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Masafumi Watanabe,Kosuke Okuwaki,Jun Woo,Mitsuhiro Kida,Hiroshi Imaizumi,Tomohisa Iwai,Hiroshi Yamauchi,Toru Kaneko,Rikiya Hasegawa,Takahiro Kurosu,Naoki Minato,Hiroki Haradome,Wasaburo Koizumi 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.4
Background/Aims: Cholecystitis can occur after the placement of covered self-expandable metallic stents for distal malignant biliaryobstructions. We aimed to identify risk factors for cholecystitis following covered self-expandable metallic stent placement. Methods: We investigated risk factors related to cholecystitis following covered self-expandable metallic stent placement in 118patients with distal malignant biliary obstructions between January 1, 2015 and April 30, 2019. Endoscopic assessments and tumorinvasion to the arteries feeding the gallbladder were determined by a pancreaticobiliary endoscopist and a radiologist, respectively. Results: The median patient age was 72 years (men, 61.0%). The flow of the contrast agent into the gallbladder and tumorinvolvement in the orifice of the cystic duct were observed in 35 (29.7%) and 35 (29.7%) patients, respectively. During theobservation period (median, 179 days), cholecystitis occurred in 18 (15.3%) patients. Multivariate analysis revealed the flow ofthe contrast agent into the gallbladder (p=0.023) and tumor involvement in the orifice of the cystic duct (p=0.005) as significantindependent risk factors associated with cholecystitis. Conclusions: The flow of the contrast agent into the gallbladder and tumor involvement in the orifice of the cystic duct are potentialindependent risk factors for cholecystitis following the placement of covered self-expandable metallic stents. A follow-up prospectivestudy is warranted to validate their influence.
Seigo Nakatani,Kosuke Okuwaki,Masafumi Watanabe,Hiroshi Imaizumi,Tomohisa Iwai,Takaaki Matsumoto,Rikiya Hasegawa,Hironori Masutani,Takahiro Kurosu,Akihiro Tamaki,Junro Ishizaki,Ayana Ishizaki,Mitsuhir 대한소화기내시경학회 2024 Clinical Endoscopy Vol.57 No.1
Background/Aims: In stereomicroscopic sample isolation processing, the cutoff value (≥4 mm) of stereomicroscopically visible white cores indicates high diagnostic sensitivity. We aimed to evaluate endoscopic ultrasound-guided tissue acquisition (EUS-TA) using a simplified stereomicroscopic on-site evaluation of upper gastrointestinal subepithelial lesions (SELs). Methods: In this multicenter prospective trial, we performed EUS-TA using a 22-gauge Franseen needle in 34 participants with SELs derived from the upper gastrointestinal muscularis propria, requiring pathological diagnosis. The presence of stereomicroscopically visible white core (SVWC) in each specimen was assessed using stereomicroscopic on-site evaluation. The primary outcome was EUS-TA’s diagnostic sensitivity with stereomicroscopic on-site evaluation based on the SVWC cutoff value (≥4 mm) for malignant upper gastrointestinal SELs. Results: The total number of punctures was 68; 61 specimens (89.7%) contained stereomicroscopically visible white cores ≥4 mm in size. The final diagnoses were gastrointestinal stromal tumor, leiomyoma, and schwannoma in 76.5%, 14.7%, and 8.8% of the cases, respectively. The sensitivity of EUS-TA with stereomicroscopic on-site evaluation based on the SVWC cutoff value for malignant SELs was 100%. The per-lesion accuracy of histological diagnosis reached the highest level (100%) at the second puncture. Conclusions: Stereomicroscopic on-site evaluation showed high diagnostic sensitivity and could be a new method for diagnosing upper gastrointestinal SELs using EUS-TA.
Masamichi Kodera,Kosuke Watanabe,Maxence Lassiège,Saman Alavi,Ryo Ohmura 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.81 No.-
Interfacial tension is one of the most important physical properties for high-precision simulations todevelop the methods of preventing plugging of pipelines in the oil and natural gas industry. This paperreports experimental data with the pendant drop method for the interfacial tension of adecane + methane + water system at temperatures between 278.2 K to 298.2 K and pressures up to10 MPa. The data show that in this temperature range the interfacial tension in the decane + methane+ water system decreases almost linearly with increasing temperature. The results also show that byincreasing the pressure of methane, the interfacial tension decreases from 53.98 mN m 1 to50.23 mN m 1 at 283.2 K and 52.23 mN m 1 to 49.74 mN m 1 at 288.2 K. The nature of the methanepressure dependence of the interfacial tension changes for pressures above around 2.00 MPa. Theinterfacial tension decreases with the pressure up to 2.00 MPa, but has no pressure dependence above2.00 MPa. It may be inferred that the decane/water interface is saturated with methane at pressuresaround 2.00 MPa and at higher pressure the interfacial tension is no longer affected by the presence ofmethane.
