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<SUP>18</SUP>F-FDG PET-CT에서 진단된 갑상선 우연종의 악성종양 발견율 및 특징
이강영,고건<SUP>1<.SUP>,김선국<SUP>1<.SUP>,고진철<SUP>1<.SUP>,김행수,최상용,박신희,박용휘<SUP>2<.SUP>,Kang Young Rhee,Gun Koh,<SUP>1<.SUP>,Sun Kuk Kim,<SUP>1<.SUP>,Jin Chul Koh,<SUP>1<.SUP>,Haeng Soo Kim,Sang Yong Choi,Shin 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.1
<B>Purpose: </B>PET-CT is often used to differentiate benign or malignant thyroid incidentalomas. In this retrospective study, we evaluated whether the <SUP>18</SUP>F-FDG uptake pattern and PET-CT findings improved accuracy over the standardized uptake value (SUV). <B>Methods:</B> <SUP>18</SUP>F-FDG PET-CT was performed on 2,178 subjects from August, 2004, to October, 2007, in Sung-ae Hospital. PET-CT was performed on 806 patients (37%) with suspected or known nonthyroidal cancer and 1,372 healthy subjects (63%) without a previous history of cancer. We investigated the clinical characteristics of patients, history, standardized uptake value (SUV), ultrasonography, and hormone levels in blood. Thyroidal cancer was confirmed by ultrasonography-guided fine needle aspiration and pathology after thyroid operation. <B>Results:</B> The prevalence of focal thyroid lesions on PET-CT was 8.8% (191/2178). Thyroid cancer confirmation was 7.9% (15/191). The maximum SUV of malignant thyroid lesions were significantly higher than that of benign lesions (7.00±3.08 vs. 4.49±1.84, P<0.001). <B>Conclusion:</B> PET-CT image interpretation that includes 18F-FDG uptake and SUV is better than PET-CT alone for differentiating benign and malignant lesions. Thyroid cancer risk increases as SUVmax levels increase. <B>(Ko</B><B></B><B>rean J Endocrine Surg 2008;8:38-42)</B>
Female adnexal tumor of probable Wolffian origin: a case report
( Sang Gap Kim ),( Jin Kuk Choi ),( Gun Sik Park ),( Kyung Seo Kim ),( Gyeong Il Nam ),( Sang Yup Oh ),( Ja Seong Koo ),( Hwa Sook Moon ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
Female adnexal tumor of probable Wolffian origin (FATWO) is a rare neoplasm arising from the remnants of the mesonephric duct, such as the broad ligament most commonly, but is also occur in mesosalpynx, fallopian tube, ovary, and peritoneum. There are no comprehensible recommendations regarding its preoperative workup and optimal treatment. It can present diagnostic difficulties and the diagnosis is based on the exclusion of other neoplasms. It should be differentiated from other possibilities with careful pathological and immunohistochemical examination. Case: A 44-year-old woman presented to our hospital after being diagnosed with an ovarian cyst. A transvaginal ultrasonography demonstrated right ovarian cyst measuring 6.25 X 4.85 cm with irregular cystic margin. MRI was performed. A 6.1 X 8.5 X 7.5 cm sized oval shaped septated cystic lesion with peripheral and septal nodular enhancing portions in right adnexa was noted. Under the impression of ovarian malignancy, single port laparoscopic mass excision was carried out. The frozen section was reported as atypical cell proliferation, with no necrosis and no mitosis. But, in microscopic findings of permanent section, the result was FATWO with mild nuclear atypia, mitosis 0-2/10HPF, moderate to marked cellularity. The results of immunohistochemical stainings were positive for vimentin and inhibin, focal positive for calretinin, CK(cocktain), Ki-67, and negative for EMA. Based on these histomorphologic findings, the diagnosis of FATWO was made. During 1year postoperative follow up, there was no sign or symptom of recurrence and metastasis. Conclusion: FATWO is usually considered as a benign lesion, but has a malignant potential. Therefore patients need long-term follow up for possible recurrence and metastasis after the initial surgical treatment.
