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RISS 인기검색어
- 검색키워드
- 저자 : Wasaburo Koizumi (검색결과 3 건)
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Shohei Ooka,Kiyonori Kobayashi,Kana Kawagishi,Masaru Kodo,Kaoru Yokoyama,Miwa Sada,Satoshi Tanabe,Wasaburo Koizumi 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.1
Background/Aims: The diagnostic algorithms used for selecting patients with obscure gastrointestinal bleeding (OGIB) for capsule endoscopy (CE) or balloon-assisted enteroscopy (BE) vary among facilities. We aimed to demonstrate the appropriate selection criteria of CE and single balloon-assisted enteroscopy (SBE) for patients with OGIB according to their conditions, by retrospectively comparing the diagnostic performances of CE and BE for detecting the source of the OGIB. Methods: We investigated 194 patients who underwent CE and/or BE. The rate of positive findings, details of the findings, accidental symptoms, and hemostasis methods were examined and analyzed. Results: CE and SBE were performed in 103 and 91 patients, respectively, and 26 patients underwent both examinations. The rate of positive findings was significantly higher with SBE (73.6%) than with CE (47.5%, p<0.01). The rate of positive findings was higher in overt bleeding cases than in occult bleeding cases for both BE and SBE. Among the overt bleeding cases, the rate was significantly higher in ongoing bleeding cases than in previous bleeding cases. Conclusions: Both CE and SBE are useful to diagnose OGIB. For overt bleeding cases and ongoing bleeding cases, SBE may be more appropriate than CE because endoscopic diagnosis and treatment can be completed simultaneously.
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Masafumi Watanabe,Kosuke Okuwaki,Jun Woo,Mitsuhiro Kida,Hiroshi Imaizumi,Tomohisa Iwai,Hiroshi Yamauchi,Toru Kaneko,Rikiya Hasegawa,Takahiro Kurosu,Naoki Minato,Hiroki Haradome,Wasaburo Koizumi 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.4
Background/Aims: Cholecystitis can occur after the placement of covered self-expandable metallic stents for distal malignant biliaryobstructions. We aimed to identify risk factors for cholecystitis following covered self-expandable metallic stent placement. Methods: We investigated risk factors related to cholecystitis following covered self-expandable metallic stent placement in 118patients with distal malignant biliary obstructions between January 1, 2015 and April 30, 2019. Endoscopic assessments and tumorinvasion to the arteries feeding the gallbladder were determined by a pancreaticobiliary endoscopist and a radiologist, respectively. Results: The median patient age was 72 years (men, 61.0%). The flow of the contrast agent into the gallbladder and tumorinvolvement in the orifice of the cystic duct were observed in 35 (29.7%) and 35 (29.7%) patients, respectively. During theobservation period (median, 179 days), cholecystitis occurred in 18 (15.3%) patients. Multivariate analysis revealed the flow ofthe contrast agent into the gallbladder (p=0.023) and tumor involvement in the orifice of the cystic duct (p=0.005) as significantindependent risk factors associated with cholecystitis. Conclusions: The flow of the contrast agent into the gallbladder and tumor involvement in the orifice of the cystic duct are potentialindependent risk factors for cholecystitis following the placement of covered self-expandable metallic stents. A follow-up prospectivestudy is warranted to validate their influence.
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Yo Kubota,Satoshi Tanabe,Mizutomo Azuma,Kazue Horio,Yoshiki Fujiyama,Takafumi Soeno,Yasuaki Furue,Takuya Wada,Akinori Watanabe,Kenji Ishido,Chikatoshi Katada,Keishi Yamashita,Wasaburo Koizumi,Chika Ku 대한위암학회 2021 Journal of gastric cancer Vol.21 No.4
Purpose: Promoter DNA methylation of various genes has been associated with metachronous gastric cancer (MGC). The cancer-specific methylation gene, cysteine dioxygenase type 1 (CDO1), has been implicated in the occurrence of residual gastric cancer. We evaluated whether DNA methylation of CDO1 could be a predictive biomarker of MGC using specimens of MGC developing on scars after endoscopic submucosal dissection (ESD). Materials and Methods: CDO1 methylation values (TaqMeth values) were compared between 33 patients with early gastric cancer (EGC) with no confirmed metachronous lesions at >3 years after ESD (non-MGC: nMGC group) and 11 patients with MGC developing on scars after ESD (MGCSE groups: EGC at the first ESD [MGCSE-1 group], EGC at the second ESD for treating MGC developing on scars after ESD [MGCSE-2 group]). Each EGC specimen was measured at five locations (at tumor [T] and the 4-point tumor-adjacent noncancerous mucosa [TAM]). Results: In the nMGC group, the TaqMeth values for T were significantly higher than that for TAM (P=0.0006). In the MGCSE groups, TAM (MGCSE-1) exhibited significantly higher TaqMeth values than TAM (nMGC) (P<0.0001) and TAM (MGCSE-2) (P=0.0041), suggesting that TAM (MGCSE-1) exhibited CDO1 hypermethylation similar to T (P=0.3638). The area under the curve for discriminating the highest TaqMeth value of TAM (MGCSE-1) from that of TAM (nMGC) was 0.81, and using the cut-off value of 43.4, CDO1 hypermethylation effectively enriched the MGCSE groups (P<0.0001). Conclusions: CDO1 hypermethylation has been implicated in the occurrence of MGC, suggesting its potential as a promising MGC predictor.
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