에서 정착된 세균에 의하여 감염되었을 것으로 생각되었다. 분리 균주에 대한 vancomycin의 MIC는 각각 258과 32㎍/mL, teicopoanin은 0.25, 0.5㎍/mL이어서 VanB 표현형으로 추측되었다. 우리 나라에서의 VRE 확산을 예방하기 위한 조치의 일환으로서 의사를 포함한 병원 직원에게 VRE 감염증의 심각성을 홍보하여야 하며, 미생물검사실에서는 임상검체에서 분리된 장구균의 vancomycin 내성을 시험하고 장내 VRE 보균자의 주기적 검색이 필요하다고 사료되었다. Vancomycin-resistant Enterococcus faecalis and E. faecium were isolated from urine and decubitus ulcer discharge, respectively, from a 65-year-old woman. Proir to the transfer to this hospital in December, 1995, she had been admitted to the Chicago Rehabilitation Center in the U.S. for the treatment of olivopontocerebellar atrophy, quadriplegia, and neurogenic bladder. She was also treated with multiple antimicrobials including vancomycin for pneumonia at intensive care unit, which suggested that she acquired the organisms in the U.S. The minimal inhibitory concentrations of vancomycin and teicoplanin against the isolates were: E. faecalis 256 ㎍/mLand 0.5㎍/mL; E. faecium 32 ㎍/mL and 0.5 ㎍/mL, respectively. The susceptibility patterns suggest the isolates are vanB type. Although other species of vancomycin-resistant Enterococcus spp. were reported previously in Korea, these isolates may be the first vancomycin-resistant E. faecalis and E. faecium from clinical specimens.

Clinical Implications of the Mitotic Index as a Predictive Factor for Malignant Transformation of Atypical Meningiomas

Sae Min Kwon,Jeong Hoon Kim,Young-Hoon Kim,Seok Ho Hong,Young Hyun Cho,Chang Jin Kim,Soo Jeong Nam 대한신경외과학회 2022 Journal of Korean neurosurgical society Vol.65 No.2

Objective : Intracranial atypical meningiomas have a poor prognosis and high rates of recurrence. Moreover, up to one-third of the recurrences undergo high-grade transformation into malignant meningiomas. We aimed to investigate the clinical factors that can predict the propensity of malignant transformation from atypical to anaplastic meningiomas. Methods : Between 2001 and 2018, all patients with atypical meningioma, in whom the tumors had undergone malignant transformation to anaplastic meningioma, were included. The patients’ medical records documenting the diagnosis of atypical meningioma prior to malignant transformation were reviewed to identify the predictors of transformation. The control group comprised 56 patients with atypical meningiomas who were first diagnosed between January 2017 and December 2018 and had no malignant transformation. Results : Nine patients in whom the atypical meningiomas underwent malignant transformation were included. The median time interval from diagnosis of atypical meningioma to malignant transformation was 19 months (range, 7–78). The study group showed a significant difference in heterogeneous enhancement (77.8% vs. 33.9%), bone invasion (55.6% vs. 12.5%), mitotic index (MI; 14.8±4.9 vs. 3.5±3.9), and Ki-67 index (20.7±13.9 vs. 9.5±7.1) compared with the control group. In multivariate analysis, increased MI (odds ratio, 1.436; 95% confidence interval, 1.127–1.900; p=0.004) was the only significant factor for predicting malignant transformation. Conclusion : An increased MI within atypical meningiomas might be used as a predictor of malignant transformation. Tumors at high risk for malignant transformation might require more attentive surveillance and management than other atypical meningiomas.

電解質平衡障碍를 隨伴한 大腸의 Villous Adenoma

權世勳(Sae Hoon Kwon),李承道(Sung Do Lee),朴聖得(Sung Duk Park),鄭檜敎(Hoe Gyo Chung) 대한외과학회 1966 Annals of Surgical Treatment and Research(ASRT) Vol.8 No.2

양자점/PVK 혼합물 기반 다중 리드 가능 메모리 디바이스

권태훈(Tae-Hoon Kwon),고준혁(Jun-Hyeok Ko),고현우(Hyun Woo Ko),김종민(Jong-Min Kim),배정연(Jeong-Yeon Bae),이승우(Seung-Woo Lee),조연주(Yeon-Joo Cho),홍현기(Hyun-Gi Hong),김세완(Sae-Wan Kim),권진범(Jin-Beom Kwon),김나리(Na-Ri Kim),강신 대한전자공학회 2018 대한전자공학회 학술대회 Vol.2018 No.11