CHOI, JAE YEON,HONG, WAN GI,CHO, JEONG HYUN,KIM, EUN MI,KIM, JONGDOO,JUNG, CHAN-HUN,HWANG, SANG-GU,UM, HONG-DUCK,PARK, JONG KUK D.A. Spandidos 2015 International journal of oncology Vol.47 No.4
<P>We previously reported that podophyllotoxin acetate (PA) radiosensitizes NCI-H460 cells. Here, we confirmed that PA treatment also induces cell death among two other non-small cell lung cancer (NSCLC) cell lines: NCI-H1299 and A549 cells (IC<SUB>50</SUB> values = 7.6 and 16.1 nM, respectively). Our experiments further showed that PA treatment was able to induce cell death via various mechanisms. First, PA dose-dependently induced cell cycle arrest at G2/M phase, as shown by accumulation of the mitosis-related proteins, p21, survivin and Aurora B. This G2/M phase arrest was due to the PA-induced inhibition of microtubule polymerization. Together, the decreased microtubule polymerization and increased cell cycle arrest induced DNA damage (reflected by accumulation of γ-H2AX) and triggered the induction of intrinsic and extrinsic apoptotic pathways, as shown by the time-dependent activations of caspase-3, -8 and -9. Second, PA time-dependently activated the pro-apoptotic ER stress pathway, as evidenced by increased expression levels of BiP, CHOP, IRE1-α, phospho-PERK, and phospho-JNK. Third, PA activated autophagy, as reflected by time-dependent increases in the expression levels of beclin-1, Atg3, Atg5 and Atg7, and the cleavage of LC3. Collectively, these results suggest a model wherein PA decreases microtubule polymerization and increases cell cycle arrest, thereby inducing apoptotic cell death via the activation of DNA damage, ER stress and autophagy.</P>
Sung Yul Chu,Jae Young Jang,Sukjin Choi,Young Jae Kim,Ki Sung Chang,Tae Kuk Ko IEEE 2011 IEEE transactions on applied superconductivity Vol.21 No.3
<P>To design a large scale superconducting fault current limiter (SFCL) for power grids, a single long-length YBCO coated conductor (CC) wire is preferred. However this single YBCO CC wire can cause a problem of unequal voltage distribution between the parts on the long wire at quench by the faults. Inhomogeneous critical current of the YBCO CCs in the SFCL is a possibility. Furthermore, sub-cooled liquid nitrogen (LN<SUB>2</SUB>) condition is usually used to increase current capacity of the SFCL. However, this sub-cooled condition can worsen the inhomogeneity between the YBCO CCs. Therefore, it is important to understand the relation between the unequal voltage distribution and the inhomogeneous critical currents in the single long length YBCO CC. In this paper, experiments with the same single YBCO CC wire were conducted in various temperature conditions, LN<SUB>2</SUB> and sub-cooled LN<SUB>2</SUB> . In both experiments, the critical currents and voltage distributions generated by faults at short-circuit tests were measured. It was observed that the inhomogeneous condition impacts on the unequal voltage distribution.</P>
Sang-Kuk Kim,Hong-Jib Choi,In-Jung Lee 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04
This study was conducted in an effort to evaluate the effect of two gibberellin biosynthetic inhitiors, mepiquat chloride (MC 200, 400, 600 ppm) and trinexapac-ethyl ethyl (TNE 100, 200, 300 ppm) on flax (Linum usitatissimum L.) seed oil composition, growth characteristics and seed yield when applied at vegetative stage. A foliar spray of 600 ppm MC was found to be most effective, resulting in decreased plant height, and an increased seed yield (1,963 kg ha-1) with highest oil content (37.2 %). Ripened seed rate ranged 90.2 –91.9% in MC treated flax and 93.7- 94.1% in TE treated flax, respectively. MC treatment increased seed yield 10.9 – 21.6% and TNE treatment also increased 7.9 –11.8% compared to the control. The significant increase of flax seed yield in MC treatment was observed 600 ppm between these concentrations. Two gibberellin biosynthetic inhibitors, MC and TNE were 1.6 – 5.5% more ripened compared to the control. An increased unsaturated fatty acid was observed when higher concentration was applied to flax plant. Endogenous GA4 content was always higher than GA1 content in both MC and TE treatment.