Novel mutations of CDKN1C in Japanese patients with Beckwith-Wiedemann syndrome
Hitomi Yatsuki,Ken Higashimoto,Kosuke Jozaki,Kayoko Koide,Junichiro Okada,Yoriko Watanabe,Nobuhiko Okamoto,Yoshinobu Tsuno,Yoko Yoshida,Kazutoshi Ueda,Kenji Shimizu,Hirofumi Ohashi,Tsunehiro Mukai,Hid 한국유전학회 2013 Genes & Genomics Vol.35 No.2
Beckwith-Wiedemann syndrome (BWS) is an imprinting-related human disease that is characterized by macrosomia, macroglossia, abdominal wall defects, and variable minor features. BWS is caused by several genetic/epigenetic alterations, such as loss of methylation at KvDMR1,gain of methylation at H19-DMR, paternal uniparental disomy of chromosome 11, CDKN1C mutations, and structural abnormalities of chromosome 11. CDKN1C is an imprinted gene with maternal preferential expression, encoding for a cyclin-dependent kinase (CDK) inhibitor. Mutations in CDKN1C are found in 40 % of familial BWS cases with dominant maternal transmission and in *5 % of sporadic cases. In this study, we searched for CDKN1C mutations in 37BWS cases that had no evidence for other alterations. We found five mutations—four novel and one known—from a total of six patients. Four were maternally inherited and one was a de novo mutation. Two frame-shift mutations and one nonsense mutation abolished the QT domain, containing a PCNA-binding domain and a nuclear localization signal. Two missense mutations occurred in the CDK inhibitory domain,diminishing its inhibitory function. The above-mentioned mutations were predicted by in silico analysis to lead to loss of function; therefore, we strongly suspect that such anomalies are causative in the etiology of BWS.
Al-Si 층교환 성장에서 ZnO 표면 거칠기가 Si 결정성에 미치는 영향
장원범,최성국,정수훈,이정우,장지호,Kosuke HARA,Haruna WATANABE,Noritaka USAMI 한국물리학회 2013 새물리 Vol.63 No.11
We have investigated the effect of the surface roughness of the zinc-oxide (ZnO) layer on the growth of a by using the polycrystalline-Si (poly-Si) layer Al-induced layer-exchange process. We found that the growth rate, grain size, crystallized fraction and preferential orientation were closely related to the surface roughness of the underlying ZnO layer. As the ZnO surface became rougher, the growth rate, grain size, and crystallized fraction increased, and a preferential orientation in the (100) direction appeared as well. The poly-Si layer that formed on ZnO with a root-mean-square roughness of 2.4 nm revealed a fast growth time (40 minutes), a large grain size (20 μm) and a high crystallized fraction (51%) with a preferential (100) orientation. 고효율 박막 태양전지의 구현을 위해 ZnO (Zinc Oxide) 박막위에 Al-Si 층교환 성장방법 (layer exchange method)을 이용하여 다결정 실리콘 (poly-Si)을 성장하였다. 특히 본 연구에서는 ZnO의 표면 거칠기가 다결정 Si 결정성에 미치는 영향을 조사하였다. ZnO 표면 거칠기에 따른 다결정 Si의 결정립의 크기 (grain size), 정렬방향 변화를 성장 중 현미경 관찰, Field-emission scanning electron microscope (FE-SEM)측정과 Electron backscatter diffraction (EBSD)을 이용해 조사하였다. ZnO의 표면 거칠기가 증가 할 수록 결정화 속도와 결정립 크기가 증가하였으며, (100)배향이 관찰되었다. 결과적으로 표면 거칠기가 2.4 nm 인 ZnO 를 이용하여 20 μm 이상의 입자크기와 높은 결정화도를 가지며 51% 이상의 (100) 배향성을 갖는 다결정 Si 박막이 구현되어, 높은 효율을 갖는 다결정 Si 박막 태양전지의 성능 향상에 기여할 수 있는 가능성을 제시하였다.
Tibo Nico Emmie Volleman,Jordy Schol,Kosuke Morita,Daisuke Sakai,Masahiko Watanab 대한척추신경외과학회 2020 Neurospine Vol.17 No.1
Low back pain remains a highly prevalent pathology engendering a tremendous socioeconomic burden. Low back pain is generally associated with intervertebral disc (IVD) degeneration, a process involving the deterioration of nucleus pulpous (NP) cells and IVD matrix. Scientific interest has directed efforts to restoring cell numbers as a strategy to enable IVD regeneration. Currently, mesenchymal stromal cells (MSCs) are being explored as cell therapy agents, due to their easy accessibility and differentiation potential. For enhancement of MSCs, growth factor supplementation is commonly applied to induce differentiation towards a chondrogenic (NP) cell phenotype. The wnt signaling pathways play a crucial role in chondrogenesis, nonetheless, literature appears to present controversies with regard to wnt3a and wnt5a for the induction of NP cells, chondrocytes, and MSCs. This review aims to summarize the reporting on wnt3a/wnt5a mediated NP cell differentiation, and to elucidate the mechanisms involved in wnt3a and wnt5a mediated chondrogenesis for potential application as cell therapy supplements for IVD regeneration. Our review suggests that wnt3a, subsequently replaced with a chondrogenic stimulating growth factor, can enhance the chondrogenic potential of MSCs in vitro. Contrariwise, wnt5a is suggested to play a role in maintaining cell potency of differentiated NP or chondrogenic cells.