Shear bond strength of dentin bonding agents cured with a plasma arc curing light

Kwon, Youngchul,Kim, Sun-Young,Chung, Sae-Joon,Han, Young-Chul,Lee, In-Bog,Son, Ho-Hyun,Um, Chung-Moon,Cho, Byeong-Hoon 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.3

광물리학적 특성 분석을 위해 Apollo 95E (DMT Systems, Orange, CA; PAC 광중합기), Elipar Freelight 2 (3M ESPE, MN, USA; LED 광중합기) 그리고 VIP Junior (Bisco, Schaumberg, IL, USA; QTH 광중합기), 3종의 광중합기의 총광강도(Total intensity)와 spectral distribution을 측정하였고 특정 파장에 해당되는 광강도 (Energy density)를 분석하였다. 상아질 전단접착강도의 측정을 위해 Scotchbond Multipurpose (3M ESPE), Single bond (3M ESPE) 그리고 Clearfll SE bond (Kuraray)가 사용되었다. Plasma Arc Curing light (Apollo 95E) 팡중합기는 여러개의 최대정점을 가지며 넓은 spectral distribution과 2307 mW/cm²의 높은 광강도를 나타내었고, VIP Junior 광중합기는 490 ㎜에서 최대정점을 갖는 넓은 spectral distribution을 나타내었고, Elipar Freeelight 2 광중합기는 462 ㎜의 최대정점 주위로 좁은 spectral distribution를 보였다. Two-Way ANOVA와 Bonferroni' s multiple comparison test를 이용하여 상아질 전단잡착강도를 분석한 결과, PAC 광중합기와 LED 광중합기 간에 유의성 있는 차이를 보이지 않았으며 (P > 0.05), 상아질 접착제와 광중합기의 교호관계에도 유의성이 없었다. 그러나 상아질 접착제는 상호간에 유의성 있는 차이를 보였다 (P< 0.001). The objective of this study was to compare dentin shear bond strength (DSBS) of dentin bonding agents (DBAs) cured with a plasma arc (PAC) light curing unit (LCU) and those cured with a light emitting diode (LED) LCU. Optical properties were also analyzed for Elipar freelight 2 (3M ESPE); LED LCU, Apollo 95E (DMT Systems); PAC LCU and VIP Junior (Bisco): Halogen LCU. The DBAs used for DSBS test were Scotchbond Multipurpose (3M ESPE), Singlebond 2 (3M ESPE) and Clearfil SE Bond (Kuraray). After DSBS testing, fractured specimens were analyzed for failure modes with SEM. The total irradiance and in-adiance between 450 ㎜ and 490 ㎜ of the LCUs were different. LED LCU showed narrow spectral distribution around its peak at 462 ㎜ whereas PAC and Haloaen LCU showed a broad spectrum. There were no significant differences in mean shear bond strength among different LCUs (P > 0.05) but were significant differences among different DBAs (P < 0.001).

취장선방세포에 있어서 분비과정에 수반되는 Cytocavitary Network의 변화에 대하여

권세훈,손태증 慶北大學校 醫科大學 1974 慶北醫大雜誌 Vol.15 No.2

Correlation between the Korean Version of Asthma Control Test and Health-Related Quality of Life in Adult Asthmatics

Kwon, Hyouk-Soo,Lee, So-Hee,Yang, Min-Suk,Lee, Sang-Min,Kim, Sae-Hoon,Kim, Deok-In,Sohn, Seong-Wook,Park, Chang-Han,Park, Heung-Woo,Kim, Sun-Sin,Cho, Sang-Heon,Min, Kyung-Up,Kim, You-Young,Chang, Yoon The Korean Academy of Medical Sciences 2008 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.23 No.4