Acute and Subchronic Inhalation Toxicity of n-Octane in Rats
Sung, Jae-Hyuck,Choi, Byung-Gil,Kim, Hyeon-Yeong,Baek, Min-Won,Ryu, Hyun-Youl,Kim, Yong-Soon,Choi, Young-Kuk,Yu, Il-Je,Song, Kyung-Seuk Occupational Safety and Health Research Institute 2010 Safety and health at work Vol.1 No.2
Objectives: We have investigated the toxic effects of the inhalation of subchronic and acute levels of n-octane. Methods: The rats were exposed to n-octane of 0, 2.34, 11.68 and 23.36 mg/L (n = 5 rats/group/gender) in an acute inhalation test (Organization for Economic Co-operation and Development (OECD) TG 403), or to 0, 0.93, 2.62 and 7.48 mg/L (n = 10 rats/group/gender) for a subchronic inhalation test (OECE TG 413), to establish a national chemical management system consistent with the Globally Harmonized Classification System (GHS). Results: Acutely-exposed rats became lethargic but recovered following discontinuation of inhalation. Other clinical symptoms such as change of body weight and autopsy finds were absent. The LC50 for the acute inhalation toxicity of n-octane was determined to exceed 23.36 mg/L and the GHS category was 'not grouping'. Subchronically-treated rats displayed no significant clinical and histopathological differences from untreated controls; also, target organs were affected hematologically, biochemically and pathologically. Therefore, the no observable adverse effect level was indicated as exceeding 7.48 mg/L and the GHS category was 'not grouping' for the specific target organ toxicity upon repeated exposure. Conclusion: However, n-octane exposure should be controlled to be below the American Conference of Industrial Hygienists recommendation (300 ppm) to prevent inhalation-related adverse health effects of workers.
Standardization of S&T Information Flow Process based on ISO9001
Sang-Kuk Kim,Byeong-Seon Choi 한국콘텐츠학회 2009 ICCC International Digital Design Invitation Exhib Vol.2009 No.12
Recently, numerous government institutions and information service organizations have shown interests in employing ISO 9001 Quality Management System(QMS) to increase their organizational performances. However, due to the gap between the system requirements and the process oriented goals in reality, they have not been able to merit from the ISO 9001 QMS. SO, Korea Institute of Science and Technology Information(KISTI) has been designed a process oriented system by incorporating the process analysis results into the existing ISO 9001 system requirements for enhancing organizational competitiveness and promoting productivity through a process standardization to S&T(Science and Technology) information flow. As a result, KISTI has been ISO 9001:2000 certificate in November 11, 2003. And we obtain a improvement of customer satisfaction and efficiency of work, reduction of work processing time using KQMS.
Choi, Jae-Hoon,Yang, Hyung-Lyeol,Ahn, Hyun-Sik,Jang, Gye-Yong,Lee, Dong-Keun,Kim, Kuk-Hee,Hahn, Sang-Hee,Kim, Chang-Hwan,Hong, Jae-Sic,Chu, Yong,Kong, Jong-Dae,Hong, Seong-Lok,Hwang, In-Sung Korean Nuclear Society 2008 Nuclear Engineering and Technology Vol.40 No.6
The KSTAR Magnet Power Supply (MPS) was dedicated to the SC coil commissioning and $1^{st}$ plasma experiment as a part of the system commissioning. Although many efforts to develop large-current power supplies that are useful for high power electronic devices have been made in various application fields, such as for large metal-plating devices, there were clear discrepancies between conventional power supply technologies and that for the SC coils due to the special SC coil load conditions. Therefore, most of the power supply technologies for the SC coils were a challenge in the domestic research area due to their limited application. However, the MPS commissioning result showed that all of the hardware and controlling software operated well, and this result finally led to the success of SC coil commissioning and the KSTAR $1^{st}$ plasma experiment. This paper will describe key features of KSTAR MPS for the $1^{st}$ plasma experiment, and will also report the commissioning results of the magnet power supplies.