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이계영,민경인,정수일,박재범,안재진,김도균,김철환 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.4
Soft tissue expansion is widely used technique in oral & maxillofacial reconstruction and provide new method of reconstruction in posttraumatic alopecia, post burn, wide scar, congenital deformity, benign tumor, tattoo, etc. Expanded tissue flaps have the advantage of increased vascularity, proximity to the defect, and similarity of color and texture. They also preclude the need to advance flaps from distant sites. Tissue expansion can be used to form a well vascularized cavity to accomodate and nourish bone grafts. The following report describes the uses of tissue expanders by allowing bone grafting to correct both soft and bony defects of mandibular region
Yongsik Kim,Minkyung Bae,Woojoon Kim,Dongsik Kong,Hyun Kwang Jung,Hyungtak Kim,Sunwoong Kim,Dong Myong Kim,Dae Hwan Kim IEEE 2012 IEEE transactions on electron devices Vol.59 No.10
<P>A combination of the multifrequency <I>C</I>- <I>V</I> and the generation-recombination current spectroscopy is proposed for a complete extraction of density of states (DOS) in amorphous InGaZnO thin-film transistors (a-IGZO TFTs) over the full subband-gap energy range (<I>EV</I> ≤ <I>E</I> ≤ <I>EC</I>) including the interface trap density between the gate oxide and the a-IGZO active layer. In particular, our result on the separate extraction of acceptor- and donor-like DOS is noticeable for a systematic design of amorphous oxide semiconductor TFTs because the former determines their dc characteristics and the latter does their threshold voltage (<I>VT</I>) instability under practical operation conditions. The proposed approach can be used to optimize the fabrication process of thin-film materials with high mobility and stability for mass-production-level amorphous oxide semiconductor TFTs.</P>
김배환 ( Bae Hwan Kim ),이준혁 ( Joon Hyuk Lee ),백두산 ( Du San Baik ),윤승욱 ( Seoung Wook Yun ),김지환 ( Ji Hwan Kim ),공재환 ( Jae Hwan Kong ),김석배 ( Seok Bae Kim ) 대한소화기학회 2007 대한소화기학회지 Vol.50 No.6
Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal tumor of the gastrointestinal tract and is generally located in the stomach and small intestine. They usually present with abdominal pain, gastrointestinal bleeding, and palpable mass. Some patients present with rare symptoms that are more common in malignant GIST. Malignant GIST combined with a liver abscess has not been reported yet in the literatures. We report a case of 67-year-old woman who suffered from liver abscess combined by malignant GIST with central necrosis and fistula in the ileum. She complained of fever, chills, and abdominal pain. Abdominal CT scan showed huge liver abscess and ileal mass with air pocket. Small bowel series showed contrast material filling into the ileal GIST mass. An operation was performed and the final diagnosis was malignant GIST of the ileum with invasion into the sigmoid colon and urinary bladder. (Korean J Gastroenterol 2007;50:393-397)
Kim, Kyung Hwan,Kim, Yong Hwy,Dho, Yun-Sik,Kim, Jung Hee,Hong, Sang Duk,Choi, Jung Won,Seol, Ho Jun,Nam, Do-Hyun,Lee, Jung-Il,Park, Chul-Kee,Kong, Doo-Sik Elsevier 2018 World neurosurgery Vol.114 No.-
<P><B>Objective</B></P> <P>Despite advances in endoscopic techniques, retrochiasmatic craniopharyngiomas (CPs) are difficult to remove completely, because the low-lying optic chiasm often provides an obstacle to an endoscopic endonasal approach. This study aimed to identify the endoscopic surgical outcomes of the retrochiasmatic CP and resolve the issues related to low-lying optic chiasm.</P> <P><B>Methods</B></P> <P>We reviewed 154 consecutive patients with CP who underwent endonasal endoscopic resection from February 2009 to April 2017 at 2 independent institutions. The topographic relationship of the tumor with the third ventricle, stalk, and optic chiasm and clinical outcomes were investigated.