<P>The Asthma Control Test (ACT) is a patient-completed questionnaire developed to assess asthma control. Health-related quality of life (HRQL) in asthmatics has shown relatively low correlations with parameters of asthma control and the relationship between the ACT and HRQL in asthmatics is yet unclear. Because revalidations of translated versions of questionnaires are critical for its utilization, we first sought to validate the Korean version of ACT and then to evaluate the relationship between the ACT and HRQL. Patients (n=117) completed the ACT and asthma-related quality of life questionnaire (AQLQ) at 3 physician visits. Pulmonary function was measured and an asthma specialist rated asthma control. The Korean version of ACT was found to be reliable, valid, and responsive to changes in asthma control over time up to three consecutive visits. ACT scores correlated significantly (<I>p</I>=0.001) with symptoms domain (r=0.72), activity domain (r=0.65), emotional domain (r=0.69), and environmental domain (r=0.67) of AQLQ. In conclusion, the Korean version of the ACT was found to be a reliable and valid tool for measuring asthma control, and to correlate well with AQLQ scores. Moreover, the ACT was responsive to changes in AQLQ scores over time.</P>

취장선방세포에 있어서 분비과정에 수반되는 Cytocavitary Network의 변화에 대하여

권세훈,손태중 慶北大學校 醫科大學 1974 慶北醫大誌 Vol.15 No.2

저자는 분비주기에 있어서 Cytocavitary network의 상호관계의 일단을 관찰할 목적으로 흰쥐에 염산 pilocarpine을 체중 1gm당 0.06㎎를 주사하고 경시적으로 취장의 외분비세포를 형태적으로 검색한 바를 요약하면 다음과 같다. 1. pilocarpine를 주사하면 주입후 1시간째 부터 모든 Cytocavitary network는 다같이 영향을 받으나, 이중 rER이 가장 초기에 그리고 가장 현저하게 변화하며 이어서 Golgi장치, zymogen granule 그리고 lysosome등순으로 영향을 받는다. 2. Intracisternal granule은 대조군에서는 전혀 볼수없고, pilccarpine을 주사하면 주사후 2~3시간째부 터 출현하기 시작하여 4시간째에 가장 많이 출현하였다가 7시간후에는 거의 출현치 않게된다. 3. rER의 수포화현상은 pilocarpine주사후 1시간째부터 시작하여 2~3시간째에 가장 현저하여지고, 4시간 째에는 공포상이 그리고 7~8시간째가 되며는 편평낭상이된다. 4. 이상의 연구결과로보아 pilocarpine으로 취장의 외분비세포를 자극하면 rER→Golgi장치→zymogen granule의 순으로 변화가 일어나며, 여기에 그밖에 세포내 cytocavitary network도 함께 가담하여 분비 를 촉진시키는 것이라 믿어지며, 이때 출현하는 intracisternal granule은 단순한 분비기능의 항진으로 일어난다고 생각하기보다 rER에서 합성된 분비단백이 Golgi장치로 이행하는 과정에서 장애된결과 나타난 현상이라 믿어지며, 또 이와같이하여 합성된 exportoble protein의 life span은 약1시간으로, 또 분비물 질의 배출에서 시작하여 분비물질의 합성 그리고 재저축까지의 주기에 소요되는 시간은 약 10시간으로 생각된다. This study was carried out to investigate the morphologic changes and interrelationship between cytocavitary networks of Arstila during secretory cycle in the pancreatic acinar cells. Twenty seven albino rats were injected 6㎎ of pilocarpine hydrochloride solution 100㎎ of body weights, intramuscularly after 2days-NPO for synchronization. Each group of 3 animals was sacrificed at 1,2,3,4,5,6,7,8 and 10 hours after single pilocarpine injection. The pancreases were extirpated out and observed under electron microscope. The results were summarized as follow: All of the cytocavitary networks were influenced from the first hour after pilocarpine injection. Intracisternal granules were not seen in the control group, but began to appear 2 to 3 hours, most abundantly 4 hours and disappeared 7 hours after the injection. Vesicular changes of rER began to appear one hour and most typically after 2 to 3 hours. Vacuolization of rER appeared 4 hours and rER was changed to flattened sac 7 to 8 hours after pilocarpine injection. As the results of above experiments, the orders of the changes in the cytocavitary network after pilocarpine injection were initially rER, next Golgi apparatus and then zymogen granules. It is considered that the appearance of the intracisternal granules is rather the result of damage in the process of transportation of excretory protein to the Golgi apparatus than the result of increased secretory activity of the cell. In this process, the life span of exportable protein is believed to be one hour and the total duration in a cycle from the excretion and synthesis of exportable protein to the reaccumulation of the protein in the cell is thought to be about 10 hours.