</P> <P><B>Results</B></P> <P>Retrochiasmatic CPs were found in 142 of 154 patients (92.2%). The median follow-up time was 25 months. Gross total resection and near-total resection were achieved in 113 patients (79.6%) and 21 patients (13.8%), respectively. Postoperative cerebrospinal fluid leaks were found in 16 patients (11.3%). Low-lying and high-lying chiasms were found in 44 patients (31.0%) and 98 patients (69.0%), respectively. Low-lying chiasm did not affect clinical outcomes including the extent of resection. Patients with low-lying chiasm showed a marginal trend for postoperative visual deterioration. The ventricular growth pattern representing the origin of the tumor and previous surgery were significantly associated with the position of the optic chiasm (<I>P</I> = 0.007 and 0.001, respectively).</P> <P><B>Conclusions</B></P> <P>An endoscopic endonasal approach is an effective surgical approach for retrochiasmatic CP, even in tumors with low-lying chiasm. However, a thorough and careful dissection is necessary to prevent visual deterioration.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Low-lying chiasm can interfere with endoscopic approach for craniopharyngioma. </LI> <LI> The position of optic chiasm is affected by tumor origin previous surgery. </LI> <LI> Low-lying chiasm does not alter clinical outcomes including extent of resection. </LI> <LI> Endoscopic endonasal approach is feasible even in the presence of low-lying chiasm. </LI> </UL> </P>
Electrical properties of polyaniline nanofibre synthesized with biocatalyst
Kim, Byoung-Kye,Kim, Yong Hwan,Won, Keehoon,Chang, Hyunju,Choi, Youngmin,Kong, Ki-jeong,Rhyu, Beoyong Whan,Kim, Ju-Jin,Lee, Jeong-O IOP Pub 2005 Nanotechnology Vol.16 No.8
<P>Polyaniline (PANI) nanofibres were synthesized using a biocatalyst (recombinant <I>Coprinus cinereus</I> peroxidase) instead of toxic chemical oxidants. Relatively uniform nanofibres with 50–100 nm diameter were easily obtained with this method, and the doping state of the PANI nanofibre could be controlled either with 1N camphorsulfonic acid (CSA) or with 30% NH<SUB>4</SUB>OH. Doped (or dedoped) PANI nanofibres were deposited on pre-patterned Au electrodes for electrical characterization. Completely dedoped PANI behaves as an insulator, while a larger current, by more than four orders of magnitude, was observed from doped PANI nanofibres. A weak p-type gate effect was observed for PANI nanofibre devices as well. As one could expect from the easy doping nature of PANI, PANI nanofibre devices show high sensitivity toward dedoping (NH<SUB>3</SUB>) gases, thereby demonstrating the possibility of using enzyme-synthesized PANI nanofibre devices as sensitive chemical sensors. </P>
Kim Jin Seok,Jang Jun Ho,Jo Deog-Yeon,Ahn Seo-Yeon,Yoon Sung-Soo,Lee Je-Hwan,Kim Sung-Hyun,Choi Chul Won,Shin Ho-Jin,Kim Min-Kyoung,Lee Jae Hoon,Mun Yeung-Chul,Kong Jee Hyun,Hyun BokJin,Nam HyunSun,Ki 대한의학회 2023 Journal of Korean medical science Vol.38 No.41
Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by uncontrolled terminal complement activation. Eculizumab, a monoclonal antibody C5 inhibitor was introduced in Korea in 2009 and has been the standard treatment option for PNH. Methods: This study assessed the long-term efficacy/safety of eculizumab in PNH using real-world data from the Korean Health Insurance Review and Assessment Service. Eighty patients who initiated eculizumab from 2009–2020 were enrolled. Results: At eculizumab initiation, the median age was 51.5 years, lactate dehydrogenase (LDH) 6.8 × upper limit of normal, and granulocyte clone size 93.0%. All patients had at least one PNH-related complication before eculizumab initiation, including renal failure (n = 36), smooth muscle spasm (n = 24), thromboembolism (n = 20), and pulmonary hypertension (n = 15). The median (range) duration of eculizumab treatment was 52.7 (1.0, 127.3) months (338.6 total treated patient-years). Despite high disease activity in the study population before treatment initiation, overall survival was 96.2% and LDH levels were stabilized in most patients during treatment. PNH-related complications at treatment initiation were resolved in 44.4% of patients with renal failure, 95.8% with smooth muscle spasm, 70.0% with thromboembolism, and 26.7% with pulmonary hypertension. Extravascular hemolysis occurred in 28.8% of patients (n = 23; 0.09 per patient-year) and breakthrough hemolysis in 18.8% (n = 15; 0.06 per patient-year). No treatment discontinuation cases related to eculizumab were observed. Conclusion: These data provided evidence for the long-term efficacy and safety of eculizumab in Korean PNH patients with high disease burdens.